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Conserved domains on  [gi|71895697|ref|NP_001026087|]
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methylosome protein WDR77 [Gallus gallus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
97-339 9.71e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 9.71e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697  97 EAGVADLRWVAD-RGILVGSDSGAVELWELDEKETLIVNKfckyEHDDMVEAVDVLAGSTRAVSGGRDFSVKVWDLPQQA 175
Cdd:COG2319 162 SGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 176 VLHSYRAHSDAVTCVAACPGkDTIFLSCAEDERILLWDTRCPKPATRIvcSACNYLPTSVLWHPqESDIFALGDESGTVA 255
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTL--TGHSGGVNSVAFSP-DGKLLASGSDDGTVR 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 256 LVDTKNPDSALSSIVHARRVTGFAFSAHSSpLLASISEDCTVAVLN-SDLSEVFRSRSHRDFVKGLSWSPsDNALLTTVG 334
Cdd:COG2319 314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                ....*
gi 71895697 335 WDHQV 339
Cdd:COG2319 392 ADGTV 396
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
97-339 9.71e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 9.71e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697  97 EAGVADLRWVAD-RGILVGSDSGAVELWELDEKETLIVNKfckyEHDDMVEAVDVLAGSTRAVSGGRDFSVKVWDLPQQA 175
Cdd:COG2319 162 SGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 176 VLHSYRAHSDAVTCVAACPGkDTIFLSCAEDERILLWDTRCPKPATRIvcSACNYLPTSVLWHPqESDIFALGDESGTVA 255
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTL--TGHSGGVNSVAFSP-DGKLLASGSDDGTVR 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 256 LVDTKNPDSALSSIVHARRVTGFAFSAHSSpLLASISEDCTVAVLN-SDLSEVFRSRSHRDFVKGLSWSPsDNALLTTVG 334
Cdd:COG2319 314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                ....*
gi 71895697 335 WDHQV 339
Cdd:COG2319 392 ADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-339 3.35e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 3.35e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697  97 EAGVADLRWVADRG-ILVGSDSGAVELWELDEKETLIVnkfckYE-HDDMVEAVDVLAGSTRAVSGGRDFSVKVWDLPQQ 174
Cdd:cd00200  51 TGPVRDVAASADGTyLASGSSDKTIRLWDLETGECVRT-----LTgHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 175 AVLHSYRAHSDAVTCVAACPGKDTIFlSCAEDERILLWDTRCPKPATRI------VCSACnylptsvlWHPQESDIFAlG 248
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVA-SSSQDGTIKLWDLRTGKCVATLtghtgeVNSVA--------FSPDGEKLLS-S 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 249 DESGTVALVDTKNPDSALSSIVHARRVTGFAFSAHSSpLLASISEDCTVAVLNSDL-SEVFRSRSHRDFVKGLSWSPSDN 327
Cdd:cd00200 196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRTgECVQTLSGHTNSVTSLAWSPDGK 274

                       250
                ....*....|..
gi 71895697 328 ALLTTvGWDHQV 339
Cdd:cd00200 275 RLASG-SADGTI 285
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 176-213 2.55e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 71895697    176 VLHSYRAHSDAVTCVAACPgKDTIFLSCAEDERILLWD 213
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
177-213 2.21e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 71895697   177 LHSYRAHSDAVTCVAACPgKDTIFLSCAEDERILLWD 213
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
97-339 9.71e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 9.71e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697  97 EAGVADLRWVAD-RGILVGSDSGAVELWELDEKETLIVNKfckyEHDDMVEAVDVLAGSTRAVSGGRDFSVKVWDLPQQA 175
Cdd:COG2319 162 SGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 176 VLHSYRAHSDAVTCVAACPGkDTIFLSCAEDERILLWDTRCPKPATRIvcSACNYLPTSVLWHPqESDIFALGDESGTVA 255
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTL--TGHSGGVNSVAFSP-DGKLLASGSDDGTVR 313

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 256 LVDTKNPDSALSSIVHARRVTGFAFSAHSSpLLASISEDCTVAVLN-SDLSEVFRSRSHRDFVKGLSWSPsDNALLTTVG 334
Cdd:COG2319 314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSP-DGRTLASGS 391


                ....*
gi 71895697 335 WDHQV 339
Cdd:COG2319 392 ADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
18-339 2.15e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 2.15e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697  18 SAGGEEDEAAAAGGPEWNIPPNAPACMERHLERAHYRADGALLLGASGLSGRCWAGSIWVFADPRRAPSEGFCTAGVQTE 97
Cdd:COG2319   5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697  98 AGVADLRWVAdrgilVGSDSGAVELWELDEKETLIVNKfckyEHDDMVEAVDVLAGSTRAVSGGRDFSVKVWDLPQQAVL 177
Cdd:COG2319  85 AFSPDGRLLA-----SASADGTVRLWDLATGLLLRTLT----GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 178 HSYRAHSDAVTCVAACPGKDTIfLSCAEDERILLWDTRCPKPATRIvcSACNYLPTSVLWHPQeSDIFALGDESGTVALV 257
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 258 DTKNPDSALSSIVHARRVTGFAFSaHSSPLLASISEDCTVAVLNSDLSEVFRS-RSHRDFVKGLSWSPsDNALLTTVGWD 336
Cdd:COG2319 232 DLATGKLLRTLTGHSGSVRSVAFS-PDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSVAFSP-DGKLLASGSDD 309


