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Conserved domains on  [gi|71480154|ref|NP_001025109|]
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rab-interacting lysosomal protein [Mus musculus]

Protein Classification

ATP-binding protein; ENTH domain-containing protein( domain architecture ID 10199244)

ATPase similar to histidine kinase domains| ENTH (Epsin N-Terminal Homology) domain-containing protein may be involved in clathrin-mediated endocytosis; similar to epsin that plays an important role as accessory proteins in clathrin-mediated endocytosis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RILP-like cd14445
Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in ...
 11-107 3.62e-21

Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in Rab interacting lysosomal protein-like 1 and 2, and appears to be conserved in Bilateria. The Rilp-like proteins regulate the concentration of ciliary membrane proteins in the primary cilium. Rilpl2 interacts with myosin-Va and has been linked to the regulation of cellular morphology in neurons; it forms a complex with Rac1 and activates Rac1-Pak signaling, dependent on myosin-Va.


:

Pssm-ID: 271220 [Multi-domain]  Cd Length: 89  Bit Score: 86.49  E-value: 3.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154  11 PSQASSSVGAGSAAELVYHLAGALGTELQGLARRFGPDAAAGLVPLVVRALELLEKAAVGPAPDSLqvsaqqaevELRRL 90
Cdd:cd14445   2 AESALDKSPSELTVVDVYDIASAIGKEFERLIDRYGPEAVAGLMPKVVRVLELLEALASRNERENL---------EIEEL 72

                        90
                ....*....|....*..
gi 71480154  91 REENQRLRQELGSGPQE 107
Cdd:cd14445  73 RLEVDRLELEKRERAQK 89
RILP pfam11461
Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil ...
 223-287 8.22e-21

Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes.


:

Pssm-ID: 463282 [Multi-domain]  Cd Length: 69  Bit Score: 84.95  E-value: 8.22e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71480154   223 SREELKQILQERNELKANVFLLKEELAYFQRELLTDHRVPGLLLEAMKVAVKKQRRKIKAKMLGT 287
Cdd:pfam11461   1 TLQELRDVLQERNELKAQLFLLQEELAYYKSGLLNEEEIPSLRLESPSPRTKPQRSKIKQEESGI 65
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 74-260 9.66e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 9.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154  74 DSLQVSAQQAEVELRRLREENQRLRQELGSGPQEERALLRQLKEVT---DRQRDELRAHNRDLQRRSQETEALQEQLQRL 150
Cdd:COG1196 256 EELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEqdiARLEERRRELEERLEELEEELAELEEELEEL 335

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154 151 LLINSELRHKLAAVQTQLRAAQDRERERQIAQDGSSQLAKEQSLEPDAATSDdpvDTQKQPGNLPEAVQCGFSREELKQI 230
Cdd:COG1196 336 EEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEE---LLEALRAAAELAAQLEELEEAEEAL 412

                       170       180       190
                ....*....|....*....|....*....|
gi 71480154 231 LQERNELKANVFLLKEELAYFQRELLTDHR 260
Cdd:COG1196 413 LERLERLEEELEELEEALAELEEEEEEEEE 442
 
Name Accession Description Interval E-value
RILP-like cd14445
Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in ...
 11-107 3.62e-21

Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in Rab interacting lysosomal protein-like 1 and 2, and appears to be conserved in Bilateria. The Rilp-like proteins regulate the concentration of ciliary membrane proteins in the primary cilium. Rilpl2 interacts with myosin-Va and has been linked to the regulation of cellular morphology in neurons; it forms a complex with Rac1 and activates Rac1-Pak signaling, dependent on myosin-Va.


Pssm-ID: 271220 [Multi-domain]  Cd Length: 89  Bit Score: 86.49  E-value: 3.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154  11 PSQASSSVGAGSAAELVYHLAGALGTELQGLARRFGPDAAAGLVPLVVRALELLEKAAVGPAPDSLqvsaqqaevELRRL 90
Cdd:cd14445   2 AESALDKSPSELTVVDVYDIASAIGKEFERLIDRYGPEAVAGLMPKVVRVLELLEALASRNERENL---------EIEEL 72

                        90
                ....*....|....*..
gi 71480154  91 REENQRLRQELGSGPQE 107
Cdd:cd14445  73 RLEVDRLELEKRERAQK 89
RILP pfam11461
Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil ...
 223-287 8.22e-21

Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes.


Pssm-ID: 463282 [Multi-domain]  Cd Length: 69  Bit Score: 84.95  E-value: 8.22e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71480154   223 SREELKQILQERNELKANVFLLKEELAYFQRELLTDHRVPGLLLEAMKVAVKKQRRKIKAKMLGT 287
Cdd:pfam11461   1 TLQELRDVLQERNELKAQLFLLQEELAYYKSGLLNEEEIPSLRLESPSPRTKPQRSKIKQEESGI 65
Jnk-SapK_ap_N pfam09744
JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins ...
 27-177 1.08e-12

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.


