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Conserved domains on  [gi|82658254|ref|NP_001032461|]
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grpE protein homolog 1, mitochondrial [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 72-213 1.32e-59

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


:

Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 183.48  E-value: 1.32e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  72 KDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKATESVPKTEIsaanphLKNLYDGLVMTEVQI 151
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE------LKNLLEGVEMTLKQL 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 82658254 152 QKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLHGRTLRPALVGV 213
Cdd:cd00446  75 LKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 72-213 1.32e-59

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 183.48  E-value: 1.32e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  72 KDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKATESVPKTEIsaanphLKNLYDGLVMTEVQI 151
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE------LKNLLEGVEMTLKQL 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 82658254 152 QKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLHGRTLRPALVGV 213
Cdd:cd00446  75 LKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
45-215 2.77e-53

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 168.56  E-value: 2.77e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254    45 ESGAQKQEPGTAEKAFLEEKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKATES 124
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   125 VPKTEIsaanphLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLHGR 204
Cdd:pfam01025  81 APENED------VKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDR 154

                         170
                  ....*....|.
gi 82658254   205 TLRPALVGVVK 215
Cdd:pfam01025 155 VLRPAMVVVSK 165
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 66-216 2.03e-50

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 160.70  E-value: 2.03e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  66 QLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKATESVPKteisaaNPHLKNLYDGLV 145
Cdd:COG0576   3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEE------DEDVKSLLEGVE 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 82658254 146 MTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLHGRTLRPALVGVVKA 216
Cdd:COG0576  77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 42-215 1.05e-42

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 142.89  E-value: 1.05e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   42 TEEESGAQKQEPGTAEKafleektqLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKA 121
Cdd:PRK14141  26 AKPYEMEDDPEPDPLEA--------LKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  122 TESVPKTEISAANPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKL 201
Cdd:PRK14141  98 LDAIPAEARAAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTVVQVVQAGYTI 177

                        170
                 ....*....|....
gi 82658254  202 HGRTLRPALVGVVK 215
Cdd:PRK14141 178 GERVLRPAMVGVAK 191
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 72-213 1.32e-59

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 183.48  E-value: 1.32e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  72 KDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKATESVPKTEIsaanphLKNLYDGLVMTEVQI 151
Cdd:cd00446   1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEE------LKNLLEGVEMTLKQL 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 82658254 152 QKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLHGRTLRPALVGV 213
Cdd:cd00446  75 LKVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
45-215 2.77e-53

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 168.56  E-value: 2.77e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254    45 ESGAQKQEPGTAEKAFLEEKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKATES 124
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   125 VPKTEIsaanphLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLHGR 204
Cdd:pfam01025  81 APENED------VKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDR 154

                         170
                  ....*....|.
gi 82658254   205 TLRPALVGVVK 215
Cdd:pfam01025 155 VLRPAMVVVSK 165
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 66-216 2.03e-50

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 160.70  E-value: 2.03e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  66 QLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKATESVPKteisaaNPHLKNLYDGLV 145
Cdd:COG0576   3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEE------DEDVKSLLEGVE 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 82658254 146 MTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLHGRTLRPALVGVVKA 216
Cdd:COG0576  77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 42-215 1.05e-42

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 142.89  E-value: 1.05e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   42 TEEESGAQKQEPGTAEKafleektqLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKA 121
Cdd:PRK14141  26 AKPYEMEDDPEPDPLEA--------LKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  122 TESVPKTEISAANPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKL 201
Cdd:PRK14141  98 LDAIPAEARAAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTVVQVVQAGYTI 177

                        170
                 ....*....|....
gi 82658254  202 HGRTLRPALVGVVK 215
Cdd:PRK14141 178 GERVLRPAMVGVAK 191
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 42-213 3.62e-34

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 120.84  E-value: 3.62e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   42 TEEESGAQKQEPGTAE-KAFLEEKTQLEEQLKdvtdkykRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEK 120
Cdd:PRK14155   6 TPAEDGPFEADDAAQEiEALKAEVAALKDQAL-------RYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  121 ATESVPKteiSAANPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSP-DGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGY 199
Cdd:PRK14155  79 ATAASPK---DSADPAVKNFIIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGY 155

                        170
                 ....*....|....
gi 82658254  200 KLHGRTLRPALVGV 213
Cdd:PRK14155 156 ELMGRLVRPAMVAV 169
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 31-216 5.21e-31

