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Conserved domains on  [gi|72003693|ref|NP_001024984|]
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Homeobox protein dve-1 [Caenorhabditis elegans]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10878077)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 2-100 1.37e-46

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


:

Pssm-ID: 211426  Cd Length: 100  Bit Score: 156.72  E-value: 1.37e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72003693   2 FPMRVIVETVRSQHCLTCSNEGHMITDTYAIVAGTTTLNQLVETVLAALGHS-SMSTSARGLIQVNNWKPLPFDQITENL 80
Cdd:cd11585   1 LPVHCVVETVDSLHESVWRRRPRVETDSYVIIPKDTLFNQLVETALLRLGYShSSAASAKGLIQIKNWKPLPFDQITDNP 80

                        90       100
                ....*....|....*....|
gi 72003693  81 DDTVENLFKDISSHVVLKIL 100
Cdd:cd11585  81 DATVGDMLGELTHVATLRIQ 100
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 387-452 9.49e-13

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 62.65  E-value: 9.49e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72003693    387 RSRLMFDPlTELPVLEKWFEENPHPTWMQIDQYTQCLNncayrenyphISQHNVKIWFKNRRAKCK 452
Cdd:smart00389   3 RKRTSFTP-EQLEELEKEFQKNPYPSREEREELAKKLG----------LSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 187-245 2.29e-03

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 36.07  E-value: 2.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 72003693    187 TLYEIPRLDKWFKSDANPSKQKMNNYLSQLNqspfrknnskISYQQICNWFTQKRSSSR 245
Cdd:smart00389   9 TPEQLEELEKEFQKNPYPSREEREELAKKLG----------LSERQVKVWFQNRRAKWK 57
 
Name Accession Description Interval E-value
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 2-100 1.37e-46

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


Pssm-ID: 211426  Cd Length: 100  Bit Score: 156.72  E-value: 1.37e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72003693   2 FPMRVIVETVRSQHCLTCSNEGHMITDTYAIVAGTTTLNQLVETVLAALGHS-SMSTSARGLIQVNNWKPLPFDQITENL 80
Cdd:cd11585   1 LPVHCVVETVDSLHESVWRRRPRVETDSYVIIPKDTLFNQLVETALLRLGYShSSAASAKGLIQIKNWKPLPFDQITDNP 80

                        90       100
                ....*....|....*....|
gi 72003693  81 DDTVENLFKDISSHVVLKIL 100
Cdd:cd11585  81 DATVGDMLGELTHVATLRIQ 100
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 1-100 1.26e-25

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


Pssm-ID: 465165  Cd Length: 105  Bit Score: 100.50  E-value: 1.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72003693     1 MFPMRVIVETVRSQHCLTCSNE--GHMITDTYAIVAGTTTLNQLVETVLAALGHS-SMSTSARGLIQVNNWKPLPFDQIT 77
Cdd:pfam16534   2 SLPVHCVVEQVESLQESNECDErtPNVEHDSYVIIPKDTLFSDLVETALLRLGYShSSAAQAKGSIQIKNWKPLSLESIT 81

                          90       100
                  ....*....|....*....|...
gi 72003693    78 ENLDDTVENLFKDISSHVVLKIL 100
Cdd:pfam16534  82 DDPDATVGDMLGDLTTVATLRIQ 104
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 387-452 9.49e-13

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 62.65  E-value: 9.49e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72003693    387 RSRLMFDPlTELPVLEKWFEENPHPTWMQIDQYTQCLNncayrenyphISQHNVKIWFKNRRAKCK 452
Cdd:smart00389   3 RKRTSFTP-EQLEELEKEFQKNPYPSREEREELAKKLG----------LSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 387-453 2.84e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 58.79  E-value: 2.84e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72003693 387 RSRLMFDPlTELPVLEKWFEENPHPTWMQIDQYTQCLNncayrenyphISQHNVKIWFKNRRAKCKR 453
Cdd:cd00086   2 RKRTRFTP-EQLEELEKEFEKNPYPSREEREELAKELG----------LTERQVKIWFQNRRAKLKR 57
Homeodomain pfam00046
Homeodomain;
387-453 3.66e-08

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 49.81  E-value: 3.66e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72003693   387 RSRLMFDPlTELPVLEKWFEENPHPTWMQIDQYTQCLNncayrenyphISQHNVKIWFKNRRAKCKR 453
Cdd:pfam00046   2 RKRTTFTP-EQLEELEKEFQENPYPSAEEREELAAQLG----------LTERQVKVWFQNRRAKWKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
397-453 6.09e-05

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 43.19  E-value: 6.09e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 72003693 397 ELPVLEKWFEENPHPTWmqidqytqclnncAYRENY---PHISQHNVKIWFKNRRAKCKR 453
Cdd:COG5576  62 QLMVLEREFEINPYPSS-------------ITRIKLsllLNMPPKSVQIWFQNKRAKEKK 108
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 187-245 2.29e-03

