|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
18-499 |
0e+00 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 554.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 18 LLLIVYIALFLDNMLLTTVVPIIPEYLlrmehpnetdilfshnsqkrvkrqwedddswdvplklgnnadidwdenpigpv 97
Cdd:cd17384 1 VLVIVYVALLLDNMLLTVVVPIIPDYL----------------------------------------------------- 27
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 98 grserrkesdrknhnsknreyndrrkymspaakkppveteepavrtiseeerhkllaSENVHVGLMFGSKALVQLLVNPW 177
Cdd:cd17384 28 ---------------------------------------------------------NENVRVGLLFASKALVQLITNPI 50
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 178 IGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDLERGSAMGIALGGL 257
Cdd:cd17384 51 VGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDDKERGKAMGIALGGL 130
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 258 ALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVLQPKIDRGE-PEGSSIKQLAKDPYIIVAAGAITIGNLGI 336
Cdd:cd17384 131 ALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEEsEEGTPWKTLLKDPYILIAAGAICFSNSGI 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 337 AMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIPSATSVAGLIIPH 416
Cdd:cd17384 211 AILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSLLGMLLVGISLILIPLAKNIYGLIIPH 290
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 417 ALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYAIADAAFCFAFALGPFFSGPLVKSLGFPTMMYIIAVISFLYAPLMF 496
Cdd:cd17384 291 FGLGLGIGMVDSSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGAIVKSIGFPWLMRIIGIINILYAPLLF 370
|
...
gi 71997647 497 LLK 499
Cdd:cd17384 371 FLR 373
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
155-499 |
3.94e-108 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 328.12 E-value: 3.94e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 155 SENVHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMG 234
Cdd:cd17383 27 NEDIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 235 MLAQAYPDDLERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVLQPKIDR-----GEPE 309
Cdd:cd17383 107 MIADRFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPVRREtranmPEPV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 310 GSSIKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGR--WL 387
Cdd:cd17383 187 GTPIHRLLMDPYIAVCAGALTMANVSLAFLEPTIANWMKDTMNASEWQMGLVWLPAFFPHVLGVYLTVKLAAKYPHyqWL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 388 SSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYAIADAAFCFAFALGPFF 467
Cdd:cd17383 267 MAAVGLAIEGASCFIVPFCTNFGVLIIPLCGICFGIALVDTALLPTLGFLVDVRHVSVYGSVYAIADISYSLAYALGPIV 346
|
330 340 350
....*....|....*....|....*....|..
gi 71997647 468 SGPLVKSLGFPTMMYIIAVISFLYAPLMFLLK 499
Cdd:cd17383 347 AGQIVHSIGFTQLNIGIGLANLLYAPVLLLLR 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
160-499 |
1.60e-70 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 230.93 E-value: 1.60e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQA 239
Cdd:cd17325 33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 240 YPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVLQPKI-------DRGEPEGSS 312
Cdd:cd17325 113 APPE-ERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRpppnkraVSAARLRSG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 313 IKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIG 392
Cdd:cd17325 192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 393 LVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRH----VGVYGSIYaiadaafCFAFALGPFFS 468
Cdd:cd17325 272 LLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrgtaMGLFNTAF-------SLGMVLGPLLG 344
|
330 340 350
....*....|....*....|....*....|.
gi 71997647 469 GPLVKSLGFPTMMYIIAVISFLYAPLMFLLK 499
Cdd:cd17325 345 GFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
160-450 |
1.85e-38 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 144.35 E-value: 1.85e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQA 239
Cdd:COG2814 47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 240 YPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVL-QPKIDRGEPEGSSIKQLAK 318
Cdd:COG2814 127 VPPE-RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLpESRPAARARLRGSLRELLR 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 319 DPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGF 398
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 71997647 399 SLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIY 450
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLY 337
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
160-450 |
1.25e-29 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 119.45 E-value: 1.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQA 239
Cdd:pfam07690 34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 240 YPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPF--------VLLALLALFDGSIQFMVLQPKIDRGEPEGS 311
Cdd:pfam07690 114 FPPE-ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFlilailslLAAVLLLLPRPPPESKRPKPAEEARLSLIV 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 312 SIKQLAKDPYIIVAAGAITIGnLGIAMLEPSLPLWMMESwGANSLERGAAFLPASISYLIGTNIFGPLAHRIGR---WLS 388
Cdd:pfam07690 193 AWKALLRDPVLWLLLALLLFG-FAFFGLLTYLPLYQEVL-GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRrrrLLL 270
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71997647 389 SFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIY 450
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLY 332
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
161-301 |
1.52e-29 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 113.13 E-value: 1.52e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 161 GLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAY 240
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71997647 241 PDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVLQP 301
Cdd:TIGR00880 81 PPE-ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
157-496 |
3.84e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 110.21 E-value: 3.84e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 157 NVHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGML 236
Cdd:cd06174 30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 237 AQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVLQPKIDRGEPE------- 309
Cdd:cd06174 110 ADLFPER-ERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARakneeas 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 310 ----GSSIKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHR-IG 384
Cdd:cd06174 189 sksvLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 385 RWLSSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYaiaDAAFCFAFALG 464
Cdd:cd06174 269 RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLL---NTFGFLGGAIG 345
|
330 340 350
....*....|....*....|....*....|...
gi 71997647 465 PFFSGPL-VKSLGFPTMMYIIAVISFLYAPLMF 496
Cdd:cd06174 346 PLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
160-495 |
5.20e-26 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 110.00 E-value: 5.20e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAF------GDSYFTL-WLARALQGVGSACTSTSG 232
Cdd:cd17385 36 IGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFldrvpdGTVFIALcFLVRIVEAVGFAAFITAS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 233 MGMLAQAYPDDLerGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVLQPKIDRGEPEGSS 312
Cdd:cd17385 116 FAIIAKEFPNNI--ATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFILPRYDDDPSPKSGS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 313 IKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWmMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIG-RWLSSFI 391
Cdd:cd17385 194 MLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPH-LRQFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKKiPKWLMVI 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 392 GLVVIGFSLLSI------PSATSVAGLIIPHALLGFSIGMIDASMFPLMgyLVDIRHVG------VYGSIYAIADAAFCF 459
Cdd:cd17385 273 GSIITGVGFLLLgpapllPIKSELWMVIIGLVLLGLSLGAALVPTFPEL--LNCAREYGfpdnlsTYGLVSGLFNAAFSL 350
|
330 340 350
....*....|....*....|....*....|....*.
gi 71997647 460 AFALGPFFSGPLVKSLGFPTMMYIIAVISFLYAPLM 495
Cdd:cd17385 351 GAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILM 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
157-502 |
2.50e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 107.65 E-value: 2.50e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 157 NVHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGML 236
Cdd:COG2271 44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 237 AQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVLqpkidrgepegssikql 316
Cdd:COG2271 124 AEWFPPK-ERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFWLL----------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 317 akdpyiIVAAGAITIGNLGIAMLepsLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGR--WLSSFIGLV 394
Cdd:COG2271 186 ------ALAYFLVYFALYGFLTW---LPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 395 VIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVG-VYGSIYaiadAAFCFAFALGPFFSGPLVK 473
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGtASGLVN----TFGFLGGALGPLLVGYLLD 332
|
330 340
....*....|....*....|....*....
gi 71997647 474 SLGFPTMMYIIAVISFLYAPLMFLLKNPP 502
Cdd:COG2271 333 ATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
160-502 |
4.78e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 104.19 E-value: 4.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQA 239
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 240 YPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDG--SIQFMVLQPKIDRGEPEGS--SIKQ 315
Cdd:COG2223 122 FPPD-RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAvlAWLFLRDPPAGAAAAAKASlrDQLE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 316 LAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLErgAAFLPASISYL--IGTNIFGPLAHRIGRWLSSFIGL 393
Cdd:COG2223 201 ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT--AGLLAALFALLgaLGRPLGGWLSDRIGGRRVLLIVF 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 394 VVIGFSLLSIPSAT-SVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVG-VYGSIYaiadaafcFAFALGPFFSGPL 471
Cdd:COG2223 279 ALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGaVYGLVG--------AAGGLGGFLGPLL 350
|
330 340 350
....*....|....*....|....*....|....*.
