|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
1-473 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 713.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 1 MPPAvgGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLV 80
Cdd:TIGR00892 1 MPPA--LPPEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 81 NKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLST 160
Cdd:TIGR00892 79 NRFGCRPVVIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLST 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 161 LAPLNQAFFMIYGWRGSFLILGGLLLNCCVAGALMRPIGPKPTTaEKEKSKGSLQEAGKyetkkgasdantdliggNPKE 240
Cdd:TIGR00892 159 LAPLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRV-SKSKSKEGLPPDGS-----------------TKKL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 241 EKKSIFQTLNTFLDLSLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVA 320
Cdd:TIGR00892 221 SKKSTAEKINRFLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIA 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 321 NTKWVRPRVQYFFAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECC 400
Cdd:TIGR00892 301 GLKWIRPHVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECC 380
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82617542 401 PVLLGPPVLGRLNDIYGDYKYTYWACGIILIVAGIYLFIGMGINYRLLEKEQKAEKQQKKESKDEETNVDVAE 473
Cdd:TIGR00892 381 AVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYINYRLLAKEQKAALEREGARDKKDAEGDSRE 453
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
19-441 |
0e+00 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 675.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRPIGPKPttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntFLDLSLF 258
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGPKP-------------------------------------------------FLDLTLF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPRVQYFFAASII 338
Cdd:cd17426 192 THRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 339 ANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGD 418
Cdd:cd17426 272 YNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGD 351
|
410 420
....*....|....*....|...
gi 82617542 419 YKYTYWACGIILIVAGIYLFIGM 441
Cdd:cd17426 352 YKYTYWACGIVLIISSIYLFIGM 374
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
19-440 |
0e+00 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 542.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRPIGPkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntfldlsLF 258
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPLGP--------------------------------------------------------LF 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPRVQYFFAASII 338
Cdd:cd17427 185 KHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVM 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 339 ANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGD 418
Cdd:cd17427 265 YNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGN 344
|
410 420
....*....|....*....|..
gi 82617542 419 YKYTYWACGIILIVAGIYLFIG 440
Cdd:cd17427 345 YKYMYFVCGAIVIVASIWLFIG 366
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
19-440 |
1.66e-142 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 414.13 E-value: 1.66e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRPigpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntfLDLSLF 258
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP-------------------------------------------------------LDFSVF 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPRVQYFFAASII 338
Cdd:cd17430 186 RDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAML 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 339 ANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGD 418
Cdd:cd17430 266 FNGLTDLCSATAADYGGLVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKN 345
|
410 420
....*....|....*....|..
gi 82617542 419 YKYTYWACGIILIVAGIYLFIG 440
Cdd:cd17430 346 YELIFYLAGSEVVLSALFLALG 367
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
19-439 |
7.35e-124 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 366.11 E-value: 7.35e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRpigpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntfldlsLF 258
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR------------------------------------------------------------LL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVrpRVQYFFAASII 338
Cdd:cd17352 181 KDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRI--GRLYLYIFTLL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 339 ANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGD 418
Cdd:cd17352 259 ILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGD 338
|
410 420
....*....|....*....|.
gi 82617542 419 YKYTYWACGIILIVAGIYLFI 439
Cdd:cd17352 339 YDAAFYFCGACLLLSGVLLFL 359
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
19-441 |
3.20e-96 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 295.53 E-value: 3.20e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRPigpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntfldlsLF 258
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP-----------------------------------------------------------FC 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPRVQYFFAASII 338
Cdd:cd17425 182 SNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 339 ANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGD 418
Cdd:cd17425 262 LNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQ 341
|
410 420
....*....|....*....|...
gi 82617542 419 YKYTYWACGIILIVAGiyLFIGM 441
Cdd:cd17425 342 YSYVFYASSIFVVSAA--LFMGL 362
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
19-437 |
1.03e-75 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 243.07 E-value: 1.03e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRPIGPKPTTAEKekskgslqeagkyetkkgasdantdliggnpkeekksiFQTLNTFLDLSLF 258
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGDPPAP--------------------------------------PRSLSAAFGLSLL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPrvQYFFAASII 338
Cdd:cd17423 203 THRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTA 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 339 ANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGD 418
Cdd:cd17423 281 LTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGD 360
|
410 420
....*....|....*....|
gi 82617542 419 YKYTYWACG-IILIVAGIYL 437
Cdd:cd17423 361 YTASFLVAGsFLLLGSLILL 380
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
19-437 |
5.60e-69 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 225.01 E-value: 5.60e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRpigpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntfldlsLF 258
Cdd:cd17422 161 LVVGALQLNIVVCGALLR------------------------------------------------------------VL 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPrvQYFFAASII 338
Cdd:cd17422 181 KEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRK--IYIELICVI 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 339 ANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLM--DLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIY 416
Cdd:cd17422 259 LLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWT 338
|
410 420
....*....|....*....|.
gi 82617542 417 GDYKYTYWACGIILIVAGIYL 437
Cdd:cd17422 339 QNYGSAFYSCAAGMALGAVFL 359
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
19-438 |
6.98e-58 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 195.80 E-value: 6.98e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRpigpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntFLDLSlf 258
Cdd:cd17424 161 LILGGFVLNLCVCGALMR-------------------------------------------------------FLLMP-- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 khrGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRP--RVQYFFAAS 336
Cdd:cd17424 184 ---DFLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKyrYFCYLFAVG 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 337 IiaNGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIY 416
Cdd:cd17424 261 M--DGLCCLFLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTT 338
|
410 420
....*....|....*....|..
gi 82617542 417 GDYKYTYWACGIILIVAGIYLF 438
Cdd:cd17424 339 GTYTAAFLLSGFSMIFSSLLLG 360
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
19-439 |
3.93e-44 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 159.60 E-value: 3.93e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLStLAPLNQAFFMIYGWRGSF 178
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFA-LAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRPIgpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntflDLSLF 258
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPI-------------------------------------------------------DFSLL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPrvQYFFAASII 338
Cdd:cd17421 185 KDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIKK--YHYHKAYLI 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 339 ANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGD 418
Cdd:cd17421 263 LCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQT 342
|
410 420
....*....|....*....|.
gi 82617542 419 YKYTYWACGIILIVAGIYLFI 439
Cdd:cd17421 343 YDCSFYLAGGCYLLSSVSFFL 363
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
19-439 |
3.27e-37 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 141.51 E-value: 3.27e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNA-----TTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGG 93
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdpeASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 94 ILSGSGLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYG 173
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 174 WRGSFLILGGLLLNCCVAGALMRPIGPKPTTAEKEKSKGSLQeagkyetkkgasdantdliggnpkeekKSIFQTLNTFL 253
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLH---------------------------SRINLFLRKIF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 254 DLSLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPRVqYFF 333
Cdd:cd17420 214 NVEIFKRKRYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKM-YLQ 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 334 AASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLN 413
Cdd:cd17420 293 VLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLR 372
|
410 420
....*....|....*....|....*.