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 111.99  E-value: 5.21e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   31 TAAQQKSSGAGTEEESGAQKQEPGTAEKAFLEEK-TQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCK 109
Cdd:PRK14139   7 NPSEQEAEEAGAAAQAAAAAAAAAEDAAPALEAElAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAE 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  110 DLLEVADILEKAtesvpkteISAANPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGkEPG 189
Cdd:PRK14139  87 SLLPVKDSLEAA--------LADESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPAEQ-EPN 157

                        170       180
                 ....*....|....*....|....*..
gi 82658254  190 TIALVTKVGYKLHGRTLRPALVGVVKA 216
Cdd:PRK14139 158 TVVAVLQKGYTIADRVLRPALVTVAAP 184
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 31-213 7.05e-30

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 109.32  E-value: 7.05e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   31 TAAQQKSSGAGTEEESGAQKQEPGTAEKAFLEEK--TQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFC 108
Cdd:PRK14140  11 EVEETEVEEAVEDEVEEETVEEESEAELLDEEQAkiAELEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  109 KDLLEVADILEKATEsvpkteISAANPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEP 188
Cdd:PRK14140  91 SDLLPALDNFERALQ------IEADDEQTKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDEDFES 164

                        170       180
                 ....*....|....*....|....*
gi 82658254  189 GTIALVTKVGYKLHGRTLRPALVGV 213
Cdd:PRK14140 165 NEVVEELQKGYKLKDRVIRPSMVKV 189
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 43-216 6.46e-28

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 103.70  E-value: 6.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   43 EEESGAQKQEPGTAEKAFLEEKT----QLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADIL 118
Cdd:PRK14151   4 EQTLDLQAPEAAQAEAAAGDDLTarvqELEEQLAAAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  119 EKATESvpkteISAANPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVG 198
Cdd:PRK14151  84 ERGLEL-----SSADDEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQKG 158

                        170
                 ....*....|....*...
gi 82658254  199 YKLHGRTLRPALVGVVKA 216
Cdd:PRK14151 159 YLLNGRLLRPAMVVVSKA 176
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 62-217 3.04e-27

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 102.36  E-value: 3.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   62 EEKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKATESVPkteiSAANPHLKNLY 141
Cdd:PRK14161  26 PEITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKP----ANSDVEVTNII 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 82658254  142 DGLVMTEVQIQKVFQKHGLVKLSPD-GQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLHGRTLRPALVGVVKAP 217
Cdd:PRK14161 102 AGVQMTKDELDKVFHKHHIEEIKPEiGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKIRDRLLRPATVQVVKKP 178
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 44-217 1.11e-26

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 101.07  E-value: 1.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   44 EESGAQKQEPGTAEKAflEEKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKATE 123
Cdd:PRK14153  24 EEAEELKEEPEDSTAD--SETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLDLLEVTDNFERALE 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  124 SVPKTEisaanpHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLHG 203
Cdd:PRK14153 102 SARTAE------DMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVPDNTIVDVCKPGYALNS 175

                        170
                 ....*....|....
gi 82658254  204 RTLRPALVGVVKAP 217
Cdd:PRK14153 176 KVIRPAMVSVARNP 189
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 43-215 5.15e-26

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 99.56  E-value: 5.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   43 EEESGAQKQEPGTAEKaflEEKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKAT 122
Cdd:PRK14149  27 KEQQGEEKQEASEKEG---EIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  123 ESVpkTEISAANPHLKnlydGLVMTEVQIQKVFQKHGLVKLSPDGQkFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLH 202
Cdd:PRK14149 104 KSA--AEVDKESALTK----GLELTMEKLHEVLARHGIEGIECLEE-FDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYK 176

                        170
                 ....*....|...
gi 82658254  203 GRTLRPALVGVVK 215
Cdd:PRK14149 177 GRVLRPAMVSIAK 189
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 34-215 5.65e-25

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 97.10  E-value: 5.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   34 QQKSSGAGTEEESgaQKQEPGTAEKAF--LEEKTQL-EEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKD 110
Cdd:PRK14144  23 ENEILEEETDEES--QHQEPALGHPSYtaLEEQLTLaEQKAHENWEKSVRALAELENVRRRMEREVANAHKYGVEKLISA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  111 LLEVADILEKATESVPKTEISAanphlknLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGT 190
Cdd:PRK14144 101 LLPVVDSLEQALQLADKNSDPS-------MHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAPGAPPNS 173

                        170       180
                 ....*....|....*....|....*
gi 82658254  191 IALVTKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14144 174 VITVFQKGYKLSDRVIRPARVIVST 198
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 44-215 1.38e-24

