NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|257196223|ref|NP_001028596|]
View 

fibronectin type III domain containing 3C2 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-698 2.16e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.92  E-value: 2.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 624 LSSTCIAIRWEEPDCHGSPITGYNIEYEDKKIVTVKRI-------TEYVLKDLQPNTTYRIRIQAINHYGLSPFSPSIRC 696
Cdd:cd00063   12 VTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtpgseTSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91


                 ..
gi 257196223 697 KT 698
Cdd:cd00063   92 TT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
584-800 3.34e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 3.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 584 AAVDTVGVGMFGGTAKVTSPGTIPGRVPVLQEVENrvpaklSSTCIAIRWEEPDchGSPITGYNIEYEDKKIVTVKRI-- 661
Cdd:COG3401  210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATAD------TPGSVTLSWDPVT--ESDATGYRVYRSNSGDGPFTKVat 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 662 ---TEYVLKDLQPNTTYRIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQ-LNCVVYGHQSLRLKWGTVSSKKKLDYFIN 736
Cdd:COG3401  282 vttTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAVGSSSITLSWTASSDADVTGYNVY 361

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 257196223 737 YNllmEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTFTTTKSPPTA 800
Cdd:COG3401  362 RS---TSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
78-450 7.10e-16

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.97  E-value: 7.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223  78 STNDGLRPSDVGSTSENNHGETEANMGAGD-NKQILGENQKKSQSSNASLKEHNTENGTQPCCFAIGKPVVSNIQTRSAT 156
Cdd:COG3401   77 SGVAAVAVAAAPPTATGLTTLTGSGSVGGAtNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANAS 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 157 VSWTLKSnekyDINSMSFELALYTSDENGIYENIYTGDGVSVALQDLQPSMVYFLRVTTMRGAEHRSVSEVVSFTTPGCE 236
Cdd:COG3401  157 GTTASSV----AGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 237 PDPPLAPTLISRTKNSLSLQWKGSNENGskISSFLLEWDEGKGEDFKSCYSGRLKQHTLFKLNPSTKYSFRLAAKNDFGC 316
Cdd:COG3401  233 PSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGN 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 317 -SNFSETAVFYTSGKAPTAPLPPKLKEAGIYSLSLEWCAPTNPnpnDTLTYVLEMEEENFGIGFKPAYDGEDLTCTVRNL 395
Cdd:COG3401  311 eSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDA---DVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGL 387

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 257196223 396 QRNTTYKFRIFACNLDGR-SKPSGEVKYTTLPARPGCPKKPYVVGMIHAHQVTIGW 450
Cdd:COG3401  388 TPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 429-523 2.23e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 429 PGCPKKPyVVGMIHAHQVTIGWDLPKDNGGmNISSYSLEVCENSDGAnlWKII--YNGTQQEFLYNDLQAATTYKLRVFC 506
Cdd:cd00063    1 PSPPTNL-RVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGD--WKEVevTPGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*..
gi 257196223 507 TSPAGQSRPSDVLTIQT 523
Cdd:cd00063   77 VNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-698 2.16e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.92  E-value: 2.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 624 LSSTCIAIRWEEPDCHGSPITGYNIEYEDKKIVTVKRI-------TEYVLKDLQPNTTYRIRIQAINHYGLSPFSPSIRC 696
Cdd:cd00063   12 VTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtpgseTSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91


                 ..
gi 257196223 697 KT 698
Cdd:cd00063   92 TT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
584-800 3.34e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 3.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 584 AAVDTVGVGMFGGTAKVTSPGTIPGRVPVLQEVENrvpaklSSTCIAIRWEEPDchGSPITGYNIEYEDKKIVTVKRI-- 661
Cdd:COG3401  210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATAD------TPGSVTLSWDPVT--ESDATGYRVYRSNSGDGPFTKVat 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 662 ---TEYVLKDLQPNTTYRIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQ-LNCVVYGHQSLRLKWGTVSSKKKLDYFIN 736
Cdd:COG3401  282 vttTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAVGSSSITLSWTASSDADVTGYNVY 361

