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Conserved domains on  [gi|93277083|ref|NP_001035269|]
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melanin-concentrating hormone receptor 2 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11607433)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
35-317 1.76e-179

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 497.80  E-value: 1.76e-179
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15339   1 VILPSFIGILCSTGLVGNILVLFTIIRSRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDV 194
Cdd:cd15339  81 CNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLESCAFNLTSPDDV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVN 274
Cdd:cd15339 161 LWYTLYQTITTFFFPLPLILICYILILCYTWEMYRKNKKAGRYNTSIPRQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVN 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 93277083 275 LQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15339 241 LSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
 
Name Accession Description Interval E-value
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
35-317 1.76e-179

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 497.80  E-value: 1.76e-179
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15339   1 VILPSFIGILCSTGLVGNILVLFTIIRSRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDV 194
Cdd:cd15339  81 CNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLESCAFNLTSPDDV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVN 274
Cdd:cd15339 161 LWYTLYQTITTFFFPLPLILICYILILCYTWEMYRKNKKAGRYNTSIPRQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVN 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 93277083 275 LQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15339 241 LSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
51-306 1.88e-48

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 163.24  E-value: 1.88e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083    51 GNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMS 128
Cdd:pfam00001   1 GNLLVILVILRNKKlRTPTNIFLLNLAVADLlFSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   129 VDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG-VESCAFDL-TSPDDVLWYTLYLTITTF 206
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGnVTVCFIDFpEDLSKPVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   207 FFPLPLILVCYILILCYTWEMYQQNKDARCCnpsvpkQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTL--AF 284
Cdd:pfam00001 161 LLPLLVILVCYTLIIRTLRKSASKQKSSERT------QRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELsrLL 234
                         250       260
                  ....*....|....*....|..
gi 93277083   285 YVGYYLSICLSYASSSINPFLY 306
Cdd:pfam00001 235 DKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
44-315 5.21e-21

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 92.15  E-value: 5.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   44 ICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWaRGGEWVFGGPLCTIITSLDTCNQFACSAI 123
Cdd:PHA03087  50 IFFFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYY-ILFQWSFGEFACKIVSGLYYIGFYNSMNF 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  124 MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAF-DLTSPDDVLWYTLYLT 202
Cdd:PHA03087 129 ITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFyNNKTMNWKLFINFEIN 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  203 ITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCnpsvpkqrvmkltKMVLVLVVVFILSAAPYHV------IQLVNLQ 276
Cdd:PHA03087 209 IIGMLIPLTILLYCYSKILITLKGINKSKKNKKAI-------------KLVLIIVILFVIFWLPFNVsvfvysLHILHFK 275
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 93277083  277 MEQPTLAFY-VGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:PHA03087 276 SGCKAVKYIqYALHVTEIISLSHCCINPLIYAFVSEFFNK 315
 
Name Accession Description Interval E-value
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
35-317 1.76e-179

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 497.80  E-value: 1.76e-179
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15339   1 VILPSFIGILCSTGLVGNILVLFTIIRSRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDV 194
Cdd:cd15339  81 CNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLESCAFNLTSPDDV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVN 274
Cdd:cd15339 161 LWYTLYQTITTFFFPLPLILICYILILCYTWEMYRKNKKAGRYNTSIPRQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVN 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 93277083 275 LQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15339 241 LSVSQPTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
35-317 9.69e-146

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 412.23  E-value: 9.69e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTV-PDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15088   1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTaPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDD 193
Cdd:cd15088  81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCYVSLPSPDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQnkdarcCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLV 273
Cdd:cd15088 161 LYWFTIYHFILGFAVPLVVITVCYILILHRLARGVAP------GNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLV 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 93277083 274 NLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15088 235 NLAMNRPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRKRL 278
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
35-317 6.10e-70

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 219.68  E-value: 6.10e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK----KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIIT 110
Cdd:cd15338   1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKfrcqQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLIT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 111 SLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTS 190
Cdd:cd15338  81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVGCALLLPN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PD-DVLWYTLYLTITTFFFPLPLILVCYILILcytweMYQQNKDARCCNPSVpKQRVMKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15338 161 PEtDTYWFTLYQFFLAFALPLVVICVVYFKIL-----QNMASTVAPLPQRSL-RVRTKKVTRMAVAICLAFFICWAPFYI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 270 IQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15338 235 LQLAHLSIDRPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
35-317 7.04e-68

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 214.47  E-value: 7.04e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIR-SRKKTVPDIYICNLAVADLVHIVGMPFLIHQWArGGEWVFGGPLCTIITSLD 113
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRySKMKTVTNIYILNLAVADELFLLGLPFLATSYL-LGYWPFGEVMCKIVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDD 193
Cdd:cd14970  80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTISCNLQWPDPPD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 V--LWYTLYLTITTFFFPLPLILVCYILILcytwemyQQNKDARccNPSVPKQRVM-----KLTKMVLVLVVVFILSAAP 266
Cdd:cd14970 160 YwgRVFTIYTFVLGFAVPLLVITVCYSLII-------RRLRSSR--NLSTSGAREKrrarrKVTRLVLVVVAVFVVCWLP 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 267 YHVIQLVNLQMEQPTLAFYVG-YYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14970 231 FHVFQIVRLLIDPPETLTVVGvFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
35-315 1.36e-52

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 174.96  E-value: 1.36e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLD 113
Cdd:cd15093   1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKmKTVTNIYILNLAIADELFMLGLPFLAASNALR-HWPFGSVLCRLVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDD 193
Cdd:cd15093  80 GINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSACNMQWPEPAA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VlWYT---LYLTITTFFFPLPLILVCYILILCytwemyQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15093 160 A-WSAgfiIYTFVLGFLLPLLIICLCYLLIVI------KVKSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVL 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 271 QLVNLQMEQPTLAFYVG-YYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15093 233 QLVNVFVQLPETPALVGvYHFVVILSYANSCANPILYGFLSDNFKK 278
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
40-310 1.12e-49

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 167.08  E-value: 1.12e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVH-IVGMPFLIHqWARGGEWVFGGPLCTIITSLDTCNQ 117
Cdd:cd00637   4 LYILIFVVGLVGNLLVILVILRNRRlRTVTNYFILNLAVADLLVgLLVIPFSLV-SLLLGRWWFGDALCKLLGFLQSVSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFkDGVESCAFDLTSPDDVLWY 197
Cdd:cd00637  83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDY-GGYCCCCLCWPDLTLSKAY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 198 TLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNP-SVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQ 276
Cdd:cd00637 162 TIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSrRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVF 241
                       250       260       270
                ....*....|....*....|....*....|....
gi 93277083 277 MEQPTLAFYVGYYLSICLSYASSSINPFLYILLS 310
Cdd:cd00637 242 GPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
51-306 1.88e-48

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 163.24  E-value: 1.88e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083    51 GNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMS 128
Cdd:pfam00001   1 GNLLVILVILRNKKlRTPTNIFLLNLAVADLlFSLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   129 VDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG-VESCAFDL-TSPDDVLWYTLYLTITTF 206
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGnVTVCFIDFpEDLSKPVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   207 FFPLPLILVCYILILCYTWEMYQQNKDARCCnpsvpkQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTL--AF 284
Cdd:pfam00001 161 LLPLLVILVCYTLIIRTLRKSASKQKSSERT------QRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELsrLL 234
                         250       260
                  ....*....|....*....|..
gi 93277083   285 YVGYYLSICLSYASSSINPFLY 306
Cdd:pfam00001 235 DKALSVTLWLAYVNSCLNPIIY 256
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
35-315 1.61e-45

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 156.50  E-value: 1.61e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLD 113
Cdd:cd15974   1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKmKTVTNIYILNLAVADELFMLGLPFLATQNAIS-YWPFGSFLCRLVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVikfKDGVESCAFDLTSPDD 193
Cdd:cd15974  80 GVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDV---QPDLNTCNISWPEPVS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VlWYT---LYLTITTFFFPLPLILVCYILILCytwemyqQNKDARCCNPSVPKQRV-MKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15974 157 V-WSTafiIYTAVLGFFGPLLVICLCYLLIVI-------KVKSSGLRVGSTKRRKSeRKVTRMVVIIVVVFVFCWLPFYM 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 270 IQLVNLQMEQPTLAFYVG-YYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15974 229 LNIVNLIVILPEEPAFVGvYFFVVVLSYANSCANPILYGFLSDNFKQ 275
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
35-317 1.68e-44

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 153.98  E-value: 1.68e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVG-MPFLIHQWARGGeWVFGGPLCTIITSL 112
Cdd:cd15095   1 WLVPLIFAIIFLVGLAGNSLVIYVVSRHREmRTVTNYYIVNLAVTDLAFLVCcVPFTAALYATPS-WVFGDFMCKFVNYM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 -DTCNQFACsAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIK-FKDGVES-CAFDLT 189
Cdd:cd15095  80 mQVTVQATC-LTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEgYWYGPQTyCREVWP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15095 159 SKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGNNQSEQLSERALRQKRKVTRMVIVVVVLFAICWLPNHV 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 270 IQLVNL--QMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15095 239 LNLWQRfdPNFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
35-317 8.16e-44

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 152.15  E-value: 8.16e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd14985   1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGpKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD-GVESCAFDLTSPD 192
Cdd:cd14985  81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENlNKTACIMLYPHEA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLTITTFFFPLPLILVCYILI---LCYTWEMYQQNKDARccnpsvpkqrvMKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd14985 161 WHFGLSLELNILGFVLPLLIILTCYFHIarsLRKRYERTGKNGRKR-----------RKSLKIIFALVVAFLVCWLPFHF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 270 IQ----LVNLQMEQP---TLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14985 230 FKfldfLAQLGAIRPcfwELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
35-315 2.74e-43

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 150.72  E-value: 2.74e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLD 113
Cdd:cd15972   1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSAsESVTNIYILNLALADELFMLGLPFLAAQNALS-YWPFGSFMCRLVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfkdGVESCAFDLTSPDD 193
Cdd:cd15972  80 AINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPG---GMGTCHIAWPEPAQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VlWYTLYLTITT---FFFPLPLILVCYILILcytwemYQQNKDARCCNPSVPKQRV--MKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15972 157 V-WRAGFIIYTAtlgFFCPLLVICLCYLLIV------VKVRSSGRRVRATSTKRRGseRKVTRMVVIVVAAFVLCWLPFY 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 269 VIQLVNLQMEQP-TLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15972 230 ALNIVNLVCPLPeEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQ 277
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
35-315 6.32e-42