gi 71997647 472 VKSL-----GFPTMMYIIAVISFLYAPLMFLLKNPP 502
Cdd:COG2223 351 FGALldatgSYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
150-499 |
3.03e-22 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 98.44 E-value: 3.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 150 HKLLASENVhVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTS 229
Cdd:cd17489 24 HDLGGSEAV-AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 230 TSGMGMLAQAYPDDLeRGSAMGIALGGLALGVLVGPPYGGLLYQWSGkelpFVLLALLALFDGSIQFMVLQ------PKI 303
Cdd:cd17489 103 TAAATLVADIIPPSR-RGEGIGYYGLATTLAMALGPALGLFLYQHLG----FAVLFIVAAVLALLALLLVFlvkdppPVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 304 DRGEPEGSSIKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSlerGAAFLPASISYLIGTNIFGPLAHRI 383
Cdd:cd17489 178 AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNA---GLFFTVYAIALLLSRPFSGKLSDRK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 384 GRWLSSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMidasMFPLMGYLVdIRHV-----GVYGSIYaiaDAAFC 458
Cdd:cd17489 255 GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGL----LFPALQALA-VDLVpphrrGAANGTF---FIFFD 326
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 71997647 459 FAFALGPFFSGPLVKSLGFPTMMYIIAVISFLYAPLMFLLK 499
Cdd:cd17489 327 LGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
160-490 |
5.62e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 88.76 E-value: 5.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQA 239
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 240 YPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVL---QPKIDRGEPEGSSIKQL 316
Cdd:cd17324 116 VPPE-KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLpslPPKKPGSLGLLSSLLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 317 AKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVI 396
Cdd:cd17324 195 LRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 397 GFSLLSIPSATSVAGLIIPHALLGFSIGMIDAsmfPLMGYLVDI--RHVGVYGSIYaiaDAAFCFAFALGPFFSGPLVKS 474
Cdd:cd17324 275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHS---ALQTRVLRLapEARGLASSLY---LAAYNLGGALGAALGGLVLDH 348
|
330
....*....|....*.
gi 71997647 475 LGFPTMMYIIAVISFL 490
Cdd:cd17324 349 GGWAGVGWVGAALLLL 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
160-490 |
7.00e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 88.40 E-value: 7.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQA 239
Cdd:cd17474 36 VGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 240 YPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGkELPFVLLALLALFdGSIQFMVLQPKIDRGEPEGSSIKQLA-- 317
Cdd:cd17474 116 FEGG-ERAKAMGLYEAALGLGIAVGPLLGGLLAAISW-RYPFFLLAALIPV-AFLAILFLLPEPKEKAKSSSATKLRDlk 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 318 ---KDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGP-LAHRIGRWLSSFIGL 393
Cdd:cd17474 193 kalRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 394 VVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYaiaDAAFCFAFALGPFFSGPLVK 473
Cdd:cd17474 273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLY---NFVRFLGQAVGPLLFGLLLE 349
|
330
....*....|....*..
gi 71997647 474 SLGFPTMMYIIAVISFL 490
Cdd:cd17474 350 IFGLSAPFLVGAAIALA 366
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
179-438 |
5.72e-18 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 85.69 E-value: 5.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 179 GPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDlERGSAMGIALGGLA 258
Cdd:cd17321 52 GRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGE-RRGRALGLWGAVVG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 259 LGVLVGPPYGGLLYQWSGKelpfvllallalfdGSIqFMVLQPkidrgepegSSIKQLAKDPYIIVAAGAITIGNLGIAM 338
Cdd:cd17321 131 IGAALGPLLGGLLLELFGW--------------RWI-FLINVP---------IGLVALLLARTFSGAVLAAFLLGAALGG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 339 LEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVV--IGFSLLS-IPSATSVAGLIIP 415
Cdd:cd17321 187 LLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLtaVGLLLLAlLGADSSVWLLLPG 266
|
250 260
....*....|....*....|...
gi 71997647 416 HALLGFSIGMIdasMFPLMGYLV 438
Cdd:cd17321 267 LVLLGLGLGLF---ATPLTNAAL 286
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
160-499 |
4.11e-17 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 83.04 E-value: 4.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMP-MFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSAcTSTSGMGMLAQ 238
Cdd:cd17490 33 IGIILGAYGISQMLLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAA-TWVSFTVLYAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 239 AYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVLQPKID--RGEPEGSSIKQL 316
Cdd:cd17490 112 YFPPD-EAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREkkPVLTELKELLSV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 317 AKDPYIIVAAG-AITIGNLGIAMLEPSLPLwMMESWGANSLERGAAFLPASISYLIGTNIFGPLAH-RIGRWLSSFIGLV 394
Cdd:cd17490 191 LKDKKLLFFSLlAILQQMITFSTTFGFTPL-IAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYkKLGERNTIIIGFL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 395 VIGFSLLSIPSATSVAGLIIPHALLGFSIGMIdasmFPLMGYLVdIRHV---------GVYGSIYaiadaafCFAFALGP 465
Cdd:cd17490 270 LLGAYCFLIPFAPNLTLLYLLQALNGFGTGIL----FPLLMSLS-IEGVpaeqrstamGFFQAIY-------ALGMFLGP 337
|
330 340 350
....*....|....*....|....*....|....
gi 71997647 466 FFSGPLVKSLGFPTMMYIIAVISFLYAPLMFLLK 499
Cdd:cd17490 338 VLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
160-497 |
1.05e-16 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 81.47 E-value: 1.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTsgmgmlAQA 239
Cdd:cd17330 36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV------AQA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 240 Y----PDDLERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVLqpkidrgepegssikq 315
Cdd:cd17330 110 YiadiTDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL---------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 316 lakdPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLI-GTNIFGPLAHRIGRWLSSFIGLV 394
Cdd:cd17330 174 ----PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILaQLLLIPRLAKRLGERKLLRLGLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 395 VIGFSLLSIPSATSVAGLIIPHALLGFSIGMidasMFPLMGYLVDiRHVGVY--GSIYAIADAAFCFAFALGPFFSGPLV 472
Cdd:cd17330 250 LAIIGLLLLPFASSVPLLVLAAAILAFGTGI----VFPALSALLS-KSVPSKeqGKAQGIIQSLQSLARIIGPLLAGPLY 324
|
330 340
....*....|....*....|....*
gi 71997647 473 KSLGFPTMMYIIAVISFLYAPLMFL 497
Cdd:cd17330 325 SFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
160-434 |
2.57e-16 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 80.70 E-value: 2.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVnpwiGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQA 239
Cdd:cd17320 40 LSAYLLGFALGQLLY----GPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 240 YPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLalfdGSIQFMVL-------QPKIDRGEPEGSS 312
Cdd:cd17320 116 YSGA-ELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL----GLLLLLLVllflpetLPEEKRKPLLSSL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 313 I---KQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIG----- 384
Cdd:cd17320 191 LrayKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGprrll 270
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 71997647 385 RWLSSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLM 434
Cdd:cd17320 271 RLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
160-498 |
4.79e-16 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 79.96 E-value: 4.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQA 239
Cdd:cd17329 37 VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 240 YPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQwSGKELPFVLLALLALFDGSIQFMVLQPKI-----DRGEPEGSSIK 314
Cdd:cd17329 117 TTPE-NRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRpkrraAEKTEILRGYK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 315 QLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTnifGPLAHRIGRWLSSFI--- 391
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQ---FPVARLVERFRLRKIlmi 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 392 GLVVIGFSLLSIPSATSVAGLIIphALLGFSIG-MIdasMFPLMGYLVD----IRHVGVYGSIYaiaDAAFCFAFALGPF 466
Cdd:cd17329 272 GILLFAIGFAVLAFANTLAVLIL--AMIVLTLGeML---VFPAVQTLVAalapPDKRGSYMGFY---ALAWGLGRAIGPL 343
|
330 340 350
....*....|....*....|....*....|..
