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Conserved domains on  [gi|85702250|ref|NP_001030065|]
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zinc finger protein 936 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 6.36e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 6.36e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 85702250     4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLENYRNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
76-420 7.28e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 7.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250  76 EYTQWDKAFKYHSHLQKlerNQTGDKNSEVFQHSKVLACQSTLQRNkrtNTGEKPYKPSYLRMHERTHTGEKPYQCNECD 155
Cdd:COG5048 132 SRDPQLPDLLSISNLRN---NPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSLLISSNVSTSIPSSSENSPL 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 156 KAFLQLRYLRLHERRHSGEKPYECNQCGKAFLHLNYLRIHERTHTGEKPYQCNQCGKAFTQRSHLQRHKVVHTGVR---- 231
Cdd:COG5048 206 SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekg 285

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 232 ---PYICNQCNKAYPQQNYLRKHERT--HTGE--KPYIC--NQCNKAFSHQSNLRIHEKTHTGEKPYKCnqcdkafshqs 302
Cdd:COG5048 286 fslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE----------- 354

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 303 NLQIHERTHTGEKPYKCNQCDKAFAHLKYLRAHERTHtqekpykcNQCGKAFLYLSCLRVHERTHTGEKP--YKCNQCDK 380
Cdd:COG5048 355 KLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLS--------NSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 85702250 381 AFAHLKYLRAHERIHTQEKPYKCNQCGKAFLLLSCLRVHE 420
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-440 2.09e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.09e-04
                          10        20
                  ....*....|....*....|....*
gi 85702250   416 LRVHERTHTGEKPYKCDQCGKAFTQ 440
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 6.36e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 6.36e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 85702250     4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLENYRNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 3.10e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 3.10e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 85702250      4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLENYRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.72e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 1.72e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 85702250   4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLENYRNLT 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
76-420 7.28e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 7.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250  76 EYTQWDKAFKYHSHLQKlerNQTGDKNSEVFQHSKVLACQSTLQRNkrtNTGEKPYKPSYLRMHERTHTGEKPYQCNECD 155
Cdd:COG5048 132 SRDPQLPDLLSISNLRN---NPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSLLISSNVSTSIPSSSENSPL 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 156 KAFLQLRYLRLHERRHSGEKPYECNQCGKAFLHLNYLRIHERTHTGEKPYQCNQCGKAFTQRSHLQRHKVVHTGVR---- 231
Cdd:COG5048 206 SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekg 285

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 232 ---PYICNQCNKAYPQQNYLRKHERT--HTGE--KPYIC--NQCNKAFSHQSNLRIHEKTHTGEKPYKCnqcdkafshqs 302
Cdd:COG5048 286 fslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE----------- 354

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 303 NLQIHERTHTGEKPYKCNQCDKAFAHLKYLRAHERTHtqekpykcNQCGKAFLYLSCLRVHERTHTGEKP--YKCNQCDK 380
Cdd:COG5048 355 KLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLS--------NSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 85702250 381 AFAHLKYLRAHERIHTQEKPYKCNQCGKAFLLLSCLRVHE 420
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-328 1.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.80e-04
                          10        20
                  ....*....|....*....|....*.
gi 85702250   303 NLQIHERTHTGEKPYKCNQCDKAFAH 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-440 2.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.09e-04
                          10        20
                  ....*....|....*....|....*
gi 85702250   416 LRVHERTHTGEKPYKCDQCGKAFTQ 440
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 6.36e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 6.36e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 85702250     4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLENYRNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 3.10e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 3.10e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 85702250      4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLENYRNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.72e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 1.72e-18
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 85702250   4 LTFDDVHVHFTREEWSLLDPSQKRLYKDVMLENYRNLT 41
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
76-420 7.28e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 7.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250  76 EYTQWDKAFKYHSHLQKlerNQTGDKNSEVFQHSKVLACQSTLQRNkrtNTGEKPYKPSYLRMHERTHTGEKPYQCNECD 155
Cdd:COG5048 132 SRDPQLPDLLSISNLRN---NPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSLLISSNVSTSIPSSSENSPL 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 156 KAFLQLRYLRLHERRHSGEKPYECNQCGKAFLHLNYLRIHERTHTGEKPYQCNQCGKAFTQRSHLQRHKVVHTGVR---- 231
Cdd:COG5048 206 SSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekg 285

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 232 ---PYICNQCNKAYPQQNYLRKHERT--HTGE--KPYIC--NQCNKAFSHQSNLRIHEKTHTGEKPYKCnqcdkafshqs 302
Cdd:COG5048 286 fslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKE----------- 354

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 303 NLQIHERTHTGEKPYKCNQCDKAFAHLKYLRAHERTHtqekpykcNQCGKAFLYLSCLRVHERTHTGEKP--YKCNQCDK 380
Cdd:COG5048 355 KLLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLS--------NSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                       330       340       350       360
                ....*....|....*....|....*....|....*....|
gi 85702250 381 AFAHLKYLRAHERIHTQEKPYKCNQCGKAFLLLSCLRVHE 420
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-447 4.93e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 4.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 192 LRIHERTHTGEKPYQCNQCGKAFTQRSHLQRHKVVHTGVRPYICNQCNKAYP------QQNYLRKHERTHTGEKPYICNQ 265
Cdd:COG5048 186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqSPSSLSSSDSSSSASESPRSSL 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 266 CNKAFSHQSNLRIHEKTHTG-EKPYKCNQCDKAFSHQSNLQIHERT--HTGE--KPYKC--NQCDKAFAHLKYLRAHERT 338
Cdd:COG5048 266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 339 HTQEKPYKC--NQCGKAFLYLS--CLRVHERTHTGEKPYK-----CNQCDKAFAHLKYLRAHERIHTQEKPY--KCNQCG 407
Cdd:COG5048 346 HTSISPAKEklLNSSSKFSPLLnnEPPQSLQQYKDLKNDKksetlSNSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCS 425

