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Conserved domains on  [gi|88501747|ref|NP_001034244|]
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TRIO and F-actin-binding protein isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 378-895 1.05e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.58  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   378 PRASSPNRT--TQRDNPRtPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPR-TPCAQRDNPRAAS 454
Cdd:PHA03247 2559 APPAAPDRSvpPPRPAPR-PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHApDPPPPSPSPAANE 2637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   455 PNRSTQRDSPRTPCAQRDN--PRASSPNRTAQRDNPRTPCAQRDNPR-----TSCTSQNTPRTPSTQADKTTASCSKWEH 527
Cdd:PHA03247 2638 PDPHPPPTVPPPERPRDDPapGRVSRPRRARRLGRAAQASSPPQRPRrraarPTVGSLTSLADPPPPPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   528 LRSACTQRDNPRTFSQGCTQKDNPGPPSPRRATQGSNSRNPSPHRTNKdiPWASFPLRPTQSDSPRTSSPSRTKQNQVPW 607
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG--PPAPAPPAAPAAGPPRRLTRPAVASLSESR 2795

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   608 ASISLRPTQGDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSA-SRTSSPLHA--APRGAPQTSLESSQPPCTV 684
Cdd:PHA03247 2796 ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGpPPPSLPLGGsvAPGGDVRRRPPSRSPAAKP 2875

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   685 CI-GHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRhtqfDPFPFLPDTSDAd 763
Cdd:PHA03247 2876 AApARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR----PQPPLAPTTDPA- 2950

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   764 nesPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESLVPSTDS----------MHEPPHiPTPVCIGH 833
Cdd:PHA03247 2951 ---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSrvsswasslaLHEETD-PPPVSLKQ 3026

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 88501747   834 RDAPsfSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPQ---VCIGHRDAPRASSPP 895
Cdd:PHA03247 3027 TLWP--PDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDpatPEAGARESPSSQFGP 3089
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 145-515 9.57e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   145 TSSSQDSNTPHDTSNSSSVDWDTTERPGVVPSRNRLTEMIPRRPQEGLRADSARKATRSPARGDTAGqrkensGSGGQSA 224
Cdd:PHA03307   58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPA------SPPPSPA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   225 GQHWAKLRSESGYFSLERQRSGQTQASSGTPPSGPRGTTQASSAQRDVFQAAPAQEAPQTSSLPRNTQRDTQRSTPRTSS 304
Cdd:PHA03307  132 PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   305 PSRVSQRD-TPRVMSTQRKNTPLSSPLRATPETLKISAPEDGTHVTPSPcvqdsslnrtsqrDSSRTPCIQWDNPRASSP 383
Cdd:PHA03307  212 PISASASSpAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRP-------------APITLPTRIWEASGWNGP 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   384 NRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCAQRdNPRAASPNRSTQRDS 463
Cdd:PHA03307  279 SSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS-PGPSPSRSPSPSRPP 357

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 88501747   464 PRTPCA---QRDNPRASSPNRTAQRDNPRTPCAQRDNPRTSCTSQNTPRTPSTQA 515
Cdd:PHA03307  358 PPADPSsprKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRP 412
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 378-895 1.05e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.58  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   378 PRASSPNRT--TQRDNPRtPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPR-TPCAQRDNPRAAS 454
Cdd:PHA03247 2559 APPAAPDRSvpPPRPAPR-PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHApDPPPPSPSPAANE 2637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   455 PNRSTQRDSPRTPCAQRDN--PRASSPNRTAQRDNPRTPCAQRDNPR-----TSCTSQNTPRTPSTQADKTTASCSKWEH 527
Cdd:PHA03247 2638 PDPHPPPTVPPPERPRDDPapGRVSRPRRARRLGRAAQASSPPQRPRrraarPTVGSLTSLADPPPPPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   528 LRSACTQRDNPRTFSQGCTQKDNPGPPSPRRATQGSNSRNPSPHRTNKdiPWASFPLRPTQSDSPRTSSPSRTKQNQVPW 607
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG--PPAPAPPAAPAAGPPRRLTRPAVASLSESR 2795

