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Conserved domains on  [gi|71993778|ref|NP_001022864|]
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Leucine-rich repeat-containing protein 58 [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-304 1.62e-31

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.51  E-value: 1.62e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  50 HIEQPEEDYDPQNVKKLDLTHNSFVIL-RGLTTFNNVSVLDVSFNSLSALPEDIGTLSSLTTLIARNNLLEHLPKGLQLL 128
Cdd:COG4886 102 DLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 129 ENLEHLYLSGNRLEYVPPVILTMRKLKTLHLGGNYIDSCPSNISVLTLLRVLYLGGNRLREIPaSIGCLDELENLGLCDN 208
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 209 ILETIPStLGDLHYLETLSLHNNRLRTLPTDILNLRRLQQLSLRNNPLVHSFVHNMDLAPPSLKELSGRTVRQNYHKVPN 288
Cdd:COG4886 261 QLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                       250
                ....*....|....*.
gi 71993778 289 LDEILPSDLVAYLGSA 304
Cdd:COG4886 340 LALSLSLLALLTLLLL 355
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-304 1.62e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.51  E-value: 1.62e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  50 HIEQPEEDYDPQNVKKLDLTHNSFVIL-RGLTTFNNVSVLDVSFNSLSALPEDIGTLSSLTTLIARNNLLEHLPKGLQLL 128
Cdd:COG4886 102 DLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 129 ENLEHLYLSGNRLEYVPPVILTMRKLKTLHLGGNYIDSCPSNISVLTLLRVLYLGGNRLREIPaSIGCLDELENLGLCDN 208
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 209 ILETIPStLGDLHYLETLSLHNNRLRTLPTDILNLRRLQQLSLRNNPLVHSFVHNMDLAPPSLKELSGRTVRQNYHKVPN 288
Cdd:COG4886 261 QLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                       250
                ....*....|....*.
gi 71993778 289 LDEILPSDLVAYLGSA 304
Cdd:COG4886 340 LALSLSLLALLTLLLL 355
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 100-282 3.40e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.75  E-value: 3.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 100 EDIGTLSSLTTLIARNNLLEHLPkGLQLLENLEHLYLSGNRLEYVPPvILTMRKLKTLHLGGNYIdSCPSNISVLTLLRV 179
Cdd:cd21340  18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRI-SVVEGLENLTNLEE 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 180 LYLGGNRLRE------IPASIGCL-DELENLGLCDNILETIpSTLGDLHYLETLSLHNNRLR---TLPTDILNLRRLQQL 249
Cdd:cd21340  95 LHIENQRLPPgekltfDPRSLAALsNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLREL 173

                       170       180       190
                ....*....|....*....|....*....|....*
gi 71993778 250 SLRNNPL--VHSFVHNMDLAPPSLKELSGRTVRQN 282
Cdd:cd21340 174 DLTGNPVckKPKYRDKIILASKSLEVLDGKEITDT 208
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-256 3.18e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 3.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   66 LDLTHNSFV--ILRGltTFNNVSVLDVSFNSLSA-LPEDIGTLSSLTTL-IARNNLLEHLPKGLQLLENLEHLYLSGNRL 141
Cdd:PLN00113 123 LNLSNNNFTgsIPRG--SIPNLETLDLSNNMLSGeIPNDIGSFSSLKVLdLGGNVLVGKIPNSLTNLTSLEFLTLASNQL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  142 E-YVPPVILTMRKLKTLHLGGNyidscpsNISvltllrvlylggnrlREIPASIGCLDELENLGLC-DNILETIPSTLGD 219
Cdd:PLN00113 201 VgQIPRELGQMKSLKWIYLGYN-------NLS---------------GEIPYEIGGLTSLNHLDLVyNNLTGPIPSSLGN 258

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 71993778  220 LHYLETLSLHNNRLR-TLPTDILNLRRLQQLSLRNNPL 256
Cdd:PLN00113 259 LKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
LRR_8 pfam13855
Leucine rich repeat;
199-256 2.71e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   199 ELENLGLCDNILETI-PSTLGDLHYLETLSLHNNRLRTL-PTDILNLRRLQQLSLRNNPL 256
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-304 1.62e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 123.51  E-value: 1.62e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  50 HIEQPEEDYDPQNVKKLDLTHNSFVIL-RGLTTFNNVSVLDVSFNSLSALPEDIGTLSSLTTLIARNNLLEHLPKGLQLL 128
Cdd:COG4886 102 DLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNL 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 129 ENLEHLYLSGNRLEYVPPVILTMRKLKTLHLGGNYIDSCPSNISVLTLLRVLYLGGNRLREIPaSIGCLDELENLGLCDN 208
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNN 260