gi 82617542 414 DIYGDYKYTYWACGIILIVAGIYLFI 439
Cdd:cd17420 373 DSTGSYTVAFYLAGVPPLIGSSLLFF 398
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
19-439 |
1.66e-35 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 135.73 E-value: 1.66e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRpigpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntfldlsLF 258
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR------------------------------------------------------------LF 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAF-LLSILAFVDMVARPSMGLVANTKWVrpRVQYFFAASI 337
Cdd:cd17429 181 TNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCI--SVWNVFILAN 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 338 IANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETlMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYG 417
Cdd:cd17429 259 FTLGVCILILPLMHTYTGLAIVCALIGFSSGYFSLMPVVT-EDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQ 337
|
410 420
....*....|....*....|..
gi 82617542 418 DYKYTYWACGIILIVAGIYLFI 439
Cdd:cd17429 338 KYDFSFYVCGLLYMVGIICLLL 359
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
19-439 |
1.10e-34 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 133.40 E-value: 1.10e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRpigpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntfldlsLF 258
Cdd:cd17428 161 LIVGALALNLLACGSLMR------------------------------------------------------------LF 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAF-LLSILAFVDMVARPSMGLVANTKWVrpRVQYFFAASI 337
Cdd:cd17428 181 KNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWV--NSLYLYVLTL 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 338 IANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETlMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYG 417
Cdd:cd17428 259 IGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWSIFPYVT-TKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQ 337
|
410 420
....*....|....*....|..
gi 82617542 418 DYKYTYWACGIILIVAGIYLFI 439
Cdd:cd17428 338 TYDIAFYFSGFCVLLGGFLLLL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-439 |
1.51e-34 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 133.85 E-value: 1.51e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSG 99
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 100 LIAASFCNTVqELYFSVGVIGGLGLAFNLNPALTMIGKYFYK-RRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:COG2223 84 LLLLALAVSY-WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLnccVAGALMRPIGPKPTTAEKEKSKGSLQEAgkyetkkgasdantdliggnpkeekksifqtlntfldLSLF 258
Cdd:COG2223 163 LILGILLL---VVAVLAWLFLRDPPAGAAAAAKASLRDQ-------------------------------------LEAL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSK-HYSSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVqYFFAASI 337
Cdd:COG2223 203 RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSD-RIGGRRV-LLIVFAL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 338 IANGLCHLAAPLSSTYIELcIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYG 417
Cdd:COG2223 281 MALGLLLLALALGSLWLFL-VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
|
410 420
....*....|....*....|..
gi 82617542 418 DYKYTYWACGIILIVAGIYLFI 439
Cdd:COG2223 360 SYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
19-437 |
8.27e-33 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 129.14 E-value: 8.27e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSE-----VSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGG 93
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAqmrfkTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 94 ILSGSGLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYG 173
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 174 WRGSFLILGGLLLNCCVAGALMRPIGPKPTTAEKEKskgslqeagkyetkkgasdantdliggnpkeeKKSIFQTLNTFL 253
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKK--------------------------------RKFKCPPLKKIF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 254 DLSLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPRVqYFF 333
Cdd:cd17464 209 NFNIWKSTGYRIWAFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKV-YLQ 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 334 AASIIANGLCHLAAPLSSTY---IELCIYAGFFGfafGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLG 410
Cdd:cd17464 288 VSSFFFIGLMSMMIPLCHVFgglIAVCLFMGLFD---GCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAG 364
|
410 420
....*....|....*....|....*..
gi 82617542 411 RLNDIYGDYKYTYWACGIILIVAGIYL 437
Cdd:cd17464 365 FLRDRLGSYDVAFYLAGVPPIIGGIIL 391
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
19-438 |
6.11e-32 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 126.23 E-value: 6.11e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLA-FNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGS 177
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 178 FLILGGLLLNCCVAGALMrPIGPKPTTAEKEKSKGSLQEAGKYETKkgasdantdliggnpkeekksifqtlntfldlsL 257
Cdd:cd17355 161 LLVLALLALLVLVPVLLL-LRRRPADLALRAYDDASPASPGSTLKE---------------------------------A 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 258 FKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPRVQYFFAASI 337
Cdd:cd17355 207 LRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 338 IAnglchLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFE--TLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDI 415
Cdd:cd17355 287 LG-----LALLLLLPFPPLALLLFAALFGLGWGATVPLTaaLAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR 361
|
410 420
....*....|....*....|...
gi 82617542 416 YGDYKYTYWACGIILIVAGIYLF 438
Cdd:cd17355 362 TGSYTAAWALAVALGLIAALLVL 384
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-435 |
1.57e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 124.60 E-value: 1.57e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 16 GGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGIL 95
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 96 SGSGLIAASFCNTVQELYFSVgVIGGLGLAFNLNPALTMIGKYFY-KRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGW 174
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 175 RGSFLILGGLLLnccVAGALMrpigpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntfld 254
Cdd:COG2271 164 RAAFLILGLPGL---LLALLR----------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 255 lslfkhrgFLLYLSGNVLMFFGLFTPLVFLSNY-GKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVQYFF 333
Cdd:COG2271 182 --------FWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSD-RLGRRRKLVLA 252
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 334 AASIIAnGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLN 413
Cdd:COG2271 253 IGLLLA-ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
|
410 420
....*....|....*....|..
gi 82617542 414 DIYGdYKYTYWACGIILIVAGI 435
Cdd:COG2271 332 DATG-YQAAFLLLAALALLAAL 352
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-397 |
5.26e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 111.60 E-value: 5.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 13 PPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVG 92
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 93 GILSGSGLIAASFCNTVQELYFSVgVIGGLGLAFNLNPALTMIGKYF-YKRRPLANGLAMAGSPVFLSTLAPLNQAFFMI 171
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAAR-FLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 172 YGWRGSFLILGGLllnCCVAGALMRPIGPKPTTAEKEKSKGSLQEagkyetkkgasdantdliggnpkeekksifqtlnt 251
Cdd:COG2814 161 FGWRWVFLVNAVL---ALLALLLLLRLLPESRPAARARLRGSLRE----------------------------------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 252 fldlsLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSK-HYSSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVq 330
Cdd:COG2814 203 -----LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLAD-RFGRRRL- 275
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 82617542 331 yfFAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIV 397
Cdd:COG2814 276 --LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-406 |
9.55e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 110.59 E-value: 9.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 22 VVIGAFISIGFSYAFpksITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLI 101
Cdd:pfam07690 1 LFLAAFLAALGRSLL---GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 102 AASFCNTVQELYFSvGVIGGLGLAFNLNPALTMIGKYF-YKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSFLI 180
Cdd:pfam07690 78 LLLFASSLWLLLVL-RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 181 LGGLLLNCCVAGALMRPIGPKPTTAEKEKSKGSLqeagkyetkkgasdantdliggnpkeekksifqtlntFLDLSLFKH 260
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL-------------------------------------IVAWKALLR 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 261 RGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVQYFFAASIIAN 340
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD-RLGRRRRLLLALLLLILA 278
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 82617542 341 GLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGP 406
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
39-438 |
3.23e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 104.05 E-value: 3.23e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 39 SITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSvGV 118
Cdd:cd06174 14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG-RF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 119 IGGLGLAFNLNPALTMIGKYF-YKRRPLANGLAMAGSPVFLSTLAPLNQAFFMI--YGWRGSFLILGGLLLNCCVAGALM 195
Cdd:cd06174 93 LLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 196 RPIGPKPTTAEKEKSKgslqeagkyetkkgasdantdliggnPKEEKKSIFqtlntfldlSLFKHRGFLLYLSGNVLMFF 275
Cdd:cd06174 173 VPDPPESARAKNEEAS--------------------------SKSVLKLLK---------RVLKNPGLWLLLLAIFLVNL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 276 GLFTPLVFLSNYGKSKHYSSEK-AAFLLSILAFVDMVARPSMGLVANTKWVRPRVQYFfaaSIIANGLCHLAAPLSSTYI 354
Cdd:cd06174 218 AYYSFSTLLPLFLLDLGGLSVAvAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI---GLLLMALGLALLLLAPSLL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 355 ELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGDYKYTYWACGIILIVAG 434
Cdd:cd06174 295 LLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
....