gi 71997647 467 FSGPLVKSLGFPTMMYIIAVISFLYAPLMFLL 498
Cdd:cd17329 344 VGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
159-282 |
3.26e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 77.23 E-value: 3.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 159 HVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQ 238
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 71997647 239 AYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFV 282
Cdd:cd17325 316 IVPPE-GRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
158-498 |
3.77e-15 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 77.63 E-value: 3.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 158 VHVGLMFGSKALVQLLVNPWIGPLT----NRIGYTMP--MFGGFVIMFCSTILFA---FGDSYFTLWLA--RALQGVGSA 226
Cdd:COG2211 46 ALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRRPwiLIGAIPLALSFVLLFTapdLSPTGKLIYALvtYLLLGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 227 CTSTSGMGMLAQAYPDDLERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELP------FVLLALLALFDGSIQFMVLQ 300
Cdd:COG2211 126 LVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAAlgyrltALIFAVLGLLAFLLTFFGTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 301 PKIDRGEPEGS---SIKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFG 377
Cdd:COG2211 206 ERPVPEEEKVSlkeSLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 378 PLAHRIGRWLSSFIGLVVIGFSLLSIP--SATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVD-------IRHVGVYGS 448
Cdd:COG2211 286 RLAKRFGKKKAFIIGLLLAALGLLLLFflGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFG 365
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 71997647 449 IYaiaDAAFCFAFALGPFFSGPLVKSLGF-------PTMMYIIAVISFLYAPLMFLL 498
Cdd:COG2211 366 IF---TFAIKLGQALAGALAGLLLALFGYvagaaqsPSALTGIRLLFFLLPAVLLLL 419
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
160-498 |
5.48e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 73.80 E-value: 5.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAF-----GDSYFTLWLARALQGVGSACTSTSGMG 234
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 235 MLAQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPF----VLLALLALFDGSIQFMVLQPKIDRGEPEG 310
Cdd:cd06173 116 LLPELVPKE-QLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFainaLSFLLSALLLLFIRRPPPAAPGESSSLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 311 SSIKQ----LAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRW 386
Cdd:cd06173 195 RDLREglryLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRG 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 387 LSSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVD----IRHVGVYGSIYaiadaafCFAFA 462
Cdd:cd06173 275 RLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPdelrGRVFSVYNALN-------SGAMP 347
|
330 340 350
....*....|....*....|....*....|....*.
gi 71997647 463 LGPFFSGPLVKSLGFPTMMYIIAVISFLYAPLMFLL 498
Cdd:cd06173 348 LGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
151-403 |
5.98e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 72.54 E-value: 5.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 151 KLLASENVHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTST 230
Cdd:COG0477 42 ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMP 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 231 SGMGMLAQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFdgSIQFMVLQPKIDRGEPEG 310
Cdd:COG0477 122 GALALIAELFPAR-ERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLL--ALVLRLRLPESRGLLLAL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 311 SSIKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSF 390
Cdd:COG0477 199 LALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLAL 278
|
250
....*....|...
gi 71997647 391 IGLVVIGFSLLSI 403
Cdd:COG0477 279 LLLLLLLLLLLLL 291
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
168-498 |
9.01e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 69.91 E-value: 9.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 168 ALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYpDDLERG 247
Cdd:cd17473 45 ALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF-EGEERA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 248 SAMGIALGGLALGVLVGPPYGGLLYQWSGKeLPFVLLALLALFDGSIQFMVLQPKIDRGEPEGSSIKQLAKDPY--IIVA 325
Cdd:cd17473 124 KMLGLQSAAMSLGGVVFLLLGGALAEIGWR-APFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWkrVLPI 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 326 AGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIPS 405
Cdd:cd17473 203 YFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 406 ATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYaiadaafCFAFALGPFFS----GPLVKSLGFPT-M 480
Cdd:cd17473 283 ASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIV-------TSAFFLGQFLSplvlGPLVNLTGGLSgA 355
|
330
....*....|....*...
gi 71997647 481 MYIIAVISFLYAPLMFLL 498
Cdd:cd17473 356 FLILGVLALVLAIVLLLL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
157-495 |
1.10e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 69.88 E-value: 1.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 157 NVHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGML 236
Cdd:COG0738 42 DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 237 AQAYPDdlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGK---ELPFVLLallalfdGSIQFMVL-----------QPK 302
Cdd:COG0738 122 AALGPE--TAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlswHLPYLIL-------AVLLLLLAllflrsklpeiEEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 303 IDRGEPEGSSIKQLAKDPYIIVAAGAItignLGIAMLEPS----LPLWMMESWGANSLERGAAFLPASISYLIGTNIFGP 378
Cdd:COG0738 193 EEEAAGSAASLKSLLKNPRLLLGGLAI----FLYVGAEGAigdwLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 379 LAHRIG--RWLSSFIGLVVIGFSLLSIPSATSVAGLIIphALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIyaiaDAA 456
Cdd:COG0738 269 LLKRFGpvRLLRLSALLAAVGLLLALLAPGPWLALIGL--ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAV----LIM 342
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 71997647 457 FCFAFALGPFFSGPLVKSLGFPTMMYIIAV---ISFLYAPLM 495
Cdd:COG0738 343 GIVGGAIGPPLIGFLADAFGLRAAFLVPLVcylLILLLALAL 384
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
181-434 |
1.54e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 69.14 E-value: 1.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 181 LTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDlERGSAMGIALGGLALG 260
Cdd:cd17503 54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPE-KRGAAMGLVGLVILLA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 261 VLVGPPYGGLLYQWSGKELPFVLLALLalfdGSIQFmVLQPKIDRGepegssikqLAKDP---YIIVAAGAITIGNLGIA 337
Cdd:cd17503 133 PAIGPTLGGWLTDNLSWRWIFYINLPI----GILAL-LLAPLLDLR---------LFKDRnftLGLLLSFLLGLGLFGAM 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 338 MLepsLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIP---SATSVAGLII 414
Cdd:cd17503 199 FL---LPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAfltPDTSLWLIIL 275
|
250 260
....*....|....*....|
gi 71997647 415 PHALLGFSIGMIdasMFPLM 434
Cdd:cd17503 276 PLFIRGLGMGLV---FMPLN 292
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
334-512 |
2.16e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 68.60 E-value: 2.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 334 LGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIPSATSVAGLI 413
Cdd:pfam07690 10 LGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 414 IPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYAIADAAFCFafaLGPFFSGPLVKSLGFPTMMYIIAVISFLYAP 493
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAA---LGPLLGGLLASLFGWRAAFLILAILSLLAAV 166
|
170
....*....|....*....
gi 71997647 494 LMFLLKNPPVLIEPTPQTQ 512
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEE 185
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
322-498 |
4.28e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 67.69 E-value: 4.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 322 IIVAAGAITIGNLGIAMLEPSLPlWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLL 401
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 402 SIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYAIADAAFCFafaLGPFFSGPLVKSLGFPTMM 481
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPA---LGPLLGGLLADLFGWRWVF 167
|
170
....*....|....*..
gi 71997647 482 YIIAVISFLYAPLMFLL 498
Cdd:COG2814 168 LVNAVLALLALLLLLRL 184
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
328-517 |
6.82e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.22 E-value: 6.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 328 AITIGNLGIAMLEPSLPLwMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIPSAT 407
Cdd:cd17325 4 ALFLDMLGYGIIIPILPL-YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 408 SVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYaiaDAAFCFAFALGPFFSGPLVKSLGFPTMMYIIAVI 487
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIF---SSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190
....*....|....*....|....*....|
gi 71997647 488 SFLYAPLMFLLKNPPVLIEPTPQTQSVELR 517
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLR 189
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
322-498 |
3.57e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.89 E-value: 3.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 322 IIVAAGAITIGNLGIAMLEpslplwMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLL 401
Cdd:COG2271 17 LAYFLNYLDRSNLSVAAPP------LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 402 SIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYaiaDAAFCFAFALGPFFSGPLVKSLGFPTMM 481
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIF---NAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170
....*....|....*..
gi 71997647 482 YIIAVISFLYAPLMFLL 498
Cdd:COG2271 168 LILGLPGLLLALLRFWL 184
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
160-495 |
6.53e-11 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 64.12 E-value: 6.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQA 239
Cdd:cd17477 33 IGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 240 YPDDlERGSAMGIALGGLALGVLVGPpyggLLYQWSGKE--LPFVLLALLALFDGSIQFMVLQPKIDRGEPEGSSIKQLA 317
Cdd:cd17477 113 ATNE-NRGRVLGLYSTVLGLGFALGP----LLLALVGTAgaLPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 318 KdpyiivAAGAITIGNLGIAMLEPS----LPLWMMESWGanSLERGAAFLPASIsylIGTNIF----GPLAHRIGR-WLS 388
Cdd:cd17477 188 R------IAPLALLGAFVAGFLEGAfyslLPLYGLRLGL--SVAQAALLLAAFV---LGGLLLqwplGWLADRFDRrRVL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 389 SFIGLVVIGFSLLsIPSATSVAGLIIPhalLGFSIGMIDASMFPL-MGYLVDIRHVGVYGSIYAIADAAFCFAFALGPFF 467
Cdd:cd17477 257 LGCALLGALAALL-LPLVPGLPLALLV---LLFLWGGAAGPLYTLaLALAGDRLPGDELVAANAALLLLYGLGSVIGPLL 332
|
330 340
....*....|....*....|....*...
