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Conserved domains on  [gi|71998945|ref|NP_001022531|]
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Galectin [Caenorhabditis elegans]

Protein Classification

galectin family protein( domain architecture ID 10049222)

galectin family protein may exclusively bind beta-galactosides such as lactose in a manner independent of metal ions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 158-276 2.49e-52

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


:

Pssm-ID: 238025  Cd Length: 127  Bit Score: 167.04  E-value: 2.49e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945 158 GLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEKSVVRNSLVNGEWGNEEREGKNPFERLTAFDLEIRNEE 237
Cdd:cd00070   9 GLKPGSTLTVKGRVLPNAKRFSINLGTGSSDIALHFNPRFDENVIVRNSFLNGNWGPEERSGGFPFQPGQPFELTILVEE 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 71998945 238 FAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 276
Cdd:cd00070  89 DKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 10-140 2.17e-47

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


:

Pssm-ID: 238025  Cd Length: 127  Bit Score: 154.71  E-value: 2.17e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945  10 PYRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDSpdfsgNDVPLHLSIRFDEGKIVYNAYTKGTWGKEERAK-NPIK 88
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGS-----SDIALHFNPRFDENVIVRNSFLNGNWGPEERSGgFPFQ 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 71998945  89 KGDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:cd00070  76 PGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 158-276 2.49e-52

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 167.04  E-value: 2.49e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945 158 GLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEKSVVRNSLVNGEWGNEEREGKNPFERLTAFDLEIRNEE 237
Cdd:cd00070   9 GLKPGSTLTVKGRVLPNAKRFSINLGTGSSDIALHFNPRFDENVIVRNSFLNGNWGPEERSGGFPFQPGQPFELTILVEE 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 71998945 238 FAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 276
Cdd:cd00070  89 DKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 158-276 1.16e-50

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 162.76  E-value: 1.16e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945    158 GLVPGKTLVVYGTPEKKAKKFNINLLKK-NGDIALHFNPRFDEKSVVRNSLVNGEWGNEEREGKNPFERLTAFDLEIRNE 236
Cdd:smart00908   3 GLSPGSSITIRGIVLPDAKRFSINLQCGpNADIALHFNPRFDEGTIVRNSKQNGKWGKEERSGGFPFQPGQPFELEILVE 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 71998945    237 EFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 276
Cdd:smart00908  83 EDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 10-140 2.17e-47

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 154.71  E-value: 2.17e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945  10 PYRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDSpdfsgNDVPLHLSIRFDEGKIVYNAYTKGTWGKEERAK-NPIK 88
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGS-----SDIALHFNPRFDENVIVRNSFLNGNWGPEERSGgFPFQ 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 71998945  89 KGDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:cd00070  76 PGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 158-276 6.67e-47

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 153.18  E-value: 6.67e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945   158 GLVPGKTLVVYGTPEKKAKKFNINLLK---KNGDIALHFNPRFDEKSVVRNSLVNGEWGNEEREGKNPFERLTAFDLEIR 234
Cdd:pfam00337   3 GLQPGSSLTIKGIVLPDAQRFSINLQTgvgPSDDIALHFNPRFDENVIVRNSRQNGQWGQEEREGGFPFQPGQPFELTIL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 71998945   235 NEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 276
Cdd:pfam00337  83 VGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 11-141 7.22e-46

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 150.84  E-value: 7.22e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945     11 YRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDspdfsGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEER-AKNPIKK 89
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTG-----GDDIALHFNPRFNENKIVCNSKLNGSWGSEEReGGFPFQP 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 71998945     90 GDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQW 141
Cdd:smart00276  76 GQPFDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSF 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 20-140 5.29e-37

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 127.76  E-value: 5.29e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945    20 EPGQTLIIRGKTIDESKRFNINLHKDspDFSGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEER-AKNPIKKGDDFDIRIR 98
Cdd:pfam00337   5 QPGSSLTIKGIVLPDAQRFSINLQTG--VGPSDDIALHFNPRFDENVIVRNSRQNGQWGQEEReGGFPFQPGQPFELTIL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 71998945    99 AHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:pfam00337  83 VGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 158-276 2.49e-52