gi 82617542 435 IYLF 438
Cdd:cd06174 375 ILLL 378
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
19-438 |
2.60e-23 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 101.72 E-value: 2.60e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGGLLLNCCVAGALMRPIGPKPTTAEKEKSKGSLQEAGKyetkkgasdantdliggnpkeekksifqtlntfldlsLF 258
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGE-------------------------------------IF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 KHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHY-SSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVQYFFAASI 337
Cdd:cd17314 204 RDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLdAPSFVTKLMSIYGLFNAFGRLLWGIVAD-FFGGRLSTLSILLTI 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 338 IANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYG 417
Cdd:cd17314 283 LGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTP 362
|
410 420
....*....|....*....|..
gi 82617542 418 DYKYTYWACGII-LIVAGIYLF 438
Cdd:cd17314 363 SYISAVYIYAVIvFLASAILLA 384
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-435 |
4.71e-23 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 101.10 E-value: 4.71e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 12 TPPDGGWGWAVVIGAFISIGFSYAFP-KSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMI 90
Cdd:COG2807 8 ARRSRRAGRWLLLLAIVLVALNLRPAiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 91 VGGILSGSGLIAASFCNTVQELYFSVGVIG-GLGLAFNLNPALtmIGKYFYKRRPLANGLA----MAGSPVFLSTLAPLN 165
Cdd:COG2807 88 LALLLLAAGLLLRSLAPSVALLLAGTALIGaGIAVGNVLLPGL--IKRWFPDRVGLMTGLYtaamGLGAALAAGLTVPLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 166 QAFfmiyGWRGSFLILGGLLLNCCVAGALMRPIGPKPTTAEKEKSKGslqeagkyetkkgasdantdliggnpkeekksi 245
Cdd:COG2807 166 AAL----GWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASL--------------------------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 246 fqtlntfldLSLFKHRGFLLylsgnVLMFFGL-----FTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVA 320
Cdd:COG2807 209 ---------RSLWRSPLAWL-----LTLFFGLqsllyYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 321 NtKWVRPRVQYFFAASIIANGLCHLA-APLSSTYielcIYAGFFGFAFGWLSSVLFETLMDLVG-PQRFSSAVGLVTIVE 398
Cdd:COG2807 275 D-RLGDRRPLLLLLGLLGLAGLLGLLlAPGSLPW----LWAVLLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVG 349
|
410 420 430
....*....|....*....|....*....|....*..
gi 82617542 399 CCPVLLGPPVLGRLNDIYGDYKYTYWACGIILIVAGI 435
Cdd:COG2807 350 YLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLV 386
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
20-435 |
3.39e-20 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 92.29 E-value: 3.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFI---SIGFSYAFpksiTVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILS 96
Cdd:cd17353 3 WLVLLGAVLmhlILGYQYAW----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 97 GSGLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAG---SPVFLStlaPLNQAFFMIYG 173
Cdd:cd17353 79 GLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGfglGSLIFS---PLIAYLINTVG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 174 WRGSFLILG-GLLLNCCVAGALMRPIGPKPTTAEKekskgslqeagkyetKKGASDANTDLIGGNPKEekksifqtlntf 252
Cdd:cd17353 156 VPTTFLILGiIFLIIIVIGAFLIRDPPKGWVPPGV---------------DPLANNAENSPRDYTPRE------------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 253 ldlSLFKHRGFLLYLSGNVLMFFGLFTpLVFLSNYGKSKHYSSEK-AAFLLSILAFVDMVARPSMGLVANtKWVRPRVqy 331
Cdd:cd17353 209 ---MLRTPTFWLLWLMFFLNATAGLML-IGQAKPIGQEFAGLDAGiAALAVSILSIFNGGGRPFWGWLSD-KIGRKNT-- 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 332 FFAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGR 411
Cdd:cd17353 282 LSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY 361
|
410 420
....*....|....*....|....
gi 82617542 412 LnDIYGDYKYTYWACGIILIVAGI 435
Cdd:cd17353 362 V-LYTGGYNAAFIIAAALSLVALA 384
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
19-438 |
2.26e-19 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 89.47 E-value: 2.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFF----KEIEGIFNATTS-EVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGG 93
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYvmllNEQEDQKDQAVQfKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 94 ILSGSGLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFlSTLAPLnqaffmiyg 173
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLF-SMLLPF--------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 174 wrgsflilgglllnccvagaLMRPIGpkpttaekekskgslqeagkyetkkgasdantDLIGGNPKEEKKSIFQTLNTFL 253
Cdd:cd17465 151 --------------------LLKMVG--------------------------------DAIGLAHTFQVLSLFMFIQIFL 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 254 DLS--LFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTkWVRPRVQY 331
Cdd:cd17465 179 SLTykVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGDL-IPGLKKIY 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 332 FFAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGR 411
Cdd:cd17465 258 LQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGL 337
|
410 420
....*....|....*....|....*..