gi 71997647 468 SGPLVKSLGFPTMMYIIAVISFLYAPLM 495
Cdd:cd17477 333 AGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
170-450 |
9.70e-11 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 63.34 E-value: 9.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 170 VQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARA-LQGVGSACTSTSGMGMLAQAYpdDLERGS 248
Cdd:cd17352 50 VSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGvLGGLGLGLIYSPAIVIVGQYF--EKKRGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 249 AMGIALGGLALGVLVGPPYGGLLYQWSGkelpfvllallalFDGSIQFM-------VLqpkidrgepeGSSIKQLAKDPY 321
Cdd:cd17352 128 ATGIAVAGSGVGTFVFPPLLRYLLDNYG-------------WRGALLILgglclnlCV----------CGLLLRLLKDPT 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 322 IIVAAGAITIGNLGIAMLEPSLPLWMMESwGANSLErgAAFLPA--SISYLIGTNIFGPLA--HRIGRWLSSFIGLVVIG 397
Cdd:cd17352 185 FVLLALGVSFAMLGFFVPFVYLPSYAKSL-GIDESD--AAFLLSiiGISDIVGRILLGLLAdkPRIGRLYLYIFTLLILG 261
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 71997647 398 FSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGV-YGSIY 450
Cdd:cd17352 262 LSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNaYGLVL 315
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
196-445 |
1.27e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 63.37 E-value: 1.27e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 196 VIMFCSTILFAFGDSYFTLWLARALQGVGSAcTSTSGMGMLAQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWS 275
Cdd:cd17504 69 AIYTAGSLLAAFAPNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPE-RVPVAQGILSATFGIGAGIGLPLGGWIVQHL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 276 GKELPFVLLALLalfdgSIQFMVLQPKIDrgepegssIKQLAKDPYIIVAAGAITIGnLGIAMLEPSLPLWMME----SW 351
Cdd:cd17504 147 GWRWIFWTAAPV-----AVLLAALVPLID--------LRLLRRRNVLLANITALLAG-FGMFMVFQLLPQLLQLptptGF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 352 GANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIP-SATSVAGLIIPHALLGFSIGMIDASM 430
Cdd:cd17504 213 GLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLAlLHSSLWALVVALLLIGIGLGLAFASL 292
|
250
....*....|....*
gi 71997647 431 FPLMGYLVDIRHVGV 445
Cdd:cd17504 293 PNIVVESVPPDRTGI 307
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
158-281 |
1.96e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 62.60 E-value: 1.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 158 VHVGLMFG----SKALVQLLVnpwIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGM 233
Cdd:cd17330 210 SQIGLLLAlvgiAGILAQLLL---IPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALS 286
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 71997647 234 GMLAQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPF 281
Cdd:cd17330 287 ALLSKSVPSK-EQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPF 333
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
161-492 |
2.71e-10 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 62.28 E-value: 2.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 161 GLMFGSKALVQLLVNPWIGPLTNRIGYTmPM-----FGGFVIMFcstiLFAFGDSYFTLWLARALQGVGSACTSTSgMGM 235
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRK-PMllrasLGMAIVIG----LMAFVTNVWQLLILRLLQGVFSGYVPNA-TAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 236 LAQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLallalfdGSIQFMV-----------LQPKID 304
Cdd:cd17391 113 IASQTPKE-KSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT-------GGLLFLAflltlffvkedFKPVEK 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 305 RGEPEGSSIKQLAKDPYIIVAAGAIT-IGNLGIAMLEPSLPLWMMESWGANS---LERGAAFLPASISYLIGTNIFGPLA 380
Cdd:cd17391 185 KKMVSTKEVWNSVPNPSLLISLFVTTfIIQLANQSIEPILTLYIRQLMGDASnlaFISGLVFSATGVSSLLSAPRLGKLG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 381 HRIGRWLSSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLmgyLVDIRHVGVYGSIYAIADAAFCFA 460
Cdd:cd17391 265 DRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSL---LAKITPKEVAGRIFGYNQSFQYLG 341
|
330 340 350
....*....|....*....|....*....|..
gi 71997647 461 FALGPFFSGPLVKSLGFPTMMYIIAVISFLYA 492
Cdd:cd17391 342 NVAGPLLGSAIAAHFGYRAVFVVTALLVLLNA 373
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
160-498 |
4.43e-10 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 61.47 E-value: 4.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLAR-ALQGVGSACTSTSGMGMLAQ 238
Cdd:cd17353 40 VALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYgVLGGIGAGIGYITPVSTAVK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 239 AYPDdlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVLQPKIDRGEPEGSSIKQLAK 318
Cdd:cd17353 120 WFPD--KRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 319 DPYIIVA------------------AGAITIGNLGIAMLEPSLPLWMMESWGANSLergAAFLpASISYLIGTNIFGPLA 380
Cdd:cd17353 198 ENSPRDYtpremlrtptfwllwlmfFLNATAGLMLIGQAKPIGQEFAGLDAGIAAL---AVSI-LSIFNGGGRPFWGWLS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 381 HRIGRWLSSFIGLVVIGFSLLSIPSATSVAGL-IIPHALLGFSIGMIdASMFPlmGYLVDI---RHVGV-YGSIYaiadA 455
Cdd:cd17353 274 DKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLfVLGVALIGFCYGGG-FALFP--ALTADFfgtKNAGTnYGLLY----T 346
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 71997647 456 AFCFAFALGPFFSGPLVKSLGFPTMMYIIAVISFLYAPLMFLL 498
Cdd:cd17353 347 AKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
177-498 |
4.69e-10 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 61.44 E-value: 4.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 177 WIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDlERGSAMGIALGG 256
Cdd:cd17323 53 IWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPE-ERGKAMGVYSLG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 257 LALGVLVGPPYGGLLYQWSGKELPFVLLALLALFdgSIQFMVLQPKIDrgepegssikqLAKDPYIIVAAGAITIgnlgi 336
Cdd:cd17323 132 PLLGPALGPIIGGFITQSLGWRWIFWFLAIISGF--CLILIFLFLPIV-----------LLLGLYVGLVYAILYL----- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 337 aMLEpSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWL---------------SSFIGLVVIGFSLL 401
Cdd:cd17323 194 -FLT-AFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLkkknggkpepearlpPAFIGAFLFPIGLF 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 402 ----SIPSATSVAGLIIPHALLGFSIGMIDASMfplMGYLVDIrHVGVYGSIYAIADAAFCFAFALGPFFSGPLVKSLGF 477
Cdd:cd17323 272 ifgwTIYPHIHWIVPIIGSAFFGFGLMLIFQSS---LTYLVDS-YPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGV 347
|
330 340
....*....|....*....|.
gi 71997647 478 PTMMYIIAVISFLYAPLMFLL 498
Cdd:cd17323 348 GWAFTLLAFISLAMIPIPFIF 368
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
161-503 |
5.00e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.43 E-value: 5.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 161 GLMFGskalvqlLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAY 240
Cdd:COG2807 63 LLAFG-------LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 241 PDdlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFdgsiqFMVL-------QPKIDRGEPEGSSI 313
Cdd:COG2807 136 PD--RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL-----ALLLwlpllrrRPAAAAAAPAAASL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 314 KQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESwGANSLERGAAFLPASISYLIGTNIFGPLAHRIGR---WLSSF 390
Cdd:COG2807 209 RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDrrpLLLLL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 391 IGLVVIGFSLLSI-PSATSVAGLIiphaLLGFSIGMIdasmFPL-MGYLVDI-RHVGVYGSIYAIADAAFCFAFALGPFF 467
Cdd:COG2807 288 GLLGLAGLLGLLLaPGSLPWLWAV----LLGLGQGGL----FPLaLTLIGLRaRTPAEAAALSGMAQSVGYLLAALGPLL 359
|
330 340 350
....*....|....*....|....*....|....*..
gi 71997647 468 SGPLVKSLGFPTM-MYIIAVISFLYAPLMFLLKNPPV 503
Cdd:COG2807 360 VGALHDATGSWTAaLLLLAALAVLMLVAGLLAGRPYV 396
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
159-260 |
7.50e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 60.76 E-value: 7.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 159 HVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQ 238
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
90 100
....*....|....*....|..