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 209 ILETIPStLGDLHYLETLSLHNNRLRTLPTDILNLRRLQQLSLRNNPLVHSFVHNMDLAPPSLKELSGRTVRQNYHKVPN 288
Cdd:COG4886 261 QLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                       250
                ....*....|....*.
gi 71993778 289 LDEILPSDLVAYLGSA 304
Cdd:COG4886 340 LALSLSLLALLTLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-256 9.11e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.19  E-value: 9.11e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  55 EEDYDPQNVKKLDLTHNSFVILRGLTTFNNVSVLDVSFNSLSALPEDIGTLSSLTTLIARNNllehlpKGLQLLENLEHL 134
Cdd:COG4886  45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESL 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 135 YLSGNRLEYVPPVILTMRKLKTLHLGGNYIDSCPSNISVLTLLRVLYLGGNRLREIPASIGCLDELENLGLCDNILETIP 214
Cdd:COG4886 119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLP 198

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 71993778 215 STLGDLHYLETLSLHNNRLRTLPTDILNLRRLQQLSLRNNPL 256
Cdd:COG4886 199 EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-256 1.03e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 1.03e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  88 LDVSFNSLSALPEDIGTLSSLTTLIARNNLLEHLPKGLQLLENLEHLYLSGNRLEYVPPVILTMRKLKTLHLGGNyidsc 167
Cdd:COG4886  32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 168 pSNISVLTLLRVLYLGGNRLREIPASIGCLDELENLGLCDNILETIPSTLGDLHYLETLSLHNNRLRTLPTDILNLRRLQ 247
Cdd:COG4886 107 -EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185


                ....*....
gi 71993778 248 QLSLRNNPL 256
Cdd:COG4886 186 ELDLSNNQI 194
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 100-282 3.40e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.75  E-value: 3.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 100 EDIGTLSSLTTLIARNNLLEHLPkGLQLLENLEHLYLSGNRLEYVPPvILTMRKLKTLHLGGNYIdSCPSNISVLTLLRV 179
Cdd:cd21340  18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRI-SVVEGLENLTNLEE 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 180 LYLGGNRLRE------IPASIGCL-DELENLGLCDNILETIpSTLGDLHYLETLSLHNNRLR---TLPTDILNLRRLQQL 249
Cdd:cd21340  95 LHIENQRLPPgekltfDPRSLAALsNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLREL 173

                       170       180       190
                ....*....|....*....|....*....|....*
gi 71993778 250 SLRNNPL--VHSFVHNMDLAPPSLKELSGRTVRQN 282
Cdd:cd21340 174 DLTGNPVckKPKYRDKIILASKSLEVLDGKEITDT 208
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-256 3.18e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 3.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   66 LDLTHNSFV--ILRGltTFNNVSVLDVSFNSLSA-LPEDIGTLSSLTTL-IARNNLLEHLPKGLQLLENLEHLYLSGNRL 141
Cdd:PLN00113 123 LNLSNNNFTgsIPRG--SIPNLETLDLSNNMLSGeIPNDIGSFSSLKVLdLGGNVLVGKIPNSLTNLTSLEFLTLASNQL 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  142 E-YVPPVILTMRKLKTLHLGGNyidscpsNISvltllrvlylggnrlREIPASIGCLDELENLGLC-DNILETIPSTLGD 219
Cdd:PLN00113 201 VgQIPRELGQMKSLKWIYLGYN-------NLS---------------GEIPYEIGGLTSLNHLDLVyNNLTGPIPSSLGN 258

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 71993778  220 LHYLETLSLHNNRLR-TLPTDILNLRRLQQLSLRNNPL 256
Cdd:PLN00113 259 LKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-268 1.57e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 1.57e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  54 PEEDYDPQNVKKLDLTHNSFVIL-RGLTTFNNVSVLDVSFNSLSALPEdIGTLSSLTTLIARNNLLEHLPKGLQLlENLE 132
Cdd:COG4886 198 PEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLANL-TNLK 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 133 HLYLSGNRLEYVPPVILTMRKLKTLHLGGNYIDSCPSNISVLTLLRVLYLGGNRLREIPASIGCLDELENLGLCDNILET 212
Cdd:COG4886 276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLL 355