gi 82617542 412 LNDIYGDYKYTYWACGIILIVAGIYLF 438
Cdd:cd17465 338 LHDYFGSYHVAFYLAGVPPIIGGTVLF 364
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
51-440 |
6.53e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.32 E-value: 6.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 51 FNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSVgVIGGLGLAFNLNP 130
Cdd:cd17325 26 LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 131 ALTMIGKYF-YKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSFLILGGLLLNCCVAGALMRPIGPKPttaekek 209
Cdd:cd17325 105 AMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 210 skgslqeagkyetkkgasdantdliggnpKEEKKSIFQTLNTFLDLSLFKHRGFLLYLSGNVLMF-FGLFTPlvFLSNYG 288
Cdd:cd17325 178 -----------------------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFaFGALEP--FLPLYA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 289 KSK-HYSSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVqyfFAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAF 367
Cdd:cd17325 227 AELgGLSPAQIGLLFGAQGLASALSQPPAGKLSD-RIGRKPL---ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82617542 368 GWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGdYKYTYWACGIILIVAGIYLFIG 440
Cdd:cd17325 303 GLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLL 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-440 |
5.72e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 76.43 E-value: 5.72e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 21 AVVIGAFISIGFSYAFPKSITVFFKEIegiFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGL 100
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDA---FGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 101 IAASFCNTVQELYFSVGVIgGLGLAF---NLNPALTMIGKYFYKRR-PLA---NGLAMAGSPVFLSTLAPLNQAFfmiyG 173
Cdd:COG0738 88 LLFALAPSYPLLLLALFLL-GLGLGLldvAANPYVAALGPETAASRlNLLhafFSLGALLGPLLGGLLILLGLSL----S 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 174 WRGSFLILGGLLLNCCVAGALMRPIGPKPTTAEKEKSKGSLqeagkyetkkgasdantdliggnpkeekksifqtlntfl 253
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASL--------------------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 254 dLSLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKS-KHYSSEKAAFLLSILAFVDMVARPSMGLVanTKWVRPRVQYF 332
Cdd:COG0738 204 -KSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFL--LKRFGPVRLLR 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 333 FAASIIANGLChLAAPLSSTYIelcIYAGFFGFAFGwlSSVLFETLMDLVG---PQRFSSAVGLVTIVECCPVLLGPPVL 409
Cdd:COG0738 281 LSALLAAVGLL-LALLAPGPWL---ALIGLALVGLG--LSLMFPTIFSLALdglGKRTAAAVSAVLIMGIVGGAIGPPLI 354
|
410 420 430
....*....|....*....|....*....|.
gi 82617542 410 GRLNDIYGdYKYTYWACGIILIVAGIYLFIG 440
Cdd:COG0738 355 GFLADAFG-LRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
44-439 |
3.94e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 70.68 E-value: 3.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 44 FKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSvGVIGGLG 123
Cdd:cd17474 22 LPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAG-RALQGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 124 LAFNLNPALTMIGKYF-YKRRP-------LANGLAMAGSPVFLSTLAplnqaffmIYGWRGSFLILGGLLLnccVAGALM 195
Cdd:cd17474 101 AAGLGPLALTLIGDLFeGGERAkamglyeAALGLGIAVGPLLGGLLA--------AISWRYPFFLLAALIP---VAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 196 RPIGPKPTTAEKEKSKGSLQEAGKyetkkgasdantdliggnpkeekksifqtlntfldlsLFKHRGFLLYLSGNVLMFF 275
Cdd:cd17474 170 LFLLPEPKEKAKSSSATKLRDLKK-------------------------------------ALRGRGLLTFLVSAFLYFF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 276 GLFTPLVFLSNY-GKSKHYSSEKAAFLLSILAFVDMVARPSMGlvantKWVRPRV--QYFFAASIIANGLCHLAAPLSST 352
Cdd:cd17474 213 LYFAFLTYLPFLlELLYGISPIIIGLLFAGWSVLLALGSLFVG-----RLLKKRFgaRRILVIGLLLYALSLLLLGFVPS 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 353 YIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGDYKYTYWACGIILIV 432
Cdd:cd17474 288 LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAA 367
|
....*..
gi 82617542 433 AGIYLFI 439
Cdd:cd17474 368 AVLLALL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
256-441 |
3.00e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 64.61 E-value: 3.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 256 SLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVqyfFAA 335
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD-RFGRRRV---LLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 336 SIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDI 415
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180
....*....|....*....|....*.
gi 82617542 416 YGdYKYTYWACGIILIVAGIYLFIGM 441
Cdd:COG2814 161 FG-WRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
66-437 |
4.30e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.57 E-value: 4.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 66 LAVMYGGGPISSV----LVNKYGSRPVMIVGGILSGSGLIAASFCNTvQELYFSVGVIGGLGLAFNLNPALTMIGKYF-Y 140
Cdd:cd17475 37 LSALNLGVAVSMLpagwLLDRFGERRVLAVGLLLMGAAALLMALVGS-YPVLLVLLFLVGAGYGSVQPGGGRAIMRWFpP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 141 KRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSFLILGGLLLNCcvAGALMRPIGPKPTTAEKEKSKGSLQEAGKy 220
Cdd:cd17475 116 RERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILA--AVLFWLFYREPPAASAATESASTLLRSLK- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 221 etkkgasdantdliggnpkeekksifqtlntfldlSLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSK-HYSSEKAA 299
Cdd:cd17475 193 -----------------------------------EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHlGLSVVAAG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 300 FLLSILAFVDMVARPSMGLVANTKWVRPRVQYFFAASIIANG--LCHLAAPLSSTY---IELCIYAGFFGFAFGWLSSVL 374
Cdd:cd17475 238 ALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAalLVLSLLSPGTPLwllVLLLILLGLFAIGWNGLYLTL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82617542 375 fetLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGDYKYTYWACGIILIVAGIYL 437
Cdd:cd17475 318 ---VAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
40-186 |
6.97e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 60.21 E-value: 6.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 40 ITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSVgVI 119
Cdd:COG0477 33 VNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAAR-AL 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 82617542 120 GGLGLAFNLNPALTMIGKYF-YKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSFLILGGLLL 186
Cdd:COG0477 112 QGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGL 179
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
73-439 |
1.30e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 59.89 E-value: 1.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 73 GPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSVGVIgGLGLAFNLNPALTMIGKYFY-KRRPLANGLAM 151
Cdd:cd17473 52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALL-GIGVAGIMTLATALIGDYFEgEERAKMLGLQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 152 AGSPvFLSTLAPLNQAFFMIYGWRGSFLI-LGGLLLNCCVAGALmrpigPKPTTAEKEKSKGSLQEAGKYETKKgasdan 230
Cdd:cd17473 131 AAMS-LGGVVFLLLGGALAEIGWRAPFLVyLLALPVLILVLLFL-----PEPARKSKSAASPGAATAAALPWKR------ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 231 tdliggnpkeekksifqtlntfldlslfkhrgFLLYLSGNVLMFFGLFTPLVFLSNYGKSKH-YSSEKAAFLLSILAFVD 309
Cdd:cd17473 199 --------------------------------VLPIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 310 MVARPSMGLVANTKwvrpRVQYFFAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSS 389
Cdd:cd17473 247 AIGALLFGRLKRRL----GKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGR 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 82617542 390 AVGLVTIVeccpVLLG----PPVLGRLNDIYGDYKYTYWACGIILIVAGIYLFI 439
Cdd:cd17473 323 AMGIVTSA----FFLGqflsPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
74-438 |
6.72e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.60 E-value: 6.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 74 PISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVqELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRpLANGLAMAG 153
Cdd:cd17489 49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV-ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 154 SPVFLSTL--APLNQAFFMIYGWRGSFLILGGLLLnccVAGALMRPIGPKPTTAEKEKSKGSLQeagkyetkkgasdant 231
Cdd:cd17489 127 LATTLAMAlgPALGLFLYQHLGFAVLFIVAAVLAL---LALLLVFLVKDPPPVAAEEAEAGTRA---------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 232 dliggnpkeekksifqtlntfldLSLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSseKAAFLLSILAFVDMV 311
Cdd:cd17489 188 -----------------------FRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 312 ARPSMGLVANtKWVRPRVQYFFAAsIIANGLCHLAAPLSStyIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAV 391
Cdd:cd17489 243 SRPFSGKLSD-RKGPKTVIIPGLL-LLALGLLLLSFAGSP--WMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 82617542 392 GLVTIVECCPVLLGPPVLGRLNDIYGdYKYTY-WACGIILIVAGIYLF 438
Cdd:cd17489 319 GTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFlLAAVVVLLALVLYIF 365
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
267-466 |
1.68e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 56.45 E-value: 1.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 267 LSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPrvqyFFAASIIANGLCHLA 346
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKR----LLLIGLLIFALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 347 APLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGdYKYTYWAC 426
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVA 156
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 82617542 427 GIIlIVAGIYLFIGMGINYRLLEKEQKAEKQQKKESKDEE 466
Cdd:cd17489 157 AVL-ALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK 195
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
267-439 |
2.36e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.89 E-value: 2.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 267 LSGNVLMFFGLFTPLVFLSNY-GKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVqyfFAASIIANGLCHL 345
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD-RFGRRRV---LLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 346 AAPLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGdYKYTYWA 425
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
|
170
....*....|....