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   608 ASISLRPTQGDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSA-SRTSSPLHA--APRGAPQTSLESSQPPCTV 684
Cdd:PHA03247 2796 ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGpPPPSLPLGGsvAPGGDVRRRPPSRSPAAKP 2875

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   685 CI-GHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRhtqfDPFPFLPDTSDAd 763
Cdd:PHA03247 2876 AApARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR----PQPPLAPTTDPA- 2950

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   764 nesPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESLVPSTDS----------MHEPPHiPTPVCIGH 833
Cdd:PHA03247 2951 ---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSrvsswasslaLHEETD-PPPVSLKQ 3026

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 88501747   834 RDAPsfSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPQ---VCIGHRDAPRASSPP 895
Cdd:PHA03247 3027 TLWP--PDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDpatPEAGARESPSSQFGP 3089
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 379-900 9.52e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 9.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   379 RASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCAQRDNPRAASPNRS 458
Cdd:pfam03154  24 QTASPDGRASPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREKGASDTEEPERATAKKSK 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   459 TQRDSprTPCAQRDNPRASSPNRTAQRDNPRTPCAQRDNPRTSCTSQNTPRTPSTQADKTTASCSKWEH---LRSACTQR 535
Cdd:pfam03154 104 TQEIS--RPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQppvLQAQSGAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   536 DNPRTFSQGCTQKDNPGPPS--PRRATQGSNSRNPSPHRTNKDIPWASFPLRPTQSDSPRTSSPSRTKQNQVPWASISLR 613
Cdd:pfam03154 182 SPPSPPPPGTTQAATAGPTPsaPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQV 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   614 PTQ-------------GDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSASRTSSPLHAAPrgAPQTSLESSQP 680
Cdd:pfam03154 262 SPQplpqpslhgqmppMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP--PSQSQLQSQQP 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   681 PctvcighRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPpymppavcigHRDAPRATSPPrhTQFDPFPFLPDTS 760
Cdd:pfam03154 340 P-------REQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP----------HLSGPSPFQMN--SNLPPPPALKPLS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   761 DAdnesPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESlvPSTDSMH----EPPHIPTPVCIGHRDA 836
Cdd:pfam03154 401 SL----STHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASH--PPTSGLHqvpsQSPFPQHPFVPGGPPP 474

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 88501747   837 PSFSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPQV---CIGHRDAPRASSPPRHPPS 900
Cdd:pfam03154 475 ITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIkeeALDEAEEPESPPPPPRSPS 541
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 145-515 9.57e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   145 TSSSQDSNTPHDTSNSSSVDWDTTERPGVVPSRNRLTEMIPRRPQEGLRADSARKATRSPARGDTAGqrkensGSGGQSA 224
Cdd:PHA03307   58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPA------SPPPSPA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   225 GQHWAKLRSESGYFSLERQRSGQTQASSGTPPSGPRGTTQASSAQRDVFQAAPAQEAPQTSSLPRNTQRDTQRSTPRTSS 304
Cdd:PHA03307  132 PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   305 PSRVSQRD-TPRVMSTQRKNTPLSSPLRATPETLKISAPEDGTHVTPSPcvqdsslnrtsqrDSSRTPCIQWDNPRASSP 383
Cdd:PHA03307  212 PISASASSpAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRP-------------APITLPTRIWEASGWNGP 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   384 NRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCAQRdNPRAASPNRSTQRDS 463
Cdd:PHA03307  279 SSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS-PGPSPSRSPSPSRPP 357

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 88501747   464 PRTPCA---QRDNPRASSPNRTAQRDNPRTPCAQRDNPRTSCTSQNTPRTPSTQA 515
Cdd:PHA03307  358 PPADPSsprKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRP 412
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 378-895 1.05e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.58  E-value: 1.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   378 PRASSPNRT--TQRDNPRtPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPR-TPCAQRDNPRAAS 454
Cdd:PHA03247 2559 APPAAPDRSvpPPRPAPR-PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHApDPPPPSPSPAANE 2637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   455 PNRSTQRDSPRTPCAQRDN--PRASSPNRTAQRDNPRTPCAQRDNPR-----TSCTSQNTPRTPSTQADKTTASCSKWEH 527
Cdd:PHA03247 2638 PDPHPPPTVPPPERPRDDPapGRVSRPRRARRLGRAAQASSPPQRPRrraarPTVGSLTSLADPPPPPPTPEPAPHALVS 2717