gi 71997647 239 AYPDDlERGSAMGIALGGLALG 260
Cdd:COG2814 324 LAPPE-ARGRASGLYNSAFFLG 344
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
173-497 |
7.96e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 60.75 E-value: 7.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 173 LVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDLERGSAMGI 252
Cdd:cd17355 53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 253 ALGGLALGVLVGPPYGGLL---YQWSGKELPFVLLALLALFDgSIQFM-------VLQPKIDRGEPE-GSSIKQLAKDPY 321
Cdd:cd17355 133 LTAGGGLGSLVFLPLGAALieaFGWRTALLVLALLALLVLVP-VLLLLrrrpadlALRAYDDASPASpGSTLKEALRSAS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 322 IIVAAGAITIGNLGIAMLEPSLPLwMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLL 401
Cdd:cd17355 212 FWLLALAFFLCGFAVVGLIVHLVP-YLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLA 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 402 SIPSATSVagliiPHALLGFSIGM--IDASMFPLMGYLVDIRH-VGVYGSIYAIADAAFCFAFALGPFFSGPLVKSLGFP 478
Cdd:cd17355 291 LLLLLPFP-----PLALLLFAALFglGWGATVPLTAALAARYFgARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSY 365
|
330
....*....|....*....
gi 71997647 479 TMMYIIAVISFLYAPLMFL 497
Cdd:cd17355 366 TAAWALAVALGLIAALLVL 384
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
173-425 |
1.35e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 59.88 E-value: 1.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 173 LVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDleRGSAMGI 252
Cdd:cd17478 46 LLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGR--RGLAMSI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 253 -ALGGlALGVLVGPPYGGLLYQ-WSGKELPFVLLALLALFdGSIQFMVLQPKIDRGEPEGSSIKQLAKDPYIIVAAGAIT 330
Cdd:cd17478 124 fSVGG-NLGFALGPLIAAALVAlFGGLGLLILLIIPGLAV-ALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 331 IGNLGIAMLEPS----LPLWMMESWGANSLERGA--AFLPASIsylIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIP 404
Cdd:cd17478 202 IIVFLRSWVLSSlttfLPFYLVQRGYSLVFAGLLlsLFLFAGA---IGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFL 278
|
250 260
....*....|....*....|.
gi 71997647 405 SATSVAgLIIPHALLGFSIGM 425
Cdd:cd17478 279 LTPGIW-SYILLVLAGFLLFA 298
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
322-499 |
8.00e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.13 E-value: 8.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 322 IIVAAGAITIGNLGIAMLEPSLPLwMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLL 401
Cdd:COG0477 16 LLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 402 SIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYAIADAAFCFafaLGPFFSGPLVKSLGFPTMM 481
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLA---LGPLLGGLLVAALGWRWIF 171
|
170
....*....|....*...
gi 71997647 482 YIIAVISFLYAPLMFLLK 499
Cdd:COG0477 172 LINAPLGLLALVLRLRLP 189
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
334-502 |
6.29e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 54.74 E-value: 6.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 334 LGIAMLEPSLPLWMMESWGANSLErGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIPSATSVAGLI 413
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQL-GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 414 IPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYaiaDAAFCFAFALGPFFSGPLV--KSLGFPTMMYIIAVISFLY 491
Cdd:cd06174 89 LGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLL---QAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLA 165
|
170
....*....|.
gi 71997647 492 APLMFLLKNPP 502
Cdd:cd06174 166 AILLLLVVPDP 176
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
328-517 |
8.05e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.52 E-value: 8.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 328 AITIGNLGIAMLEPSLPLWMMEsWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIPSAT 407
Cdd:cd17489 4 ANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 408 SVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYAIADAAFCFafaLGPFFSGPLVKSLGFPTMMYIIAVI 487
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMA---LGPALGLFLYQHLGFAVLFIVAAVL 159
|
170 180 190
....*....|....*....|....*....|
gi 71997647 488 SFLYAPLMFLLKNPPVLIEPTPQTQSVELR 517
Cdd:cd17489 160 ALLALLLVFLVKDPPPVAAEEAEAGTRAFR 189
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
158-261 |
6.95e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 6.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 158 VHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAF---GDSYFTLWLARALQGVGSACTSTSGMG 234
Cdd:cd17321 204 LQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTN 283
|
90 100 110
....*....|....*....|....*....|.
gi 71997647 235 MLAQAYPDDlERGSAMGIA----LGGLALGV 261
Cdd:cd17321 284 AALSSVPKE-KAGAASGILntarQLGGALGV 313
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
322-518 |
8.12e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.42 E-value: 8.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 322 IIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLL 401
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 402 SIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRHVGVYGSIYaiaDAAFCFAFALGPFFSGPLVKSLGFPTMM 481
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLA---AGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190
....*....|....*....|....*....|....*...
gi 71997647 482 YIIAVISFLYAPL-MFLLKNPPVLIEPTPQTQSVELRQ 518
Cdd:COG2223 163 LILGILLLVVAVLaWLFLRDPPAGAAAAAKASLRDQLE 200
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
178-282 |
1.52e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.62 E-value: 1.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 178 IGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDLeRGSAMGIALGGL 257
Cdd:cd17370 254 AGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAEL-RGTAYGLFNTVV 332
|
90 100
....*....|....*....|....*
gi 71997647 258 ALGVLVGPPYGGLLYQWSGKELPFV 282
Cdd:cd17370 333 GIGWLLASLIAGYLWDLISPSAAFL 357
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
158-276 |
1.68e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.26 E-value: 1.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 158 VHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSyfTLWLARALQGVGSACT---STSGMG 234
Cdd:COG2223 241 ATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALG--SLWLFLVLFLLLGLALgggNGAVFA 318
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 71997647 235 MLAQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSG 276
Cdd:COG2223 319 LVPDIFPTK-NAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
151-490 |
2.17e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.01 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 151 KLLASENVHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTST 230
Cdd:cd17333 24 EAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 231 SGMGMLAQAYPDDleRGSAMGIALGGLALGVLVGPPYGGLLYQWSGK-ELPFVLLALLALFDGSIQFMVL-------QPK 302
Cdd:cd17333 104 GANTFVGALFEES--SATRLNVLHGFFGLGALIGPLIATSLLTSELSwSWAYLIIGLIYLLLAILILLTLfpelpsaRNP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 303 IDRGEPEGSSIKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLErgAAFLPAS--ISYLIGTNIFGPLA 380
Cdd:cd17333 182 QQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGL--AGYLLSGfwVGITIGRLLGGPIS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 381 HRIGRWLSSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIgmidASMFP-LMGYLVDI--RHVGVYGSIYaiaDAAF 457
Cdd:cd17333 260 RRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFM----AALFPtILSLGISNlpYAKGKGTSVL---LAAG 332
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 71997647 458 CFAFALGPFFSGPLVKSLG-------FPTMMYIIAVISFL 490
Cdd:cd17333 333 SIGGAIIPFIMGFIAEAVGiqtamllITILYAIIFVLALL 372
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
322-495 |
3.53e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.28 E-value: 3.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 322 IIVAAGAITIGNLGIAMLEPSLPLwMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIG-FSL 400
Cdd:TIGR00895 19 IILSFLIMLMDGYDLAAMGFAAPA-ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSvFTL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 401 LSIpSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDIRH----VGVYGSIYaiadaafCFAFALGPFFSGPLVKSLG 476
Cdd:TIGR00895 98 LCA-LATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFrgtaVGLMFCGY-------PIGAAVGGFLAGWLIPVFG 169
|
170
....*....|....*....
gi 71997647 477 FPTMMYIIAVISFLYAPLM 495
Cdd:TIGR00895 170 WRSLFYVGGIAPLLLLLLL 188
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
188-426 |
5.61e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 48.71 E-value: 5.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 188 TMPMFGGF-------VIMFCSTILFAFGD-------SYFTLWLARALQGVGSActstsGMGMLAQAYPDDL----ERGSA 249
Cdd:cd17502 46 FQPIYGKLsdlfgrkWVLLIAIVIFELGSllcglapNMTMLIVGRAIQGIGGG-----GLMSLAFIIIADLvpprERGKY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 250 MGIALGGLALGVLVGPPYGGLLYQ---WS---GKELPFvllallalfdGSIQFMVLqpkidrgepegssikqlakdPYII 323
Cdd:cd17502 121 QGYIGAVFGIASVAGPLIGGAFTDhlsWRwcfYINLPI----------GGLALALL--------------------RTIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 324 VA--AGAITIGNLGIAMLEpsLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGR----WLSSFIGLVVIG 397
Cdd:cd17502 171 LSsiFGFLFGGALFGLIYY--LPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRykplIVIGTILMSVGA 248
|
250 260
....*....|....*....|....*....