gi 82617542 426 CGIILIVAGIYLFI 439
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
20-441 |
3.39e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.31 E-value: 3.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFI-SIGFSYAFPkSITVFFKEIEGIfnaTTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17329 2 WVLLIGSFLnRLGFFMVWP-FMAIYLHQQLGL---SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQeLYFSVGVIGGLGLAFNLNPALTMIG--------KYFYKRRPLANGLAMAgspvflstLAPLNQAFFM 170
Cdd:cd17329 78 GFALLGFAHSPW-LFAIALVLTGFGGGLFEPASEAMIAdvttpenrTRAFSLLYWAINLGVA--------IGPLLGGLLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 171 IYGWRGSFLILGGLLLNCC-VAGALMRPIGPKPTTAEKEKSKGSLQeagkyetkkgasdantdliggnpkeekksifqtl 249
Cdd:cd17329 149 LYSFRLLFLAAAVLFLLAAlVLLFLLPETRPKRRAAEKTEILRGYK---------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 250 ntfldlSLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSKHYSSEKA-AFLLSILAFVDMVARPSMGLVANTKwvRPR 328
Cdd:cd17329 195 ------IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPVARLVERF--RLR 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 329 VQYFFAASIIANGLchLAAPLSSTYIELCIYAGFFGFA--FGW-LSSVLFETLMDLVGPQRFSSAVGLVTIVEccpVLLG 405
Cdd:cd17329 267 KILMIGILLFAIGF--AVLAFANTLAVLILAMIVLTLGemLVFpAVQTLVAALAPPDKRGSYMGFYALAWGLG---RAIG 341
|
410 420 430
....*....|....*....|....*....|....*.
gi 82617542 406 PPVLGRLNDIYGDYkYTYWACGIILIVAGIYLFIGM 441
Cdd:cd17329 342 PLVGGLLLDLLGPG-LPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
41-397 |
1.07e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 54.12 E-value: 1.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 41 TVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSvGVIG 120
Cdd:cd17503 16 NVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIF-RILQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 121 GLGLAFNLNPALTMIGKYfYKRRPLANGLAMAGSPVFLS-TLAPLNQAFFMIY-GWRGSFLIlgglLLNCCVAGALMRPI 198
Cdd:cd17503 95 GFGGGVLIPLAQTILLRI-YPPEKRGAAMGLVGLVILLApAIGPTLGGWLTDNlSWRWIFYI----NLPIGILALLLAPL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 199 gpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntfLDLSLFKHRGFLLYLSGNVLMFFGLF 278
Cdd:cd17503 170 ------------------------------------------------------LDLRLFKDRNFTLGLLLSFLLGLGLF 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 279 TPLVFLSNY-GKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPRVQYFFAASIIANGLCHLAAPLSSTYIELC 357
Cdd:cd17503 196 GAMFLLPLYlQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIIL 275
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 82617542 358 IYAgFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIV 397
Cdd:cd17503 276 PLF-IRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTI 314
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-197 |
2.51e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.56 E-value: 2.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFISIGFSYAFPKSITVFFKEIEGIfnaTTSEVSWISSIMLAVMYGGGPISSVLVNKYGSR--PVMIVGGILSG 97
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEVRGL---SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 98 SGLIAASFCNTVQELYFSVGVIGGLGLAFnlNPALTMIGKYFY--KRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWR 175
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGA--FGLLWALAAELFpkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|..
gi 82617542 176 GSFLILGGLLLNCCVAGALMRP 197
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLR 359
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
272-479 |
9.56e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 9.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 272 LMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTKWVRPrvqyFFAASIIANGLCHLAAPLSS 351
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKR----LLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 352 TYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGdYKYTYWACGIILI 431
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALAL 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 82617542 432 VAGIylfigmgINYRLLEKEQKAEKQQKKESKDEETNVDVAEKPKEVI 479
Cdd:cd17325 162 LALV-------LALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLL 202
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
20-439 |
2.57e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.49 E-value: 2.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSG 99
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 100 LIAASFCNTVQELYFSVGVIgGLGLAFNLNPALTMIGKYFYKR-RPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSF 178
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLL-GVAEAGFFPGAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 179 LILGglllnccVAGALMRPIgpkpttaekekskgslqeagkyetkkgasdantdliggnpkeekksIFQTLNTFLDLSLf 258
Cdd:cd17319 161 IIEG-------LLGLLLAVL----------------------------------------------WWFYLRQVWGLAL- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 259 khrGFLLYLSgnVLMFFGLFTPLVFLSNYGkskhYSSEKAAFLLSI---LAFVDMVArpsMGLVANTKWVRPRVQYF--- 332
Cdd:cd17319 187 ---GYFGINY--ALYGLLTWLPTYLKQARG----FSLKQVGLLAAIpflAGAIGMIL---GGRLSDRLLRGARRLVIiig 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 333 FAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGwlssVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRL 412
Cdd:cd17319 255 LLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASP----VFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYL 330
|
410 420
....*....|....*....|....*..
gi 82617542 413 NDIYGDYKYTYWACGIILIVAGIYLFI 439
Cdd:cd17319 331 VDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
20-126 |
1.08e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFISIGFSYAFPKSITVFFkeIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSG 99
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100
....*....|....*....|....*...