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 146.91  E-value: 6.32e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLD 113
Cdd:cd15971   1 AFLTFIYFVVCIIGLCGNTLVIYVILRYAKmKTVTNIYILNLAIADELFMLGLPFLAIQVALV-HWPFGKAICRVVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfKDGVESCAFDLTSPDD 193
Cdd:cd15971  80 GINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQT-KHGRSSCTIIWPGESS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VlWYT---LYLTITTFFFPLPLILVCYILILCytwemyQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15971 159 A-WYTgfiIYTFILGFFVPLTIICLCYLFIII------KVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIF 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 271 QLVNLQME-QPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15971 232 NVSSVSVSiSPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKK 277
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
35-317 2.91e-41

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 145.49  E-value: 2.91e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNIL-IVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILaLWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCaFDLTSPDD 193
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTC-FEFLSEWL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLYLTITTFFFPLPL--ILVCYILILcytWEMYQQNKDARccnPSVPKQRVMkltKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd14982 160 ASAAPIVLIALVVGFLIPLliILVCYSLII---RALRRRSKQSQ---KSVRKRKAL---RMILIVLAVFLVCFLPYHVTR 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 93277083 272 LVNLQMEQPTLA-------FYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14982 231 ILYLLVRLSFIAdcsarnsLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
36-315 6.78e-41

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 144.28  E-value: 6.78e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMI-GIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIhQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15970   1 ILISFIySVVCLVGLCGNSMVIYVILRYAKmKTATNIYILNLAIADELLMLSVPFLV-TSTLLRHWPFGSLLCRLVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDD 193
Cdd:cd15970  80 AINMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVACNMQMPEPSQ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 --VLWYTLYLTITTFFFPLPLILVCYILILCYTWEM-----YQQNKDARccnpsvpkqrvMKLTKMVLVLVVVFILSAAP 266
Cdd:cd15970 160 rwLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVValkagWQQRKRSE-----------RKITLMVMMVVTVFVICWMP 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 267 YHVIQLVNLQMEQPTLAFyvgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15970 229 FYVVQLVSVFVGQHDATV---SQLSVILGYANSCANPILYGFLSDNFKR 274
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
35-315 1.06e-39

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 141.15  E-value: 1.06e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLD 113
Cdd:cd15973   1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKmKTATNIYILNLAIADELFMLSVPFLAASAALQ-HWPFGSAMCRTVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDD 193
Cdd:cd15973  80 GINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLIWPHPAW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLYLTITTFFFPLPLILVCYILILCYTWEM-----YQQNKDARccnpsvpkqrvMKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15973 160 SAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAValkagWQQRRKSE-----------KKITRMVLMVVTVFVICWMPFY 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 269 VIQLVNLQMeqPTLAFYVGyYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15973 229 VVQLLNLFL--PRLDATVN-HASLILSYANSCANPILYGFLSDNFRR 272
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
35-317 2.57e-39

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 140.04  E-value: 2.57e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgeWVFGGPLCTIITSLD 113
Cdd:cd14984   1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKlRSMTDVYLLNLALADLLFVLTLPFWAVYAADG--WVFGSFLCKLVSALY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKViKFKDGVESCAFDLTSPDD 193
Cdd:cd14984  79 TINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQV-SEENGSSICSYDYPEDTA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYT---LYLTITTFFFPLPLILVCYILILCytwemyqqnKDARCCNPSvpKQRVMKLTkmvLVLVVVFILSAAPYHVI 270
Cdd:cd14984 158 TTWKTllrLLQNILGFLLPLLVMLFCYSRIIR---------TLLRARNHK--KHRALRVI---FAVVVVFFLCWLPYNIV 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 271 QLVN----LQMEQPTLAF--YVGYYLSIC--LSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14984 224 LLLDtlqlLGIISRSCELskSLDYALQVTesLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
35-317 6.08e-39

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 139.66  E-value: 6.08e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWArGGEWVFGGPLCTIITSL 112
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHmRTVTNYFLVNLAVADlLVSLFCMPLTLLENV-YRPWVFGEVLCKAVPYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKV------IKFKDGVESCAF 186
Cdd:cd14993  80 QGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELeeiissEPGTITIYICTE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 187 DLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWemYQQNKDARCCNPSVPKQRVM----KLTKMVLVLVVVFIL 262
Cdd:cd14993 160 DWPSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLW--RRKPPGDRGSANSTSSRRILrskkKVARMLIVVVVLFAL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 93277083 263 SAAPYHVIQLV----NLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14993 238 SWLPYYVLSILldfgPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
35-315 1.44e-37

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 135.68  E-value: 1.44e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIR-SRKKTVPDIYICNLAVADLVHIVGMPFLIHQwARGGEWVFGGPLCTIITSLD 113
Cdd:cd15094   1 LISAVLYGLICIVGLVGNGLVIYVVLRyAKMKTVTNLYILNLAVADECFLIGLPFLIVT-MILKYWPFGAAMCKIYMVLT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfKDGVESCAFDLTSPDD 193
Cdd:cd15094  80 SINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVP-DSGRYSCTIVWPDSSA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 V---LWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARccnpsvPKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15094 159 VngqKAFTLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKE------KRRSHRKVTRLVLTVISVYIICWLPYWAF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 271 QL----VNLQMEQPTLAFYVgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15094 233 QVhlifLPPGTDMPKWEILM-FLLLTVLSYANSMVNPLLYAFLSENFRK 280
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
35-315 4.51e-37

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 134.31  E-value: 4.51e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLD 113
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKmKTATNIYIFNLALADALATSTLPFQSAKYLME-TWPFGELLCKAVLSID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDd 193
Cdd:cd15089  80 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAVVCMLQFPSPS- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 vlWYTLYLT-----ITTFFFPLPLILVCYILilcytweMYQQNKDARCCNPSVPKQRVM-KLTKMVLVLVVVFILSAAPY 267
Cdd:cd15089 159 --WYWDTVTkicvfIFAFVVPILVITVCYGL-------MILRLRSVRLLSGSKEKDRNLrRITRMVLVVVAAFIICWTPI 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 268 HVIQLVN--LQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15089 230 HIFVIVWtlVDIDRRNPLVVAALHLCIALGYANSSLNPVLYAFLDENFKR 279
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
37-317 4.76e-37

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 134.37  E-value: 4.76e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTC 115
Cdd:cd15168   3 LPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSsAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLFYF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKViKFKDGVESCaFDLTSPDDV- 194
Cdd:cd15168  83 NLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATT-GRKNNRTTC-YDTTSPEELn 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 --LWYTLYLTITTFFFPLPLILVCYILILCYtweMYQQNKDarccNPSV-PKQRVMKLTKMvlvLVVVFILSAAPYHVIQ 271
Cdd:cd15168 161 dyVIYSMVLTGLGFLLPLLIILACYGLIVRA---LIRKLGE----GVTSaLRRKSIRLVII---VLALFAVCFLPFHVTR 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 272 LVNL--------QMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15168 231 TINLaarllsgtASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
35-315 1.82e-36

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 132.77  E-value: 1.82e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLD 113
Cdd:cd15091   1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKmKTATNIYIFNLALADALVTTTMPFQSTVYLMN-SWPFGDVLCKIVISID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVY-SKVIKFKDGVESCAFDLTSPD 192
Cdd:cd15091  80 YYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLgGTKVREDVDSTECSLQFPDDD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVlWYTLYLTITTFFFplPLILVCYILILCYTWeMYQQNKDARCCNPSVPKQR-VMKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15091 160 YS-WWDTFMKICVFIF--AFVIPVLIIIVCYTL-MILRLKSVRLLSGSREKDRnLRRITRLVLVVVAVFVVCWTPIHIFI 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 93277083 272 LVNLQMEQP-TLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15091 236 LVEALGSVShSTAAVSSYYFCIALGYTNSSLNPILYAFLDENFKR 280
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
37-317 2.03e-36

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 132.56  E-value: 2.03e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNIL-IVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTC 115
Cdd:cd14999   2 IGTVLSLMCVVGVAGNVYtLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLK-KWYFGDVGCRLLFSLDFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIrINLGLWAASFILALPVWVYSKVIKFKD---GVESCAFDLTSPD 192
Cdd:cd14999  81 TMHASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKL-LAGVIWLLSLLLTLPMAIMIRLVTVEDksgGSKRICLPTWSEE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLTITTFFFPLPLILVCYILILCYTWEmyQQNKDARCCNPSVPKQRVMkltKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd14999 160 SYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWL--SQAAASNSSRKRLPKQKVL---KMIFTIVLVFWACFLPFWIWQL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 273 VNLQMEQPTLAFYV---GYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14999 235 LYLYSPSLSLSPRTttyVNYLLTCLTYSNSCINPFLYTLLTKNYKEYL 282
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
35-316 4.06e-36

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 131.80  E-value: 4.06e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGN-ILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15193   1 IYIPILYLIIFFTGLLGNlFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVEScafdlTSPDD 193
Cdd:cd15193  81 AVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLINESVCVED-----SSSRF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDArccnpsvpKQRVMKLTKMVLVLVVVFILSAAPY------ 267
Cdd:cd15193 156 FQGISLATLFLTFVLPLIVILFCYCSILVRLRRHFHGAKRT--------GRRRRNSLRIVFAIVTAFVLSWLPFntlkav 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 268 -HVIQLVNLQMEQPT-LAFYVGYYLSICLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15193 228 rLLLELGGGVLPCHTtVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRRR 278
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
35-317 1.42e-34

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 127.93  E-value: 1.42e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRS-RKKTVPDIYICNLAVADLVHIVGMP-----FLIHQWArggewvFGGPLCTI 108
Cdd:cd15087   1 VALPVIYSVICAVGLTGNTAVIYVILRApKMKTVTNVFILNLAIADDLFTLVLPiniaeHLLQQWP------FGELLCKL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 109 ITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTR--WRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAF 186
Cdd:cd15087  75 ILSIDHYNIFSSIYFLTVMSVDRYLVVLATVRSRRmpYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSNELGRKSCVL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 187 DLTSPDDVLWYT--LYLTITTFFFPLPLILVCYILILCYTWEMyQQNKDARCCNPSvpKQRVmklTKMVLVLVVVFILSA 264
Cdd:cd15087 155 SFPSPESLWFKAsrIYTLVLGFAIPVSTICILYTMMLYKLRNM-RLNSNAKALDKA--KKKV---TLMVLVVLAVCLFCW 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 265 APYHVIQLVNLQMEQPTLAFYVGY-YLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15087 229 TPFHLSTVVALTTDLPQTPLVIGIsYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
40-315 4.77e-33