gi 71997647 398 FSLLSIPSATSVAGLIIPHALLGFSIGMI 426
Cdd:cd17502 249 GLLTTLTLDTSKWLLIGYLILLGLGLGIG 277
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
161-250 |
9.53e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.96 E-value: 9.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 161 GLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLW---LARALQGVGSACTSTSGMGM-L 236
Cdd:cd17503 217 GLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWliiLPLFIRGLGMGLVFMPLNTLaL 296
|
90
....*....|....
gi 71997647 237 AQAYPDDLERGSAM 250
Cdd:cd17503 297 NSLPPEQIGDATAL 310
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
176-435 |
1.02e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 48.14 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 176 PWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDlERGSAMGIALG 255
Cdd:TIGR00711 55 PLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPE-KRGRAMAIWGL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 256 GLALGVLVGPPYGGLL---YQW-----------------SGKELPFVLLALLALFDG------SIQFMVLQPKIDRGEPE 309
Cdd:TIGR00711 134 TVLVAPALGPTLGGWIienYHWrwiflinvpigiivvvvAFFILPRDKPAASENFDFlgllllSVGLGSLLYGLSEGPER 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 310 GSSIKQLAKDPYIIVAAG------------------------AITIGNLGIAMLEPS-------LPLWMMESWGANSLER 358
Cdd:TIGR00711 214 GWFDSNEILILSITGLVAiiafvvweltddnplvdlrlfkyrNFTIGCVYMSLLGLGlygsfylLPLYLQQVLGYTALQA 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 359 GAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSI-----PSATSVAgLIIPHALLGFSIGMidaSMFPL 433
Cdd:TIGR00711 294 GLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLILYAVGFYWRaftftPDTPFLA-IALPQFIRGFGMGC---FFMPL 369
|
..
gi 71997647 434 MG 435
Cdd:TIGR00711 370 TT 371
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
160-430 |
2.67e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 2.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIG-YTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQ 238
Cdd:cd17370 36 VGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 239 AYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKELP------FVLLALLALFDGSIQFMVLQPKIDRGEPEGSS 312
Cdd:cd17370 116 ATPPS-GRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRtifllaAIPALLALLILLFVVKEYPRPPKLRKKSKKTS 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 313 IKQLAKD-PYIIVAAGAITIGNLGIAMLEpslpLWMMESWGANSLERgAAFLPASISYLIGTNIFGPLAHRIGRWLSSFI 391
Cdd:cd17370 195 LKKLPKAfWLYLLAVALFALGNFSFAFLI----LRAQELGLSAALIP-LLYALFNLVYALAAYPAGRLSDRIGRKKLLIL 269
|
250 260 270
....*....|....*....|....*....|....*....
gi 71997647 392 GLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASM 430
Cdd:cd17370 270 GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIE 308
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
320-501 |
3.09e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.39 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 320 PYIIVAAGAITIGnLGIAMLEPSLPlWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFS 399
Cdd:COG0738 9 ALIAIYLLFFLWG-FATALWGPLIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 400 LLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVDI---RHVGVYGSIYaiadaafCFAFALGPFFSGPLVK--- 473
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPEtaaSRLNLLHAFF-------SLGALLGPLLGGLLILlgl 159
|
170 180
....*....|....*....|....*...
gi 71997647 474 SLGFPTMMYIIAVISFLYAPLMFLLKNP 501
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLRSKLP 187
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
157-271 |
3.73e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.02 E-value: 3.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 157 NVHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGML 236
Cdd:cd17319 37 PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKAL 116
|
90 100 110
....*....|....*....|....*....|....*
gi 71997647 237 AQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLL 271
Cdd:cd17319 117 AEWFPAR-ERGRATGLFNSGAPLGAAIGPPLSGWL 150
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
168-450 |
4.73e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 45.91 E-value: 4.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 168 ALVQLLVNPWIGPLTNRIGYTMPMFGGFVIM--FCSTILFAFGDSyfTLWLARALQGVGSACTSTSGM---GMLAQ-AYP 241
Cdd:COG2270 62 GLLVALLAPVLGAIADRSGRKKPFLAFFTLLgvLATAALFFVAPG--GLWLGLLLFVLANIGFEGSLVfynAFLPDiATP 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 242 DDLERGSAMGIALG--------GLALGVLVGPPYGGLL-----YQWSGkelPFVLLAllalFDGSIQFMVL---QPKIDR 305
Cdd:COG2270 140 EEIGRVSGLGWALGylggvlllLINLALFLKPEAFGLPdageaVRISF---LLTALW----WLLFALPLFLflpERPRPG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 306 GEPEGSSI-----------KQLAKDP-----------Y------IIVAAGAITIGNLGIAmlepslplwmmeswganSLE 357
Cdd:COG2270 213 PAPPRGAVragfrelrrtlRELRRYRdllrfllayffYrdgvqtVIAFAGIYAAGVLGFS-----------------TTE 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 358 RGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYL 437
Cdd:COG2270 276 LIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARL 355
|
330
....*....|...
gi 71997647 438 VDIRHVGVYGSIY 450
Cdd:COG2270 356 IPPGREAEFFGLY 368
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
365-494 |
7.13e-05 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 45.30 E-value: 7.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 365 ASISYLIGTNIFGPLAHRIGRW--LSSFIGLVVIGFSLLSI----PSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLV 438
Cdd:cd17485 252 GSLVSIAGSLLGGYLLKRRGRRrlLLLGGLLRLLLLGLYTLlalgGSGLNWVLLLASLALLHLVGGMITTALFTLMMDCS 331
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 71997647 439 DIRHVGVYGSIYAIADAAFCFafaLGPFFSGPLVKSLGFPTMMYIIAVISFLYAPL 494
Cdd:cd17485 332 QQAQAGTDYTLLATVEVLGKL---LFGSLAGFLADHLGYAAAFLLFAILSALSVLL 384
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
156-503 |
8.18e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 44.99 E-value: 8.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 156 ENVHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMP-----MFGGFVIMFCSTILFA----FGDSYFTLWLARALQGVGSA 226
Cdd:pfam13347 31 SAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGrrrpwLLLSAIILAVSFILLFtppeLGRAPLFIWLLATYILLRIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 227 --CTSTSGMGMLAQAYPDDLERGSAMGI-----ALGGLALGVLVGPpyggLLYQWSGKELP-------------FVLLAL 286
Cdd:pfam13347 111 ytFFEIPYWSLGPELTRDYDERTSLTSYrsffsVGGGLLAAALAFP----LVLILGGTGLErkgyrifaligavLMLLGV 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 287 LALFDGSIQFMVLQPKIDRGEPEGSS----IKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAAF 362
Cdd:pfam13347 187 IITAAGTKERVSMRSKEDTGQKEAGSlldmLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 363 LPAsISYLIGTNIFGPLAHRIGR---WLSSFIgLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMGYLVD 439
Cdd:pfam13347 267 VFT-IGALLGIPLWPPLAKRIGKkntYILGAL-ITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVD 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 440 -------IRHVGVYGSIYaiaDAAFCFAFALGPFFSGPLVKSLGFPT-------------MMYIIAVISFLYAPLMFLLK 499
Cdd:pfam13347 345 ygelrtgKRREGTFFAMW---SFISKLATGVGLGVSGLLLSAFGYNAgdsvqspqavtaiRLLYAVLPAVLFLVALLLLY 421
|
....
gi 71997647 500 NPPV 503
Cdd:pfam13347 422 FYPL 425
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
179-433 |
2.05e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 43.74 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 179 GPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTstsgmGMLAQAYPDDLERGSAMGIALGGLA 258
Cdd:PRK11652 64 GPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVG-----GVMARTLPRDLYEGTQLRHANSLLN 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 259 LGVLVGP---PY-GGLLYQWSGKELPFVllaLLALFDGSIQFMVLQ------PKIDRGEPEGSSIKQLAKDP----YIIV 324
Cdd:PRK11652 139 MGILVSPllaPLiGGLLTTLFGWRACYL---FLLLLGAGVTFSMARwmpetrPADARRTRVLASYRTLLSNRrfncYLLM 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 325 AAGAITignlGIAMLEPSLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIP 404
Cdd:PRK11652 216 LIGTLA----GIAVFEACSGVLMGAVLGLSSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLLMWIP 291
|
250 260 270
....*....|....*....|....*....|..
