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Conserved domains on  [gi|79315297|ref|NP_001030871|]
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biotin/lipoyl attachment domain-containing protein [Arabidopsis thaliana]

Protein Classification

acetyl-CoA carboxylase biotin carboxyl carrier protein( domain architecture ID 11423502)

acetyl-CoA carboxylase biotin carboxyl carrier protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

CATH:  2.40.50.100
Gene Ontology:  GO:0003989|GO:0006633|GO:0009317
PubMed:  1370469
SCOP:  4002909
TCDB:  3.B.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 96-184 7.38e-16

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 70.69  E-value: 7.38e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79315297  96 AALEASGSTNYVLVTSPAVGKFQRSRTVKGKkqsPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSV 175
Cdd:COG0511  50 AAAAAAAASGGGAVKSPMVGTFYRAPSPGAK---PFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPV 126


                ....*....
gi 79315297 176 GYGDPLVAV 184
Cdd:COG0511 127 EYGQPLFVI 135
 
Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 96-184 7.38e-16

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 70.69  E-value: 7.38e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79315297  96 AALEASGSTNYVLVTSPAVGKFQRSRTVKGKkqsPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSV 175
Cdd:COG0511  50 AAAAAAAASGGGAVKSPMVGTFYRAPSPGAK---PFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPV 126


                ....*....
gi 79315297 176 GYGDPLVAV 184
Cdd:COG0511 127 EYGQPLFVI 135
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 109-184 1.90e-14

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 64.74  E-value: 1.90e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79315297 109 VTSPAVGKFQRsrtvkgkkqsPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAV 184
Cdd:cd06850   2 VTAPMPGTVVK----------VLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 109-182 3.98e-10

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 53.76  E-value: 3.98e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 79315297   109 VTSPAVGKFQRSRTVKGKKqspscKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLV 182
Cdd:pfam00364   3 IKSPMIGESVREGVVEWLV-----KVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLA 71
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 109-186 4.20e-09

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 55.23  E-value: 4.20e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 79315297  109 VTSPAVGKFQRSRTvkgkkqspscKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAVLP 186
Cdd:PRK09282 525 VTSPMPGTVVKVKV----------KEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIEP 592
 
Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 96-184 7.38e-16

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 70.69  E-value: 7.38e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79315297  96 AALEASGSTNYVLVTSPAVGKFQRSRTVKGKkqsPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSV 175
Cdd:COG0511  50 AAAAAAAASGGGAVKSPMVGTFYRAPSPGAK---PFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPV 126


                ....*....
gi 79315297 176 GYGDPLVAV 184
Cdd:COG0511 127 EYGQPLFVI 135
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 109-184 1.90e-14

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 64.74  E-value: 1.90e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79315297 109 VTSPAVGKFQRsrtvkgkkqsPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAV 184
Cdd:cd06850   2 VTAPMPGTVVK----------VLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 109-182 3.98e-10

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 53.76  E-value: 3.98e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 79315297   109 VTSPAVGKFQRSRTVKGKKqspscKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLV 182
Cdd:pfam00364   3 IKSPMIGESVREGVVEWLV-----KVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLA 71
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 109-186 4.20e-09

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 55.23  E-value: 4.20e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 79315297  109 VTSPAVGKFQRSRTvkgkkqspscKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAVLP 186
Cdd:PRK09282 525 VTSPMPGTVVKVKV----------KEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIEP 592
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 133-182 6.17e-07

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 45.16  E-value: 6.17e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 79315297  133 KEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLV 182
Cdd:PRK08225  18 KVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQEGDFVNEGDVLL 67
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
109-184 5.59e-06

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 42.69  E-value: 5.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79315297  109 VTSPAVGKFQRsrtvkgkKQSPSC----KEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAV 184
Cdd:PRK07051   6 IVSPLPGTFYR-------RPSPDAppyvEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARI 78
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 41-186 2.81e-05

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 43.29  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79315297   41 NPIPVADISPTVAPPIPSEPMNKSASSAPSPSQAKPSSEKVSPFKntsygkpaklaaleasgstnyvlvtSPAVGKFQRS 120
Cdd:PLN02983 157 PPHAMPPASPPAAQPAPSAPASSPPPTPASPPPAKAPKSSHPPLK-------------------------SPMAGTFYRS 211

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 79315297  121 rtvKGKKQSPSCKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAVLP 186
Cdd:PLN02983 212 ---PAPGEPPFVKVGDKVQKGQVVCIIEAMKLMNEIEADQSGTIVEILAEDGKPVSVDTPLFVIEP 274
PRK05889 PRK05889
biotin/lipoyl-binding carrier protein;
133-185 3.80e-05

biotin/lipoyl-binding carrier protein;


Pssm-ID: 180306 [Multi-domain]  Cd Length: 71  Bit Score: 40.18  E-value: 3.80e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 79315297  133 KEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDpLVAVL 185
Cdd:PRK05889  19 NEGDQIGKGDTLVLLESMKMEIPVLAEVAGTVSKVSVSVGDVIQAGD-LIAVI 70
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 133-184 1.27e-03

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 36.20  E-value: 1.27e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 79315297 133 KEGDAIKEGQVIGylhQLGTE---LPVTSDVAGEVLKLLSDDGDSVGYGDPLVAV 184
Cdd:COG0508  25 KEGDTVKEGDPLA---EVETDkatMEVPAPAAGVLLEILVKEGDTVPVGAVIAVI 76
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
133-184 2.30e-03

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 37.99  E-value: 2.30e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 79315297  133 KEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLVAV 184
Cdd:PRK14040 541 TEGQTVAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKEGDAVAVGDTLLTL 592
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 36-182 2.43e-03

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 36.76  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79315297   36 IGAATNPIPVADISPTVAPPIPSEPMnksassapspsqakPSSEKVSpfkntsygKPAKLAALEAsgstnyvLVTSPAVG 115
Cdd:PRK05641  43 IDLSAVQEQVPTPAPAPAPAVPSAPT--------------PVAPAAP--------APAPASAGEN-------VVTAPMPG 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 79315297  116 KFQRSRTvkgkkqspscKEGDAIKEGQVIGYLHQLGTELPVTSDVAGEVLKLLSDDGDSVGYGDPLV 182
Cdd:PRK05641  94 KILRILV----------REGQQVKVGQGLLILEAMKMENEIPAPKDGVVKKILVKEGDTVDTGQPLI 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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