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 71993778 213 IPSTLGDLHYLETLSLHNNRLRTLPTDILNLRRLQQLSLRNNPLVHSFVHNMDLAP 268
Cdd:COG4886 356 LNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
83-297 4.78e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 4.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   83 NNVSVLDVSFNSLSALPEDIGtlSSLTTLIARNNLLEHLPKGLQllENLEHLYLSGNRLEYVPPVIltmrklktlhlggn 162
Cdd:PRK15370 178 NNKTELRLKILGLTTIPACIP--EQITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATL-------------- 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  163 yidscPSNISVLTLLRvlylggNRLREIPASIGclDELENLGLCDNILETIPSTLGDlhYLETLSLHNNRLRTLPTDIln 242
Cdd:PRK15370 240 -----PDTIQEMELSI------NRITELPERLP--SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHL-- 302

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71993778  243 lrrlqqlslrNNPLVHSFVHNMDLA------PPSLKelsgrTVRQNYHKVPNLDEILPSDL 297
Cdd:PRK15370 303 ----------PSGITHLNVQSNSLTalpetlPPGLK-----TLEAGENALTSLPASLPPEL 348
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-256 5.05e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 5.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   66 LDLTHNSFV--ILRGLTTFNNVSVLDVSFNSLSA-LPEDIGTLSSLTTLIARNNLLE-HLPKGLQLLENLEHLYLSGNRL 141
Cdd:PLN00113 337 LQLWSNKFSgeIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  142 EYVPPVILTmrKLKTLhlggNYIDSCPSNIS--------VLTLLRVLYLGGNR-LREIPASIGClDELENLGLCDN-ILE 211
Cdd:PLN00113 417 SGELPSEFT--KLPLV----YFLDISNNNLQgrinsrkwDMPSLQMLSLARNKfFGGLPDSFGS-KRLENLDLSRNqFSG 489

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 71993778  212 TIPSTLGDLHYLETLSLHNNRLR-TLPTDILNLRRLQQLSLRNNPL 256
Cdd:PLN00113 490 AVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQL 535
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
82-256 4.66e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.78  E-value: 4.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   82 FNNVSVLDVSFNSLSALPedigtlSSLTTLIARNNLLEHLPKglqLLENLEHLYLSGNRLEYVPPVILTMRKLKTLHlgg 161
Cdd:PRK15387 304 LQELSVSDNQLASLPALP------SELCKLWAYNNQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKLWAYN--- 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  162 NYIDSCPSnisVLTLLRVLYLGGNRLREIPAsigCLDELENLGLCDNILETIPSTLGDLHyleTLSLHNNRLRTLPTDIL 241
Cdd:PRK15387 372 NRLTSLPA---LPSGLKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLPMLPSGLL---SLSVYRNQLTRLPESLI 442

                        170
                 ....*....|....*
gi 71993778  242 NLRRLQQLSLRNNPL 256
Cdd:PRK15387 443 HLSSETTVNLEGNPL 457
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 79-260 7.14e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 51.41  E-value: 7.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778    79 LTTFNNVSVLDVS-FNSLSALPEDIGTLSSLTTL-IARNNLLEHLPKGLQLlENLEHLYLSG-NRLEYVPPVILTmrkLK 155
Cdd:PLN03210  653 LSMATNLETLKLSdCSSLVELPSSIQYLNKLEDLdMSRCENLEILPTGINL-KSLYRLNLSGcSRLKSFPDISTN---IS 728

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   156 TLHLGGNYIDSCPSNISV--LTLLRVLYLGGNRLRE-----IPASIGCLDELENLGLCDN-ILETIPSTLGDLHYLETLS 227
Cdd:PLN03210  729 WLDLDETAIEEFPSNLRLenLDELILCEMKSEKLWErvqplTPLMTMLSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLE 808