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 167.04  E-value: 2.49e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945 158 GLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEKSVVRNSLVNGEWGNEEREGKNPFERLTAFDLEIRNEE 237
Cdd:cd00070   9 GLKPGSTLTVKGRVLPNAKRFSINLGTGSSDIALHFNPRFDENVIVRNSFLNGNWGPEERSGGFPFQPGQPFELTILVEE 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 71998945 238 FAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 276
Cdd:cd00070  89 DKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 158-276 1.16e-50

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 162.76  E-value: 1.16e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945    158 GLVPGKTLVVYGTPEKKAKKFNINLLKK-NGDIALHFNPRFDEKSVVRNSLVNGEWGNEEREGKNPFERLTAFDLEIRNE 236
Cdd:smart00908   3 GLSPGSSITIRGIVLPDAKRFSINLQCGpNADIALHFNPRFDEGTIVRNSKQNGKWGKEERSGGFPFQPGQPFELEILVE 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 71998945    237 EFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 276
Cdd:smart00908  83 EDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 158-277 7.03e-49

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 158.55  E-value: 7.03e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945    158 GLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEKSVVRNSLVNGEWGNEEREGKNPFERLTAFDLEIRNEE 237
Cdd:smart00276   8 GLKPGQTLTVRGIVLPDAKRFSINLLTGGDDIALHFNPRFNENKIVCNSKLNGSWGSEEREGGFPFQPGQPFDLTIIVQP 87

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 71998945    238 FAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQV 277
Cdd:smart00276  88 DHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSF 127
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 10-140 2.17e-47

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 154.71  E-value: 2.17e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945  10 PYRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDSpdfsgNDVPLHLSIRFDEGKIVYNAYTKGTWGKEERAK-NPIK 88
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGS-----SDIALHFNPRFDENVIVRNSFLNGNWGPEERSGgFPFQ 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 71998945  89 KGDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:cd00070  76 PGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 158-276 6.67e-47

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 153.18  E-value: 6.67e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945   158 GLVPGKTLVVYGTPEKKAKKFNINLLK---KNGDIALHFNPRFDEKSVVRNSLVNGEWGNEEREGKNPFERLTAFDLEIR 234
Cdd:pfam00337   3 GLQPGSSLTIKGIVLPDAQRFSINLQTgvgPSDDIALHFNPRFDENVIVRNSRQNGQWGQEEREGGFPFQPGQPFELTIL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 71998945   235 NEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 276
Cdd:pfam00337  83 VGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 11-141 7.22e-46

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 150.84  E-value: 7.22e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945     11 YRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDspdfsGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEER-AKNPIKK 89
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTG-----GDDIALHFNPRFNENKIVCNSKLNGSWGSEEReGGFPFQP 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 71998945     90 GDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQW 141
Cdd:smart00276  76 GQPFDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSF 127
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 20-140 1.44e-44

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 146.97  E-value: 1.44e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945     20 EPGQTLIIRGKTIDESKRFNINLHKDSPDfsgnDVPLHLSIRFDEGKIVYNAYTKGTWGKEER-AKNPIKKGDDFDIRIR 98
Cdd:smart00908   5 SPGSSITIRGIVLPDAKRFSINLQCGPNA----DIALHFNPRFDEGTIVRNSKQNGKWGKEERsGGFPFQPGQPFELEIL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 71998945     99 AHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:smart00908  81 VEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 20-140 5.29e-37

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 127.76  E-value: 5.29e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998945    20 EPGQTLIIRGKTIDESKRFNINLHKDspDFSGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEER-AKNPIKKGDDFDIRIR 98
Cdd:pfam00337   5 QPGSSLTIKGIVLPDAQRFSINLQTG--VGPSDDIALHFNPRFDENVIVRNSRQNGQWGQEEReGGFPFQPGQPFELTIL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 71998945    99 AHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:pfam00337  83 VGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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