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Conserved domains on  [gi|157167158|ref|NP_001034975|]
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zinc finger protein 808 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 3.13e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 3.13e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 157167158   24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
397-839 4.75e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 4.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 397 KTYKCNECGKAFNHQSSLARHHILHTGEKPYKC--EECDKVFSQKSTLERHKRIHTGEKPYKCkvCDTAFTCNSQLARHR 474
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 475 RIHTGEKTYKCNECRK---TFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASlvYHRRLHTLEKSYKCTVCNKVFMRN 551
Cdd:COG5048  110 LSSSSSNSNDNNLLSShslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--SNSLHPPLPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 552 SvlavHTRIHTAKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEACDKVFGQKSALESHKRIHTGEKPYRCQVCDTA 631
Cdd:COG5048  188 I----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 632 FTWNSQLARHTRIHTGEKT-------YKCNECGKTFSYKSSLVWHRR--LHGGE--KSYKCKV--CDKAFVCRSYVAKHT 698
Cdd:COG5048  264 SLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 699 RIHSGMKPYKC--NECSKTFS-----NRSSLVCHRRIHSGEKPYKC--SECSKTFSQKATLLCHRRLHSGEKPYKCndcg 769
Cdd:COG5048  344 LLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC---- 419

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 770 ntfrhwsslvyhrrlhtgeksyKCTVCDKAFVRNSYLARHIRIHTAEKPYkCNECGKAFNEQSHLSRHHR 839
Cdd:COG5048  420 ----------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-585 5.14e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 5.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 206 NNYGNNPLNSSLLPQKQEvhmreKSFPCNESGKAFNCSSL--LRKHQIPHLGDKQYKCDVCGKLFNHKQYLACHRRCHTG 283
Cdd:COG5048   42 SFSRLEHLTRHIRSHTGE-----KPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 284 E-KPYKCKECGKSFSYKSSLTCHHRLHTGVKPYKCNECGKVFRQ----------------------NSALVIHKAIHTGE 340
Cdd:COG5048  117 SnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSNVSTSI 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 341 KPYKCNECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKAFACHSYLANHTRIHSGEKTYKCNECGKAFNHQSSLARHHIL 420
Cdd:COG5048  197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 421 HTGE-------KPYKCEECDKVFSQKSTLERHKR--IHTGE--KPYKCKV--CDTAFTCNSQLARHRRIHTGEKTYKCNE 487
Cdd:COG5048  277 ESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL 356

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 488 CRKTFSRRSSL-------LCHRRLHSGEKPYKC--NQCGNTFRHRASLVYHRRLHTLEKS--YKCTVCNKVFMRNSVLAV 556
Cdd:COG5048  357 LNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                        410       420
                 ....*....|....*....|....*....
gi 157167158 557 HTRIHTAKKPYkCNECGKAFNQQSHLSRH 585
Cdd:COG5048  437 HKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
861-885 9.50e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.50e-04
                          10        20
                  ....*....|....*....|....*
gi 157167158  861 HLKRHRIIHTGEKPYKCNECGKAFS 885
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
833-858 1.85e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 157167158  833 HLSRHHRIHTGEKPYKCEACDKVFSR 858
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 3.13e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 3.13e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 157167158   24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
24-60 8.45e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 8.45e-17
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157167158    24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-60 5.38e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.50  E-value: 5.38e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 157167158  24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
397-839 4.75e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 4.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 397 KTYKCNECGKAFNHQSSLARHHILHTGEKPYKC--EECDKVFSQKSTLERHKRIHTGEKPYKCkvCDTAFTCNSQLARHR 474
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 475 RIHTGEKTYKCNECRK---TFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASlvYHRRLHTLEKSYKCTVCNKVFMRN 551
Cdd:COG5048  110 LSSSSSNSNDNNLLSShslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--SNSLHPPLPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 552 SvlavHTRIHTAKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEACDKVFGQKSALESHKRIHTGEKPYRCQVCDTA 631
Cdd:COG5048  188 I----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 632 FTWNSQLARHTRIHTGEKT-------YKCNECGKTFSYKSSLVWHRR--LHGGE--KSYKCKV--CDKAFVCRSYVAKHT 698
Cdd:COG5048  264 SLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 699 RIHSGMKPYKC--NECSKTFS-----NRSSLVCHRRIHSGEKPYKC--SECSKTFSQKATLLCHRRLHSGEKPYKCndcg 769
Cdd:COG5048  344 LLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC---- 419