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 95.14  E-value: 1.38e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   44 EESGAQKQEPGTAEKAFLEEKTQLEE---QLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEK 120
Cdd:PRK14159   9 ENENAENSEHLQDENLQNIEDVEQNKlqkDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  121 ATESVPKTEISaanphLKnLYDGLVMTEVQIQKVFQKHGlVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYK 200
Cdd:PRK14159  89 AVNVECHDEIS-----LK-IKEGVQNTLDLFLKKLEKHG-VALIKEEKEFDPNLHEAMFHVDSENHQSGEVVQVLQKGYK 161

                        170
                 ....*....|....*
gi 82658254  201 LHGRTLRPALVGVVK 215
Cdd:PRK14159 162 IADRVIRPTKVSVAK 176
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 42-215 8.30e-24

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 93.45  E-value: 8.30e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   42 TEEESGAQKQEPGTAEKAFLEEKTQ-------LEEQLKDVTDKYK----RALADTENLRQRSQKMIDDAKLYGIQGFCKD 110
Cdd:PRK14150  14 SEEIEAEVEQQEEADEAELEDELDEadariaeLEAQLAEAQAEERdsvlRARAEVENIRRRAEQDVEKAHKFALEKFANE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  111 LLEVADILEKATESVPKTeisaaNPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGT 190
Cdd:PRK14150  94 LLPVIDNLERALQAADKE-----NEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESEDHEPNT 168

                        170       180
                 ....*....|....*....|....*
gi 82658254  191 IALVTKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14150 169 VMMVMQKGYTLNGRLLRPAMVMVSK 193
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 35-215 1.78e-23

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 92.89  E-value: 1.78e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   35 QKSSGAGTEEESGAQKQEPGTAEKAFLEEKTQLEEqLKDVTDKYK----RALADTENLRQRSQKMIDDAKLYGIQGFCKD 110
Cdd:PRK14148  17 ETAAQVETAQESASGALEELSVEEQLERAKDTIKE-LEDSCDQFKdealRAKAEMENIRKRAERDVSNARKFGIEKFAKE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  111 LLEVADILEKATESVPKTEISAAnphlknLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGT 190
Cdd:PRK14148  96 LLPVIDSIEQALKHEVKLEEAIA------MKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIPNPEFEDNT 169

                        170       180
                 ....*....|....*....|....*
gi 82658254  191 IALVTKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14148 170 IFDVFQKGYMLNGRIVRAAKVVIVK 194
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 36-213 4.63e-23

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 91.82  E-value: 4.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   36 KSSGAGTEEESGAQKQEPGTAEKAFLEEKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVA 115
Cdd:PRK14162  20 EAPKKEAKEAPKEEDQEKQNPVEDLEKEIADLKAKNKDLEDKYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAM 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  116 DILEKATeSVPKTEISAanphlKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEP-GTIALV 194
Cdd:PRK14162 100 DNLERAL-AVKADDEAA-----KQLKKGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQTVAAENDDQkDHVVQV 173

                        170
                 ....*....|....*....
gi 82658254  195 TKVGYKLHGRTLRPALVGV 213
Cdd:PRK14162 174 LQKGYQYKDRTLRPAMVVV 192
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 63-215 1.22e-22

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 90.01  E-value: 1.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   63 EKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKAtesvpkteISAANPHLKNLYD 142
Cdd:PRK14147  26 EVESLRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDAG--------LTAAGTEPSPLRD 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 82658254  143 GLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14147  98 GLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKGYLLNERLLRPALVVVAK 170
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 34-216 2.15e-21

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 87.42  E-value: 2.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   34 QQKSSGAGTEEESGAQKQEPGTAEKAFLEekTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLE 113
Cdd:PRK10325  20 DQHEEIEAVEPEASAEQVDPRDEKIANLE--AQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  114 VADILEKATESVPKteisaANPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIAL 193
Cdd:PRK10325  98 VIDSLDRALEVADK-----ANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLG 172

                        170       180
                 ....*....|....*....|...
gi 82658254  194 VTKVGYKLHGRTLRPALVGVVKA 216
Cdd:PRK10325 173 IMQKGYTLNGRTIRAAMVTVAKA 195
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 43-215 3.35e-21

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 86.90  E-value: 3.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   43 EEESGAQKQEPGTAEKAFLEEK-TQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEKA 121
Cdd:PRK14145  32 EQAQQNQPQQQTVDEIEELKQKlQQKEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILELLPVMDNFERA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  122 TESvpkteisaaNPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTIALVTKVGYKL 201
Cdd:PRK14145 112 LAS---------SGDYNSLKEGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEVEGKQPNEIIEVFQKGYYL 182