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   528 LRSACTQRDNPRTFSQGCTQKDNPGPPSPRRATQGSNSRNPSPHRTNKdiPWASFPLRPTQSDSPRTSSPSRTKQNQVPW 607
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG--PPAPAPPAAPAAGPPRRLTRPAVASLSESR 2795

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   608 ASISLRPTQGDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSA-SRTSSPLHA--APRGAPQTSLESSQPPCTV 684
Cdd:PHA03247 2796 ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGpPPPSLPLGGsvAPGGDVRRRPPSRSPAAKP 2875

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   685 CI-GHRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRhtqfDPFPFLPDTSDAd 763
Cdd:PHA03247 2876 AApARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR----PQPPLAPTTDPA- 2950

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   764 nesPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESLVPSTDS----------MHEPPHiPTPVCIGH 833
Cdd:PHA03247 2951 ---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSrvsswasslaLHEETD-PPPVSLKQ 3026

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 88501747   834 RDAPsfSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPQ---VCIGHRDAPRASSPP 895
Cdd:PHA03247 3027 TLWP--PDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDpatPEAGARESPSSQFGP 3089
PHA03247 PHA03247
large tegument protein UL36; Provisional
 450-902 1.95e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.81  E-value: 1.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   450 PRAASPNRS--TQRDSPRtPCAQRDNPRASSPNRTAQRDNPRTPCAQRDNPRTscTSQNTPRTPSTQAdkttascskweh 527
Cdd:PHA03247 2559 APPAAPDRSvpPPRPAPR-PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRG--PAPPSPLPPDTHA------------ 2623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   528 lrsactqrdnprtfsqgctqkdnPGPPSPRRATQGSNSRNPSPHRTNKDIPWASFPLRPTQSDSPRTSSPSRTKQNQVP- 606
Cdd:PHA03247 2624 -----------------------PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPp 2680

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   607 --WASISLRPTQGDKPQTSAPtrlaHNDPPQQYSPSLATTSSSSHNPGHSSASRTS--SPLHAAPRGAPQTSLESSQPPC 682
Cdd:PHA03247 2681 qrPRRRAARPTVGSLTSLADP----PPPPPTPEPAPHALVSATPLPPGPAAARQASpaLPAAPAPPAVPAGPATPGGPAR 2756

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   683 TVCIGHRDAPRASSPPRYFQYDPFPFFPDPR-SSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTqfdPFPFLPDTSD 761
Cdd:PHA03247 2757 PARPPTTAGPPAPAPPAAPAAGPPRRLTRPAvASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS---PAGPLPPPTS 2833

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   762 ADNESPQHDPPQFPPPVCIGYRDAP----RASSPPRQFPEPSFFQDLPRASTES---LVPSTDSMHEPPHIPTPVCIGHR 834
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRRLArpaVSRSTESFALPPDQPERPPQPQA 2913

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 88501747   835 DAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPP-------QVCIGHRDAPRASSPPRHPPSDI 902
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAvpqpwlgALVPGRVAVPRFRVPQPAPSREA 2988
PHA03247 PHA03247
large tegument protein UL36; Provisional
 428-850 2.42e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.96  E-value: 2.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   428 ASSPNRTTQRDNPRTPCAQRD-----NPRAASPNRSTQRDSPRTPCAQRDNPRASSPNRTAQRDN--PRTPCAQRDNPRT 500
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPsepavTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDThaPDPPPPSPSPAAN 2636

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   501 SCTSQNTPRTPSTQADKTTASCSKWEHLRSACTQRDNPRTFSQgcTQKDNPGPPSPRRATQGSNSRNPSPHRTNKDIP-- 578
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP--PQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPha 2714

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   579 WASFPLRPTQSDSPRTSSPSRTKQNQVPWASISLRPTQGDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHS-SAS 657
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASlSES 2794