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 123.06  E-value: 4.77e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGGeWVFGGPLCTIITSLDTcnq 117
Cdd:cd14967   5 FLSLIILVTVFGNLLVILAVYRNRRlRTVTNYFIVSLAVADlLVALLVMPFSAVYTLLGY-WPFGPVLCRFWIALDV--- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSA-IMT--VMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPddv 194
Cdd:cd14967  81 LCCTAsILNlcAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNK--- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 lWYTLYLTITTFFFPLPLILVCYILILCYTwemyqqnkdarccnpsvpkQRVMKLTKMVLVLVVVFILSAAPYHVIQLVN 274
Cdd:cd14967 158 -IYVLVSSVISFFIPLLIMIVLYARIFRVA-------------------RRELKAAKTLAIIVGAFLLCWLPFFIIYLVS 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 93277083 275 lQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd14967 218 -AFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRR 257
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
35-315 2.00e-32

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 122.33  E-value: 2.00e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQwARGGEWVFGGPLCTIITSL 112
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSmQTVTNIFILNLAVSDLlLCLVSLPFTLIY-TLTKNWPFGSILCKLVPSL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFrltRWRTRYKT-IRINLGLWAASFILALPVWVYSKVIKFKDG-----VESCAF 186
Cdd:cd15203  80 QGVSIFVSTLTLTAIAIDRYQLIVYPT---RPRMSKRHaLLIIALIWILSLLLSLPLAIFQELSDVPIEilpycGYFCTE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 187 DLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCY---TWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILS 263
Cdd:cd15203 157 SWPSSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKlrkRVKKKRGKRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVC 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 264 AAPYHVIQLV---NLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15203 237 WLPLNLFNLLrdfEPLPQIDGRHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
42-317 4.27e-32

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 120.87  E-value: 4.27e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  42 GIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd14974   8 ALIFLLGLPGNGLVIWVAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVISLNMFASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYL 201
Cdd:cd14974  88 FLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEDYDLRRSRHKAL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 202 TITTFFF----PLPLILVCYILILCytwemyqQNKDARCCNPSVPkqrvmklTKMVLVLVVVFILSAAPYHVIQLVNL-Q 276
Cdd:cd14974 168 TVIRFLCgfllPLLIIAICYSVIAV-------KLRRKRLAKSSKP-------LRVLLAVVVAFFLCWLPYHVFALLELvA 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 93277083 277 MEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14974 234 AAGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
43-314 1.19e-31

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 119.97  E-value: 1.19e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFlihqwaRG-----GEWVFGGPLCTIITSLDTCN 116
Cdd:cd15092   9 IVCVVGLVGNCLVMYVILRHTKmKTATNIYIFNLALADTLVLLTLPF------QGtdiflGFWPFGNALCKTVIAIDYYN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 117 QFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVEsCAFDLTSPDDvLW 196
Cdd:cd15092  83 MFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIE-CLVEIPTPQD-YW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 197 ---YTLYLTITTFFFPLPLILVCYILilcytweMYQQNKDARCCNPSVPKQR-VMKLTKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15092 161 dpvFGICVFLFSFIIPVLIISVCYSL-------MIRRLRGVRLLSGSKEKDRnLRRITRLVLVVVAVFVGCWTPIQIFVL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 93277083 273 VNLQMEQPTLAFYVGY-YLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15092 234 AQGLGVQPSSETAVAIlRFCTALGYVNSSLNPVLYAFLDENFK 276
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
35-315 2.25e-31

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 119.33  E-value: 2.25e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIR-SRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLD 113
Cdd:cd15090   1 ITIMALYSIVCVVGLFGNFLVMYVIVRyTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGNILCKIVISID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKViKFKDGVESCAFDLTSPDd 193
Cdd:cd15090  80 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATT-KYRQGSIDCTLTFSHPS- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 vlWY-----TLYLTITTFFFPLPLILVCYILilcytweMYQQNKDARCCNPSVPKQR-VMKLTKMVLVLVVVFILSAAPY 267
Cdd:cd15090 158 --WYwenllKICVFIFAFIMPVLIITVCYGL-------MILRLKSVRMLSGSKEKDRnLRRITRMVLVVVAVFIVCWTPI 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 268 HVIQLVNLQMEQPTLAFY-VGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15090 229 HIYVIIKALVTIPETTFQtVSWHFCIALGYTNSCLNPVLYAFLDENFKR 277
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
35-315 6.82e-31

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 117.95  E-value: 6.82e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIV-GMPFLIHQWARGGeWVFGGPLCTIITSL 112
Cdd:cd14971   1 WIVPLFFALIFLLGLVGNSLVILVVARNKPmRSTTNLFILNLAVADLTFLLfCVPFTATIYPLPG-WVFGDFMCKFVHYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG-VESCAFDLTSP 191
Cdd:cd14971  80 QQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGnRTVCSEAWPSR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSvpKQRVmklTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd14971 160 AHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRA--KRKV---TRLVLVVVVLFAACWGPIHAIL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 93277083 272 L-VNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd14971 235 LlVALGPFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRK 279
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
35-311 1.06e-30

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 117.65  E-value: 1.06e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGN-ILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15194   1 GFLPILYCLVFLVGAVGNaILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVwVYSKVIKFKDGVESCAFDLTSPDD 193
Cdd:cd15194  81 SVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPT-LLSRELKKYEEKEYCNEDAGTPSK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLYLtITTFFFPLPLILVCYILI---LCYTWEMYQQNkdarccnpsvpKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15194 160 VIFSLVSL-IVAFFLPLLSILTCYCTIiwkLCHHYQKSGKH-----------QKKLRKSIKIVFIVVAAFVFSWMPFNLF 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 271 QLV----NLQMEQPTLAF---YVGYYLSICLSYASSSINPFLYILLSG 311
Cdd:cd15194 228 KALaiasGLQVEVTCLPYtlaQLGMEVSAPLAFANSCANPFIYYFFDR 275
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
35-316 2.24e-30

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 117.17  E-value: 2.24e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRS--RKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15190  11 ALIPVIYMLVFVLGLSGNGLVLWTVFRSkrKRRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKF-KDGVESCAFD---L 188
Cdd:cd15190  91 VFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLeGTNKVICDMDysgV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 189 TSPDDVLWYTLYLTITT----FFFPLPLILVCYILILCyTWEMYQQNkdarCCNPSVPKQRvmKLTKMVLVLVVVFILSA 264
Cdd:cd15190 171 VSNESEWAWIAGLGLSStvlgFLLPFLIMLTCYFFIGR-TVARHFSK----LRRKEDKKKR--RLLKIIITLVVTFALCW 243
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 265 APYHVIQLVNLQMEQPTLAFYVGYYL--------SICLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15190 244 LPFHLVKTLYALMYLGILPFSCGFDLflmnahpyATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
35-315 6.68e-30

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 115.47  E-value: 6.68e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIV-GMPFLIHQWARGgEWVFGGPLCTIITSL 112
Cdd:cd15096   1 IVVPVIFGLIFIVGLIGNSLVILVVLsNQQMRSTTNILILNLAVADLLFVVfCVPFTATDYVLP-TWPFGDVWCKIVQYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD---GVESCAFDLT 189
Cdd:cd15096  80 VYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFsseAYSYCTFLTE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMyqqnkDARCCNPSVPKQRVMKL-TKMVLVLVVVFILSAAPYH 268
Cdd:cd15096 160 VGTAAQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQ-----KSPGGRRSAESQRGKRRvTRLVVVVVVVFAICWLPIH 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 269 VIQLVNLQMEQP-TLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15096 235 IILLLKYYGVLPeTVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRK 282
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
35-314 1.32e-29

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 114.47  E-value: 1.32e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNIL-IVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15162   1 VFLPAVYTLVFVVGLPANGMaLWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPD- 192
Cdd:cd15162  81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITTCHDVLPEQl 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 ---DVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARccnpsvpKQRVMKLTkmvLVLVVVFILSAAPYHV 269
Cdd:cd15162 161 lvgDWFYYFLSLAIVGFLIPFILTASCYVATIRTLAALEDENSEKK-------KKRAIKLA---ATVLAIFIICFAPSNL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 270 IQLVN--LQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15162 231 LLLAHysLISSSGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
35-317 3.14e-29

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 113.68  E-value: 3.14e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15192   1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKlKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD-GVESCAFDLTSPD 192
Cdd:cd15192  81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENtNITVCAFHYPSQN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLT--ITTFFFPLPLILVCYILILCYTWEMYQQNKDarccnpsvpKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15192 161 STLLVGLGLMknLLGFLIPFLIILTCYTLIGKALKKAYEIQRN---------KPRNDEIFKMIMAVVLFFFFCWIPHQIF 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 271 QL--VNLQMEQPTLAFYV-----GYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15192 232 TFldVLIQLKVIQDCHIAdivdtAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
35-313 1.29e-28

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 112.45  E-value: 1.29e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHI-VGMPF----LIHQWarggEWVFGGPLCTI 108
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSlRTTTNYYLFSLAVSDLLILlVGLPVelynFWWQY----PWAFGDGGCKL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 109 ITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKV----IKFKDGVESC 184
Cdd:cd14979  77 YYFLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIqylnGPLPGPVPDS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 185 AF-DLTSPDDVLWYTLYLTITTFF-FPLPLILVCYILILCYTWEMYQQNKDARC-----CNPSVPKQRVMKLTKMVLVLV 257
Cdd:cd14979 157 AVcTLVVDRSTFKYVFQVSTFIFFvLPMFVISILYFRIGVKLRSMRNIKKGTRAqgtrnVELSLSQQARRQVVKMLGAVV 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 258 VVFILSAAPYHVIQLVNLQMEQPTL----AFYVGYYLSICLSYASSSINPFLYILLSGNF 313
Cdd:cd14979 237 IAFFVCWLPFHAQRLMFSYASKEDTflfdFYQYLYPISGILFYLSSAINPILYNLMSSRF 296
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
35-315 1.68e-28

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 111.74  E-value: 1.68e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK---KTVPDIYICNLAVADLVHIV-GMPFLIHQWARGgEWVFGGPLCTIIT 110
Cdd:cd15098   1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPgkrRSTTNVFILNLSIADLFFLLfCVPFQATIYSLP-EWVFGAFMCKFVH 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 111 SLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVES--CAFDL 188
Cdd:cd15098  80 YFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTASNQtfCWENW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 189 TSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQqnkdarccNPSVPKQRVMK-LTKMVLVLVVVFILSAAPY 267
Cdd:cd15098 160 PEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKLK--------NMSKKSERSKKkTAQTVLVVVVVFGISWLPH 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 268 HVIQL-VNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15098 232 HIIHLwVEFGDFPLTQASFVLRITAHCLAYANSCVNPIIYAFLSENFRK 280
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
36-317 2.51e-28