gi 82617542 100 LIAASFCNTVQ-ELYFSVGVIGGLGLAF 126
Cdd:COG2211 308 LLLLFFLGPGNlWLLLVLAALAGIGLGA 335
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
73-182 |
1.47e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 44.95 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 73 GPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSvGVIGGLGLAFNLNPALTMIGKYF-YKRRPLANGLAM 151
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIA-RFLQGFGAAFALVAGAALIADIYpPEERGVALGLMS 93
|
90 100 110
....*....|....*....|....*....|.
gi 82617542 152 AGSPVFLSTLAPLNQAFFMIYGWRGSFLILG 182
Cdd:TIGR00880 94 AGIALGPLLGPPLGGVLAQFLGWRAPFLFLA 124
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
47-435 |
2.57e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.42 E-value: 2.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 47 IEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSvGVIGGLGLAf 126
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG-RALQGIGGA- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 127 nLNP-ALTMIGKYFYKRR-PLANGL--AMAGSPVFLSTL--APLNQaffmIYGWRGSFLILGGLllncCVAGALMRPIgp 200
Cdd:cd17504 100 -VFPlAFALVREEFPPERvPVAQGIlsATFGIGAGIGLPlgGWIVQ----HLGWRWIFWTAAPV----AVLLAALVPL-- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 201 kpttaekekskgslqeagkyetkkgasdantdliggnpkeekksifqtlntfLDLSLFKHRGFLLYLSGNVLMFFGLFT- 279
Cdd:cd17504 169 ----------------------------------------------------IDLRLLRRRNVLLANITALLAGFGMFMv 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 280 ----PLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANTkwVRPRVQYFFAASIIANGLCHLAApLSSTYIE 355
Cdd:cd17504 197 fqllPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIAR--VGPRRVLLIGLVISAVGLLLLAL-LHSSLWA 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 356 LCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIY------------GDYKYTY 423
Cdd:cd17504 274 LVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYtvsitsggvpteGAYVLAF 353
|
410
....*....|..
gi 82617542 424 WACGIILIVAGI 435
Cdd:cd17504 354 LIGAALALAALL 365
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-196 |
3.51e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.03 E-value: 3.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPksitVFFKEIegiFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17325 205 FLAIFVLAFAFGALEPFLP----LYAAEL---GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFSVGVIgGLGLAFNLNPALTMIGKYFYKR-RPLANG-------LAMAGSPVFLSTLAplnqaffM 170
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLALL-GLGLGLVFPATLALLADIVPPEgRGTAMGlfntafsLGMVLGPLLGGFLY-------D 349
|
170 180
....*....|....*....|....*.
gi 82617542 171 IYGWRGSFLILGGLLLNCCVAGALMR 196
Cdd:cd17325 350 AFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
51-186 |
3.85e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 45.65 E-value: 3.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 51 FNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFsVGVIGGLGLAFNLNP 130
Cdd:cd17365 29 WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPN 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 82617542 131 ALTMIGKYF-YKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSFLILGGLLL 186
Cdd:cd17365 108 AITLVSEYApARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPL 164
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
19-182 |
5.30e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 45.43 E-value: 5.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 19 GWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:TIGR00895 15 QWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 99 GLIAASFCNTVQELYFsVGVIGGLGLAFNLNPALTMIGKYFYKR-RPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGS 177
Cdd:TIGR00895 95 FTLLCALATNVTQLLI-LRFLAGLGLGGLMPNLNALVSEYAPKRfRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSL 173
|
....*
gi 82617542 178 FLILG 182
Cdd:TIGR00895 174 FYVGG 178
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
278-439 |
5.82e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.29 E-value: 5.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 278 FTPLvFLSNYGKSkhyssekaAFLLSILAFVDMVARPSMGLVANTKWVRPRVQYFFA-ASIIANGLCHLAAPLSSTYIEL 356
Cdd:cd17490 217 FTPL-IAKQLGAS--------SFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIiIGFLLLGAYCFLIPFAPNLTLL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 357 CIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGdYKYTYWACGIILIVAGIY 436
Cdd:cd17490 288 YLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAIL 366
|
...
gi 82617542 437 LFI 439
Cdd:cd17490 367 SLA 369
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
20-135 |
8.60e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 8.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFIsIGFSYAFPKSITVFFkeIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSG 99
Cdd:cd17321 171 SGAVLAAFL-LGAALGGLLFLLPLY--LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247
|
90 100 110
....*....|....*....|....*....|....*...
gi 82617542 100 LIAASFCNTVQELYFSVG--VIGGLGLAFNLNPALTMI 135
Cdd:cd17321 248 LLLLALLGADSSVWLLLPglVLLGLGLGLFATPLTNAA 285
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
269-443 |
1.02e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.48 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 269 GNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANtkWVRPRvqYFFAASIIANGLCHLAAP 348
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD--RFGRR--RVLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 349 LSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGdYKYTYWACGI 428
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-WRAAFLILGL 172
|
170
....*....|....*
gi 82617542 429 ILIVAGIYLFIGMGI 443
Cdd:COG2271 173 PGLLLALLRFWLLAL 187
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
86-465 |
1.18e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.51 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 86 RPVMIVGGILSGSGLIAA----SFCNTVQELYFSVGVIGgLGLAFNLN--PALTMIGKYF--YKRRPLANG----LAMAG 153
Cdd:COG2211 81 RPWILIGAIPLALSFVLLftapDLSPTGKLIYALVTYLL-LGLAYTLVniPYSALGAELTpdYEERTRLSSwrfaFAGLG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 154 SPVFLSTLAPLNQAFF--MIYGWRGSFLILGGLLLNCCVAGALmrpigpkpTTAEKEKskgslqeagkyetkkgasdant 231
Cdd:COG2211 160 GLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLTFF--------GTKERPV---------------------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 232 dliggnPKEEKKSIFQTLntfldLSLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKSK-HYSSEKAAFLLSILAFVDM 310
Cdd:COG2211 210 ------PEEEKVSLKESL-----KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAAL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 311 VARPSMGLVANtKWVRPRVqyfFAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGW--LSSVLFETLMDLV------ 382
Cdd:COG2211 279 LGAPLWPRLAK-RFGKKKA---FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLgaILVLPWAMLADVVdydewk 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 383 -GPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYG-------------DYKYTYWACGIILIVAGIYLFIGmginYRLL 448
Cdd:COG2211 355 tGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsaltGIRLLFFLLPAVLLLLAALLLLF----YPLT 430
|
410
....*....|....*..
gi 82617542 449 EKEQKAEKQQKKESKDE 465
Cdd:COG2211 431 RERHAEIRAELAARRAA 447
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-206 |
1.20e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.49 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFISIGFSYAFPKSITVFFKEIegiFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSG 99
Cdd:COG2223 208 WLLSLLYFGTFGSFIGFSSWLPPYLVDQ---FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 100 LIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMIGKYF-YKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYG-WRGS 177
Cdd:COG2223 285 LLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAA 364
|
170 180
....*....|....*....|....*....