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   658 RTSSPLHAAPRGAPqtsleSSQPPCTVCIGHRDAPRASSPPRYFQYDPFPFFPDPRSSESESP----------HHEPPYM 727
Cdd:PHA03247 2795 RESLPSPWDPADPP-----AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvRRRPPSR 2869

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   728 PPAVCIGHRDAPRATS---PPRHTQFDPFPFLPDTSDADNESPQHDPPQFPPPVCIGYRDAPRASSPPRqfPEPSFFQDL 804
Cdd:PHA03247 2870 SPAAKPAAPARPPVRRlarPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR--PQPPLAPTT 2947

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 88501747   805 PRASTESLVPSTDSMHEPPHIPTPVCIGHRDAPSfSSPPRQAPEPS 850
Cdd:PHA03247 2948 DPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ-PAPSREAPASS 2992
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 189-593 7.62e-08

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 56.62  E-value: 7.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747  189 QEGLRADSarKATRSPARGDTAGQRKEnsGSGGQSAGQhwAKLRSESGYFSLERQRSGQTQASSGTPPSGPRGTTQASSA 268
Cdd:PTZ00449 530 EEGEHEDS--KESDEPKEGGKPGETKE--GEVGKKPGP--AKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSA 603

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747  269 QRDVFQAAPaqEAPQTSSLPRNTQRDTQRSTPRTS-SPSRVSQRDTPRVMSTQRKNTPLSSPLRATPETLKISAPED--- 344
Cdd:PTZ00449 604 QRPTRPKSP--KLPELLDIPKSPKRPESPKSPKRPpPPQRPSSPERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDyld 681

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747  345 ---GTHVTPSPCVQDSSLNRTSQRDSSRTPCIQWDNPRASSPNRTTQRDNPRTPCTQrdnPRASSPNRTTQRDNPRTPCT 421
Cdd:PTZ00449 682 aaaKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGD---PDAEQPDDIEFFTPPEEERT 758

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747  422 QRDNPRASSPNRTTQRDNPRTpcaqrdnpraasPNRSTQRDSPRTPCAQRDNPRASSPNRTAqrDNPRTPCAQRDNPRTS 501
Cdd:PTZ00449 759 FFHETPADTPLPDILAEEFKE------------EDIHAETGEPDEAMKRPDSPSEHEDKPPG--DHPSLPKKRHRLDGLA 824

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747  502 CTSQNTPRTPSTQADKTTASCSKWEHLRS---ACTQRDNPRTFSQGC-TQKDNPGPPSPRRATQGSNSRNPSPHRTNKDI 577
Cdd:PTZ00449 825 LSTTDLESDAGRIAKDASGKIVKLKRSKSfddLTTVEEAEEMGAEARkIVVDDDGTEADDEDTHPPEEKHKSEVRRRRPP 904

                        410
                 ....*....|....*.
gi 88501747  578 PWASFPLRPTQSDSPR 593
Cdd:PTZ00449 905 KKPSKPKKPSKPKKPK 920
PHA03247 PHA03247
large tegument protein UL36; Provisional
 586-966 1.47e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   586 PTQSDSPRTSSPSRTKQNQVPWAsislrPTQGDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSASRTSSPLHA 665
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDA-----PPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   666 APRGAPQTSLESSQPPcTVCIGHR-----DAPRASSPPRYFQYD--PFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDA 738
Cdd:PHA03247 2644 PTVPPPERPRDDPAPG-RVSRPRRarrlgRAAQASSPPQRPRRRaaRPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   739 PRATSPPRHTQFDPFPFLPDTSDADNESPQHDPPQFPPPVCIGyrdaPRASSPPRQFPEPSFfQDLPRASTESLVPSTDS 818
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG----PPAPAPPAAPAAGPP-RRLTRPAVASLSESRES 2797

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   819 MHEPPH---IPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSME----------SLAPSIDSLHGCPLLPPQVCIGH 885
Cdd:PHA03247 2798 LPSPWDpadPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGppppslplggSVAPGGDVRRRPPSRSPAAKPAA 2877

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   886 RDAPRASSPPRH--PPSDIGLLAPSPPPGSSGSRGSAPPGETRHNLEREEYTMLADLPPPRRLAQRGPEPQAQGSNEGRT 963
Cdd:PHA03247 2878 PARPPVRRLARPavSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG 2957


