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Conserved domains on  [gi|71896361|ref|NP_001026105|]
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acidic leucine-rich nuclear phosphoprotein 32 family member B [Gallus gallus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 705725)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_9 super family cl25994
Leucine-rich repeat;
59-146 5.44e-11

Leucine-rich repeat;


The actual alignment was detected with superfamily member pfam14580:

Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 59.78  E-value: 5.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361    59 NLPKLNKLRKLELSDNRISGGLEVLAERTPNLTHLNLSGNKIKDINTLEPLKKLPNLHSLDLFNCEVTMLINYRESVFTL 138
Cdd:pfam14580  59 GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYK 138


                  ....*...
gi 71896361   139 LPQLTYLD 146
Cdd:pfam14580 139 VPQLRLLD 146
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
59-146 5.44e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 59.78  E-value: 5.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361    59 NLPKLNKLRKLELSDNRISGGLEVLAERTPNLTHLNLSGNKIKDINTLEPLKKLPNLHSLDLFNCEVTMLINYRESVFTL 138
Cdd:pfam14580  59 GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYK 138


                  ....*...
gi 71896361   139 LPQLTYLD 146
Cdd:pfam14580 139 VPQLRLLD 146
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 33-147 9.63e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 9.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361  33 KIVGLSSdFENLEFLSMINVNLLSISNLPKLNKLRKLELSDNRIS-----GGLEVLAE------RTPN------------ 89
Cdd:cd21340  38 KIENLEF-LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISvveglENLTNLEElhienqRLPPgekltfdprsla 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361  90 -----LTHLNLSGNKIKDINTLEPLKKL-----------------------PNLHSLDLFNCEVTMLINYRESVFTLLPQ 141
Cdd:cd21340 117 alsnsLRVLNISGNNIDSLEPLAPLRNLeqldasnnqisdleelldllsswPSLRELDLTGNPVCKKPKYRDKIILASKS 196


                ....*.
gi 71896361 142 LTYLDG 147
Cdd:cd21340 197 LEVLDG 202
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-146 4.57e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 4.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361  24 LDNCRSDDGKIVGLSSDFENLEFLSMINVNLLSI-SNLPKLNKLRKLELSDNRISGGLEVLAERTpNLTHLNLSGNKIKD 102
Cdd:COG4886  95 LTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTD 173

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 71896361 103 INtlEPLKKLPNLHSLDLFNCEVTMLinyrESVFTLLPQLTYLD 146
Cdd:COG4886 174 LP--EELGNLTNLKELDLSNNQITDL----PEPLGNLTNLEELD 211
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 32-146 3.89e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361   32 GKIVGLSSDFENLEFLSMINVNLLSisNLPKL---NKLRKLELSDNRISGGLEVLAERTPNLTHLNLSGNKIKDINTLEp 108
Cdd:PLN00113 442 GRINSRKWDMPSLQMLSLARNKFFG--GLPDSfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE- 518

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 71896361  109 LKKLPNLHSLDLFNCEVTMLInyrESVFTLLPQLTYLD 146
Cdd:PLN00113 519 LSSCKKLVSLDLSHNQLSGQI---PASFSEMPVLSQLD 553
 
Name Accession Description Interval E-value
LRR_9 pfam14580
Leucine-rich repeat;
59-146 5.44e-11

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 59.78  E-value: 5.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361    59 NLPKLNKLRKLELSDNRISGGLEVLAERTPNLTHLNLSGNKIKDINTLEPLKKLPNLHSLDLFNCEVTMLINYRESVFTL 138
Cdd:pfam14580  59 GFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYK 138


                  ....*...
gi 71896361   139 LPQLTYLD 146
Cdd:pfam14580 139 VPQLRLLD 146
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 33-147 9.63e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 9.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361  33 KIVGLSSdFENLEFLSMINVNLLSISNLPKLNKLRKLELSDNRIS-----GGLEVLAE------RTPN------------ 89
Cdd:cd21340  38 KIENLEF-LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISvveglENLTNLEElhienqRLPPgekltfdprsla 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361  90 -----LTHLNLSGNKIKDINTLEPLKKL-----------------------PNLHSLDLFNCEVTMLINYRESVFTLLPQ 141
Cdd:cd21340 117 alsnsLRVLNISGNNIDSLEPLAPLRNLeqldasnnqisdleelldllsswPSLRELDLTGNPVCKKPKYRDKIILASKS 196