                         170       180       190
                  ....*....|....*....|....*....|....
gi 71993778   228 LHNNR-LRTLPTDIlNLRRLQQLSLRNNPLVHSF 260
Cdd:PLN03210  809 IENCInLETLPTGI-NLESLESLDLSGCSRLRTF 841
PLN03150 PLN03150
hypothetical protein; Provisional
 121-206 7.27e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.97  E-value: 7.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  121 LPKGLQLLENLEHLYLSGNRLE-YVPPVILTMRKLKTLHLGGNYID-SCPSNISVLTLLRVLYLGGNRLR-EIPASIGCL 197
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALGGR 513

                         90
                 ....*....|....*.
gi 71993778  198 -------DELENLGLC 206
Cdd:PLN03150 514 llhrasfNFTDNAGLC 529
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-256 7.72e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 7.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   66 LDLTHNSFV--ILRGLTTFNNVSVLDVSFNSLSA-LPEDIGTLSSLTTL-IARNNLLEHLPKGLQLLENLEHLYLSGNRL 141
Cdd:PLN00113 241 LDLVYNNLTgpIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLdLSDNSLSGEIPELVIQLQNLEILHLFSNNF 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  142 EYVPPVILT-MRKLKTLHLGGNYID-SCPSNISVLTLLRVLYLGGNRLR-EIPASIGCLDELENLGLCDNILET-IPSTL 217
Cdd:PLN00113 321 TGKIPVALTsLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSL 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 71993778  218 GDLHYLETLSLHNNRLR-TLPTDILNLRRLQQLSLRNNPL 256
Cdd:PLN00113 401 GACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440
PLN03150 PLN03150
hypothetical protein; Provisional
 168-233 1.35e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.20  E-value: 1.35e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71993778  168 PSNISVLTLLRVLYLGGNRLR-EIPASIGCLDELENLGLCDNILE-TIPSTLGDLHYLETLSLHNNRL 233
Cdd:PLN03150 435 PNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
199-256 2.71e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 2.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   199 ELENLGLCDNILETI-PSTLGDLHYLETLSLHNNRLRTL-PTDILNLRRLQQLSLRNNPL 256
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
84-141 9.41e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 9.41e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778    84 NVSVLDVSFNSLSALPEDI-GTLSSLTTLIARNNLLEHL-PKGLQLLENLEHLYLSGNRL 141
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-162 1.05e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 1.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  61 QNVKKLDLTHNSFVILRGLTTFNNVSVLDVSFNSLSA------LPEDIGTLS-SLTTL-IARNNLLEhlPKGLQLLENLE 132
Cdd:cd21340  68 VNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPgekltfDPRSLAALSnSLRVLnISGNNIDS--LEPLAPLRNLE 145

                        90       100       110
                ....*....|....*....|....*....|...
gi 71993778 133 HLYLSGNRL---EYVPPVILTMRKLKTLHLGGN 162
Cdd:cd21340 146 QLDASNNQIsdlEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
106-164 5.96e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 5.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71993778   106 SSLTTLIARNNLLEHLPKG-LQLLENLEHLYLSGNRLEYVPPVILT-MRKLKTLHLGGNYI 164
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 143-218 1.89e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 1.89e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71993778  143 YVPPVILTMRKLKTLHLGGNYID-SCPSNISVLTLLRVLYLGGNRLR-EIPASIGCLDELENLGLCDNILE-TIPSTLG 218
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 119-237 1.89e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 43.71  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   119 EHLPKGLQLL----------------ENLEHLYLSGNRLEYVPPVILTMRKLKTLHL-GGNYIDSCPsNISVLTLLRVLY 181
Cdd:PLN03210  585 DYLPPKLRLLrwdkyplrcmpsnfrpENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIP-DLSMATNLETLK 663

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   182 LGG-NRLREIPASIGCLDELENLGL--CDNiLETIPSTLgDLHYLETLSLHN-NRLRTLP 237
Cdd:PLN03210  664 LSDcSSLVELPSSIQYLNKLEDLDMsrCEN-LEILPTGI-NLKSLYRLNLSGcSRLKSFP 721
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-141 2.80e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   61 QNVKKLDLTHNSF--VILRGLTTFNNVSVLDVSFNSLSA-LPEDIGTLSSLTTL-IARNNLLEHLPKGLQLLENLEHLYL 136
Cdd:PLN00113 475 KRLENLDLSRNQFsgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLdLSHNQLSGQIPASFSEMPVLSQLDL 554