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 110.94  E-value: 2.51e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15967   2 FLPPVYILVFVVGLVGNVWGLKSLLANWKKLGNiNVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVikfKDGVESCaFDLTSPD-- 192
Cdd:cd15967  82 LNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKT---NSNGTKC-FDTTFNDyl 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 -DVLWYTLYLTITTFFFPLPLILVCY---ILILCYTWEMYQqnkdarccnpsVPKQRVMKLtkmVLVLVVVFILSAAPYH 268
Cdd:cd15967 158 eSYLTYSLGWTVTGFVIPLLIILGCYghvVVVLCRNNNVDK-----------GLKQRCLKL---VIILIVLFSVCYIPYH 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 269 VIQLVNL---------QMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15967 224 VFRNLNLlsrilqkqgSCTQWFRGIYIAHQVSRGLVCLNSALNPLVYLMGSEDILSRI 281
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
48-313 3.17e-28

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 110.68  E-value: 3.17e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWArGGEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15121  14 GFPGNLFVVWSVLcRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLS-GGGWEFGSVVCKLCHYVCGVSMYASIFLITL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTF 206
Cdd:cd15121  93 MSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKLCIPYHPSVGHEAFQYLFETITGF 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 207 FFPLPLILVCYILILCytweMYQQNKDARccnpsvpKQRVMKLTKMVLVLVVVFILsaaPYHV---IQLVNLQMEQPTLA 283
Cdd:cd15121 173 LLPFTAIVTCYSTIGR----RLRSARFRR-------KRRTNRLVVLIIATFALFWL---PYHVvnlIQVAGALQNQAGNA 238
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 93277083 284 FyVGYYLS------ICLSYASSSINPFLYILLSGNF 313
Cdd:cd15121 239 S-VLKAAKlarpnvTALAFLSSSVNPVLYAFAGGSL 273
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
48-311 9.22e-28

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 109.49  E-value: 9.22e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd14975  14 GLPGNSFVIWSILIKVKQrSVTMLLVLNLALADLAVLLTLPVWIYFLATG-TWDFGLAACKGCVYVCAVSMYASVFLITL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYsKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTF 206
Cdd:cd14975  93 MSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAF-RHVEETVENGMCKYRHYSDGQLVFHLLLETVVGF 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 207 FFPLPLILVCYILILcytwEMYQQNKDARccnpsvpKQRVMKLtkmVLVLVVVFILSAAPYHV---IQLVNLQMEQPTLA 283
Cdd:cd14975 172 AVPFTAVVLCYSCLL----RRLRRRRFRR-------RRRTGRL---IASVVVAFAACWLPYHVgnlLEVVSELIGGSKMA 237
                       250       260       270
                ....*....|....*....|....*....|....
gi 93277083 284 FYVGY------YLSICLSYASSSINPFLYILLSG 311
Cdd:cd14975 238 GTLGKvaeagrPIAGALAFLSSSINPLLYAFAAR 271
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
48-316 1.16e-27

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 109.12  E-value: 1.16e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTII---RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGeWVFGGPLCTIITSLDTCNQFACSAIM 124
Cdd:cd15122  14 GLPGNGFIIWSILwkmKARGRSVTCILILNLAVADGAVLLLTPFFITFLTRKT-WPFGQAVCKAVYYLCCLSMYASIFII 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 125 TVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVES-CAFDLTSPDDVLWYTLYLTI 203
Cdd:cd15122  93 GLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRiCEPCHASRGHAIFHYTFETL 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 204 TTFFFPLPLILVCYILILcytwemyqqnkdARCCNPSVpkQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNL--QMEQPT 281
Cdd:cd15122 173 VAFVLPFGVILFSYSVIL------------VRLKGARF--RRRARVEKLIAAIVVAFALLWVPYHVVNLLQVvaNLAPGE 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 93277083 282 LAFYVGYYLSI------CLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15122 239 VLEKLGGAAKAaragatALAFFSSSVNPLLYVFAAGDLIKT 279
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
42-317 1.26e-27

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 108.90  E-value: 1.26e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  42 GIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCNqFA 119
Cdd:cd15001   7 VITFVLGLIGNSLVIFVVARFRRmRSVTNVFLASLATADLlLLVFCVPLKTAEYFSP-TWSLGAFLCKAVAYLQLLS-FI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 120 CSAI-MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFK----DGVESCAFDLTSPDDV 194
Cdd:cd15001  85 CSVLtLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYEsengVTVYHCQKAWPSTLYS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFFPLPLILVCYILIlcytwemyqqnkdarccnpsvpkqRVMKLTKMVLVLVVVFILSAAPYHVIQLVN 274
Cdd:cd15001 165 RLYVVYLAIVIFFIPLIVMTFAYARD------------------------TRKQVIKMLISVVVLFAVCWGPLLIDNLLV 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 275 LQMEQPTLAFYVGYYLSIC---LSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15001 221 SFDVISTLHTQALKYMRIAfhlLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
36-317 4.77e-27

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 107.53  E-value: 4.77e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSR-KKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15191   2 AIPVLYSIIFILGFLGNSLVVCVFCHQSgPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRwRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD-GVESCAFDLTSPDD 193
Cdd:cd15191  82 LNLFASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEElGVNACIMAFPNEKY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWY---TLYLTITTFFFPLPLILVCYILIlcytWEMYQQNKdarccNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15191 161 AQWSaglALMKNTLGFLIPLIVIATCYFGI----GRHLLKTK-----GFGKNKQRRDKVLKMVAAVVLAFLICWFPFHVL 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 271 QLVNLQMEQPTL-------AFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15191 232 TFLDALARMGVInncwvitVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
36-310 1.04e-26

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 106.70  E-value: 1.04e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15160   2 FLPVVYSFVFVVGLPANCLALWVLYLQIKKeNVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDV 194
Cdd:cd15160  82 TNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDEPNHTLCYEKYPMEGWQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFFPLPLILVCYILILcytwemyqqnkDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVN 274
Cdd:cd15160 162 ASYNYARFLVGFLIPLSLILFFYRRVL-----------RAVRQSPSLEREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVR 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 93277083 275 LQME--QPTL-----AFYVGYYLSICLSYASSSINPFLYILLS 310
Cdd:cd15160 231 SVIElvQNGLcgfekRVFTAYQISLCLTSLNCVADPILYIFVT 273
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
35-317 1.34e-26

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 106.39  E-value: 1.34e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPD-IYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15369   1 RFVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAvIYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD-GVESCaFDLTSPD 192
Cdd:cd15369  81 YCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDlGITTC-HDVLNEQ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLY----LTITTFFFPLPLILVCYILILcytWEMYQQNKDARCCNpsvpKQRVMKLTkmvLVLVVVFILSAAPYH 268
Cdd:cd15369 160 LLMGYYVYyfsiFSCLFFFVPLIITTVCYVSII---RCLSSSSDVANSSK----KTRALFMA---VAVFCVFVICFGPTN 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 269 VIQL---VNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15369 230 VLLLahyVRFAYTSTNDASYFAYLLCVCVGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
35-315 1.89e-26

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 105.62  E-value: 1.89e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARggEWVFGGPLCTIITSLD 113
Cdd:cd15173   1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKlRTLTDIFLVNLAVADLLFLCTLPFWAYSAAH--EWIFGTVMCKITNGLY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIR--INLGLWAASFILALPVWVYSKVIKFKDGVESCAFDltsP 191
Cdd:cd15173  79 TINLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWGkvVCTLVWVISLLLSLPQFIYSEVRNLSSKICSMVYP---P 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLWYTLYLTITT-FFFPLPLILVCYILILcytwemyQQNKDARccnpSVPKQRVMKLTKMvlvLVVVFILSAAPYHVI 270
Cdd:cd15173 156 DAIEVVVNIIQMTVgFFLPLLAMIICYSVII-------KTLLHAK----GFQKHKSLKIIFV---VVAVFILTQLPYNIM 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 271 QLVNLQMEQPTLAFYVGYYLSI--CLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15173 222 KLIRTLHIENTDSTNFKYAILIteAIAYLHACLNPILYAFVGVKFRK 268
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
41-317 1.40e-25

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 103.83  E-value: 1.40e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADL-VHIVGMPFLIHQWARGGeWVFGGPLCTI---ITSLdtc 115
Cdd:cd14969   7 LSLIGVLGVVLNGLVIIVFLKKKKLrTPLNLFLLNLALADLlMSVVGYPLSFYSNLSGR-WSFGDPGCVIygfAVTF--- 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 nqFACSAI--MTVMSVDRYFALVQPFRLTRWRTRYKTIRInLGLWAASFILALPVWV-YSKVIKFKDGVeSCAFDLTSPD 192
Cdd:cd14969  83 --LGLVSIstLAALAFERYLVIVRPLKAFRLSKRRALILI-AFIWLYGLFWALPPLFgWSSYVPEGGGT-SCSVDWYSKD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DV-LWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRV-MKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd14969 159 PNsLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTKKAeKKVAKMVLVMIVAFLIAWTPYAVV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 271 QLVNLQMEQPTLAFYVGYYLSIcLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14969 239 SLYVSFGGESTIPPLLATIPAL-FAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
42-315 1.82e-25

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 103.56  E-value: 1.82e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  42 GIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIV-GMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFA 119
Cdd:cd15134   8 GIIFVTGVVGNLCTCIVIARNRSmHTATNYYLFSLAVSDLLLLIlGLPFELYTIWQQYPWVFGEVFCKLRAFLSEMSSYA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 120 CSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD---------GVESCAFDLTS 190
Cdd:cd15134  88 SVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIVYLEYpptsgealeESAFCAMLNEI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVLWYTLYltiTTFFFPLPLILVCyILILCYTWEMYQQNKDAR-CCNPSVPKQRVM---KLTKMVLVLVVVFILSAAP 266
Cdd:cd15134 168 PPITPVFQLS---TFLFFIIPMIAII-VLYVLIGLQLRRSTLLRRgQRSVSGGRRSSQsrrTVLRMLVAVVVAFFICWAP 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 93277083 267 YHVIQLV---NLQMEQPTLAFYVG-YYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15134 244 FHAQRLLtvyAKNMTPPYLFINRIlFYISGVLYYVSSTVNPILYNVMSAKYRQ 296
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
36-317 2.68e-25

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 102.87  E-value: 2.68e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRKKTVP---DIYICNLAVAD-LVHIVGMPFLIHQWARGGeWVFGGPLCTIITS 111
Cdd:cd15002   1 LVPILLGVICLLGFAGNLMVIGILLNNARKGKPsliDSLILNLSAADlLLLLFSVPFRAAAYSKGS-WPLGWFVCKTADW 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTCNQFACSAIMTVMSVDRYFALVQPFRlTRWRTRYKTIRINLGLWAASFILALPVWVYSKViKFKDGVESCAFDLTSP 191
Cdd:cd15002  80 FGHACMAAKSFTIAVLAKACYMYVVNPTK-QVTIKQRRITAVVASIWVPACLLPLPQWLFRTV-KQSEGVYLCILCIPPL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 --DDVLWYTLYLTITTFFFPLPLILVCYililcytWEMYQQNKDARCCNPSVPKQ-RVMKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15002 158 ahEFMSAFVKLYPLFVFCLPLTFALFYF-------WRAYGQCQRRGTKTQNLRNQiRSRKLTHMLLSVVLAFTILWLPEW 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 269 VIQLVNLQMEQPTLAFYVGY-YLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15002 231 VAWLWLIHIKSSGSSPPQLFnVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
35-315 3.99e-25