                ....*.
gi 71896361 142 LTYLDG 147
Cdd:cd21340 197 LEVLDG 202
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
24-146 4.57e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 4.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361  24 LDNCRSDDGKIVGLSSDFENLEFLSMINVNLLSI-SNLPKLNKLRKLELSDNRISGGLEVLAERTpNLTHLNLSGNKIKD 102
Cdd:COG4886  95 LTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTD 173

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 71896361 103 INtlEPLKKLPNLHSLDLFNCEVTMLinyrESVFTLLPQLTYLD 146
Cdd:COG4886 174 LP--EELGNLTNLKELDLSNNQITDL----PEPLGNLTNLEELD 211
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-116 1.98e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.98e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 71896361  47 LSMINVNLLSISNLPKLNKLRKLELSDNRIS--GGLEVLaertPNLTHLNLSGNKIKDINTLEPLKKLPNLH 116
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITkiENLEFL----TNLTHLYLQNNQIEKIENLENLVNLKKLY 74
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-146 3.71e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 3.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361  39 SDFENLEFLSMINVNLLSIS-NLPKLNKLRKLELSDNRISGgLEVLAERTpNLTHLNLSGNKIKDIntlEPLKKLPNLHS 117
Cdd:COG4886 202 GNLTNLEELDLSGNQLTDLPePLANLTNLETLDLSNNQLTD-LPELGNLT-NLEELDLSNNQLTDL---PPLANLTNLKT 276

                        90       100
                ....*....|....*....|....*....
gi 71896361 118 LDLFNCEVTMLINYRESVFTLLPQLTYLD 146
Cdd:COG4886 277 LDLSNNQLTDLKLKELELLLGLNSLLLLL 305
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 57-120 1.60e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 1.60e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71896361  57 ISNLPKLNKLRKLELSDNRISG-GLEVLAE---RTPNLTHLNLSGNKIKD---INTLEPLKKLPNLHSLDL 120
Cdd:COG5238 285 AKALQGNTTLTSLDLSVNRIGDeGAIALAEglqGNKTLHTLNLAYNGIGAqgaIALAKALQENTTLHSLDL 355
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 88-123 2.30e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 2.30e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 71896361    88 PNLTHLNLSGNKIKDIntlEPLKKLPNLHSLDLFNC 123
Cdd:pfam12799   1 PNLEVLDLSNNQITDI---PPLAKLPNLETLDLSGN 33
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 57-120 3.90e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 3.90e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71896361  57 ISNLPKLNKLRKLELSDNRIS-GGLEVLAE--RTP-NLTHLNLSGNKIKD---INTLEPLKKLPNLHSLDL 120
Cdd:COG5238 229 AEALKGNKSLTTLDLSNNQIGdEGVIALAEalKNNtTVETLYLSGNQIGAegaIALAKALQGNTTLTSLDL 299
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-163 3.64e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 3.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361  39 SDFENLEFLSMINVNLLSISNLPKLNKLRKLELSDNRISgGLEVLAErTPNLTHLNLSGNKIKDIN--TLEPLKKLPNLH 116
Cdd:COG4886 225 ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLT-DLPPLAN-LTNLKTLDLSNNQLTDLKlkELELLLGLNSLL 302

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 71896361 117 SLDLFNCEVTMLINYRESVFTLLPQLTYLDGFDADEQEAPDSDPEAD 163
Cdd:COG4886 303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLAL 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 32-146 3.89e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 3.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71896361   32 GKIVGLSSDFENLEFLSMINVNLLSisNLPKL---NKLRKLELSDNRISGGLEVLAERTPNLTHLNLSGNKIKDINTLEp 108
Cdd:PLN00113 442 GRINSRKWDMPSLQMLSLARNKFFG--GLPDSfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE- 518

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 71896361  109 LKKLPNLHSLDLFNCEVTMLInyrESVFTLLPQLTYLD 146
Cdd:PLN00113 519 LSSCKKLVSLDLSHNQLSGQI---PASFSEMPVLSQLD 553
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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