                 ....*
gi 71993778  137 SGNRL 141
Cdd:PLN00113 555 SQNQL 559
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-243 5.61e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 5.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  62 NVKKLDLTHNSFVILRGLTTFNNVSVLDVSFNSLSALPEdIGTLSSLTTLIARNN-----LLEHLPKGLQLLENLEHLYL 136
Cdd:COG4886 229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNqltdlKLKELELLLGLNSLLLLLLL 307

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 137 SGNRLEYVPPVILTMRKLKTLHLGGNYIDSCPSNISVLTLLRVLYLGGNRLREIPASIGCLDELENLGLCDNILETIPST 216
Cdd:COG4886 308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387

                       170       180
                ....*....|....*....|....*..
gi 71993778 217 LGDLHYLETLSLHNNRLRTLPTDILNL 243
Cdd:COG4886 388 TLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_8 pfam13855
Leucine rich repeat;
130-187 9.37e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 9.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   130 NLEHLYLSGNRLEYVPPVILT-MRKLKTLHLGGNYIDSCPSN-ISVLTLLRVLYLGGNRL 187
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 94-275 2.19e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 2.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  94 SLSALPEDIGTLSSLTTLIARNNLLEHLPKGLQLL-------ENLEHLYLSGNRL--EYVPPVILTMRK--LKTLHLGGN 162
Cdd:cd00116  39 AAKALASALRPQPSLKELCLSLNETGRIPRGLQSLlqgltkgCGLQELDLSDNALgpDGCGVLESLLRSssLQELKLNNN 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778 163 YID------SCPSNISVLTLLRVLYLGGNRLreipasigcldeleNLGLCDNILETIPStLGDLHyleTLSLHNNRL--- 233
Cdd:cd00116 119 GLGdrglrlLAKGLKDLPPALEKLVLGRNRL--------------EGASCEALAKALRA-NRDLK---ELNLANNGIgda 180

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 71993778 234 --RTLPTDILNLRRLQQLSLRNNPLVHSFVHNMDLAPPSLKELS 275
Cdd:cd00116 181 giRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLE 224
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-157 2.73e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 2.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  83 NNVSVLDVSFNSLSALpEDIGTLSSLTTLIARNNLLEHLPKGLQLLEN---LEHLYLSGNRLEYVP----PVILTMRKLK 155
Cdd:cd21340 120 NSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELLDLLSSwpsLRELDLTGNPVCKKPkyrdKIILASKSLE 198


                ..
gi 71993778 156 TL 157
Cdd:cd21340 199 VL 200
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 25-207 7.59e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 38.32  E-value: 7.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778    25 YPNGSTKSDELVLHDYGLEEIPMRYHIEQPEE--DYDPQNVKKLDLTHnsfvILRGLTTFNNVSVLDVSFN---SLSALP 99
Cdd:PLN03210  720 FPDISTNISWLDLDETAIEEFPSNLRLENLDEliLCEMKSEKLWERVQ----PLTPLMTMLSPSLTRLFLSdipSLVELP 795

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778   100 EDIGTLSSLTTL-IARNNLLEHLPKGLQlLENLEHLYLSG-NRLEYVPPVILTMRKLKtlhLGGNYIDSCPSNISVLTLL 177
Cdd:PLN03210  796 SSIQNLHKLEHLeIENCINLETLPTGIN-LESLESLDLSGcSRLRTFPDISTNISDLN---LSRTGIEEVPWWIEKFSNL 871

                         170       180       190
                  ....*....|....*....|....*....|.
gi 71993778   178 RVLYLGG-NRLREIPASIGCLDELENLGLCD 207
Cdd:PLN03210  872 SFLDMNGcNNLQRVSLNISKLKHLETVDFSD 902
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-187 7.71e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.72  E-value: 7.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71993778  84 NVSVLDVSFNSLSALP-EDI-GTLSSLTTL----IARNNLLE----HLPKGLQLLENLEHLYLSGNRLEYVPPVIL---- 149
Cdd:cd00116 138 ALEKLVLGRNRLEGAScEALaKALRANRDLkelnLANNGIGDagirALAEGLKANCNLEVLDLNNNGLTDEGASALaetl 217

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 71993778 150 -TMRKLKTLHLGGNYIDS------CPSNISVLTLLRVLYLGGNRL 187
Cdd:cd00116 218 aSLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCNDI 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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