                  ...
gi 88501747   964 RSP 966
Cdd:PHA03247 2958 AVP 2960
PHA03247 PHA03247
large tegument protein UL36; Provisional
 625-900 5.73e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 5.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   625 PTRLAHNDPPQQYSPSLATTSSSSHNPGHSSASRTSSPLHAAPRGAPQTSLESSQPPCTVCIGHRDAPRAS----SPPRY 700
Cdd:PHA03247 2475 PGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASddagDPPPP 2554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   701 FQYDPFPFFPD---------PRSSE------SESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFD---PFPFLPDTSDA 762
Cdd:PHA03247 2555 LPPAAPPAAPDrsvppprpaPRPSEpavtsrARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDthaPDPPPPSPSPA 2634

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   763 DNESPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDL--------PRASTESLVPSTDSMHEPPHIPTPVCIGHR 834
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAssppqrprRRAARPTVGSLTSLADPPPPPPTPEPAPHA 2714

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 88501747   835 DAPSFSSPP-----RQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPqvcighrdAPRASSPPRHPPS 900
Cdd:PHA03247 2715 LVSATPLPPgpaaaRQASPALPAAPAPPAVPAGPATPGGPARPARPPTTA--------GPPAPAPPAAPAA 2777
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 379-900 9.52e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 9.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   379 RASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCAQRDNPRAASPNRS 458
Cdd:pfam03154  24 QTASPDGRASPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSAKRQREKGASDTEEPERATAKKSK 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   459 TQRDSprTPCAQRDNPRASSPNRTAQRDNPRTPCAQRDNPRTSCTSQNTPRTPSTQADKTTASCSKWEH---LRSACTQR 535
Cdd:pfam03154 104 TQEIS--RPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQTQppvLQAQSGAA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   536 DNPRTFSQGCTQKDNPGPPS--PRRATQGSNSRNPSPHRTNKDIPWASFPLRPTQSDSPRTSSPSRTKQNQVPWASISLR 613
Cdd:pfam03154 182 SPPSPPPPGTTQAATAGPTPsaPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQV 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   614 PTQ-------------GDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSASRTSSPLHAAPrgAPQTSLESSQP 680
Cdd:pfam03154 262 SPQplpqpslhgqmppMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP--PSQSQLQSQQP 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   681 PctvcighRDAPRASSPPRYFQYDPFPFFPDPRSSESESPHHEPpymppavcigHRDAPRATSPPrhTQFDPFPFLPDTS 760
Cdd:pfam03154 340 P-------REQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP----------HLSGPSPFQMN--SNLPPPPALKPLS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   761 DAdnesPQHDPPQFPPPVCIGYRDAPRASSPPRQFPEPSFFQDLPRASTESlvPSTDSMH----EPPHIPTPVCIGHRDA 836
Cdd:pfam03154 401 SL----STHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASH--PPTSGLHqvpsQSPFPQHPFVPGGPPP 474

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 88501747   837 PSFSSPPRQAPEPSLFFQDPPGTSMESLAPSIDSLHGCPLLPPQV---CIGHRDAPRASSPPRHPPS 900
Cdd:pfam03154 475 ITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIkeeALDEAEEPESPPPPPRSPS 541
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 145-515 9.57e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   145 TSSSQDSNTPHDTSNSSSVDWDTTERPGVVPSRNRLTEMIPRRPQEGLRADSARKATRSPARGDTAGqrkensGSGGQSA 224
Cdd:PHA03307   58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPA------SPPPSPA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   225 GQHWAKLRSESGYFSLERQRSGQTQASSGTPPSGPRGTTQASSAQRDVFQAAPAQEAPQTSSLPRNTQRDTQRSTPRTSS 304
Cdd:PHA03307  132 PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   305 PSRVSQRD-TPRVMSTQRKNTPLSSPLRATPETLKISAPEDGTHVTPSPcvqdsslnrtsqrDSSRTPCIQWDNPRASSP 383
Cdd:PHA03307  212 PISASASSpAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRP-------------APITLPTRIWEASGWNGP 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   384 NRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPRTPCAQRdNPRAASPNRSTQRDS 463
Cdd:PHA03307  279 SSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVS-PGPSPSRSPSPSRPP 357