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 257196223 737 YNllmEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTFTTTKSPPTA 800
Cdd:COG3401  362 RS---TSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
78-450 7.10e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.97  E-value: 7.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223  78 STNDGLRPSDVGSTSENNHGETEANMGAGD-NKQILGENQKKSQSSNASLKEHNTENGTQPCCFAIGKPVVSNIQTRSAT 156
Cdd:COG3401   77 SGVAAVAVAAAPPTATGLTTLTGSGSVGGAtNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANAS 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 157 VSWTLKSnekyDINSMSFELALYTSDENGIYENIYTGDGVSVALQDLQPSMVYFLRVTTMRGAEHRSVSEVVSFTTPGCE 236
Cdd:COG3401  157 GTTASSV----AGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 237 PDPPLAPTLISRTKNSLSLQWKGSNENGskISSFLLEWDEGKGEDFKSCYSGRLKQHTLFKLNPSTKYSFRLAAKNDFGC 316
Cdd:COG3401  233 PSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGN 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 317 -SNFSETAVFYTSGKAPTAPLPPKLKEAGIYSLSLEWCAPTNPnpnDTLTYVLEMEEENFGIGFKPAYDGEDLTCTVRNL 395
Cdd:COG3401  311 eSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDA---DVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGL 387

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 257196223 396 QRNTTYKFRIFACNLDGR-SKPSGEVKYTTLPARPGCPKKPYVVGMIHAHQVTIGW 450
Cdd:COG3401  388 TPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-327 3.07e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.76  E-value: 3.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 237 PDPPLAPTLISRTKNSLSLQWKGSNENGSKISSFLLEWDEGKGEDFKSCYSGRLKQ--HTLFKLNPSTKYSFRLAAKNDF 314
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSEtsYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 257196223 315 GCSNFSETAVFYT 327
Cdd:cd00063   81 GESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
624-691 3.27e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 3.27e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 257196223  624 LSSTCIAIRWEEPDCHGSPITGYNIEYEDKK-------IVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLSPFS 691
Cdd:pfam00041  11 VTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsgepwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 625-688 5.81e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 5.81e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 257196223   625 SSTCIAIRWEEP--DCHGSPITGYNIEYED-----KKIVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLS 688
Cdd:smart00060  13 TSTSVTLSWEPPpdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
238-320 4.55e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223  238 DPPLAPTLISRTKNSLSLQWKGSNENGSKISSFLLE-WDEGKGEDFKSCY-SGRLKQHTLFKLNPSTKYSFRLAAKNDFG 315
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEyRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
gi 257196223  316 CSNFS 320
Cdd:pfam00041  81 EGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 429-523 2.23e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 429 PGCPKKPyVVGMIHAHQVTIGWDLPKDNGGmNISSYSLEVCENSDGAnlWKII--YNGTQQEFLYNDLQAATTYKLRVFC 506
Cdd:cd00063    1 PSPPTNL-RVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGD--WKEVevTPGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*..
gi 257196223 507 TSPAGQSRPSDVLTIQT 523
Cdd:cd00063   77 VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 237-317 3.55e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 3.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223   237 PDPPLAPTLISRTKNSLSLQWKGSNENG--SKISSFLLEWDEGKGEDFKSCYSGRLKQHTLFKLNPSTKYSFRLAAKNDF 314
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 257196223   315 GCS 317
Cdd:smart00060  81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 702-793 3.74e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 3.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 702 PPEPPQLNCVVYGHQSLRLKWGTVSSKKK--LDYFINYNLLMEDRSGRFSVIyRGPDVTHKVQKLSEYTEYKFKIQACNE 779
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpiTGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 257196223 780 AGEGPESDIYTFTT 793
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 702-783 1.26e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 1.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223   702 PPEPPQLNCVVYGHQSLRLKWGTVSSKKKLDYFINYNLLMEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEA 780
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 257196223   781 GEG 783
Cdd:smart00060  81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 429-513 4.06e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 4.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223   429 PGCPKKPyVVGMIHAHQVTIGWDLPKDNGGMN-ISSYSLEVCEnsDGANLWKIIYNGTQQEFLYNDLQAATTYKLRVFCT 507
Cdd:smart00060   1 PSPPSNL-RVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYRE--EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*.
gi 257196223   508 SPAGQS 513
Cdd:smart00060  78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
703-786 1.11e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223  703 PEPPQLNCVVYGHQSLRLKW-------GTVSSkkkldYFINY-NLLMEDRSGRFSViyRGPDVTHKVQKLSEYTEYKFKI 774
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWtpppdgnGPITG-----YEVEYrPKNSGEPWNEITV--PGTTTSVTLTGLKPGTEYEVRV 73