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 102.73  E-value: 3.99e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPF----LIHQwarggEWVFGGPLCTI 108
Cdd:cd15927   1 YVVPILFALIFLVGVLGNGTLILIFLRNKSmRNVPNIFILSLALGDlLLLLTCVPFtstiYTLD-----SWPFGEFLCKL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 109 ITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFkDGVESCAFDL 188
Cdd:cd15927  76 SEFLKDTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTF-TLTDNQTIQI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 189 TSPDDVLWYTLYLTITT-------FFFPLPLILVCYILILCYTWemYQQNKDARCCNPSVPKQ---RVmKLTKMVLVLVV 258
Cdd:cd15927 155 CYPYPQELGPNYPKIMVllrflvyYLIPLLIIGVFYVLMARHLI--RSTRNIGSGQNQAAQRQieaRK-KVAKTVLAFVV 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 93277083 259 VFILSAAPYHVIQL---VNLQMEQPTLAFYvgYYLSI---CLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15927 232 LFAVCWLPRHVFMLwfhFAPNGLVDYNAFW--HVLKIvgfCLSFINSCVNPVALYLLSGSFRR 292
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-316 4.57e-25

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 102.16  E-value: 4.57e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNI--LIVFTIIRSRKkTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15189   2 IIPPFIFSLCLFGLLGNLfvLLVFLLHRRRL-TVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD-GVESCAFDLTSPD 192
Cdd:cd15189  81 KVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDlNITACVLLYPHEA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLTITTFFFPLPLILVCYILILcytwEMYQQNKDARCCNpsvpKQRVMKLTKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15189 161 WHFAHIVLLNIVGFLLPLLVITFCNYNIL----QALRTREESTRCE----DRNDSKATALVLAVTLLFLVCWGPYHFFTF 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 273 VNLQMEQPTL-------AFYVGYYLSICLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15189 233 LDFLFDVGVLdecfwehFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRRK 283
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
35-317 8.87e-25

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 101.36  E-value: 8.87e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15372   1 RLVPSLYTLVFLVGLPANGLALWVLATQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDV 194
Cdd:cd15372  81 GNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLCHDVLPLDEQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLY----LTITTFFFPLPLILVCYILILCYTwemyqqnkdarccnpSVPKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15372 161 DTYLFYyfacLAVLGFLLPLVVILFCYGSVLHTL---------------LRSGQRYGHAMKLTVLVLVSFVLCFTPSNLL 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 271 QLVNLQMEQPTL--AFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15372 226 LLLHYSDPTLDDggNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFRDKV 274
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
43-316 1.44e-24

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 100.61  E-value: 1.44e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSA 122
Cdd:cd15115   9 LTFLLGVPGNGLVIWVAGLKMKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVLNMFASVF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 123 IMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfKDGVESCAFDltspddvlwYTLYLT 202
Cdd:cd15115  89 TLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVT-DGNHTRCGYD---------FLVAIT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 203 ITT----FFFPLPLILVCYILIlcytwemyqqnkdARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQME 278
Cdd:cd15115 159 ITRavfgFLLPLLIIAACYSFI-------------AFRMQRGRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGD 225
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 93277083 279 QPTLAFYVGY-YLSICLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15115 226 PPLSKVLMSWdHLSIALAYANSCLNPVLYVFMGKDFKKK 264
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
42-317 1.71e-24

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 101.04  E-value: 1.71e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  42 GIICSTGLVGNILIVF---TIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQF 118
Cdd:cd14976   8 MVVFTVGLLGNLLVLYllkSNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKLNMY 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYT 198
Cdd:cd14976  88 SSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHTLCLLRFPKNSSVTRWY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 199 LYL-------TITTFFFPLPLILVCYILILCYTwemyQQNKDARccnpsvpKQRVMKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd14976 168 NWLgmyqlqkVVLGFFLPLGIITLSYLLLLRFL----QRKRGGS-------KRRKSRVTKSVFIVVLSFFICWLPNQALS 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 272 L------VNLQMEQPT--LAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14976 237 LwsalikFDDVPFSDAffAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
43-317 1.93e-24

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 100.59  E-value: 1.93e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSA 122
Cdd:cd15119   9 VAFVLGVPGNAIVIWVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAVLNMFASVL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 123 IMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESC--AFDLTSPDDVLWYTLY 200
Cdd:cd15119  89 FLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELSINVTICfnNFHKHDGDLIVMRHTI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 201 LTITTFF----FPLPLILVCYILIlcyTWEMYQQNkdarccnpsvpKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQ 276
Cdd:cd15119 169 LVWVRFFfgflFPLLTMVVCYSLL---AIKVKRRT-----------LLISSKFFWTISAVIVAFFVCWTPYHIFSILELS 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 93277083 277 MEQPTLAFYV---GYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15119 235 IHHSSYLHNVlraGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
35-317 3.19e-24

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 99.97  E-value: 3.19e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFtIIRSR---KKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITS 111
Cdd:cd15926   1 IIISIVYSVVCALGLVGNLLVLY-LMKSKqgwKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCA-FDLTS 190
Cdd:cd15926  80 VTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVkFPDNR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVLWYTLYLT---ITTFFFPLPLILVCYILILCYTwemyqqnKDARCCNPSVpkQRVMKLTKMVLVLVVVFILSAAPY 267
Cdd:cd15926 160 GNAQFWLGLYHAqkvLLGFLIPLGIISLCYLLLVRFI-------TDKNITGSST--KRRSKVTKSVTIVVLSFFLCWLPN 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 268 HVIQLVNLQMEQPTLAFYVGYYL--------SICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15926 231 QALTTWGILIKLNVVHFSYEYFTtqvyifpiTVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
35-317 3.49e-24

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 99.73  E-value: 3.49e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15159   1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKiNSTTLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVwVYSKVIKFKDGVESCaFDLTSPDD 193
Cdd:cd15159  81 YINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPL-LFMPMTKEMGGRITC-MEYPNFEK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VL---WYTLYLTITTFFFPLPLILVCYILILCytwEMYQQNKDarccNPSVPKQ-RVMKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15159 159 IKrlpLILLGACVIGFGVPVGIILFCYSQITL---KLCRTAKE----NPLTEKSgHHKKACNVILLVLLVFVVCFSPYHL 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 270 --IQLVNLQME-QPTL----AFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15159 232 niIQFMIRKLLyQPSCselkAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
37-306 3.67e-24

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 99.77  E-value: 3.67e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFT-IIRSRKKTVPDI-YICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15376   3 LWPILGVEFLVAVLGNGLALWLfVTRERRPWHTGVvFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFrLTRWRTRYKTIR-INLGLWAASFILALPVWVYSKVikfKDGVESCAFDLTSPDD 193
Cdd:cd15376  83 CNLYGSIFFITCISLNRYLGIVHPF-FTRSHVRPKHAKlVSLAVWLLVAALSAPVLSFSHL---EVERHNKTECLGTAVD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 -----VLWYTLYLTITTFFFPLPLILVCYILILCYTWEmyqqnkdarccNPSVPKQRVMKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15376 159 srlptYLPYSLFLAVVGCGLPFLLTLASYLAIVWAVLR-----------SPGITTLEKRKVAALVAVVVALYAVSFVPYH 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 93277083 269 VIQLVNL------QMEQPTLAFYVGYYLSICLSYASSSINPFLY 306
Cdd:cd15376 228 ILRNLNLyrrlqwLKAAASLRIYFAYQVTKGLVTLNMCIHPLLY 271
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
48-314 4.49e-24

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 99.87  E-value: 4.49e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15928  14 GASGNLLTVLVIGRSRDmRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSETCTYASILHITA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLT---SPDDVLWYTLYLTI 203
Cdd:cd15928  94 LSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTvvnVSSGLLSVMLWVST 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 204 TTFFFPLPLILVCYILIlcyTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTL- 282
Cdd:cd15928 174 SFFFVPMVCLSLLYGLI---GRALWDRRQRSRTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHVGRVIFNHSRASTKh 250
                       250       260       270
                ....*....|....*....|....*....|....*
gi 93277083 283 AFYVGYY---LSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15928 251 LHYVSQYfnlVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
49-317 5.26e-24

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 99.62  E-value: 5.26e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPF-----LIHqwarggEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd15207  15 VVGNVLVCLVVAKNPRmRTVTNYFILNLAVSDlLVGVFCMPFtlvdnILT------GWPFGDVMCKLSPLVQGVSVAASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPF--RLTRWRTRYKTIRInlglWAASFILALPVWVYS--KVIKFKDGVESCAFDLTSPDDVL-- 195
Cdd:cd15207  89 FTLVAIAVDRYRAVVHPTepKLTNRQAFVIIVAI----WVLALAIMIPQALVLevKEYQFFRGQTVHICVEFWPSDEYrk 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLYLTITTFFFPLPLILVCYILILCYTWemYQQN----KDARCCNPSVPKQRVmKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15207 165 AYTTSLFVLCYVAPLLIIAVLYVRIGYRLW--FKPVpgggSASREAQAAVSKKKV-RVIKMLIVVVVLFALSWLPLHTVT 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 272 LV----NLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15207 242 MLddfgNLSPNQREVLYVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
35-317 1.60e-23

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 97.92  E-value: 1.60e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15368   1 VILPVVYSLVALISIPGNLFSLWLLCfHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD-GVESCaFDLTS-- 190
Cdd:cd15368  81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKElNITTC-FDVLKwt 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 --PDDVLWYTLYLTITTFFFPLPLIL--VCYILILcytWEMYQQNKDarccNPSVPKQRVMKLTKMvlvLVVVFILSAAP 266
Cdd:cd15368 160 mlPNIAAWAAFLFTLFILLFLIPFIItvYCYVLII---LKLVQTSER----YGREQKRRAIYLALI---VLLVFITCFAP 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 267 YHVIQLVN----LQMEQptlAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15368 230 NNFILLAHmvsrLFYGK---SLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
35-316 1.78e-23

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 97.92  E-value: 1.78e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPD-IYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15968   1 ILLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTaIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVesCAFDLTSPDD 193
Cdd:cd15968  81 YFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRT--VCYDLAPPAL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLY---LTITTFFFPLPLILVCYILILCytwEMYQQNKDArccnPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15968 159 FPHYVPYgmaLTVSGFLLPFSIILWCYCLVVR---TLCRTLGPA----EPPAQARRRKSIRTIVTVTLLFALCFLPFHIT 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 93277083 271 QLVNLQME-------QPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15968 232 RTIYLAVRvtpgvpcHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGRR 284
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
41-317 2.06e-23