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 85702250 408 KAFLLLSCLRVHERTHTGEKPYKCDQCGKaFTQRSHLKTH 447
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-453 6.36e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 6.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 175 KPYECNQCGKAFLHLNYLRIHERTHTGEKPYQCNQ--CGKAFTQRSHLQRHKVVHTGVRPYICNQCNkaYPQQNYLRKHE 252
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSL--PLSNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 253 RTHTGEKPYICNQC-NKAFSHQSNLRIHEKTHTGEKPYKC---------NQCDKAFSHQSNL---------------QIH 307
Cdd:COG5048 110 LSSSSSNSNDNNLLsSHSLPPSSRDPQLPDLLSISNLRNNplpgnnsssVNTPQSNSLHPPLpanslskdpssnlslLIS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 308 ERTHTGEKPYKCNQCDKAFAHLKYLRAHERTHTQEKPYKCNQCGKAFLYLSclrVHERTHTGEKPYKCNQCDKAFAHLKY 387
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL---LSQSPSSLSSSDSSSSASESPRSSLP 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 388 LRAHERIHTQE----------KPYKCNQCGKAFLLLSCLRVHERT--HTGE--KPYKCD--QCGKAFTQRSHLKTHKVIH 451
Cdd:COG5048 267 TASSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLH 346


                ..
gi 85702250 452 TG 453
Cdd:COG5048 347 TS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
98-451 4.05e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250  98 TGDKNSEVFQHSKVLACQSTLQ------RNKRT-NTGEKPYKPSYLRMHERTHTGEKPYQCNECDKAFLQLRYLRLHE-- 168
Cdd:COG5048   4 TSSQSSSSNNSVLSSTPKSTLKslsnapRPDSCpNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhl 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 169 RRHSGEKPYECNQCGKAFLHLNYLRIHERTHTGE-KPYQCNQCGKAFTQRsHLQRHKVVhtgvrpYICNQCNKAYPQQNY 247
Cdd:COG5048  84 RTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSR-DPQLPDLL------SISNLRNNPLPGNNS 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 248 LRKHERTHTGEK-PYICNQCNKAFSHQSNLRIHEKTHTGEKPYKCNQCDKAFSHQSNLQIHERTHTGEKPYKCNQCDKAF 326
Cdd:COG5048 157 SSVNTPQSNSLHpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLS 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 327 AHLKYLR------AHERTHTQEKPYKCNQCGKAFLYLSCLRVHERTHTG-EKPYKCNQCDKAFAHLKYLRAHER--IHTQ 397
Cdd:COG5048 237 PKSLLSQspsslsSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSG 316

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 398 E--KPYKC--NQCGKAFLLLSCLRVHERTHTGEKPYKC--DQCGKAFTQRSHLKTHKVIH 451
Cdd:COG5048 317 EslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 258-368 1.05e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85702250 258 EKPYICNQCNKAFSHQSNLRIHEKTH----TGEKPYKCN--QCDKAFSHQSNLQIHERT-HTGEKPYKCNQCDKafahlk 330
Cdd:COG5189 315 KLPCTNSSSNGKLAHGGERNIDTPSRmlkvKDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK------ 388

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 85702250 331 ylraHERTHTQEKPYKCNQCGKAFLYLSCLRVHeRTHT 368
Cdd:COG5189 389 ----MNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-328 1.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.80e-04
                          10        20
                  ....*....|....*....|....*.
gi 85702250   303 NLQIHERTHTGEKPYKCNQCDKAFAH 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-440 2.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.09e-04
                          10        20
                  ....*....|....*....|....*
gi 85702250   416 LRVHERTHTGEKPYKCDQCGKAFTQ 440
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-300 2.67e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.67e-04
                          10        20
                  ....*....|....*....|....*.
gi 85702250   275 NLRIHEKTHTGEKPYKCNQCDKAFSH 300
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
360-384 2.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.75e-04
                          10        20
                  ....*....|....*....|....*
gi 85702250   360 LRVHERTHTGEKPYKCNQCDKAFAH 384
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
135-160 3.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 85702250   135 YLRMHERTHTGEKPYQCNECDKAFLQ 160
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
191-216 5.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 85702250   191 YLRIHERTHTGEKPYQCNQCGKAFTQ 216
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-356 1.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 85702250   331 YLRAHERTHTQEKPYKCNQCGKAFLY 356
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-410 2.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.08e-03
                          10        20
                  ....*....|....*....|....
gi 85702250   387 YLRAHERIHTQEKPYKCNQCGKAF 410
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
163-188 2.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 85702250   163 YLRLHERRHSGEKPYECNQCGKAFLH 188
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 145-200 2.68e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.68e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 85702250 145 GEKPYQCN--ECDKAFLQ---LRYLRLH------------ERRHSG----EKPYECNQCGKAFLHLNYLRIHeRTHT 200
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNqngLKYHMLHghqnqklhenpsPEKMNIfsakDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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