JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 85725074   302 MRNEHKDLIKQNAQLQQENQELH-ERISRLE-KELQQHRSHSSL 343
Cdd:pfam09744  87 WEQETKDLLSQVESLEEENRRLEaDHVSRLEeKEAELKKEYSKL 130

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 85725074   302 MRNEHKDLIKQNAQLQQENQELH-ERISRLE-KELQQHRSHSSL 343
Cdd:pfam09744  87 WEQETKDLLSQVESLEEENRRLEaDHVSRLEeKEAELKKEYSKL 130

Basic leucine zipper (bZIP) domain of Activating Transcription Factor-4 (ATF-4) and similar proteins: a DNA-binding and dimerization domain; ATF-4 was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). It is a Basic leucine zipper (bZIP) transcription factor that has been reported to act as both an activator or repressor. It is a critical component in both the unfolded protein response (UPR) and amino acid response (AAR) pathways. Under certain stress conditions, ATF-4 transcription is increased; accumulation of ATF-4 induces the expression of genes involved in amino acid metabolism and transport, mitochondrial function, redox chemistry, and others that ensure protein synthesis and recovery from stress. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 85725074 300 NKMRNEHKDLIKQNAQLQQENQELHERISRLEKELQQ 336
Cdd:cd14692  19 QKKREEKEELLSEEEELEDRNRELKDEVEELQREINY 55

JNK_SAPK-associated protein-1; This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF pfam00621 domain at their C-terminal end.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 85725074   302 MRNEHKDLIKQNAQLQQENQELH-ERISRLE-KELQQHRSHSSL 343
Cdd:pfam09744  87 WEQETKDLLSQVESLEEENRRLEaDHVSRLEeKEAELKKEYSKL 130

Septum formation initiator; DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation. These proteins are mainly composed of an amino terminal coiled-coil.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 85725074   301 KMRNEHKDLIKQNAQLQQENQELHERISRLEK 332
Cdd:pfam04977  10 QLKQEIAQLQAEIAKLKQENEELEAEIKDLKS 41

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];

                        10        20
                ....*....|....*....|....*....
gi 85725074 302 MRNEHKDLIKQNAQLQQENQELHERISRL 330
Cdd:COG2919  34 LRQEIAELEAENAKLKARNAELEAEVADL 62