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 97.83  E-value: 2.06e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADL-VHIVGMPFLIhQWARGGEWVFGGPLCTIITSLDTCNQF 118
Cdd:cd14986   7 LGVLFVFTLVGNGLVILVLRRKRKKRSRvNIFILNLAIADLvVAFFTVLTQI-IWEATGEWVAGDVLCRIVKYLQVVGLF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVMSVDRYFALVQPFRLTRWRTRYKtiRINLGLWAASFILALP-VWVYSKVIKfKDGVESCAFDLTSPDDVLWY 197
Cdd:cd14986  86 ASTYILVSMSLDRYQAIVKPMSSLKPRKRAR--LMIVVAWVLSFLFSIPqLVIFVEREL-GDGVHQCWSSFYTPWQRKVY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 198 TLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRV--------------MKLTKMVLVLVVVFILS 263
Cdd:cd14986 163 ITWLATYVFVIPLIILSYCYGRILRTIWIRSRQKTDRPIAPTAMSCRSVscvssrvslisrakIKTIKMTLVIILAFILC 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 264 AAPYHVIQLVNLQMEQPTLAFYVgYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14986 243 WTPYFIVQLLDVYAGMQQLENDA-YVVSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
38-317 2.75e-23

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 97.57  E-value: 2.75e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  38 PSMIGIICSTGLVGNILIVFTIIRS-RKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCN 116
Cdd:cd15921   4 PTAYILIFILGLTGNSISVYVFLSQyRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLYVN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 117 QFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAAsFILALPVWVYSKVIKFKDGVESCafdLTSPDDVLW 196
Cdd:cd15921  84 MYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWIL-MGLASSPLLFAKSKQHDEGSTRC---LELAHDAVD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 197 YTLYLTITTFFF----PLPLILVCYILILcytwemyqqnkdARCCNPSVPKQRVM----KLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15921 160 KLLLINYVTLPVgfvvPFMTVIFCYIFII------------KNLLKPSPALGRTRpsrrKACALIIISLGIFLVCFLPYH 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 269 VIQLVNLQMEQPT-------LAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15921 228 IVRTIHLITERQIkescgyiLRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
37-317 3.71e-23

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 97.13  E-value: 3.71e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFlihqWARGG--EWVFGGPLCTIITSLD 113
Cdd:cd15174   3 LPPLYWLIFLVGAVGNSLVVLIYTYYRRrKTMTDVYLLNLAIADLLFLCTLPF----WATAAssGWVFGTFLCKVVNSMY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIR--INLGLWAASFILALPVWVYSKViKFKDGVESCAFDLTSP 191
Cdd:cd15174  79 KINFYSCMLLLTCISVDRYIAIVQATKAHNSKNKRLLYSklVCFFVWLLSTILSLPEILFSQS-KEEESVTTCTMVYPSN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DD----VLWYTLYLTItTFFFPLPLILVCYILIlcyTWEMYQQNKDARccnpsvpkqrvMKLTKMVLVLVVVFILSAAPY 267
Cdd:cd15174 158 ESnrfkVAVLALKVTV-GFFLPFVVMVICYTLI---IHTLLQAKRFQK-----------HKALKVIIAVVTVFVLSQLPY 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 268 HVIQLVN-LQMEQPTLA-------FYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15174 223 NSILLIKtINAYNITITdcatsqnLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
35-317 4.85e-23

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 97.02  E-value: 4.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVAD-LVHIVGMPFLIHQwARGGEWVFGGPLCTIITSL 112
Cdd:cd15083   1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPaNYLIINLAISDfLMCILNCPLMVIS-SFSGRWIFGKTGCDMYGFS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 dtCNQFACSAIMTV--MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWV-YSKVIKFKDGVeSCAFDLT 189
Cdd:cd15083  80 --GGLFGIMSINTLaaIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFgWSRYVLEGLLT-SCSFDYL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDVL-WYTLYLTITTFFFPLPLILVCYILILC----YTWEMYQQNKDARCCNPSVPKQRV---MKLTKMVLVLVVVFI 261
Cdd:cd15083 157 SRDDANrSYVICLLIFGFVLPLLIIIYCYSFIFRavrrHEKAMKEMAKRFSKSELSSPKARRqaeVKTAKIALLLVLLFC 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 262 LSAAPYHVIQLVNLQMEQPTLAFYVGyYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15083 237 LAWTPYAVVALIGQFGYLEVLTPLAT-AIPAAFAKTSAIYNPVIYAFSHPKFRRAL 291
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
49-315 5.73e-23

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 96.31  E-value: 5.73e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPF-LIHQWARggEWVFGGPLCTIITSLDTCNQFACSAIMT 125
Cdd:cd15206  15 VVGNILVIVTLVQNKRmRTVTNVFLLNLAVSDLlLAVFCMPFtLVGQLLR--NFIFGEVMCKLIPYFQAVSVSVSTFTLV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVeSCAFDLTSPDDV--LWYTLYLTI 203
Cdd:cd15206  93 AISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPG-GHKCREVWPNEIaeQAWYVFLDL 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 204 TTFFFPLPLILVCYILIlcyTWEMYQQnkdarccnpsvpKQRVMkltKMVLVLVVVFILSAAPYHVIQLVNLqMEQPTLA 283
Cdd:cd15206 172 MLLVIPGLVMSVAYGLI---SWTLLEA------------KKRVI---RMLFVIVVEFFICWTPLYVINTWKA-FDPPSAA 232
                       250       260       270
                ....*....|....*....|....*....|....*
gi 93277083 284 FYVGY---YLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15206 233 RYVSSttiSLIQLLAYISSCVNPITYCFMNKRFRQ 267
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
36-316 6.27e-23

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 96.41  E-value: 6.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15380   2 VLPTFIIAICFFGLLGNLFVLFVFLLPRRRlTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD-GVESCAFDLTSPDD 193
Cdd:cd15380  82 ANLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPDlNISACILLFPHEAW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKdARCCNPsvpkqRVMKLTKMVLVLVVVFILSAAPYHVIQLV 273
Cdd:cd15380 162 HFARRVELNIVGFLLPLAAIVFFNFHIIASLRERTEESR-KRCGGL-----KDTKATRLILTLVLMFLVCWTPYHFFAFL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 274 N--LQMEQPTLAFY-----VGYYLSICLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15380 236 DflFQVEVIQGCFWeefidLGLQLANFFAFANSCLNPVIYVFAGKLFRTK 285
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
37-317 1.09e-22

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 95.60  E-value: 1.09e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFTIIR-SRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGgeWVFGGPLCTIITSLDTC 115
Cdd:cd15175   3 LPAMYSVICFLGLLGNGLVILTYIYfKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKK--WVFGEEMCKAVYCLYKM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTR--YKTIRINLGLWAASFILALPVWVYSKVIKfKDGVESCAFdltSPDD 193
Cdd:cd15175  81 SFFSGMLLLMCISIDRYFAIVQAASAHRHRSRavFISKVSSLGVWVLAFILSIPELLYSGVNN-NDGNGTCSI---FTNN 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLYLTITT----FFFPLPLILVCYILILCYTWEMYQQNKDarccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15175 157 KQTLSVKIQISQmvlgFLVPLVVMSFCYSVIIKTLLQARNFEKN--------------KAIKVIIAVVVVFVVFQLPYNS 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 270 IQLVNLQM----------EQPTLAFyvGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15175 223 VMLVSTLSsfkgnttdcdYSKNLDF--ALDVTYSLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
36-306 1.86e-22

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 95.17  E-value: 1.86e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMP-FLIHQWARggEWVFGGPLCTIITSL 112
Cdd:cd15336   2 TVGSVILIIGITGMLGNALVIYAFCRSKKlRTPANYFIINLAVSDfLMSLTQSPiFFVNSLHK--RWIFGEKGCELYAFC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCnqFACSAIMTVM--SVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWV-YSKVIkfKDGVE-SCAFD- 187
Cdd:cd15336  80 GAL--FGITSMITLLaiSLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFgWSAYV--PEGLLtSCTWDy 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LTSPDDVLWYTLYLTITTFFFPLPLILVCYILILC---YTWEMYQQNKDARCCNPSVPKQRV---MKLTKMVLVLVVVFI 261
Cdd:cd15336 156 MTFTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLairSTGREVQKLGSQDRKEKAKQYQRMkneWKMAKIAFVVILLFV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 93277083 262 LSAAPYHVIQLVNLQMEQPTLAFYVGYYLSIcLSYASSSINPFLY 306
Cdd:cd15336 236 LSWSPYACVALIAWAGYAHLLTPYMKSVPAV-IAKASAIYNPIIY 279
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
37-317 2.36e-22

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 94.83  E-value: 2.36e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMI--GIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15116   1 ILSMViySVVFVLGVLGNGLVIFITGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVI-KFKDGVESC--AFDLTSP 191
Cdd:cd15116  81 LNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTApSQNNNKIICfnNFSLSGD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLW-----------YTLYLTITTFFFPLPLILVCYILILCytweMYQQNKDARCCNPsvpkqrvmklTKMVLVLVVVF 260
Cdd:cd15116 161 NSSPEvnqlrnmrhqvMTITRFLLGFLIPFTIIICCYAAIVL----KLKRNRLAKSSKP----------FKIIAAVIVTF 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 261 ILSAAPYHVIQLVNLQMEQ-PTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15116 227 FLCWAPYHILNLLEMEATRsPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
35-315 2.59e-22

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 94.78  E-value: 2.59e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVH-IVGMPFLIhQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15393   1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRmRTVTNIFIANLAVADIIIgLFSIPFQF-QAALLQRWVLPRFMCPFCPFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRltRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG-----VESCAFD 187
Cdd:cd15393  80 QVLSVNVSVFTLTVIAVDRYRAVIHPLK--ARCSKKSAKIIILIIWILALLVALPVALALRVEELTDKtnngvKPFCLPV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQ--QNKDARCCNPSVPKQRVMkltKMVLVLVVVFILSAA 265
Cdd:cd15393 158 GPSDDWWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKApgNAQDVRDDEILKNKKKVI---KMLIIVVALFALCWL 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 266 PYhviQLVNLQME-QPTLAFY----VGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15393 235 PL---QTYNLLNEiKPEINKYkyinIIWFCSHWLAMSNSCYNPFIYGLYNEKFKR 286
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
35-317 2.93e-22