gi 82617542 178 FLILGGLLLnCCVAGALMRPIGPKPTTAE 206
Cdd:COG2223 365 FLVFAVLAL-VALVLTLLLYRRPRRAAAA 392
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
51-433 |
1.35e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.08 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 51 FNATTSEVSWISSIMlAVMYG-GGPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFS-VGVIGGLGLAFNL 128
Cdd:cd17324 29 FGVSVAQAGLLVSAY-ALGYAlGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLArALAGLAHGGFWAI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 129 npALTMIGKYF-YKRRPLANGLAMAGSPVFLSTLAPLNQAFFMIYGWRGSFLILGGLLLnccVAGALMRPIGPKpttaEK 207
Cdd:cd17324 108 --AAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL---LAALLLWRLLPS----LP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 208 EKSKGSLQEAGKYetkkgasdantdliggnpkeekksifqtlntfldLSLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNY 287
Cdd:cd17324 179 PKKPGSLGLLSSL----------------------------------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 288 GKSKHY-SSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVQYFFAASIIANGLCHLAAPLSSTYIELCIyagFFGFA 366
Cdd:cd17324 225 LTDVPGfSSSAIIGLLLLFGVAGVVGSPLAGRLAD-RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLV---LWGLG 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 82617542 367 FGWLSSVLFETLMDLVGPQRfSSAVGLVTIVECCPVLLGPPVLGRLNDIYGdYKYTYWACGIILIVA 433
Cdd:cd17324 301 FFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGG-WAGVGWVGAALLLLA 365
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
255-395 |
3.21e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.93 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 255 LSLFKHRGFLLYLSGNVLMFFGLFTPLVFLSNYGKS-KHYSSEKAAFLLSILAFVDMVARPSMGLVAntKWVRPRVQYFF 333
Cdd:cd17321 162 VALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLA--DRFGPRLVLVA 239
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82617542 334 AASIIANGLCHLA-APLSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVT 395
Cdd:cd17321 240 GLLLTAVGLLLLAlLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILN 302
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
20-195 |
4.47e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 42.65 E-value: 4.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFISIGFSYAFPKSITVFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSG 99
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 100 LIAASFCNTVQELYFSVGVIG---GLGLAfnlnPALTMIGKYF-YKRRPLANGLaMAGSPVFLSTLAPLNQAFFM-IYGW 174
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGLNGlfqSMGWP----PCVKLLGNWFsKKERGTVYGI-WSTSHNFGGILAPILAASLAsYYGW 156
|
170 180
....*....|....*....|.
gi 82617542 175 RGSFLILGGLllnCCVAGALM 195
Cdd:cd17312 157 RAAFLVPGIV---GLVVAIIL 174
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
20-135 |
4.55e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.56 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFISIGFSYAFPKSITVFFKEIEGI-FNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGS 98
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQLLQLPTPTgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAV 259
|
90 100 110
....*....|....*....|....*....|....*..
gi 82617542 99 GLIAASFCNTVQELYFSVGVIGGLGLAFNLNPALTMI 135
Cdd:cd17504 260 GLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIV 296
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
44-394 |
1.05e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.41 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 44 FKEIEGIFNATTSEVSWISSIMLAVMYGG----GPISSvlvnKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSvGVI 119
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGqllyGPLSD----RFGRRPVLLAGLLLFILASLLCALASSIEQLLIA-RFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 120 GGLGLAFNLNPALTMIGKYfYKRRPLANGLAMAGSPVFLS-TLAPLNQAFFMIY-GWRGSFLILGGLLLNCCVAGALMRP 197
Cdd:cd17320 97 QGLGAAAGSVVARAIVRDL-YSGAELAKIFSLLMMILAIApALAPLLGGLLLLFfGWRAIFVFLALLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 198 igpkpttaekekskgslqeagkyETKKgasdantdliggnPKEEKKSIFQTLNTFldLSLFKHRGFLLYLSGNVLMFFGL 277
Cdd:cd17320 176 -----------------------ETLP-------------EEKRKPLLSSLLRAY--KRVLKNRRFLGYALALGLSFAGL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 278 FT-----PLVFLSNYGkskhYSSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVQYFFAASIIANGLCHLAAPLSS- 351
Cdd:cd17320 218 FAylaaaPFIYIEQLG----LSPAQFGLLFALNAIALILGSLLNGRLVR-RFGPRRLLRLGLLLLLAAALVLLLAALLGg 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 82617542 352 -TYIELCIYAGFFGFAFGWLSSVLFETLMDLVgPQRFSSAVGLV 394
Cdd:cd17320 293 lSLWPLVAPLFLIFFGFGLIFPNATSLALEPF-PHVAGTASALL 335
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
298-441 |
1.43e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 298 AAFLLSILAFVDMVARPSMGLVANtKWVRPRVqyfFAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFET 377
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSD-RIERRRL---LLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAY 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 82617542 378 LMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGdYKYTYWACGIILIVAGIYLFIGM 441
Cdd:cd17324 112 AADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLALLAALLLWRLL 174
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
22-195 |
1.57e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.09 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 22 VVIGAFISIGFSYAFPKSITVFFKE-----IEGIFNA--TTSEVSWISSIMLAVMYGGG----PISSVLVNKYGSRPVMI 90
Cdd:cd17357 4 VAFGGSFQFGYNIGVVNAPQEVFKEfindtLVDRYGLnlSDSELDLLWSLIVSIFFIGGaigsFISAFLANRFGRKNGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 91 VGGILSGSGLIAASFCNtvqelyfsvgvigglglaFNLNPALTMIGKYFYKrrpLANGLAMAGSPVFLSTLAPlnqaffm 170
Cdd:cd17357 84 ISNALLVVSSLLMFLSK------------------SAKSPELLIFGRFLVG---IACGLSTGFVPMYLQEISP------- 135
|
170 180
....*....|....*....|....*.