                        170
                 ....*....|....
gi 82658254  202 HGRTLRPALVGVVK 215
Cdd:PRK14145 183 KDKVIRPSLVKVAK 196
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 33-217 4.13e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 87.48  E-value: 4.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   33 AQQKSSGAGTEEESGAQKQEPGTAEKAFLEEKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLL 112
Cdd:PRK14143  45 AAEAESSPDSGSAASETAADNAARLAQLEQELESLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEIL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  113 EVADILEKATESV-PKTEISAAnphLKNLYDGLVMtevQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGTI 191
Cdd:PRK14143 125 PVVDNFERARQQLkPEGEEAQA---LHRSYQGLYK---QLVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVV 198

                        170       180
                 ....*....|....*....|....*.
gi 82658254  192 ALVTKVGYKLHGRTLRPALVGVVKAP 217
Cdd:PRK14143 199 LEELQRGYHLGGRVLRHAMVKVSMGP 224
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 32-213 6.30e-21

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 86.40  E-value: 6.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   32 AAQQKSSGAGteeeSGAQKQEPGTAEKAF-----LE-EKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQ 105
Cdd:PRK14154  27 AEEEQEEGGG----DGSQEMEPHREGLEFpsrekLEgQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSK 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  106 GFCKDLLEVADILEKATESvPKTEisaaNPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPD-GQKFDPYEHEAVFHAPVE 184
Cdd:PRK14154 103 QLITDLLPVADSLIHGLES-PASE----DPQVKSMRDGMSLTLDLLHNTLAKHGVQVINPNpGDPFDPALHEAMSVQAVP 177

                        170       180
                 ....*....|....*....|....*....
gi 82658254  185 GKEPGTIALVTKVGYKLHGRTLRPALVGV 213
Cdd:PRK14154 178 DAKPDTIIQVLQKGYQLNGRVLRAARVIV 206
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 42-215 9.09e-18

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 77.66  E-value: 9.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   42 TEEESGAQKQEPGTAEKAfleekTQLEEQLKDVT-------DKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEV 114
Cdd:PRK14158  25 AAQGKPEAAQPVAAADRI-----KELEEALAAKEaeaaanwDKYLRERADLENYRKRVQKEKEELLKYGNESLILEILPA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  115 ADILEKATESVPKTEISAanphlknLYDGLVMTEVQIQKVFQKHGLVKL-SPDGQKFDPYEHEAVFHAPVEGKEPGTIAL 193
Cdd:PRK14158 100 VDNMERALDHADEESMSA-------IIEGIRMTLSMLLSTLKKFGVTPVeAEKGTPFDPAYHQAMCQVESAEQEPNTVVA 172

                        170       180
                 ....*....|....*....|..
gi 82658254  194 VTKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14158 173 VFQKGYLLNERLLRPAMVSVAT 194
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 32-217 3.82e-14

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 68.83  E-value: 3.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   32 AAQQKSSGAGTEEESGAQKQEPGTAEKAFLEEKTQLEEQLKDVTDkYKRAL----ADTENLRQRSQKMIDDAKLYGIQGF 107
Cdd:PRK14157  51 NAGADAAPAAAEGEAKAAAEKTGEAQSDSDDTLTPLGQAKKEAAE-YLEALqrerAEFINYRNRTQKEQDRFRQHGIIDV 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  108 CKDLLEVADILEKATESvpkteisaanphlKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKE 187
Cdd:PRK14157 130 LTALLPALDDIDRIREH-------------SEMDDSFKAVAAKIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKPDPDAE 196

                        170       180       190
                 ....*....|....*....|....*....|
gi 82658254  188 PGTIALVTKVGYKLHGRTLRPALVgVVKAP 217
Cdd:PRK14157 197 KETVDTVVEAGYRIGDRVIRAARV-VVASP 225
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 35-215 2.46e-13

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 66.29  E-value: 2.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   35 QKSSGAGTEEESGAQKQEPGTAEKAFLEEKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEV 114
Cdd:PRK14146  34 NSEESQTITEETQEQAVEGAETETSLQKELDNAKKEIESLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNP 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  115 ADILEKATESVPKTeisaanPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVfhAPVEGKE--PGTIA 192
Cdd:PRK14146 114 IDNLERVGATQNQS------EELKPFVEGVKMILKEFYSVLEKSNVIRFDPKGEPFDPMSMEAL--SSEEGDQysEETVI 185

                        170       180
                 ....*....|....*....|....*..
gi 82658254  193 LVTKVGYKLH----GRTLRPALVGVVK 215
Cdd:PRK14146 186 DVYQAGYYYKenedKFTLRPARVRIGK 212
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 30-213 1.17e-11