gi 71997647 405 S---ATSVAGLIIPHALLGFSIGMidasMFPL 433
Cdd:PRK11652 292 GwfgVMNVWTLLVPAALFFFGAGM----LFPL 319
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
179-434 |
2.16e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 43.83 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 179 GPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDlERGSAMGIALGGLA 258
Cdd:cd17371 55 GILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPAR-HRGKALGYVQSGWA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 259 LGVLVGPPYGGLLYQWSGKELP----FVLLALLALFDGSIQFMVLQPKIDRGEPEGSSIKQLAKDPYIIVAAGAITIGNL 334
Cdd:cd17371 134 VGWLLATLLAALLFPLLPPEIAwrvlFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 335 GIAMLEPSLPLWmmesWGAN-------SLERGAAFLPASIsYLIGTNI--------FGPLAHRIGR-------WLSSFIG 392
Cdd:cd17371 214 ASLLATGALGGY----YGITtwlpsylTGERGLSFEGSAG-YLVVTILggflgylaGGFLADRIGRrnnfalfALGSAIS 288
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 71997647 393 LVVIGFSLLSiPSATSVAGLIiphalLGFSIGMIDASMFPLM 434
Cdd:cd17371 289 ILLYFFLPLS-PTLILILGFP-----LGFFASGPFSGMGAYL 324
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
159-426 |
3.56e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 43.01 E-value: 3.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 159 HVGLMFGSKALVQLLVNPWIGPLTNRIG----YTMPMFgGFVIMFcstILFAFGDSYFTLWLARALQGVgsactsTSGMG 234
Cdd:cd17388 39 HYGVLLALYALMQFIFAPILGALSDRFGrrpvLLLSLA-GAALDY---LLMAFAPTLWWLYLGRIIAGI------TGATG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 235 MLAQAYPDDL----ERGSAMGIALGGLALGVLVGPPYGGLLYQWSGKeLPFVLLALLALFDGSIQFMVL---QPKIDRGE 307
Cdd:cd17388 109 AVAAAYIADVtppeQRARNFGLLGAAFGLGFIAGPALGGLLGEISPR-APFLVAAGLNGLNFLLGLFVLpesLPPERRRA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 308 PEGssikqlakdpyiivaAGAITIGNLGIAMLEPSLPLWMmeswGANSLERGAAFLPASISYLIGTNIFGplahrigrWL 387
Cdd:cd17388 188 FRW---------------RRANPFGSLRWLTGFPGLLGLL----AVFFLIQLIGQVPATTWVLFTEDRFD--------WS 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 71997647 388 SSFIGLVVIGFSLLSIPSATSVAGLIIPH------ALLGFSIGMI 426
Cdd:cd17388 241 PTMVGLSLAVFGLLHALFQAFVTGPIAKRlgekraILLGLAADAL 285
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
168-408 |
3.60e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.99 E-value: 3.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 168 ALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDlERG 247
Cdd:cd17328 44 IISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKE-KRT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 248 SAMGIALGGLALGVLVGPPYGGLLYQWSGK-ELPFVLLALLALFDGSIQFMVLQPKIdRGEPEGS------------SIK 314
Cdd:cd17328 123 RALGVFYFAIPLGSGLGYVVGGLVAQATGGwRWAFRVTGVLGVLLAILLLLFVREPP-RGAAEGGvmakstatsflaDLK 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 315 QLAKDP-YIIVAAGAI--TIGNLGIAMLEPSLPLWMMESWGANSLERGAAFLPAS-ISYLIGTNIFGPLAHRIGR----- 385
Cdd:cd17328 202 ALAKNPsFILSTLGFTavSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITcIAGVLGVLLGGILADRLRRktpra 281
|
250 260
....*....|....*....|....*
gi 71997647 386 --WLSSFIGLVVIGFSLLSIPSATS 408
Cdd:cd17328 282 dpLVCAVGLLAAAPFLFLALVLALS 306
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
160-265 |
3.88e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 42.97 E-value: 3.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSacTSTSGMGMLAQA 239
Cdd:cd17472 34 IGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVMALLADL 111
|
90 100 110
....*....|....*....|....*....|
gi 71997647 240 YPDDlERGSAM---GIALG-GLALGVLVGP 265
Cdd:cd17472 112 TREE-NRTKAMaliGASIGiAFAISMVLGP 140
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
161-445 |
4.88e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 42.73 E-value: 4.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 161 GLMFGskALVqllvnpwIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAY 240
Cdd:TIGR00895 64 GMAFG--ALF-------FGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 241 PDDLeRGSAMGIALGGLALGVLVGPPYGGLL---YQWS-----GKELPFVLLALLALF-DGSIQFMV------------- 298
Cdd:TIGR00895 135 PKRF-RGTAVGLMFCGYPIGAAVGGFLAGWLipvFGWRslfyvGGIAPLLLLLLLMRFlPESIDFLVskrpetvrrivna 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 299 ----LQPKIDRGEPEGSSIKQLAKDPYIIVAAG-----------AITIGNLGIAMLEPSLPLWMMESWGanSLERGAAFL 363
Cdd:TIGR00895 214 iapqMQAEAQSALPEQKSTQGTKRSVFKALFQGktaritvllwlLYFMLLVGVYFLTNWLPKLMVELGF--SLSLAATGG 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 364 PA-SISYLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIPSATSVAGLIIPHALLGFSIGMIDASMFPLMG--YLVDI 440
Cdd:TIGR00895 292 ALfNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMAlfYPTAI 371
|
....*
gi 71997647 441 RHVGV 445
Cdd:TIGR00895 372 RATGV 376
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
161-265 |
1.22e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 161 GLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAY 240
Cdd:cd17473 236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLV 315
|
90 100
....*....|....*....|....*
gi 71997647 241 PDDLeRGSAMGIALGGLALGVLVGP 265
Cdd:cd17473 316 PPEL-RGRAMGIVTSAFFLGQFLSP 339
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
152-426 |
1.31e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 41.38 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 152 LLASENVH-----VGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMF-CSTILFAFGDSYFTLWLARA-LQGVG 224
Cdd:cd17471 21 LFLTEELGasplqIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGaLGYLLFAFLRNYWVLLLVGVvLLSLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 225 SACTSTSgMGMLAQAYPDDLERGSAMGIAL--GGLALGVLVGPPYGGLLYQWSGKELPFVLLALLALFDGSIQFMVL-QP 301
Cdd:cd17471 101 AAAFPQL-FALAREYADRSSGRDATLFNSVlrAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLpSV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 302 KIDRG-EPEGSSIKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERG-----AAFL--PASIsyligt 373
Cdd:cd17471 180 KPPAQkATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGllfglAAALeiPIML------ 253
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 71997647 374 nIFGPLAHRIG-RWLSSFIGLVVIGFSLLsIPSATSVAGLIIPHALLGFSIGMI 426
Cdd:cd17471 254 -LAGLLAKRFGkRRLLLAGFLAGVLFYLG-LALATSLWQLIALQLLNAIFIGIT 305
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
151-497 |
1.61e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.05 E-value: 1.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 151 KLLASENVHVGLMFGSKALVQLLVNPWIGPLTNRIGytmPMFGgFVIMF----CSTILFAFGDSYFTLWLAR-------A 219
Cdd:cd17331 28 KKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFG---PRAA-LVLSFlssaLSYLLLAFASSVPMLFLSRlpsvfmhA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 220 LQGVGSACTSTSgmgmlaqaypDDLERGSAMG---IALGglaLGVLVGPPYGGLLYQWSGKELP--------FVLLALLA 288
Cdd:cd17331 104 MQAAQMVVTDLT----------DPGERAAALGrlgLSYG---IGMVVGSFLGGLLTKKFGEQAAalvaavgsLLSIVLVI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 289 LFDGSiQFMVLQPKIDRGEPEGSS------IKQLAKDPYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGAaF 362
Cdd:cd17331 171 LLIPS-NTKSKREKEAKESASPPSvfnlkeILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGY-L 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 363 LPASISYLIGTNIF--GPLAHRIGRWLSSFIGLVVIGFSLLSIPSATSVAG---LIIPHALLGFSIGMIDASMfplMGYL 437
Cdd:cd17331 249 MSYAGVLGMVVQGLlvGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQllvLLLPLVIGGSVLYTVITSL---LTKA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 438 VDIRHVGvygSIYAIADAAFCFAFALGPFFSGPLVKSLGFPTMMYIIAVISFLYAPLMFL 497
Cdd:cd17331 326 VPPEDTG---TALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
179-492 |
2.10e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 179 GPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDLeRGSAMGIALGGLA 258
Cdd:cd17316 57 GYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKR-RGFALGLLQSGWA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 259 LGVLVGPPYGGLLYQWSGKE----LPFVLLALLALFDGSIQFMVLQpkidrgepegssikqlakdpyIIVAAGAITIGNL 334
Cdd:cd17316 136 LGALLAALVASLLIPLLSGDwgwrILFLIGALPALLALLLRRRTLL---------------------LILLWFFISFGYY 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 335 GIAMLepsLPLWMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIGR--WLSSFIGLVVIGFSLLSIPSATSVAGL 412
Cdd:cd17316 195 GLTTF---LPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRkkTLVIGLILSGILALPLFYLLSGSPTLL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 413 IIPHALLGFSIGMIDASMFPLMG--YLVDIRHVGVyGSIYaiadAAFCFAFALGPFFSGPLVKSLGFPTMMYIIAVISFL 490
Cdd:cd17316 272 LLLLFILSFFVGGVWGALYAYLAelFPTEVRATGV-GLSY----NLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
..