gi 82617542 171 iYGWRGSFLILGGLLLNC-CVAGALM 195
Cdd:cd17357 136 -SELRGALGSLTQIGVTLgILLGQVF 160
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
58-439 |
2.56e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.29 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 58 VSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLIAASFC-----NTVQELYFSVGVIGGLGLAFnlNPAL 132
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAFF--GPAR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 133 TMIGKYFYKRRPLANGLAMAGSPVFLSTLA--PLNQAFFMIYGWRGSFLILGGLLLnccVAGALMRPIGPKPttaekeks 210
Cdd:cd06173 114 QALLPELVPKEQLVRANALNSLATQLARIIgpALGGLLVALLGPGGAFAINALSFL---LSALLLLFIRRPP-------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 211 kgslqeagkyetkkgasdantdliggNPKEEKKSIFQTLNTFLDLSLFKHRGFLLYLSGNVLMFFGLFTPL-VFLSNYGK 289
Cdd:cd06173 183 --------------------------PAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALtVLLPLLAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 290 SKHYSSEKAAFLLSILAFVDMVArpsMGLVANTKWVRPRVQYFFAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGw 369
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALL---GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGG- 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 82617542 370 LSSVLFETLMDLVGPQRFSSAV-GLVTIVECCPVLLGPPVLGRLNDIYGdYKYTYWACGIILIVAGIYLFI 439
Cdd:cd06173 313 LFNVPLNTLLQLRVPDELRGRVfSVYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLL 382
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
23-192 |
3.46e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.95 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 23 VIGAFIS-IGFSYAFpksitvFFKEIEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILS--GSG 99
Cdd:pfam00083 18 VIGAFLTlIDFFKNF------GLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFviGAV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 100 LIAASFCNTVQELYFSVGVIGGLGLafnlnpaltmigkyfykrrplanGLAMAGSPVFLSTLAPLNQAFFMIyGWRGSFL 179
Cdd:pfam00083 92 LQGAAKGKWSVYQLIVGRVLVGIGV-----------------------GGASVLAPMYISEIAPKKLRGALG-SLYQLAI 147
|
170
....*....|...
gi 82617542 180 ILGGLLLNCCVAG 192
Cdd:pfam00083 148 TFGILLAYIFGLG 160
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
54-397 |
4.73e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.53 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 54 TTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLIAASFCNTVQELYFSVGVIG-GLGLAFNLNPAL 132
Cdd:cd06179 30 PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGiGAGTQGLGAAVA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 133 TMIgkYFYKRRPLANGLAMAGSPVFlSTLAPL-NQAFFMIY--GWRGSFLILggLLLNCCVAGALM---RPigPKPTTAE 206
Cdd:cd06179 110 SEL--VPNKYRGLVQGVVNLVASPG-SALGPLiAGALVEANaaGWRWIFYIN--AIFNALALILLFffyHP--PPRPQLH 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 207 KEKSKGSLQE-----------------------AGKYetkkGASDANT---------DLIGGNPKEEKKSIFQTLNTFLd 254
Cdd:cd06179 183 GSSTRQKLKRldwvglflliaglvlfllglswgGNPY----PWSSAHViaplviggvLLIAFGLYEWKGTKDGLLPPRL- 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 255 lsLFKHRGFLLYL-----SGNVLMFFGLFTPLVFLSNYGKskhySSEKAAFLLSILAFVDMVARPSMGLVAnTKWVRPRV 329
Cdd:cd06179 258 --LFRGRNFALILivafvEGMIFYSLNIFWPQQISLLFTT----DPLKAGLYQLPFGLGTLFGAILAGLLL-TKIKHIKW 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 82617542 330 QYFFAASIIANGLCHLAAPLSSTYIELCIYAGFFGFAFGWLSSVLFeTLMDLVGPQRF-SSAVGLVTIV 397
Cdd:cd06179 331 QLVAGFVLFTAFLALLALITPDNKALAIAFSVLAGIGIGGPLVLAI-VIVQLSVPPEDiGTASGLLGSA 398
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
26-186 |
5.14e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.23 E-value: 5.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 26 AFISIGFSYAFPKSITVFFKEIegiFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSGLIAASF 105
Cdd:cd17333 4 SFFSNGLTDALLGILGPSLEEA---FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 106 CNTVQeLYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLaMAGSPVFLSTLAPLNQAFFM--IYGWRGSFLILGG 183
Cdd:cd17333 81 TPSIY-LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNV-LHGFFGLGALIGPLIATSLLtsELSWSWAYLIIGL 158
|
...
gi 82617542 184 LLL 186
Cdd:cd17333 159 IYL 161
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
269-441 |
7.88e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.71 E-value: 7.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 269 GNVLMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVqyfFAASIIANGLCHLAAP 348
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD-RFGPRRV---LLIGLLLLGIGLLLLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 349 LSSTYIELCIYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPVLGRLNDIYGdYKYTYWACGI 428
Cdd:COG2223 89 LAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-WRNAFLILGI 167
|
170
....*....|...
gi 82617542 429 ILIVAGIYLFIGM 441
Cdd:COG2223 168 LLLVVAVLAWLFL 180
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
272-457 |
8.26e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 38.33 E-value: 8.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 272 LMFFGLFTPLVFLSNYGKSKHYSSEKAAFLLSILAFVDMVARPSMGLVANtKWVRPRVQYFFAASIIANGLCHLAAPLSS 351
Cdd:cd17335 8 FFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALAD-RFGKRKALLLLSLLAAVLFFLSLFFVAQI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 352 ---TYIELCIYAGFFGFAFGWLSSVLFETL---MDLVGPQRFSSAVGLVtiveccpvlLGPPVLGRLNDIYGDYKYTYWA 425
Cdd:cd17335 87 fwlLLLLVILGAFFSAPVVPLVDSITLQYLgeeRERYGKQRLWGSIGFG---------IAALLVGILIDRSSTYKNYTIA 157
|
170 180 190
....*....|....*....|....*....|..
gi 82617542 426 cgiiLIVAGIYLFIGMGINYRLLEKEQKAEKQ 457
Cdd:cd17335 158 ----FYVFAVLMLLALLLALKFPFRPKHPEPN 185
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
16-186 |
8.51e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 8.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 16 GGWGWAVVIGAFISIGFSYAFPKSitvffkeiEGIFNATTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGIL 95
Cdd:cd17316 4 AGLGWFFDAYDFFLIGFVAPVLAA--------EFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 96 SGSGLIAASFCNTVqELYFSVGVIGGLGLAFNLNPALTMIGKYFYKRRP-----LANGLAMAGSPVFLSTLAPLNQAFFM 170
Cdd:cd17316 76 FGLATLLIGLLPTP-ILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRgfalgLLQSGWALGALLAALVASLLIPLLSG 154
|
170
....*....|....*.
gi 82617542 171 IYGWRGSFLILGGLLL 186
Cdd:cd17316 155 DWGWRILFLIGALPAL 170
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-186 |
9.22e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.30 E-value: 9.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 20 WAVVIGAFISIGFSYAFPKSITVFFKEIEGIfnaTTSEVSWISSIMLAVMYGGGPISSVLVNKYGSRPVMIVGGILSGSG 99
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDVLGL---SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82617542 100 LIAASFCNTVQELYFSVGVIgGLGLAfNLNPA-LTMIGKYFYKRRPLANGLAMAGSpVFLSTLAPLNQAFFM-IYGWRGS 177
Cdd:COG0738 290 LLLALLAPGPWLALIGLALV-GLGLS-LMFPTiFSLALDGLGKRTAAAVSAVLIMG-IVGGAIGPPLIGFLAdAFGLRAA 366
|
....*....
gi 82617542 178 FLILGGLLL 186
Cdd:COG0738 367 FLVPLVCYL 375
|
|
| |