                          90
                  ....*....|..
gi 257196223  775 QACNEAGEGPES 786
Cdd:pfam00041  74 QAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-698 2.16e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.92  E-value: 2.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 624 LSSTCIAIRWEEPDCHGSPITGYNIEYEDKKIVTVKRI-------TEYVLKDLQPNTTYRIRIQAINHYGLSPFSPSIRC 696
Cdd:cd00063   12 VTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVevtpgseTSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTV 91


                 ..
gi 257196223 697 KT 698
Cdd:cd00063   92 TT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
584-800 3.34e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 3.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 584 AAVDTVGVGMFGGTAKVTSPGTIPGRVPVLQEVENrvpaklSSTCIAIRWEEPDchGSPITGYNIEYEDKKIVTVKRI-- 661
Cdd:COG3401  210 AATDTGGESAPSNEVSVTTPTTPPSAPTGLTATAD------TPGSVTLSWDPVT--ESDATGYRVYRSNSGDGPFTKVat 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 662 ---TEYVLKDLQPNTTYRIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQ-LNCVVYGHQSLRLKWGTVSSKKKLDYFIN 736
Cdd:COG3401  282 vttTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSgLTATAVGSSSITLSWTASSDADVTGYNVY 361

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 257196223 737 YNllmEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTFTTTKSPPTA 800
Cdd:COG3401  362 RS---TSGGGTYTKIAETVTTTsYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGE 424
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
78-450 7.10e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.97  E-value: 7.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223  78 STNDGLRPSDVGSTSENNHGETEANMGAGD-NKQILGENQKKSQSSNASLKEHNTENGTQPCCFAIGKPVVSNIQTRSAT 156
Cdd:COG3401   77 SGVAAVAVAAAPPTATGLTTLTGSGSVGGAtNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANAS 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 157 VSWTLKSnekyDINSMSFELALYTSDENGIYENIYTGDGVSVALQDLQPSMVYFLRVTTMRGAEHRSVSEVVSFTTPGCE 236
Cdd:COG3401  157 GTTASSV----AGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 237 PDPPLAPTLISRTKNSLSLQWKGSNENGskISSFLLEWDEGKGEDFKSCYSGRLKQHTLFKLNPSTKYSFRLAAKNDFGC 316
Cdd:COG3401  233 PSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGN 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 317 -SNFSETAVFYTSGKAPTAPLPPKLKEAGIYSLSLEWCAPTNPnpnDTLTYVLEMEEENFGIGFKPAYDGEDLTCTVRNL 395
Cdd:COG3401  311 eSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDA---DVTGYNVYRSTSGGGTYTKIAETVTTTSYTDTGL 387