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 770 ntfrhwsslvyhrrlhtgeksyKCTVCDKAFVRNSYLARHIRIHTAEKPYkCNECGKAFNEQSHLSRHHR 839
Cdd:COG5048  420 ----------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-585 5.14e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 5.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 206 NNYGNNPLNSSLLPQKQEvhmreKSFPCNESGKAFNCSSL--LRKHQIPHLGDKQYKCDVCGKLFNHKQYLACHRRCHTG 283
Cdd:COG5048   42 SFSRLEHLTRHIRSHTGE-----KPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 284 E-KPYKCKECGKSFSYKSSLTCHHRLHTGVKPYKCNECGKVFRQ----------------------NSALVIHKAIHTGE 340
Cdd:COG5048  117 SnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSNVSTSI 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 341 KPYKCNECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKAFACHSYLANHTRIHSGEKTYKCNECGKAFNHQSSLARHHIL 420
Cdd:COG5048  197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 421 HTGE-------KPYKCEECDKVFSQKSTLERHKR--IHTGE--KPYKCKV--CDTAFTCNSQLARHRRIHTGEKTYKCNE 487
Cdd:COG5048  277 ESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL 356

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 488 CRKTFSRRSSL-------LCHRRLHSGEKPYKC--NQCGNTFRHRASLVYHRRLHTLEKS--YKCTVCNKVFMRNSVLAV 556
Cdd:COG5048  357 LNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                        410       420
                 ....*....|....*....|....*....
gi 157167158 557 HTRIHTAKKPYkCNECGKAFNQQSHLSRH 585
Cdd:COG5048  437 HKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
861-885 9.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.50e-04
                          10        20
                  ....*....|....*....|....*
gi 157167158  861 HLKRHRIIHTGEKPYKCNECGKAFS 885
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
833-858 1.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 157167158  833 HLSRHHRIHTGEKPYKCEACDKVFSR 858
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
805-829 1.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....*
gi 157167158  805 YLARHIRIHTAEKPYKCNECGKAFN 829
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 3.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 157167158  357 HLSRHQRLHTGVKPYKCKICEKAFAC 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 816-893 3.34e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 816 EKPYKCN--ECGKAFNEQSHLsRHHRIHTGEKPYKCEACDKVfsrkshlkRHRIIHTGEKPYKCNECGKAFSDRSTLIHH 893
Cdd:COG5189  347 GKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 3.13e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 3.13e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 157167158   24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
24-60 8.45e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 8.45e-17
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157167158    24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-60 5.38e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.50  E-value: 5.38e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 157167158  24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
397-839 4.75e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 4.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 397 KTYKCNECGKAFNHQSSLARHHILHTGEKPYKC--EECDKVFSQKSTLERHKRIHTGEKPYKCkvCDTAFTCNSQLARHR 474
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 475 RIHTGEKTYKCNECRK---TFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASlvYHRRLHTLEKSYKCTVCNKVFMRN 551
Cdd:COG5048  110 LSSSSSNSNDNNLLSShslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--SNSLHPPLPANSLSKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 552 SvlavHTRIHTAKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEACDKVFGQKSALESHKRIHTGEKPYRCQVCDTA 631
Cdd:COG5048  188 I----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 632 FTWNSQLARHTRIHTGEKT-------YKCNECGKTFSYKSSLVWHRR--LHGGE--KSYKCKV--CDKAFVCRSYVAKHT 698
Cdd:COG5048  264 SLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 699 RIHSGMKPYKC--NECSKTFS-----NRSSLVCHRRIHSGEKPYKC--SECSKTFSQKATLLCHRRLHSGEKPYKCndcg 769
Cdd:COG5048  344 LLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC---- 419