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 88501747   464 PRTPCA---QRDNPRASSPNRTAQRDNPRTPCAQRDNPRTSCTSQNTPRTPSTQA 515
Cdd:PHA03307  358 PPADPSsprKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRP 412
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 563-757 2.19e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 42.00  E-value: 2.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747  563 SNSRNPSPHRTNKDIPWASFPLRPTQSDSPRTSSPSRTKQNQVPWASISLRPTQGD-------------KPQTSAPTRLA 629
Cdd:PRK08691 365 SCDANAVIENTELQSPSAQTAEKETAAKKPQPRPEAETAQTPVQTASAAAMPSEGKtagpvsnqenndvPPWEDAPDEAQ 444

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747  630 HNDPPQQYSPSLATTSSSSHNPGHSSASR-------TSSPLHAAPRGAPQTSLESSQPPCTVCIGHrdapraSSPPRYFQ 702
Cdd:PRK08691 445 TAAGTAQTSAKSIQTASEAETPPENQVSKnkaadneTDAPLSEVPSENPIQATPNDEAVETETFAH------EAPAEPFY 518

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 88501747  703 YDPFPFFPDPRSSESESPhhEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLP 757
Cdd:PRK08691 519 GYGFPDNDCPPEDGAEIP--PPDWEHAAPADTAGGGADEEAEAGGIGGNNTPSAP 571
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 284-759 2.40e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.83  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   284 TSSLPRNTQRDTQRSTPRTSSPSrVSQRDTPrvmstqrKNTPLSSPLRATPetlkisapedgthVTPSPCVQDSSLNRTS 363
Cdd:pfam05109 445 TTGLPSSTHVPTNLTAPASTGPT-VSTADVT-------SPTPAGTTSGASP-------------VTPSPSPRDNGTESKA 503

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   364 QRDSSRTPCIQWDNPRASSPnrttqrdnprTPCTQRDNPRASSPnrTTQRDNPRTPCTQrDNPRASSPnrttqrdnprTP 443
Cdd:pfam05109 504 PDMTSPTSAVTTPTPNATSP----------TPAVTTPTPNATSP--TLGKTSPTSAVTT-PTPNATSP----------TP 560

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   444 CAQRDNPRAASPnrSTQRDSPRTPCAqrdnprASSPNRTAQRDNPRTPCAQRDNPRTSCTSqNTPRTPSTQADKTTASCS 523
Cdd:pfam05109 561 AVTTPTPNATIP--TLGKTSPTSAVT------TPTPNATSPTVGETSPQANTTNHTLGGTS-STPVVTSPPKNATSAVTT 631

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   524 KWEHLRSACTQRDNPRtfsqgctqkdnpgPPSPRRATQGSNSRNPSPHrtnkdIPWASfPLRPTQSDSPRTSSPSRTKQN 603
Cdd:pfam05109 632 GQHNITSSSTSSMSLR-------------PSSISETLSPSTSDNSTSH-----MPLLT-SAHPTGGENITQVTPASTSTH 692

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   604 QVPWASISLRPtqGDKPQTSAPTRLAHNDPPQQYSPSLATTSSSSHNPGHSSASRTSSPLHAAPRGAPQTSLESSQppct 683
Cdd:pfam05109 693 HVSTSSPAPRP--GTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKH---- 766

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 88501747   684 vCIGHrDAPRASSPPRYFQYDpfpffpdprSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDT 759
Cdd:pfam05109 767 -TTGH-GARTSTEPTTDYGGD---------STTPRTRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTS 831
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 611-821 4.32e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 4.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747  611 SLRPTQGDKPQTSAPTrlahNDPPQQYSPSLATTSSSSHNPGHSSASRTSSPLHAAPRGAPQTSLESSQPPCTVCIGHRD 690
Cdd:PRK07764 606 SGPPEEAARPAAPAAP----AAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP 681

