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Conserved domains on  [gi|72000275|ref|NP_001024094|]
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Ground-like domain-containing protein [Caenorhabditis elegans]

Protein Classification

Ground-like domain-containing protein( domain architecture ID 10514438)

Ground-like domain-containing protein may bind and modulate the activity of Patched-like membrane molecules

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ground-like pfam04155
Ground-like domain; This family consists of the ground-like domain and is specific to C. ...
 260-330 3.31e-25

Ground-like domain; This family consists of the ground-like domain and is specific to C.elegans. It has been proposed that the ground-like domain containing proteins may bind and modulate the activity of Patched-like membrane molecules, reminiscent of the modulating activities of neuropeptides.


:

Pssm-ID: 461200  Cd Length: 73  Bit Score: 96.54  E-value: 3.31e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72000275   260 DPLCNSDDLRKVVIDNIDDQ-LNSSKRMIQLAAEAQFGGRFDVICANGDFSY-VTNTELYCQETKGDISCYTY 330
Cdd:pfam04155   1 GEKCNSEELKKIIEKNIGTCnLSESKRAIQKAAEARFGGSFEVICSEGDFSYsIFAGTLYCKVEKDGVTCLAY 73
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 45-163 5.26e-06

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 5.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   45 SGGNIVQGYVGAPQQGGYAAAPQYPQQGGYGGAQQGFQAAPAPYQPQGGYQAGPAPVQGYQPQAQVPAGGYQAPVQPAPG 124
Cdd:PRK07764 664 DGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP 743

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 72000275  125 PAEVAPAQVQAGGNYQDAPAQVAEVATAQESAPPPSEAA 163
Cdd:PRK07764 744 EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
 
Name Accession Description Interval E-value
Ground-like pfam04155
Ground-like domain; This family consists of the ground-like domain and is specific to C. ...
 260-330 3.31e-25

Ground-like domain; This family consists of the ground-like domain and is specific to C.elegans. It has been proposed that the ground-like domain containing proteins may bind and modulate the activity of Patched-like membrane molecules, reminiscent of the modulating activities of neuropeptides.


Pssm-ID: 461200  Cd Length: 73  Bit Score: 96.54  E-value: 3.31e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72000275   260 DPLCNSDDLRKVVIDNIDDQ-LNSSKRMIQLAAEAQFGGRFDVICANGDFSY-VTNTELYCQETKGDISCYTY 330
Cdd:pfam04155   1 GEKCNSEELKKIIEKNIGTCnLSESKRAIQKAAEARFGGSFEVICSEGDFSYsIFAGTLYCKVEKDGVTCLAY 73
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 45-163 5.26e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 5.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   45 SGGNIVQGYVGAPQQGGYAAAPQYPQQGGYGGAQQGFQAAPAPYQPQGGYQAGPAPVQGYQPQAQVPAGGYQAPVQPAPG 124
Cdd:PRK07764 664 DGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP 743

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 72000275  125 PAEVAPAQVQAGGNYQDAPAQVAEVATAQESAPPPSEAA 163
Cdd:PRK07764 744 EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 47-168 2.34e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.87  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275    47 GNIVQGYVGAPQ---QGGYAAAPQYPQQGGYGgaqqgfqaAPAPYQPQGGYQAGPapvQGYQPQAQVPAGGYQApvQPAP 123
Cdd:TIGR01628 388 GSPMGGAMGQPPyygQGPQQQFNGQPLGWPRM--------SMMPTPMGPGGPLRP---NGLAPMNAVRAPSRNA--QNAA 454

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 72000275   124 GPAEVAPAQVQAGGNYQDAPA-------------QVAEVATAQESAPPPSEAAYTGEQ 168
Cdd:TIGR01628 455 QKPPMQPVMYPPNYQSLPLSQdlpqpqstasqggQNKKLAQVLASATPQMQKQVLGER 512
 
Name Accession Description Interval E-value
Ground-like pfam04155
Ground-like domain; This family consists of the ground-like domain and is specific to C. ...
 260-330 3.31e-25

Ground-like domain; This family consists of the ground-like domain and is specific to C.elegans. It has been proposed that the ground-like domain containing proteins may bind and modulate the activity of Patched-like membrane molecules, reminiscent of the modulating activities of neuropeptides.


Pssm-ID: 461200  Cd Length: 73  Bit Score: 96.54  E-value: 3.31e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72000275   260 DPLCNSDDLRKVVIDNIDDQ-LNSSKRMIQLAAEAQFGGRFDVICANGDFSY-VTNTELYCQETKGDISCYTY 330
Cdd:pfam04155   1 GEKCNSEELKKIIEKNIGTCnLSESKRAIQKAAEARFGGSFEVICSEGDFSYsIFAGTLYCKVEKDGVTCLAY 73
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 45-163 5.26e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.06  E-value: 5.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   45 SGGNIVQGYVGAPQQGGYAAAPQYPQQGGYGGAQQGFQAAPAPYQPQGGYQAGPAPVQGYQPQAQVPAGGYQAPVQPAPG 124
Cdd:PRK07764 664 DGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPP 743

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 72000275  125 PAEVAPAQVQAGGNYQDAPAQVAEVATAQESAPPPSEAA 163
Cdd:PRK07764 744 EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 55-168 3.52e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 3.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   55 GAPQQGGYAAAPQYPQQGGYGGAQQGFQAAPAPyQPQGGYQAGPAPVQGYQPQAQVPAGGYQAPVQPA--PGPAEVAPAQ 132
Cdd:PRK07764 397 AAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAP-QPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSaqPAPAPAAAPE 475