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 770 ntfrhwsslvyhrrlhtgeksyKCTVCDKAFVRNSYLARHIRIHTAEKPYkCNECGKAFNEQSHLSRHHR 839
Cdd:COG5048  420 ----------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
313-725 1.73e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 1.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 313 KPYKCNECGKVFRQNSALVIHKAIHTGEKPYKCN--ECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKafACHSYLANHT 390
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 391 RIHSGEKTYKCN-ECGKAFNHQSSLARHHILHTGEKPYKCEECDKVFSQKSTLERHKRIHTGEKPYKCKvcdtAFTCNSQ 469
Cdd:COG5048  110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSK----DPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 470 LARHRRIHTGEKTYKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASLVYHRRL-HTLEKSYKCTVCNKVF 548
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 549 -MRNSVLAVHTRIHTAK-----KPYKCNECGKAFNQQSHLSRHRR--LHTGE--KPYKC--EACDKVFGQKSALESHKRI 616
Cdd:COG5048  266 pTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 617 HTGEKPYRC--QVCDTAFT-----WNSQLARHTRIHTGEKTYKC--NECGKTFSYKSSLVWHRRLH--GGEKSYKCKVCD 685
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHlsFRPYNCKNPPCS 425

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 157167158 686 KAFVcRSYVAKHTRIHSGMKPYKCNECSKTFSNRSSLVCH 725
Cdd:COG5048  426 KSFN-RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
341-746 6.58e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 6.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 341 KPYKCNECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKAFACHSYLANHT---RIHSGEKTYKCNECGKAFNHQSSLARH 417
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhlrTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 418 HILHTGEKPYKCEECDKVFSQKSTLERHKRIHTGEKPYKCKVCDTAFTCNSQLARHRRIHTGektykcNECRKTFSRRSS 497
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA------NSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 498 LLCHRRLHSGEKPYKCNQCGNTFRHRASLVYHRRLHTLEKSYKCTVCNKVFMRNSVLA------VHTRIHTAKKPYKCNE 571
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslsSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 572 CGKAFNQQSHLSRHRRLHTG-EKPYKCEACDKVFGQKSALESHKR--IHTGE--KPYRC--QVCDTAFTWNSQLARHTRI 644
Cdd:COG5048  266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 645 HTGEKTYKCNECGKTFSYKSSL----VWHRRLHGGEKSYKCKVCD-----KAFVCRSYVAKHTRIHSGMKP--YKCNECS 713
Cdd:COG5048  346 HTSISPAKEKLLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                        410       420       430
                 ....*....|....*....|....*....|...
gi 157167158 714 KTFSNRSSLVCHRRIHSGEKPYKCSECSKTFSQ 746
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
563-897 4.43e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 4.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 563 AKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEA--CDKVFGQKSALESHKRIHTGEKPYRC-QVCDTAFTWNSQLA 639
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 640 RHTRIHTGEKTYKCNECGKTFSYKSSLVWHRRLHGGEKSYKCKVCDKAFVCRSYVAKHTRIHSGMkpykcNECSKTFSNR 719
Cdd:COG5048  110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 720 SSLVCHRRIHSGEKPYKCSECSKTFSQKATLLcHRRLHSGEKPYKCNDCGNTFRHwsSLVYHRRLHTGeKSYKCTVCDKA 799
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSS-DQNLENSSSSLPLTTNSQLSPK--SLLSQSPSSLS-SSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 800 FVRNSYLARHIRIHTAE----------KPYKCNECGKAFNEQSHLSRH--HRIHTGE--KPYKC--EACDKVFSRKSHLK 863
Cdd:COG5048  261 PRSSLPTASSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALK 340