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747  691 APRASSPPryfqydPFPFFPDPRSSESESPHHEPPYMPPAVCIGHRDAPRATSPPRHTQFDPFPFLPDTSDADNESPQHD 770
Cdd:PRK07764 682 PPAPAPAA------PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAP 755

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 88501747  771 PPQFPPPVCIGYRDAPRASSPPRQ-FPEPSFFQDLPRASTESLVPSTDSMHE 821
Cdd:PRK07764 756 AQPPPPPAPAPAAAPAAAPPPSPPsEEEEMAEDDAPSMDDEDRRDAEEVAME 807
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 553-851 7.29e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 7.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   553 PPSPRRATQGSNSRNPSPHRTNkdiPWASFPLRPTQSDSPRTSSPSRTKqnqvPWASISLRPTQGDKPQTSAPTRLAHND 632
Cdd:PHA03307   72 PPGPGTEAPANESRSTPTWSLS---TLAPASPAREGSPTPPGPSSPDPP----PPTPPPASPPPSPAPDLSEMLRPVGSP 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   633 PPQQYSPSLATTSSSSHNPGHSSASRTSSPLHAAPRGAPQTSLESSQPPCTVCIGHRDAPRASSPPRYFQYDPFPFFPDP 712
Cdd:PHA03307  145 GPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAP 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   713 RSSESESPHHEPPYMPPAVCIGHRDAPRATSP-PRHTQFDPFPFLPDTSDADNESPQHDPPQFPPPVCIGYRDAPRASSP 791
Cdd:PHA03307  225 GRSAADDAGASSSDSSSSESSGCGWGPENECPlPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPG 304

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   792 PRQFPEPSFFQDLPRASTESLVPSTDSMHEPPHiptpVCIGHRDAPSFSSPPRQAPEPSL 851
Cdd:PHA03307  305 SGPAPSSPRASSSSSSSRESSSSSTSSSSESSR----GAAVSPGPSPSRSPSPSRPPPPA 360
PHA03247 PHA03247
large tegument protein UL36; Provisional
 46-525 9.13e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 9.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747    46 PSSAEAPYCDLPRCPPALQNPLRTTTCVGQSVHSLGLGLGQEPQRVWS-----PTTALPAEGPAAAPKNRHQDSEGIPYL 120
Cdd:PHA03247 2498 PGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASddagdPPPPLPPAAPPAAPDRSVPPPRPAPRP 2577

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   121 EGLARSSCTDDNDNKDEDEDP-------NSNTSSSQDSNTPHDTSNSSSVDWDTTERPGVVPSRNRLTEMIPRRPQEGLR 193
Cdd:PHA03247 2578 SEPAVTSRARRPDAPPQSARPrapvddrGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPA 2657

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   194 ADSARKATRSPARGDTAGQRKENSGSGGQSAGQHWAKLRSESGYFSLERQ-RSGQTQASSGTP-PSGPRGTTQASSAQRD 271
Cdd:PHA03247 2658 PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTpEPAPHALVSATPlPPGPAAARQASPALPA 2737

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   272 VFQAAPAQEAPQTSSLPRNTQRDTQRSTPRTSSPSRVSQRDTPR------VMSTQRKNTPLSSPLRATPETLKISAPED- 344
Cdd:PHA03247 2738 APAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRrltrpaVASLSESRESLPSPWDPADPPAAVLAPAAa 2817

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   345 -------GTHVTPSPCVQDSSLNRTSQRDSSRTPCIQWDNPRASSPNRTTQRDNPRTPCTQRDNPRASSPNRTTQRDNPR 417
Cdd:PHA03247 2818 lppaaspAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES 2897

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88501747   418 TPCTQRDNPRASSPNRTTQ-RDNPRTPCAQRDNPRAASPNRSTQRDSPRTPCAQRDNPRASSPNRTAQRDNPRTPCAQRD 496
Cdd:PHA03247 2898 FALPPDQPERPPQPQAPPPpQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRF 2977

                         490       500       510
                  ....*....|....*....|....*....|
gi 88501747   497 NPRTSCTSQNTPR-TPSTQADKTTASCSKW 525
Cdd:PHA03247 2978 RVPQPAPSREAPAsSTPPLTGHSLSRVSSW 3007
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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