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 257196223 396 QRNTTYKFRIFACNLDGR-SKPSGEVKYTTLPARPGCPKKPYVVGMIHAHQVTIGW 450
Cdd:COG3401  388 TPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVDAVPLTDVAGATA 443
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 237-327 3.07e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.76  E-value: 3.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 237 PDPPLAPTLISRTKNSLSLQWKGSNENGSKISSFLLEWDEGKGEDFKSCYSGRLKQ--HTLFKLNPSTKYSFRLAAKNDF 314
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSEtsYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 257196223 315 GCSNFSETAVFYT 327
Cdd:cd00063   81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
298-528 3.42e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.58  E-value: 3.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 298 LNPSTKYSFRLAAKNDFGCSNFSETAVFYTSGKAPTAPLPPKLKEAGIYSLSLEWcaptNPNPNDTLT-YVLEMEEENFG 376
Cdd:COG3401  199 IEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSW----DPVTESDATgYRVYRSNSGDG 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 377 iGFKPAYDGEDLTCTVRNLQRNTTYKFRIFACNLDG-RSKPSGEVKYTTLPARPGCPKKPYVVgMIHAHQVTIGWDLPKD 455
Cdd:COG3401  275 -PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTAT-AVGSSSITLSWTASSD 352

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 257196223 456 NggmNISSYSLEVCENSDGaNLWKIIYNGTQQEFLYNDLQAATTYKLRVFCTSPAG-QSRPSDVLTIQTPTLPP 528
Cdd:COG3401  353 A---DVTGYNVYRSTSGGG-TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAAS 422
fn3 pfam00041
Fibronectin type III domain;
624-691 3.27e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 3.27e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 257196223  624 LSSTCIAIRWEEPDCHGSPITGYNIEYEDKK-------IVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLSPFS 691
Cdd:pfam00041  11 VTSTSLTVSWTPPPDGNGPITGYEVEYRPKNsgepwneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
326-793 7.70e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.34  E-value: 7.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 326 YTSGKAPTAPLPPKLKEAGIYSLSLEWCAPTNPNPNDTLTYVLEMEEENFGIGFKPAYDGEDLTCTVR-----NLQRNTT 400
Cdd:COG3401  125 ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLvdgggDIEPGTT 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 401 YKFRIFACNLDGRSKPSGEVKYTTLPARPGCPKKPYVVgMIHAHQVTIGWDlpkDNGGMNISSYSLEVCENSDGAnlWKI 480
Cdd:COG3401  205 YYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTAT-ADTPGSVTLSWD---PVTESDATGYRVYRSNSGDGP--FTK 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 481 IYNGTQQEFLYNDLQAATTYKLRVFCTSPAG-QSRPSDVLTIQTPTLPPEScrsqplrgktkgkdanlpdnhsvngkpea 559
Cdd:COG3401  279 VATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAA----------------------------- 329

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 560 hvrgkkakgphqdrkvhPSsekkcaavdtvgvgmfGGTAKVTSPGTipgrvpvlqevenrvpaklsstcIAIRWEEPDch 639
Cdd:COG3401  330 -----------------PS----------------GLTATAVGSSS-----------------------ITLSWTASS-- 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 640 GSPITGYNIEYEDK------KIVTVKRITEYVLKDLQPNTTYRIRIQAINHYGL-SPFSPSIRCKTKPLPPEPPQLNCVV 712
Cdd:COG3401  352 DADVTGYNVYRSTSgggtytKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNeSAPSEEVSATTASAASGESLTASVD 431

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 713 YGHQ--SLRLKWGTVSSKKKLDYFINYNLlmeDRSGRFSVIYRGPDVTHKVQKLSEYTEYKFKIQACNEAGEGPESDIYT 790
Cdd:COG3401  432 AVPLtdVAGATAAASAASNPGVSAAVLAD---GGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNS 508