                ...
gi 71895697 337 HQV 339
Cdd:COG2319 310 GTV 312
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-339 3.35e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 3.35e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697  97 EAGVADLRWVADRG-ILVGSDSGAVELWELDEKETLIVnkfckYE-HDDMVEAVDVLAGSTRAVSGGRDFSVKVWDLPQQ 174
Cdd:cd00200  51 TGPVRDVAASADGTyLASGSSDKTIRLWDLETGECVRT-----LTgHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 175 AVLHSYRAHSDAVTCVAACPGKDTIFlSCAEDERILLWDTRCPKPATRI------VCSACnylptsvlWHPQESDIFAlG 248
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVA-SSSQDGTIKLWDLRTGKCVATLtghtgeVNSVA--------FSPDGEKLLS-S 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 249 DESGTVALVDTKNPDSALSSIVHARRVTGFAFSAHSSpLLASISEDCTVAVLNSDL-SEVFRSRSHRDFVKGLSWSPSDN 327
Cdd:cd00200 196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRTgECVQTLSGHTNSVTSLAWSPDGK 274

                       250
                ....*....|..
gi 71895697 328 ALLTTvGWDHQV 339
Cdd:cd00200 275 RLASG-SADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
97-299 2.82e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 2.82e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697  97 EAGVADLRWVADRGILV-GSDSGAVELWELDEKETLIVNKFckyeHDDMVEAVDVLAGSTRAVSGGRDFSVKVWDLPQQA 175
Cdd:COG2319 204 TGAVRSVAFSPDGKLLAsGSADGTVRLWDLATGKLLRTLTG----HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 176 VLHSYRAHSDAVTCVAACPGkDTIFLSCAEDERILLWDTRCPKPATRIvcSACNYLPTSVLWHPQeSDIFALGDESGTVA 255
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRTL--TGHTGAVRSVAFSPD-GKTLASGSDDGTVR 355

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 71895697 256 LVDTKNPDSALSSIVHARRVTGFAFSAHSSpLLASISEDCTVAV 299
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-357 3.89e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 3.89e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 139 YEHDDMVEAVDVLAGSTRAVSGGRDFSVKVWDLPQQAVLHSYRAHSDAVTCVAACPGKDTIFlSCAEDERILLWDTRCPK 218
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 219 PATRIVCSACNylPTSVLWHPqESDIFALGDESGTVALVDTKNPDSALSSIVHARRVTGFAFSaHSSPLLASISEDCTVA 298
Cdd:cd00200  85 CVRTLTGHTSY--VSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS-PDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71895697 299 VLNSDLSEVFRS-RSHRDFVKGLSWSPSDNALLTTVG------WDHQVLHHTVPIpTGEASGINCV 357
Cdd:cd00200 161 LWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSdgtiklWDLSTGKCLGTL-RGHENGVNSV 225
WD40 COG2319
WD40 repeat [General function prediction only];
97-261 2.41e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 2.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697  97 EAGVADLRWVADRGILV-GSDSGAVELWELDEKETLIVNKfckyEHDDMVEAVDVLAGSTRAVSGGRDFSVKVWDLPQQA 175
Cdd:COG2319 246 SGSVRSVAFSPDGRLLAsGSADGTVRLWDLATGELLRTLT----GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 176 VLHSYRAHSDAVTCVAACPGKDTIfLSCAEDERILLWDTRCPKPATRIvcSACNYLPTSVLWHPqESDIFALGDESGTVA 255
Cdd:COG2319 322 LLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLATGELLRTL--TGHTGAVTSVAFSP-DGRTLASGSADGTVR 397


                ....*.
gi 71895697 256 LVDTKN 261
Cdd:COG2319 398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-339 3.06e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 3.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 177 LHSYRAHSDAVTCVAACPGKDTIfLSCAEDERILLWDT------RCPKPATRIVcsacnylpTSVLWHPQeSDIFALGDE 250
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLL-ATGSGDGTIKVWDLetgellRTLKGHTGPV--------RDVAASAD-GTYLASGSS 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 251 SGTVALVDTKNPDSALSSIVHARRVTGFAFSaHSSPLLASISEDCTVAVLNSDLSEVFRS-RSHRDFVKGLSWSPsDNAL 329
Cdd:cd00200  72 DKTIRLWDLETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTlRGHTDWVNSVAFSP-DGTF 149

                       170
                ....*....|
gi 71895697 330 LTTVGWDHQV 339
Cdd:cd00200 150 VASSSQDGTI 159
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-213 7.64e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 7.64e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71895697 109 RGILVGSDSGAVELWELDEKETLIVNKfckyEHDDMVEAVDVLAGSTRAVSGGRDFSVKVWDLPQQAVLHSYRAHSDAVT 188
Cdd:cd00200 190 EKLLSSSSDGTIKLWDLSTGKCLGTLR----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                        90       100
                ....*....|....*....|....*
gi 71895697 189 CVAACPGKDTIFlSCAEDERILLWD 213
Cdd:cd00200 266 SLAWSPDGKRLA-SGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 176-213 2.55e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.55e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 71895697    176 VLHSYRAHSDAVTCVAACPgKDTIFLSCAEDERILLWD 213
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
177-213 2.21e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 2.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 71895697   177 LHSYRAHSDAVTCVAACPgKDTIFLSCAEDERILLWD 213
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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