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 157167158 864 RHRIIHTGEKPYKC--NECGKAFSDRSTLIHHQAIH 897
Cdd:COG5048  341 RHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
256-626 1.40e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 256 DKQYKCDVCGKLFNHKQYLACHRRCHTGEKPYKC--KECGKSFSYKSSLTCHHRLHTGVKPYKCNecGKVFRQNSALVIH 333
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 334 KAIHTGEKPYKCNECgkAFNQQSHLSRHQRLHTGVKPYKcKICEKAFACHSYLAN------------------------- 388
Cdd:COG5048  109 SLSSSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISN-LRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssnls 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 389 ---HTRIHSGEKTYKCNECGKAFNHQSSLARHHILHTGEKPYKCEECDKVFSQKSTLERHKRIHTGEKPYKCKVCDTAFT 465
Cdd:COG5048  186 lliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 466 CNSQLARHRRIHTGEKT-------YKCNECRKTFSRRSSLLCHRR--LHSGE--KPYKC--NQCGNTFRHRASLVYHRRL 532
Cdd:COG5048  266 PTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 533 HTLEKSYKC--TVCNKVFMRNSV-----LAVHTRIHTAKKPYKC--NECGKAFNQQSHLSRHRRLHTGEKP--YKCEACD 601
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                        410       420
                 ....*....|....*....|....*
gi 157167158 602 KVFGQKSALESHKRIHTGEKPYRCQ 626
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-585 5.14e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 5.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 206 NNYGNNPLNSSLLPQKQEvhmreKSFPCNESGKAFNCSSL--LRKHQIPHLGDKQYKCDVCGKLFNHKQYLACHRRCHTG 283
Cdd:COG5048   42 SFSRLEHLTRHIRSHTGE-----KPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 284 E-KPYKCKECGKSFSYKSSLTCHHRLHTGVKPYKCNECGKVFRQ----------------------NSALVIHKAIHTGE 340
Cdd:COG5048  117 SnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSNVSTSI 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 341 KPYKCNECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKAFACHSYLANHTRIHSGEKTYKCNECGKAFNHQSSLARHHIL 420
Cdd:COG5048  197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 421 HTGE-------KPYKCEECDKVFSQKSTLERHKR--IHTGE--KPYKCKV--CDTAFTCNSQLARHRRIHTGEKTYKCNE 487
Cdd:COG5048  277 ESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL 356

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 488 CRKTFSRRSSL-------LCHRRLHSGEKPYKC--NQCGNTFRHRASLVYHRRLHTLEKS--YKCTVCNKVFMRNSVLAV 556
Cdd:COG5048  357 LNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                        410       420
                 ....*....|....*....|....*....
gi 157167158 557 HTRIHTAKKPYkCNECGKAFNQQSHLSRH 585
Cdd:COG5048  437 HKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
481-897 6.39e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 6.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 481 KTYKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQ--CGNTFRHRASLVYHRRLHTLEKSYKCtvCNKVFMRNSVLAVHT 558
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 559 RIHTAKKPYKCNECgkAFNQQSHLSRHRRLHTGEKPYKCEACDKvfgQKSALESHKRIHTGEKPYRCQVCDTAFTWNSQL 638
Cdd:COG5048  110 LSSSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISNLRNNPL---PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 639 AR--HTRIHTGEKTYKCNECGKTFSYKSSLVWHRRLHGGEKSYKCKVCDKAFVCRSYVAKHTrihSGMKPYKCNECSKTF 716
Cdd:COG5048  185 SLliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPS---SLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 717 -SNRSSLVCHRRIHSgekpYKCSECSKTFSqkatllchrrlhsgeKPYKCNDCGNTFRHWSSLVYHRR--LHTGE--KSY 791
Cdd:COG5048  262 rSSLPTASSQSSSPN----ESDSSSEKGFS---------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPF 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 792 KCTV--CDKAFVRNSYLARHIRIHTAEKPYKCNEC------GKAFNEQSHLSRHHRIHTGEKPYKCEA---CDKVFSRKS 860
Cdd:COG5048  323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSETLsnsCIRNFKRDS 402

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 157167158 861 HLKRHRIIHTGEKPY--KCNECGKAFSDRSTLIHHQAIH 897
Cdd:COG5048  403 NLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-419 4.74e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 4.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 104 QEIEKEIHNIEFQCQEDERNGHEAPTTK-IKKLTGSTDQHDHRHAGNKPIKDQLGSSFYSHLP-----ELHIFQIKGEIA 177
Cdd:COG5048  135 PQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPsssenSPLSSSYSIPSS 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 178 NQLEKSTSDASSVSTSQRiSCRPQIHISNNYGNNPLNSSLLPQKQEVHMREKSFPcNESGKAFNCSSLLrKHQIPhlgDK 257
Cdd:COG5048  215 SSDQNLENSSSSLPLTTN-SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA-SSQSSSPNESDSS-SEKGF---SL 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 258 QYKCDVCGKLFNHKQYLACHRRC--HTGE--KPYKCKE--CGKSFSYKSSLTCHHRLHTGVKPYKC--NECGKVFRQNS- 328
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLn 368