                 ...
gi 257196223 791 FTT 793
Cdd:COG3401  509 VSV 511
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 625-688 5.81e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 5.81e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 257196223   625 SSTCIAIRWEEP--DCHGSPITGYNIEYED-----KKIVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLS 688
Cdd:smart00060  13 TSTSVTLSWEPPpdDGITGYIVGYRVEYREegsewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 332-424 8.68e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.43  E-value: 8.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 332 PTAPLPPKLKEAGIYSLSLEWCAPTNPNPNDTlTYVLEMEEENFGIGFK-PAYDGEDLTCTVRNLQRNTTYKFRIFACNL 410
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPIT-GYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 257196223 411 DGRSKPSGEVKYTT 424
Cdd:cd00063   80 GGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
238-320 4.55e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 57.04  E-value: 4.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223  238 DPPLAPTLISRTKNSLSLQWKGSNENGSKISSFLLE-WDEGKGEDFKSCY-SGRLKQHTLFKLNPSTKYSFRLAAKNDFG 315
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEyRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
gi 257196223  316 CSNFS 320
Cdd:pfam00041  81 EGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
572-869 1.87e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 61.56  E-value: 1.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 572 DRKVHPSSEKKCAAVDTVGVGMFGGTAKVTSPGTIPGRVPVLQEVENRVPAKLSSTCIAIRWEEPDCHGSPITGYNIEYE 651
Cdd:COG3401  102 SVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 652 DKKIVTVKRITEYVLKDLQPNTTYRIRIQAINHYGLSPFSPSIRCKTKPLPPEPPQ-LNCVVYGHQSLRLKWGTVSSKKK 730
Cdd:COG3401  182 TTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTgLTATADTPGSVTLSWDPVTESDA 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 731 LDYFINYNllmEDRSGRFSVIYRGPDVTHKVQKLSEYTEYKFKIQACNEAG-EGPESDIYTFTTTKSPPTALKAPKVHPL 809
Cdd:COG3401  262 TGYRVYRS---NSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSGLTATAV 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 257196223 810 NNNCCEIKWESlePIEGDPIIYCLQVNTGK--KANQIYKGPN-TSFSFSNYHANSRYRFKVCA 869
Cdd:COG3401  339 GSSSITLSWTA--SSDADVTGYNVYRSTSGggTYTKIAETVTtTSYTDTGLTPGTTYYYKVTA 399
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 429-523 2.23e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.20  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 429 PGCPKKPyVVGMIHAHQVTIGWDLPKDNGGmNISSYSLEVCENSDGAnlWKII--YNGTQQEFLYNDLQAATTYKLRVFC 506
Cdd:cd00063    1 PSPPTNL-RVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGD--WKEVevTPGSETSYTLTGLKPGTEYEFRVRA 76

