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Conserved domains on  [gi|71067112|ref|NP_001025009|]
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homeobox protein PKNOX2 isoform 1 [Mus musculus]

Protein Classification

homeobox protein( domain architecture ID 11243274)

homeobox protein is involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 96-181 1.90e-51

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


:

Pssm-ID: 465140  Cd Length: 86  Bit Score: 169.06  E-value: 1.90e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71067112    96 GSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNL 175
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIERAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKVHELCDNFCHRYITCLKGKMPSDLV 80


                  ....*.
gi 71067112   176 LRNDLG 181
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 307-345 6.53e-20

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 82.56  E-value: 6.53e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 71067112   307 LFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 345
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
PLN02983 super family cl33616
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 3-66 6.28e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


The actual alignment was detected with superfamily member PLN02983:

Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 38.28  E-value: 6.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71067112    3 QHASPAPALTMMatqnvPPPPYQDSPQMTATAQPpskaqavhisAPSATASTPVPSAPIDPQAQ 66
Cdd:PLN02983 143 QPPPPAPVVMMQ-----PPPPHAMPPASPPAAQP----------APSAPASSPPPTPASPPPAK 191
 
Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 96-181 1.90e-51

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


Pssm-ID: 465140  Cd Length: 86  Bit Score: 169.06  E-value: 1.90e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71067112    96 GSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNL 175
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIERAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKVHELCDNFCHRYITCLKGKMPSDLV 80


                  ....*.
gi 71067112   176 LRNDLG 181
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 307-345 6.53e-20

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 82.56  E-value: 6.53e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 71067112   307 LFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 345
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 288-345 9.31e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 65.73  E-value: 9.31e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 71067112    288 SKNKRGVLPKHATNIMRSWlFQHlmHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 345
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKE-FQK--NPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 289-345 9.55e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 65.73  E-value: 9.55e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 71067112 289 KNKRGVLPKHATNIMRSWlFQHlmHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 345
Cdd:cd00086   1 RRKRTRFTPEQLEELEKE-FEK--NPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 3-66 6.28e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 38.28  E-value: 6.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71067112    3 QHASPAPALTMMatqnvPPPPYQDSPQMTATAQPpskaqavhisAPSATASTPVPSAPIDPQAQ 66
Cdd:PLN02983 143 QPPPPAPVVMMQ-----PPPPHAMPPASPPAAQP----------APSAPASSPPPTPASPPPAK 191
 
Name Accession Description Interval E-value
Meis_PKNOX_N pfam16493
N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of ...
 96-181 1.90e-51

N-terminal of Homeobox Meis and PKNOX1; Meis_PKNOX_N is a family found at the N-terminus of Meis, Myeloid ecotropic viral integration site, transcription regulators and PKNOX1 regulators, PBX/knotted 1 homeobox 1, homeobox proteins.


Pssm-ID: 465140  Cd Length: 86  Bit Score: 169.06  E-value: 1.90e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71067112    96 GSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNL 175
Cdd:pfam16493   1 GGDVCSSDSFDEDIAVFAKQIERAEKPIFSPNPELDNLMIKAIQVLRIHLLELEKVHELCDNFCHRYITCLKGKMPSDLV 80


                  ....*.
gi 71067112   176 LRNDLG 181
Cdd:pfam16493  81 LDDREG 86
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 307-345 6.53e-20

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 82.56  E-value: 6.53e-20
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 71067112   307 LFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 345
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 288-345 9.31e-14

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 65.73  E-value: 9.31e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 71067112    288 SKNKRGVLPKHATNIMRSWlFQHlmHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 345
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKE-FQK--NPYPSREEREELAKKLGLSERQVKVWFQNRRAK 55
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 289-345 9.55e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 65.73  E-value: 9.55e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 71067112 289 KNKRGVLPKHATNIMRSWlFQHlmHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 345
Cdd:cd00086   1 RRKRTRFTPEQLEELEKE-FEK--NPYPSREEREELAKELGLTERQVKIWFQNRRAK 54
Homeodomain pfam00046
Homeodomain;
307-345 5.14e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 43.64  E-value: 5.14e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 71067112   307 LFQhlMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRR 345
Cdd:pfam00046  18 EFQ--ENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 3-66 6.28e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 38.28  E-value: 6.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71067112    3 QHASPAPALTMMatqnvPPPPYQDSPQMTATAQPpskaqavhisAPSATASTPVPSAPIDPQAQ 66
Cdd:PLN02983 143 QPPPPAPVVMMQ-----PPPPHAMPPASPPAAQP----------APSAPASSPPPTPASPPPAK 191
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
4-75 7.91e-03

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 38.08  E-value: 7.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71067112    4 HASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQaVHISAPSATASTP------VPSAPIDPQAQLE-----ADKR 72
Cdd:PRK13042  29 NATTPSSTKVEAPQSTPPSTKVEAPQSKPNATTPPSTK-VEAPQQTPNATTPsstkveTPQSPTTKQVPTEinpkfKDLR 107


                 ...
gi 71067112   73 AVY 75
Cdd:PRK13042 108 AYY 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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