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 329 ----ALVIHKAIHTGEKPYKC--NECGKAFNQQSHLSRHQRLHTGVKP--YKCKICEKAFACHSYLANHTRIHSgEKTYK 400
Cdd:COG5048  369 neppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPL 447

                        330
                 ....*....|....*....
gi 157167158 401 CNECGKAFNHQSSLARHHI 419
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 782-866 5.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 5.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 782 RRLHT-GEKSYKCTV--CDKAFVRNSYLARHiRIHtaekpykcNECGKAFNEQSHLSRHHRIHTGEKPYKCEACDKVFSR 858
Cdd:COG5189  340 RMLKVkDGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410


                 ....*...
gi 157167158 859 KSHLKRHR 866
Cdd:COG5189  411 LNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
861-885 9.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.50e-04
                          10        20
                  ....*....|....*....|....*
gi 157167158  861 HLKRHRIIHTGEKPYKCNECGKAFS 885
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 565-641 1.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157167158 565 KPYKCN--ECGKAFNQQSHLSRHRrLHTGEKPYKCEACDKvfgqksalESHKRIHTGEKPYRCQVCDTAFTWNSQLARH 641
Cdd:COG5189  348 KPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 395-474 1.75e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 395 GEKTYKCN--ECGKAFNHQSSLaRHHILHTGEKPYKCEECDKvfsqkstlERHKRIHTGEKPYKCKVCDTAFTCNSQLAR 472
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 157167158 473 HR 474
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
833-858 1.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 157167158  833 HLSRHHRIHTGEKPYKCEACDKVFSR 858
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 451-535 1.87e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 451 GEKPYKCKV--CDTAFTCNSQLARHRrihtgektyKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASLVY 528
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*..
gi 157167158 529 HRRLHTL 535
Cdd:COG5189  417 HRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
805-829 1.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....*
gi 157167158  805 YLARHIRIHTAEKPYKCNECGKAFN 829
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 3.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 157167158  357 HLSRHQRLHTGVKPYKCKICEKAFAC 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 816-893 3.34e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 816 EKPYKCN--ECGKAFNEQSHLsRHHRIHTGEKPYKCEACDKVfsrkshlkRHRIIHTGEKPYKCNECGKAFSDRSTLIHH 893
Cdd:COG5189  347 GKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
442-466 3.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.95e-03
                          10        20
                  ....*....|....*....|....*
gi 157167158  442 LERHKRIHTGEKPYKCKVCDTAFTC 466
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
638-662 4.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.53e-03
                          10        20
                  ....*....|....*....|....*
gi 157167158  638 LARHTRIHTGEKTYKCNECGKTFSY 662
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 703-782 4.68e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 4.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 703 GMKPYKCN--ECSKTFSNRSSLVCHRrihsgekpyKCSECSKTFSQKATLLCHRRLHSGEKPYKCNDCGNTFRHWSSLVY 780
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 157167158 781 HR 782
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
329-354 5.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 157167158  329 ALVIHKAIHTGEKPYKCNECGKAFNQ 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 283-361 5.71e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 5.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157167158 283 GEKPYKCKECGKSFSYKSSLTC-HHRLHtgvkpykcNECGKVFRQNSALVIHKAIHTGEKPYKCNECGKAFNQQSHLSRH 361
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLkYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-604 7.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.55e-03
                          10        20
                  ....*....|....*....|....
gi 157167158  581 HLSRHRRLHTGEKPYKCEACDKVF 604
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-298 9.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 9.28e-03
                          10        20
                  ....*....|....*....|..
gi 157167158  277 HRRCHTGEKPYKCKECGKSFSY 298
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
470-494 9.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.65e-03
                          10        20
                  ....*....|....*....|....*
gi 157167158  470 LARHRRIHTGEKTYKCNECRKTFSR 494
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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