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 94.39  E-value: 2.93e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIR-SRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15157   1 VIYPTVYLIIFVLGVVGNGLSIYVFLQpSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTrYKTIRINLG-LWAasFILALPVWVYSKVIKFKDGVESCaFDLTSP- 191
Cdd:cd15157  81 YVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTS-IKYARILCAvIWI--FVMAASSPLLSKGTSKYNSQTKC-LDLHPSk 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 -DDVLWYTLYLTITTFFFPLPLILVCYILILcytwemyqqnkdARCCNPSVPKQRVM----KLTKMVLVLVVVFILSAAP 266
Cdd:cd15157 157 iDKLLILNYIVLVVGFILPFCTLSICYILII------------KALLKPRVPQSKLRvshkKALLTIIITLILFLLCFLP 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 267 YHVIQLVNLQMEQPT---LAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15157 225 YHILRTVHLMQWSEGqcnLRLHKAVVITLCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
36-317 4.64e-22

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 93.58  E-value: 4.64e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLI--HQWarggEWVFGGPLCTIITSL 112
Cdd:cd15182   2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKlKTLTNIFILNLAISDLLFTFTLPFWAsyHSS----GWIFGEILCKAVTSI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCafDLTSPD 192
Cdd:cd15182  78 FYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDEDGSLC--EYSSIK 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLTItTFFFPLPLILVCYILILCYTWEMYQQNKDarccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYHVI-- 270
Cdd:cd15182 156 WKLGYYYQQNL-FFLIPLGIIVYCYVRILQTLMRTRTMRKH--------------RTVKLIFVIVLVFFLSWAPYNIVif 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 271 --QLVNLQMEQPTLAFYVGYYLSICLSYASS--SINPFLYILLSGNFQKRL 317
Cdd:cd15182 221 lrSLKDLTIPICECSKQLDYAFYICRNIAFShcCLNPVFYVFVGVKFRNHL 271
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
35-317 5.15e-22

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 93.78  E-value: 5.15e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFtIIRSRKKTVP---DIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITS 111
Cdd:cd15925   1 ILVALAYGLVCAIGLLGNLAVMY-LLRNCARRAPppiDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKdGVESCAFDLTSP 191
Cdd:cd15925  80 ATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVC-GVELCLLKFPSN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLWYTLYLTITTFFFPLPLILVCYILILCYtweMYQQNKDARccnpsvPKQRVMKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15925 159 YWLGAYHLQRVVVAFVVPLGVITTSYLLLLSF---LQQHKVNQN------NRQRQSVIARSVRLVVASFFLCWFPNHVVT 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 272 ----LVNLQMEQPTLAFYV----GYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15925 230 fwgvLVKFRAVPWNSTFYFihtyVFPVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
38-316 6.11e-22

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 93.68  E-value: 6.11e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  38 PSMIGIICSTGLVGN--ILIVFTIIRSRKkTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTC 115
Cdd:cd15381   4 PIYLWIIFVLGTIENafVLIVFCLHKSSC-TVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD-GVESCAFDLTSPDDV 194
Cdd:cd15381  83 NLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEyNITACVLDYPSEGWH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFFPLPLILVCYILILcytwEMYQQNKDARCcnPSVPKQRvmKLTKMVLVLVVVFILSAAPYHVIQLVN 274
Cdd:cd15381 163 VALNILLNVVGFLIPLSIITFCSTQII----QVLRNNKMQKF--KEIQTER--KATVLVLAVLLMFFICWLPFHIFTFLD 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 275 -------LQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15381 235 tlhklglISGCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRKK 283
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
42-317 6.46e-22

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 93.71  E-value: 6.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  42 GIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd15118   8 GIVSTLGIVENLLILWVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNMFVSG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFD----LTSPDDVL-- 195
Cdd:cd15118  88 FLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKDGRKLCYYNfalfSPSPDNNHpi 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 --WYTLYLTITTFFF----PLPLILVCYILIlcytwEMYQQNKDARccnpsvpkqRVMKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15118 168 ckQRQEGLAISKLLLafliPLVIIAVSYAVV-----SLIIRHRCRR---------RPGRFVRLVVSVVVSFALCWAPYHI 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 270 IQLVNLQME-QPTLAFYVGYYLSICLSYA--SSSINPFLYILLSGNFQKRL 317
Cdd:cd15118 234 FSIIEVMAHnQHSLRPLVIQGLPFATTLAflNSVLNPVLYVFSCPDFCNKI 284
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
35-317 8.28e-22

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 93.32  E-value: 8.28e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15370   1 VFLPIVYIIVFVVGLPSNAMALWVFLfRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRyKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPD- 192
Cdd:cd15370  81 YGNMYCSILFMTCLSVQRYWVIVNPMSHSRKKAN-IAIGISLAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVLPEQl 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 ---DVLWYTLYLTITTFFFPLPLILVCYILILcytwemyqQNKDARCCNPSVPKQRvMKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15370 160 lvgDMFNYFLSLAIGVFLFPAFLTAVAYVLMI--------RALKSSINDESIEKKR-KRAIKLIVTVLVMYLICFTPSNL 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 270 IQLVN--LQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15370 231 LLVVHyfLLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFRDHV 280
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
48-317 1.08e-21

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 92.85  E-value: 1.08e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVM 127
Cdd:cd15114  14 GVPGNALVAWVTGFEAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLILLNMYASVLLLTAI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 128 SVDRYFALVQPfrltRWRTRYKTIRINLGLWAASFILAL----PVWVYSKVIK--FKDGVEsCAFDLTSPDDVLWytlYL 201
Cdd:cd15114  94 SADRCLLVLRP----VWCQNHRRARLAWIACGAAWLLALlltvPSFIYRRIHQehFPEKTV-CVVDYGGSTGVEW---AV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 202 TITTFFF----PLPLILVCYILILCYTWemyqqnkdARCCNPSvpkqrvMKLTKMVLVLVVVFILSAAPYHVIQLVnLQM 277
Cdd:cd15114 166 AIIRFLLgflgPLVVIASCHGVLLVRTW--------SRRRQKS------RRTLKVVTAVVVGFFLCWTPYHVVGLI-IAA 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 93277083 278 EQPTLAFYV----GYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15114 231 SAPNSRLLAnalkADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
35-317 1.19e-21

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 92.83  E-value: 1.19e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVHIVGMPFLIHQWARGgeWVFGGPLCTIITSLD 113
Cdd:cd15180   1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNlSVTDTFILHLALADILLLVTLPFWAVQAVHG--WIFGTGLCKLAGAVF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVES-CAFDLTSPD 192
Cdd:cd15180  79 KINFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQNKTeCVHNFPQSD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLT--ITTFFFPLPLILVCYILILCYTWEMYQQNKdarccnpsvpKQRVMKLtkmVLVLVVVFILSAAPYHVI 270
Cdd:cd15180 159 TYWWLALRLLyhIVGFLLPLAVMVYCYTSILLRLLRSSQGFQ----------KQRAIRV---IVAVVVVFFLCWTPYNIA 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 271 QLVNLQMEQPTLAFYVGYYLSI--------CLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15180 226 LLVDTLIDLSVLDRNCGTESRLdialsvtsSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
43-317 2.52e-21

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 91.95  E-value: 2.52e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgeWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd15178   9 LVFLLSLPGNSLVVLVILYNRRsRSSTDVYLLHLAIADLLFALTLPFWAVSVVKG--WIFGTFMCKLVSLLQEANFYSGI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPFRlTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIK-FKDGVESCA--FDLTSPDD----- 193
Cdd:cd15178  87 LLLACISVDRYLAIVHATR-ALTQKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKpPNSGRTVCYenLGNESADKwrvvl 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 -VLWYTLyltitTFFFPLPLILVCYILILCytwEMYQQNkdarccnpSVPKQRVMKLtkmVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15178 166 rILRHTL-----GFLLPLVVMLFCYGFTIK---TLLQTR--------SFQKHRAMRV---IFAVVLAFLLCWLPYNVTVL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 93277083 273 VNLQM------------EQPTLAFYVgyylSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15178 227 IDTLMrtklitetcelrNHVDVALYV----TQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
37-317 3.12e-21

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 91.90  E-value: 3.12e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTC 115
Cdd:cd15377   3 LPAVYILVFITGFLGNSVAIWMFVfHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCaFDLTSPDDVL 195
Cdd:cd15377  83 NLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITC-YDTTSDEYLR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLY---LTITTFFFPLPLILVCYILILCYTweMYQQNKDARCCNPSVPKQRVMkltkMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15377 162 SYFIYsmcTTVAMFCVPFILILGCYGLIVRAL--IYKDMKYTEENNAPLRRKSIY----LVIIVLTVFAVSYLPFHVMKT 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 273 VNLQ----MEQPTLA-----FYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15377 236 LNLRarldFQTPAMCafndrVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
35-316 3.34e-21

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 91.43  E-value: 3.34e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKT--VPDIYICNLAVADLVHIV-GMPFLIHQWARGGeWVFGGPLCTIITS 111
Cdd:cd15097   1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSGhnTTNLFILNLSVADLCFILfCVPFQATIYSLEG-WVFGSFLCKAVHF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKdgvescAFDLTSP 191
Cdd:cd15097  80 FIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYA------NSTVCMP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLWYTLYLTITTFFF----PLPLILVCYILILCYTWEMYQQNKDArccnpSVPKQRVMKLTKMVLVLVVVFILSAAPY 267
Cdd:cd15097 154 GWEEARRKAMDTCTFAFgyliPVLVVSLSYTRTIKYLWTAVDPLEAM-----SESKRAKRKVTKMIIIVTALFCLCWLPH 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 268 HVIQLVNLQMEQP-TLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15097 229 HVVILCYLYGDFPfNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKG 278
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
35-314 3.38e-21

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 91.74  E-value: 3.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFT-IIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARggEWVFGGPLCTIITSLD 113
Cdd:cd15172   1 VFVPVIYSLICVVGLIGNSLVVITyAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEAH--QWIFGNFSCKLLRGIY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNqFACSAIM-TVMSVDRYFALVQPFRLTRWRTR---YKTIrINLGLWAASFILALPVWVYSKVIKFK-DGVESCAFDL 188
Cdd:cd15172  79 AIN-FYSGMLLlACISVDRYIAIVQATKSFRLRSRtlaYSKL-ICAAVWLLAILISLPTFIFSEVYDFGlEEQYVCEPKY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 189 -TSPDDVLWYTLYLTITT---FFFPLPLILVCYILILcytwEMYQQNKDArccnpsvpkQRvMKLTKMVLVLVVVFILSA 264
Cdd:cd15172 157 pKNSTAIMWKLLVLSLQVslgFFIPLLVMIFCYSFII----KTLLQAQNS---------QR-HKAVRVVVAVVLVFLVCQ 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 265 APYHVIQLV-----NLQMEQPTLAFY-VGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15172 223 VPYNIVLLIeainlGEQQSCSSEKAVaYAKTITECLAFFHCCLNPVLYAFIGVKFR 278
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
44-315 5.21e-21