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 61.69  E-value: 1.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   30 CTAAQQKSSGAGTEEESGAQKQEPGTAEKAFLEEKTQLEEQLKDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCK 109
Cdd:PRK14160  36 FEEIEKEEIIEDSEESNEVKIEELKDENNKLKEENKKLENELEALKDRLLRTVAEYDNYRKRTAKEKEGIYSDACEDVLK 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  110 DLLEVADILEKATesvpkteisAANPHLKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGqKFDPYEHEAVFHAPVEGKEPG 189
Cdd:PRK14160 116 ELLPVLDNLERAA---------AVEGSVEDLKKGIEMTVKQFKTSLEKLGVEEISTEG-EFDPNLHNAVMHVEDENYGEN 185

                        170       180
                 ....*....|....*....|....
gi 82658254  190 TIALVTKVGYKLHGRTLRPALVGV 213
Cdd:PRK14160 186 EIVEVFQKGYKRGDKVIRYSMVKV 209
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 41-213 2.03e-11

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 60.23  E-value: 2.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   41 GTEEESGAQKQEPGTAEKAFLEEKTQLEEqlkDVTDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKDLLEVADILEK 120
Cdd:PRK14156  16 ATETEETVEEVVEETPEKSELELANERAD---EFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNLER 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  121 A------TESVPKteisaanphlknlydGLVMTEVQIQKVFQKHGLVKLSPDgqKFDPYEHEAVFHAPVEGKEPG-TIAL 193
Cdd:PRK14156  93 AlaveglTDDVKK---------------GLEMVQESLIQALKEEGVEEVAVD--SFDHNLHMAVQTLPADDEHPAdSIAQ 155

                        170       180
                 ....*....|....*....|
gi 82658254  194 VTKVGYKLHGRTLRPALVGV 213
Cdd:PRK14156 156 VFQKGYKLHERLLRPAMVVV 175
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 53-214 2.62e-10

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 58.09  E-value: 2.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   53 PGTAEKAfleEKTQLEEQLKDVTDKYKRALADTENLRQRS----QKMIDDAKLYGIQgfckDLLEVADILEKAT-----E 123
Cdd:PRK14142  34 PGGTAAA---DAAHTEDKVAELTADLQRVQADFANYRKRAlrdqQAAADRAKASVVS----QLLGVLDDLERARkhgdlE 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  124 SVPkteisaanphLKNLYDGLvmtevqiQKVFQKHGLVKLSPDGQKFDPYEHEAVFHA--PVEGKEPgTIALVTKVGYKL 201
Cdd:PRK14142 107 SGP----------LKSVADKL-------DSALTGLGLVAFGAEGEDFDPVLHEAVQHEgdGGQGSKP-VIGTVMRQGYQL 168

                        170
                 ....*....|...
gi 82658254  202 HGRTLRPALVGVV 214
Cdd:PRK14142 169 GEQVLRHALVGVV 181
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 38-215 2.95e-10

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 57.83  E-value: 2.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   38 SGAGTEEESGAQKQEPGTAEKAFLEEKTQLEEQLKDV-------TDKYKRALADTENLRQRSQKMIDDAKLYGIQGFCKD 110
Cdd:PRK14163  16 SGATPDDAEPKAASEEGAAPAGDAAATAGLTAQLDQVrtalgerTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  111 LLEVADILEKATESvpkteisaanphlKNLYDGLVMTEVQIQKVFQKHGLVKLSPDGQKFDPYEHEAVFHAPVEGKEPGT 190
Cdd:PRK14163  96 LLPVLDDVGRAREH-------------GELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETT 162

                        170       180
                 ....*....|....*....|....*
gi 82658254  191 IALVTKVGYKLHGRTLRPALVGVVK 215
Cdd:PRK14163 163 CVAILQPGYRIGERTIRPARVAVAE 187
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 56-211 1.53e-06

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 47.10  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254   56 AEKAFLEEKTQLEEQLKDVTDKYKRALADTENLRQRS----QKMIDDAKlygiQGFCKDLLEVADILEKATESVPKTEis 131
Cdd:PRK14164  71 PELADDGEASTVEAQLAERTEDLQRVTAEYANYRRRTererQAIIETAK----AGVATDLLPILDDLDLAEQHGDLNE-- 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82658254  132 aaNPhLKNLYDGLVmtevqiqKVFQKHGLVKLSPDGQKFDPYEHEAVfHAPVEGKEPgTIALVTKVGYKLHGRTLRPALV 211
Cdd:PRK14164 145 --GP-LKAFSDKLT-------NVLAGLKVEKFGEEGDAFDPEIHEAV-QDLSSGDEK-VLGTVLRKGYRMGDRVLRTAMV 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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