gi 71997647 491 YA 492
Cdd:cd17316 347 VA 348
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
191-277 |
3.04e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.94 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 191 MFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDDLERGSAMGIALGGLALGVLVGPPYGGL 270
Cdd:cd17476 66 FVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGL 145
|
....*..
gi 71997647 271 LYQWSGK 277
Cdd:cd17476 146 FAQLAWW 152
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
187-430 |
4.41e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 39.73 E-value: 4.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 187 YTMPMFGGFVIMFCSTILF----AFGDSYFTLWLARALQGVGSACTSTSGMGMLAQAYPDdLERGSAMGIALGGLALGVL 262
Cdd:TIGR00894 103 YVFKWSIGIGMFLSSVISIvipwAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPP-KERSRLLGMSTSGFQLGTF 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 263 VGPPYGGLLyQWSGKELPFVLLALLALFDG-SIQFMVL-------QPKIDRGEPE--GSSI-------------KQLAKD 319
Cdd:TIGR00894 182 IFLPISGWL-CESWGGWPMIFYVFGIVGCAwSLLWFVFpaddpsiHPCISKFEKKyiNSSLqgqkgstrqslpiKAIPKS 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 320 PYIIVAAGAITIGNLGIAMLEPSLPLWMMESWGANSLERGaafLPASISYLIGTnIFGPLAHRIGRWLSS---------- 389
Cdd:TIGR00894 261 LPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENG---LLSSLPYLFAW-LCSIFAGYLADFLKSsktlsltaar 336
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 71997647 390 ----FIGLVVIGFSLLSIPSATS-----VAGLIIPHALLGFSI-GMIDASM 430
Cdd:TIGR00894 337 kifnGIGGLGPGIFAYALPYLSAafyltIIILTLANAVSSGPLaGVLINSL 387
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
162-237 |
4.50e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.51 E-value: 4.50e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71997647 162 LMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAF--GDSYFTLWLARALQGVGSACTSTSGMGMLA 237
Cdd:cd17332 260 LLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFlpPGNLVLILVLAVLAGIGYGGANLLPWAMLA 337
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
159-275 |
6.11e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.14 E-value: 6.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 159 HVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGDSYFTLWLARALQGVGSACTSTSGMGMLAQ 238
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMR 111
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 71997647 239 AYPDDlERGSAMGIALGGLALGVLVGP---PYGGLLYQWS 275
Cdd:cd17475 112 WFPPR-ERGLAMGIRQTGVPLGGALAAallPPLALHYGWR 150
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
158-276 |
6.89e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.79 E-value: 6.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 158 VHVGLMFGSKALVQLLVNPWIGPLTNRIGYTMPMFGGFVIMFCSTILFAFGD-SYFTLWLARALQGVGSACTSTSGMGML 236
Cdd:cd17355 245 AAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPfPPLALLLFAALFGLGWGATVPLTAALA 324
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 71997647 237 AQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQWSG 276
Cdd:cd17355 325 ARYFGAR-SYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
333-498 |
6.93e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.71 E-value: 6.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 333 NLGIAMLEpslplwMMESWGANSLERGAAFLPASISYLIGTNIFGPLAHRIG-RWLssfIGLVVIGFSLLSIPS--ATSV 409
Cdd:cd17319 21 NISVAAPT------IMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGaRKV---LAVSMLLWSLFTALTgfATSL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 410 AGLIIPHALLGFSigmiDASMFPLMGYLV----DIRHVGVYGSIYAIADAAFCFafaLGPFFSGPLVKSLGFPTMMYIIA 485
Cdd:cd17319 92 TSLYVLRFLLGVA----EAGFFPGAIKALaewfPARERGRATGLFNSGAPLGAA---IGPPLSGWLLLLFGWRWAFIIEG 164
|
170
....*....|...
gi 71997647 486 VISFLYAPLMFLL 498
Cdd:cd17319 165 LLGLLLAVLWWFY 177
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
328-509 |
7.06e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 328 AITIGNLGIAMLEPSLPLWMMESwGANSLERGAAFLPASISYLIGTNIFGPLAHRIGR-----WLSSFIGLVVIGFSLLS 402
Cdd:cd06173 7 AQLLSALGDWIFTVALPWLVLQL-TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRrrlliLADLLRALLAAVLALLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 403 IPSATSVAGLIIphalLGFSIGMIDASMFP-LMGYLVDIRHVGVYGSIYAIADAAFCFAFALGPFFSGPLVKSLGFPTMM 481
Cdd:cd06173 86 LLGSLSLWLLLV----LAFLLGIASAFFGPaRQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF 161
|
170 180
....*....|....*....|....*...
gi 71997647 482 YIIAVISFLYAPLMFLLKNPPVLIEPTP 509
Cdd:cd06173 162 AINALSFLLSALLLLFIRRPPPAAPGES 189
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
160-446 |
7.86e-03 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 38.64 E-value: 7.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 160 VGLMFGSKALVQLLVnPWIGPLTNR------------IGYTMPMFGGFVIMFCSTILFAFGDSYFTLW---LARALQGVG 224
Cdd:cd06176 38 VGLLIALHYLVAPLR-VWIGHRSDThplrgyrrtpyiWLGMLLLALGLALAPFAALLLAGAAFWLGLAlavLAFLLYGIG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 225 SACTSTSGMGMLAQAYPDDlERGSAMGIALGGLALGVLVGPPYGGLLYQwsgkelPFVLLALLALFDG-SIQFMVL---- 299
Cdd:cd06176 117 VGAAGTAFLALLADLTPEE-RRPRAVTVVWTMLILGIIVTAIVFGRLLD------PYSPERLIQVFQIvALVALLLalla 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 300 -------------QPKIDRGEPEGSSIKQLAKDPYIIVAAGAITIGNLGIAMLEPslplwMMESWGA------------- 353
Cdd:cd06176 190 lwgverrrsraalAAEEAPPETFREALRLLWASPQARRFFIFLFLSTLALFMQDV-----ILEPFGGevfgmsvgettrl 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 354 NSLERGAAFLPasisyLIGTNIFGPLAHRIGRWLSSFIGLVVIGFSLLSIPSATSVAGLIIPH-ALLGFSIGMIDASMFP 432
Cdd:cd06176 265 TAIWGGGTLLG-----MLLAGFLLSRRLGKKRTAALGCLLSALGFLLLALAGLLGNPWLFRPGvFLLGLGNGLFTVGALT 339
|
330
....*....|....
gi 71997647 433 LMGYLVDIRHVGVY 446
Cdd:cd06176 340 LMMDLTGEGTAGLF 353
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
161-271 |
9.59e-03 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 38.34 E-value: 9.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997647 161 GLMFGSKALVQLLVNPWIGPLTNRIGYTM-PMFGGFVIMFCSTILFAFGDSYFTLW-----LARALQGVGSactstsGMG 234
Cdd:cd17326 39 GWVVAAYSLGQLVFSPVFGYWSNKTSSVKePLIVSILIAIVGNILYALAEYFPSNRkyvmlVARFLIGVGA------GNV 112
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 71997647 235 MLAQAYPDDL----ERGSAMGIALGGLALGVLVGPPYGGLL 271
Cdd:cd17326 113 AVLRAYVAAAstlkDRTRAMAVISAAQALGFIVGPALQAAF 153
|
|
| |