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 36.07  E-value: 2.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 72003693    187 TLYEIPRLDKWFKSDANPSKQKMNNYLSQLNqspfrknnskISYQQICNWFTQKRSSSR 245
Cdd:smart00389   9 TPEQLEELEKEFQKNPYPSREEREELAKKLG----------LSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 187-245 9.59e-03

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 34.53  E-value: 9.59e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 72003693 187 TLYEIPRLDKWFKSDANPSKQKMNNYLSQLNqspfrknnskISYQQICNWFTQKRSSSR 245
Cdd:cd00086   8 TPEQLEELEKEFEKNPYPSREEREELAKELG----------LTERQVKIWFQNRRAKLK 56
 
Name Accession Description Interval E-value
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 2-100 1.37e-46

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


Pssm-ID: 211426  Cd Length: 100  Bit Score: 156.72  E-value: 1.37e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72003693   2 FPMRVIVETVRSQHCLTCSNEGHMITDTYAIVAGTTTLNQLVETVLAALGHS-SMSTSARGLIQVNNWKPLPFDQITENL 80
Cdd:cd11585   1 LPVHCVVETVDSLHESVWRRRPRVETDSYVIIPKDTLFNQLVETALLRLGYShSSAASAKGLIQIKNWKPLPFDQITDNP 80

                        90       100
                ....*....|....*....|
gi 72003693  81 DDTVENLFKDISSHVVLKIL 100
Cdd:cd11585  81 DATVGDMLGELTHVATLRIQ 100
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 1-100 1.26e-25

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


Pssm-ID: 465165  Cd Length: 105  Bit Score: 100.50  E-value: 1.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72003693     1 MFPMRVIVETVRSQHCLTCSNE--GHMITDTYAIVAGTTTLNQLVETVLAALGHS-SMSTSARGLIQVNNWKPLPFDQIT 77
Cdd:pfam16534   2 SLPVHCVVEQVESLQESNECDErtPNVEHDSYVIIPKDTLFSDLVETALLRLGYShSSAAQAKGSIQIKNWKPLSLESIT 81

                          90       100
                  ....*....|....*....|...
gi 72003693    78 ENLDDTVENLFKDISSHVVLKIL 100
Cdd:pfam16534  82 DDPDATVGDMLGDLTTVATLRIQ 104
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 387-452 9.49e-13

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 62.65  E-value: 9.49e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 72003693    387 RSRLMFDPlTELPVLEKWFEENPHPTWMQIDQYTQCLNncayrenyphISQHNVKIWFKNRRAKCK 452
Cdd:smart00389   3 RKRTSFTP-EQLEELEKEFQKNPYPSREEREELAKKLG----------LSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 387-453 2.84e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 58.79  E-value: 2.84e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72003693 387 RSRLMFDPlTELPVLEKWFEENPHPTWMQIDQYTQCLNncayrenyphISQHNVKIWFKNRRAKCKR 453
Cdd:cd00086   2 RKRTRFTP-EQLEELEKEFEKNPYPSREEREELAKELG----------LTERQVKIWFQNRRAKLKR 57
Homeodomain pfam00046
Homeodomain;
387-453 3.66e-08

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 49.81  E-value: 3.66e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 72003693   387 RSRLMFDPlTELPVLEKWFEENPHPTWMQIDQYTQCLNncayrenyphISQHNVKIWFKNRRAKCKR 453
Cdd:pfam00046   2 RKRTTFTP-EQLEELEKEFQENPYPSAEEREELAAQLG----------LTERQVKVWFQNRRAKWKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
397-453 6.09e-05

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 43.19  E-value: 6.09e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 72003693 397 ELPVLEKWFEENPHPTWmqidqytqclnncAYRENY---PHISQHNVKIWFKNRRAKCKR 453
Cdd:COG5576  62 QLMVLEREFEINPYPSS-------------ITRIKLsllLNMPPKSVQIWFQNKRAKEKK 108
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 187-245 2.29e-03

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 36.07  E-value: 2.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 72003693    187 TLYEIPRLDKWFKSDANPSKQKMNNYLSQLNqspfrknnskISYQQICNWFTQKRSSSR 245
Cdd:smart00389   9 TPEQLEELEKEFQKNPYPSREEREELAKKLG----------LSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 187-245 9.59e-03

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 34.53  E-value: 9.59e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 72003693 187 TLYEIPRLDKWFKSDANPSKQKMNNYLSQLNqspfrknnskISYQQICNWFTQKRSSSR 245
Cdd:cd00086   8 TPEQLEELEKEFEKNPYPSREEREELAKELG----------LTERQVKIWFQNRRAKLK 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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