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 72000275  133 VQAGGNYQDAPAQVAEVATAQESAPPPSEAAYTGEQ 168
Cdd:PRK07764 476 PTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 60-179 1.68e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 1.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   60 GGYAAAPQYPQQGGYGGAQQGFQAAPAPYQPQGGYQAGPAPvQGYQPQAQVPAggyqapVQPAPGPAEVAPAQVQAGGNy 139
Cdd:PRK07764 385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAP-AAAPQPAPAPA------PAPAPPSPAGNAPAGGAPSP- 456

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 72000275  140 QDAPAQVAEVATAQESAPPPSEAAYTGEQEVVASLAREEP 179
Cdd:PRK07764 457 PPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA 496
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 47-168 2.34e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.87  E-value: 2.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275    47 GNIVQGYVGAPQ---QGGYAAAPQYPQQGGYGgaqqgfqaAPAPYQPQGGYQAGPapvQGYQPQAQVPAGGYQApvQPAP 123
Cdd:TIGR01628 388 GSPMGGAMGQPPyygQGPQQQFNGQPLGWPRM--------SMMPTPMGPGGPLRP---NGLAPMNAVRAPSRNA--QNAA 454

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 72000275   124 GPAEVAPAQVQAGGNYQDAPA-------------QVAEVATAQESAPPPSEAAYTGEQ 168
Cdd:TIGR01628 455 QKPPMQPVMYPPNYQSLPLSQdlpqpqstasqggQNKKLAQVLASATPQMQKQVLGER 512
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 56-163 3.02e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 3.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   56 APQQGGYAAAPQYPQQGGYGGAQQGFQAAPAPYQPQGGYQAGPAPVQGY--QPQAQVPAGGYQAPVQPAPGPAEVAPAQV 133
Cdd:PRK07764 614 RPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDAsdGGDGWPAKAGGAAPAAPPPAPAPAAPAAP 693

                         90       100       110
                 ....*....|....*....|....*....|
gi 72000275  134 QAGGNYQDAPAQVAEVATAQESAPPPSEAA 163
Cdd:PRK07764 694 AGAAPAQPAPAPAATPPAGQADDPAAQPPQ 723
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 54-173 7.79e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 7.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   54 VGAPQQGGYAAAPQYPQQGGYGGAQQGFQAAPA--PYQPQGGYQAGPAPVQGYQPQAQVPAggyQAPVQPAPGPAEVAPA 131
Cdd:PRK07764 647 VAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAapPPAPAPAAPAAPAGAAPAQPAPAPAA---TPPAGQADDPAAQPPQ 723

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 72000275  132 QVQAGGNYQDAPAQVAEVATAQESAPPPSEAAYTGEQEVVAS 173
Cdd:PRK07764 724 AAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPA 765
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 55-164 2.74e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 2.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   55 GAPQQGGYAAAPQYPQQGGYGGAQQGFQAAPAPYQPQGGYQAGPAPVQGYQPQAQVPAGGyQAPVQPAPGPAEVAPAQvQ 134
Cdd:PRK07764 636 PAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAG-AAPAQPAPAPAATPPAG-Q 713

                         90       100       110
                 ....*....|....*....|....*....|....
gi 72000275  135 AGGNYQDAPAQVAEVATAQESA----PPPSEAAY 164
Cdd:PRK07764 714 ADDPAAQPPQAAQGASAPSPAAddpvPLPPEPDD 747
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 54-178 2.77e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 2.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   54 VGAPQQGGYAAAPQYPQQGGYGGAQQGFQAAPAPYQPQGGYQAGPAPVQGYQPQAQVPAGGYQAPVQPAPGPAEVAPAQV 133
Cdd:PRK07764 691 AAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAP 770

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 72000275  134 QAGgnyQDAPAQVAEVATAQESAPPPSEAAYTGEQEVVASLAREE 178
Cdd:PRK07764 771 AAA---PPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEE 812
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 83-173 7.46e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 37.92  E-value: 7.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   83 AAPAPYQPQGGYQAGPAPVQGYQPQAQVPAggyQAPVQPAPGPAEVAPAQVQAGgnyQDAPAQVAEVATAQESAPPPSEA 162
Cdd:PRK07994 370 VPPQSAAPAASAQATAAPTAAVAPPQAPAV---PPPPASAPQQAPAVPLPETTS---QLLAARQQLQRAQGATKAKKSEP 443

                         90
                 ....*....|.
gi 72000275  163 AYTGEQEVVAS 173
Cdd:PRK07994 444 AAASRARPVNS 454
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
83-163 7.51e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 37.93  E-value: 7.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   83 AAPAPyqPQGGYQAGPAPVQGYQPQAQVPAGGYQAPVQPAPGPAEVAPAQVQAGGNYQDAPAQVAEVATAQ------ESA 156
Cdd:PRK12323 372 AGPAT--AAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASargpggAPA 449


                 ....*..
gi 72000275  157 PPPSEAA 163
Cdd:PRK12323 450 PAPAPAA 456
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 63-179 8.37e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 37.77  E-value: 8.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72000275   63 AAAPQYPQQGGYGGAQQGFQAAPAPYQPQGGYQAGPAPVQGYQPQAQVPAGGYQAPVqPAPGPAEVAPAQVQAGgnyQDA 142
Cdd:PRK14951 381 PARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAA-PAAAPAAVALAPAPPA---QAA 456

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 72000275  143 PAQVAEVATAQESAPPPSEAAYTGEQEVVASLAREEP 179
Cdd:PRK14951 457 PETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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