                         90
                 ....*....|....*..
gi 257196223 507 TSPAGQSRPSDVLTIQT 523
Cdd:cd00063   77 VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 237-317 3.55e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.54  E-value: 3.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223   237 PDPPLAPTLISRTKNSLSLQWKGSNENG--SKISSFLLEWDEGKGEDFKSCYSGRLKQHTLFKLNPSTKYSFRLAAKNDF 314
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 257196223   315 GCS 317
Cdd:smart00060  81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 702-793 3.74e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 54.81  E-value: 3.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 702 PPEPPQLNCVVYGHQSLRLKWGTVSSKKK--LDYFINYNLLMEDRSGRFSVIyRGPDVTHKVQKLSEYTEYKFKIQACNE 779
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGpiTGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 257196223 780 AGEGPESDIYTFTT 793
Cdd:cd00063   80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 702-783 1.26e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 1.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223   702 PPEPPQLNCVVYGHQSLRLKWGTVSSKKKLDYFINYNLLMEDRSGRFSVIYRGPDVT-HKVQKLSEYTEYKFKIQACNEA 780
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 257196223   781 GEG 783
Cdd:smart00060  81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 332-414 1.97e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 1.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223   332 PTAPLPPKLKEAGIYSLSLEWCAPTNPNPNDTLTYVLEMEEENFGIGFKPAYDGEDLTCTVRNLQRNTTYKFRIFACNLD 411
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 257196223   412 GRS 414
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
141-219 4.02e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223  141 AIGKPVVSNIQTRSATVSWTLKSNEKYDINSmsFELALYTSDENG--IYENIyTGDGVSVALQDLQPSMVYFLRVTTMRG 218
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPITG--YEVEYRPKNSGEpwNEITV-PGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  .
gi 257196223  219 A 219
Cdd:pfam00041  79 G 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 429-513 4.06e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 4.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223   429 PGCPKKPyVVGMIHAHQVTIGWDLPKDNGGMN-ISSYSLEVCEnsDGANLWKIIYNGTQQEFLYNDLQAATTYKLRVFCT 507
Cdd:smart00060   1 PSPPSNL-RVTDVTSTSVTLSWEPPPDDGITGyIVGYRVEYRE--EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*.
gi 257196223   508 SPAGQS 513
Cdd:smart00060  78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
334-417 5.14e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 5.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223  334 APLPPKLKEAGIYSLSLEWCAPTNPNPNDTlTYVLEMEEENfGIGFKPAY--DGEDLTCTVRNLQRNTTYKFRIFACNLD 411
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSWTPPPDGNGPIT-GYEVEYRPKN-SGEPWNEItvPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                  ....*.
gi 257196223  412 GRSKPS 417
Cdd:pfam00041  80 GEGPPS 85
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
344-504 9.01e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.40  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 344 GIYSLSLEWCAPTNPNP------NDTLTYVLEMEEENFGIGFKPAYDGedltctvrnlqrntTYKFRIFACNLDGRSKPS 417
Cdd:COG4733  550 AVTTLTVSWDAPAGAVAyevewrRDDGNWVSVPRTSGTSFEVPGIYAG--------------DYEVRVRAINALGVSSAW 615

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 418 GEVKYTTLPARPGCPKKP---YVVGMIhaHQVTIGWDLPKDNGgmnISSYSLEVCENSDGANLWKIIYNGTQQEFLYNDL 494
Cdd:COG4733  616 AASSETTVTGKTAPPPAPtglTATGGL--GGITLSWSFPVDAD---TLRTEIRYSTTGDWASATVAQALYPGNTYTLAGL 690

                        170
                 ....*....|
gi 257196223 495 QAATTYKLRV 504
Cdd:COG4733  691 KAGQTYYYRA 700
fn3 pfam00041
Fibronectin type III domain;
703-786 1.11e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223  703 PEPPQLNCVVYGHQSLRLKW-------GTVSSkkkldYFINY-NLLMEDRSGRFSViyRGPDVTHKVQKLSEYTEYKFKI 774
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWtpppdgnGPITG-----YEVEYrPKNSGEPWNEITV--PGTTTSVTLTGLKPGTEYEVRV 73

                          90
                  ....*....|..
gi 257196223  775 QACNEAGEGPES 786
Cdd:pfam00041  74 QAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 141-232 4.65e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 4.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223 141 AIGKPVVSNIQTRSATVSWTLKSNEKYDInsMSFELALYTSDENGIYE-NIYTGDGVSVALQDLQPSMVYFLRVTTMRGA 219
Cdd:cd00063    3 PPTNLRVTDVTSTSVTLSWTPPEDDGGPI--TGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                         90
                 ....*....|...
gi 257196223 220 EHRSVSEVVSFTT 232
Cdd:cd00063   81 GESPPSESVTVTT 93
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 152-232 8.71e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 36.62  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257196223  152 TRSATVSWTLKSNEKYDINSMSFELALYTSDENGIYENIYTGDGV-----SVALQDLQPSMVYFLRVttmrGAEHRSVSE 226
Cdd:pfam16656  12 STSMTVSWVTPSAVTSPVVQYGTSSSALTSTATATSSTYTTGDGGtgyihRATLTGLEPGTTYYYRV----GDDNGGWSE 87


                  ....*.
gi 257196223  227 VVSFTT 232
Cdd:pfam16656  88 VYSFTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH