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Conserved domains on  [gi|79325243|ref|NP_001031707|]
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dihydrofolate reductase [Arabidopsis thaliana]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FSH1 super family cl47855
Serine hydrolase (FSH1); This is a family of serine hydrolases.
 10-166 1.07e-45

Serine hydrolase (FSH1); This is a family of serine hydrolases.


The actual alignment was detected with superfamily member pfam03959:

Pssm-ID: 461110  Cd Length: 208  Bit Score: 148.97  E-value: 1.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79325243    10 RKPRFLCLHGFRTSGEIMKIQLHKWPKSVIDR-LDLVFLDAPFPCQGKSDV--------EGIFDPPYYEWFQFNKEFTEY 80
Cdd:pfam03959   2 KKKKVLCLHGFGQSGEIFRAKTGALRKLLKKLgVEFVYLDAPFELAEPADLpgsesekdEGEDDEPYRAWFFGDDDTNEY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79325243    81 TNFEKCLEYLEDRMIKLGPFDGLIGFSQGAILSGGLPGLQAKGIAFQkVPKIKFVIIIGGAKLKSAKLAENAYSSSLETL 160
Cdd:pfam03959  82 LGLDESLDYVRDYIKENGPFDGILGFSQGAALAAILASLLEEGLPLS-HPPLKFAILFSGFRPRPPIYQEYYSEDPIQTP 160


                  ....*.
gi 79325243   161 SLHFLG 166
Cdd:pfam03959 161 SLHVIG 166
 
Name Accession Description Interval E-value
FSH1 pfam03959
Serine hydrolase (FSH1); This is a family of serine hydrolases.
 10-166 1.07e-45

Serine hydrolase (FSH1); This is a family of serine hydrolases.


Pssm-ID: 461110  Cd Length: 208  Bit Score: 148.97  E-value: 1.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79325243    10 RKPRFLCLHGFRTSGEIMKIQLHKWPKSVIDR-LDLVFLDAPFPCQGKSDV--------EGIFDPPYYEWFQFNKEFTEY 80
Cdd:pfam03959   2 KKKKVLCLHGFGQSGEIFRAKTGALRKLLKKLgVEFVYLDAPFELAEPADLpgsesekdEGEDDEPYRAWFFGDDDTNEY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79325243    81 TNFEKCLEYLEDRMIKLGPFDGLIGFSQGAILSGGLPGLQAKGIAFQkVPKIKFVIIIGGAKLKSAKLAENAYSSSLETL 160
Cdd:pfam03959  82 LGLDESLDYVRDYIKENGPFDGILGFSQGAALAAILASLLEEGLPLS-HPPLKFAILFSGFRPRPPIYQEYYSEDPIQTP 160


                  ....*.
gi 79325243   161 SLHFLG 166
Cdd:pfam03959 161 SLHVIG 166
 
Name Accession Description Interval E-value
FSH1 pfam03959
Serine hydrolase (FSH1); This is a family of serine hydrolases.
 10-166 1.07e-45

Serine hydrolase (FSH1); This is a family of serine hydrolases.


Pssm-ID: 461110  Cd Length: 208  Bit Score: 148.97  E-value: 1.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79325243    10 RKPRFLCLHGFRTSGEIMKIQLHKWPKSVIDR-LDLVFLDAPFPCQGKSDV--------EGIFDPPYYEWFQFNKEFTEY 80
Cdd:pfam03959   2 KKKKVLCLHGFGQSGEIFRAKTGALRKLLKKLgVEFVYLDAPFELAEPADLpgsesekdEGEDDEPYRAWFFGDDDTNEY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 79325243    81 TNFEKCLEYLEDRMIKLGPFDGLIGFSQGAILSGGLPGLQAKGIAFQkVPKIKFVIIIGGAKLKSAKLAENAYSSSLETL 160
Cdd:pfam03959  82 LGLDESLDYVRDYIKENGPFDGILGFSQGAALAAILASLLEEGLPLS-HPPLKFAILFSGFRPRPPIYQEYYSEDPIQTP 160


                  ....*.
gi 79325243   161 SLHFLG 166
Cdd:pfam03959 161 SLHVIG 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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