Pssm-ID: 462875 [Multi-domain]  Cd Length: 150  Bit Score: 64.94  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154    27 VYHLAGALGTELQGLARRFGPDAAAGLVPLVVRALELLEKAAVGpapdslqvsAQQAEVELRRLREENQRLRQELgsgpQ 106
Cdd:pfam09744   1 VYDLASSIGKEFERLIDRYGEDVVKGLMPKVVNVLELLESLASR---------NQEHNVELEELREDNEQLETQY----E 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71480154   107 EERALLRQLKEVTDRQRDELRAHNRDLQRRSQETEALQEQLQRLLLINSELRHklAAVQTQLRAAQDRERE 177
Cdd:pfam09744  68 REKALRKRAEEELEEIEDQWEQETKDLLSQVESLEEENRRLEADHVSRLEEKE--AELKKEYSKLHERETE 136
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 74-260 9.66e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 9.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154  74 DSLQVSAQQAEVELRRLREENQRLRQELGSGPQEERALLRQLKEVT---DRQRDELRAHNRDLQRRSQETEALQEQLQRL 150
Cdd:COG1196 256 EELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEqdiARLEERRRELEERLEELEEELAELEEELEEL 335

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154 151 LLINSELRHKLAAVQTQLRAAQDRERERQIAQDGSSQLAKEQSLEPDAATSDdpvDTQKQPGNLPEAVQCGFSREELKQI 230
Cdd:COG1196 336 EEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEE---LLEALRAAAELAAQLEELEEAEEAL 412

                       170       180       190
                ....*....|....*....|....*....|
gi 71480154 231 LQERNELKANVFLLKEELAYFQRELLTDHR 260
Cdd:COG1196 413 LERLERLEEELEELEEALAELEEEEEEEEE 442
 
Name Accession Description Interval E-value
RILP-like cd14445
Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in ...
 11-107 3.62e-21

Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2); This domain is found in Rab interacting lysosomal protein-like 1 and 2, and appears to be conserved in Bilateria. The Rilp-like proteins regulate the concentration of ciliary membrane proteins in the primary cilium. Rilpl2 interacts with myosin-Va and has been linked to the regulation of cellular morphology in neurons; it forms a complex with Rac1 and activates Rac1-Pak signaling, dependent on myosin-Va.


Pssm-ID: 271220 [Multi-domain]  Cd Length: 89  Bit Score: 86.49  E-value: 3.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154  11 PSQASSSVGAGSAAELVYHLAGALGTELQGLARRFGPDAAAGLVPLVVRALELLEKAAVGPAPDSLqvsaqqaevELRRL 90
Cdd:cd14445   2 AESALDKSPSELTVVDVYDIASAIGKEFERLIDRYGPEAVAGLMPKVVRVLELLEALASRNERENL---------EIEEL 72

                        90
                ....*....|....*..
gi 71480154  91 REENQRLRQELGSGPQE 107
Cdd:cd14445  73 RLEVDRLELEKRERAQK 89
RILP pfam11461
Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil ...
 223-287 8.22e-21

Rab interacting lysosomal protein; RILP contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes.


Pssm-ID: 463282 [Multi-domain]  Cd Length: 69  Bit Score: 84.95  E-value: 8.22e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71480154   223 SREELKQILQERNELKANVFLLKEELAYFQRELLTDHRVPGLLLEAMKVAVKKQRRKIKAKMLGT 287
Cdd:pfam11461   1 TLQELRDVLQERNELKAQLFLLQEELAYYKSGLLNEEEIPSLRLESPSPRTKPQRSKIKQEESGI 65
Jnk-SapK_ap_N pfam09744
JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins ...
 27-177 1.08e-12

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.


Pssm-ID: 462875 [Multi-domain]  Cd Length: 150  Bit Score: 64.94  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154    27 VYHLAGALGTELQGLARRFGPDAAAGLVPLVVRALELLEKAAVGpapdslqvsAQQAEVELRRLREENQRLRQELgsgpQ 106
Cdd:pfam09744   1 VYDLASSIGKEFERLIDRYGEDVVKGLMPKVVNVLELLESLASR---------NQEHNVELEELREDNEQLETQY----E 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71480154   107 EERALLRQLKEVTDRQRDELRAHNRDLQRRSQETEALQEQLQRLLLINSELRHklAAVQTQLRAAQDRERE 177
Cdd:pfam09744  68 REKALRKRAEEELEEIEDQWEQETKDLLSQVESLEEENRRLEADHVSRLEEKE--AELKKEYSKLHERETE 136
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 74-260 9.66e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 9.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154  74 DSLQVSAQQAEVELRRLREENQRLRQELGSGPQEERALLRQLKEVT---DRQRDELRAHNRDLQRRSQETEALQEQLQRL 150
Cdd:COG1196 256 EELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEqdiARLEERRRELEERLEELEEELAELEEELEEL 335

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71480154 151 LLINSELRHKLAAVQTQLRAAQDRERERQIAQDGSSQLAKEQSLEPDAATSDdpvDTQKQPGNLPEAVQCGFSREELKQI 230
Cdd:COG1196 336 EEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEE---LLEALRAAAELAAQLEELEEAEEAL 412

                       170       180       190
                ....*....|....*....|....*....|
gi 71480154 231 LQERNELKANVFLLKEELAYFQRELLTDHR 260
Cdd:COG1196 413 LERLERLEEELEELEEALAELEEEEEEEEE 442
GemC1_CC cd22588
central coiled-coil domain of geminin coiled-coil domain-containing protein 1; Geminin ...
 76-117 4.90e-03

central coiled-coil domain of geminin coiled-coil domain-containing protein 1; Geminin coiled-coil domain-containing protein 1 (GemC1), which, together with McIdas (also called Idas or multicilin) and geminin, controls both the cell cycle and differentiation decisions in cells. GemC1 binds to geminin and is implicated in DNA replication control. It also functions as an early regulator of multiciliogenesis. GemC1 and Idas specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors, resulting in centriole amplification and cilia formation. GemC1 belongs to the geminin family of proteins that also includes geminin and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of GemC1.


Pssm-ID: 439142  Cd Length: 61  Bit Score: 35.21  E-value: 4.90e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 71480154  76 LQVSAQQAEVELRRLREENQRLRQELGSgpqeerALLRQLKE 117
Cdd:cd22588  18 LQDTLLQKEEELARLHEENNKLRQFLNS------SFVKCLEE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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