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 92.15  E-value: 5.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   44 ICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWaRGGEWVFGGPLCTIITSLDTCNQFACSAI 123
Cdd:PHA03087  50 IFFFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYY-ILFQWSFGEFACKIVSGLYYIGFYNSMNF 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  124 MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAF-DLTSPDDVLWYTLYLT 202
Cdd:PHA03087 129 ITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFyNNKTMNWKLFINFEIN 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  203 ITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCnpsvpkqrvmkltKMVLVLVVVFILSAAPYHV------IQLVNLQ 276
Cdd:PHA03087 209 IIGMLIPLTILLYCYSKILITLKGINKSKKNKKAI-------------KLVLIIVILFVIFWLPFNVsvfvysLHILHFK 275
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 93277083  277 MEQPTLAFY-VGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:PHA03087 276 SGCKAVKYIqYALHVTEIISLSHCCINPLIYAFVSEFFNK 315
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
43-314 6.97e-21

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 91.08  E-value: 6.97e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC 120
Cdd:cd15357   9 VIFVVGVIGNLLVCLVILKHQNmKTPTNYYLFSLAVSDLlVLLFGMPLEVYEMWSNYPFLFGPVGCYFKTALFETVCFAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIK--FKDGVESCAFDLTSPDDVLW-Y 197
Cdd:cd15357  89 ILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNTSIHGIKLqyFPNGTLIPDSATCTVVKPLWiY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 198 TLYLTITTFFF---PLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRvmKLTKMVLVLVVVFILSAAPYHVIQL-- 272
Cdd:cd15357 169 NLIIQITSLLFyvlPMGVISVLYYLMGLKLRGDKSLEADEMNVNIQRPSRK--SVTKMLFVLVLVFAICWAPFHVDRLff 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 93277083 273 --VNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15357 247 sfVVEWTEPLANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFR 290
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
50-273 7.89e-21

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 90.83  E-value: 7.89e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  50 VGNILIVFTIIRSRKKTVP--DIYICNLAVADL-VHIVGMPFLIhQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15382  16 VGNLTVLLILLRNRRRKRSrvNILLMHLAIADLlVTFIMMPLEI-GWAATVAWLAGDFLCRLMLFFRAFGLYLSSFVLVC 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRtryKTIRINLGL-WAASFILALP-VWVYS-----KVIKFKDGVESCAFdlTSPDDVLWYTL 199
Cdd:cd15382  95 ISLDRYFAILKPLRLSDAR---RRGRIMLAVaWVISFLCSIPqSFIFHveshpCVTWFSQCVTFNFF--PSHDHELAYNI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 200 YLTITTFFFPLPLILVCYILILcytWEMYQQNK----DARCCNPSVPKQRV---------MKLTKMVLVLVVVFILSAAP 266
Cdd:cd15382 170 FNMITMYALPLIIIVFCYSLIL---CEISRKSKekkeDVSEKSSSVRLRRSsvgllerarSRTLKMTIVIVLVFIICWTP 246

                ....*..
gi 93277083 267 YHVIQLV 273
Cdd:cd15382 247 YFIMSLW 253
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
36-317 8.33e-21

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 90.58  E-value: 8.33e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTI-IRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd14991   2 ILPPLLILEFVLGLPGNVVALWIFcFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQP-FRLTRWRTRyKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAF-DLTSPD 192
Cdd:cd14991  82 VNRSASIAFLTAVALDRYFKVVHPhHRVNRMSVK-AAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFsSYTKPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCcnpsvpkQRVMKLTKMvlvLVVVFILSAAP------ 266
Cdd:cd14991 161 LSIRWHNALFLLEFFLPLGLIVFCSVRIACNLRIRQSLGKQARV-------QRAIRLVFL---VVIVFVLCFLPsiiagl 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 267 -YHVIQLVNLQMEQPTLAfyVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14991 231 lALVFKNLGSCRCLNSVA--QLFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
35-317 1.10e-20

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 90.20  E-value: 1.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15373   1 ILLPVSYGIVFVVGLVLNILALYVFLfRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRW-RTRYkTIRINLGLWAASFILALPVWVYSKvIKFKDGVESCaFDLTSP- 191
Cdd:cd15373  81 YTNLYCSILFLLCISVHRFLGVCYPVRSLRWlKVRY-ARIVSVVVWVIVLACQSPVLYFVT-TSDKGGNITC-HDTSSPe 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 --DDVLWYTLYLTITTFFFPLPLILVCYILilcytweMYQQNKDARCCNPSVPKQRvMKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15373 158 lfDQFVVYSSVMLVLLFCVPFVVILVCYAL-------MVRKLLKPSAGTSTNSRSK-KKSVKMIIIVLAVFILCFLPFHV 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 270 IQLV-----NLQMEQPTL-AFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15373 230 TRTLyysfrSMDLSCGTLnAINLAYKVTRPLASANSCLDPILYFLAGQSFRSNL 283
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
37-315 1.91e-20

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 89.36  E-value: 1.91e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFT-IIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTC 115
Cdd:cd15375   3 LPVMYSIIFIVGFPGNIIAIFVyLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFIFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfKDGVESCaFDLTS---PD 192
Cdd:cd15375  83 NLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKE-KNNRTIC-LDFTSsdnLN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLTITTFFFPLPLILVCYILILCytweMYQQNKDARCCNpsvpKQRVMKLTkmvLVLVVVFILSAAPYHVIQL 272
Cdd:cd15375 161 TIWWYNWILTVLGFLLPLVIVTLCYTRIIY----TLAKGPHTGSAS----KQKARRLI---ILILLVFYVCFLPFHILRV 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 273 VNLQMEQPTLA------FYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15375 230 VRIETRLPPVScclkhqVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQ 278
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
35-313 2.21e-20

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 89.31  E-value: 2.21e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITSL 112
Cdd:cd15051   1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRlRNLTNYFIVSLAVTDlLLGLLVLPFSAIYELRG-EWPLGPVFCNIYISL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCnqFACSAIMT--VMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPVWV----YSKVIKFKDGVESCA 185
Cdd:cd15051  80 DVM--LCTASILNlfAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSfLPIHLgwntPDGRVQNGDTPNQCR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 186 FDLTSPddvlwYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVM-----KLTKMVLVLVVVF 260
Cdd:cd15051 158 FELNPP-----YVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAKRINALTPASTANSSKSAAtarehKATVTLAAVLGAF 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 261 ILSAAPYHVI-QLVNLQMEQPTlafYVGYYLSICLSYASSSINPFLYILLSGNF 313
Cdd:cd15051 233 IICWFPYFTYfTYRGLCGDNIN---ETALSVVLWLGYANSALNPILYAFLNRDF 283
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
51-316 2.43e-20

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 89.38  E-value: 2.43e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  51 GNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIhQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMS 128
Cdd:cd15195  17 GNLTVLIQLFRRRRaKSHIQILIMHLALADLmVTFFNMPMDA-VWNYTVEWLAGDLMCRVMMFLKQFGMYLSSFMLVVIA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 129 VDRYFALVQPFRLTRWRTRYKtiRINLGLWAASFILALP-VWVYSKVIKFKD--GVESCAFDLTSPDDVLW--YTLYLTI 203
Cdd:cd15195  96 LDRVFAILSPLSANQARKRVK--IMLTVAWVLSALCSIPqSFIFSVLRKMPEqpGFHQCVDFGSAPTKKQErlYYFFTMI 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 204 TTFFFPLPLILVCYILILCYTWEMYQQNKDA------RCCNPSVPKQRvMKLTKMVLVLVVVFILSAAPYHVIQL---VN 274
Cdd:cd15195 174 LSFVIPLIITVTCYLLILFEISKMAKRARDTpisnrrRSRTNSLERAR-MRTLRMTALIVLTFIVCWGPYYVLGLwywFD 252
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 93277083 275 LQMEQPTLAFYVGYYLSicLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15195 253 KESIKNLPPALSHIMFL--LGYLNPCLHPIIYGVFMKEIRNW 292
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
35-221 3.07e-20

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 88.74  E-value: 3.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARggEWVFGGPLCTIITSLD 113
Cdd:cd15186   1 IFLSIFYSLVFAFGLVGNLLVVLALTNSGKsKSITDIYLLNLALSDLLFVATLPFWTHYLIN--EWGLHNAMCKLTTAFF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfkdgvESCAFDLTSPDD 193
Cdd:cd15186  79 FIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKE-----NECLGDYPEVLQ 153
                       170       180       190
                ....*....|....*....|....*....|.
gi 93277083 194 VLWYTLY---LTITTFFFPLPLILVCYILIL 221
Cdd:cd15186 154 EIWPVLRnveLNFLGFLLPLLIMSYCYFRII 184
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
43-317 4.05e-20

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 88.64  E-value: 4.05e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICST---GLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFA 119
Cdd:cd15117   6 IYSSAfvlGTLGNGLVIWVTGFRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNLFA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 120 CSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYsKVIKFKDGVESCAFDL-----TSPDDV 194
Cdd:cd15117  86 SVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVF-RDTRKENGCTHCYLNFdpwneTAEDPV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLY------LTITTFFF----PLPLILVCYILILCYTWEMyqqnkdaRCCNPSVPKqrvmkltKMVLVLVVVFILSA 264
Cdd:cd15117 165 LWLETVvqrlsaQVITRFVLgflvPLVIIGGCYGLIAARLWRE-------GWVHSSRPF-------RVLTAVVAAFFLCW 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 265 APYHV---IQLVNLQMEQPTLAFYVGYY--LSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15117 231 FPFHLvslLELVVILNQKEDLNPLLILLlpLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
35-317 4.68e-20

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 88.29  E-value: 4.68e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgeWVFGGPLCTIITSLD 113
Cdd:cd15177   1 VFQPCVYLVVFVLGLVGNGLVLATHTRYRRlRSMTDVYLLNLALADLLLLLTLPFAAAETLQG--WIFGNAMCKLIQGLY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQ--PFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfKDGVESCafDLTSP 191
Cdd:cd15177  79 AINFYSGFLFLTCISVDRYVVIVRatSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVEN-RSELSSC--RMIFP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLWYTLYLTITT-----FFFPLPLILVCYILILcytwEMYQQNKDARccnpsvpKQRVMKLTKMvlvLVVVFILSAAP 266
Cdd:cd15177 156 EVVSRTVKGATALTqvvlgFAIPLIVMAVCYAAIG----RTLLAARGWE-------RHRALRVIAA---LVVAFVLFQLP 221
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 93277083 267 YHVIQLVNL------------QMEQPTLAFYVgyylSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15177 222 YSVVLLLDTadllatlelscsQSKRKDIALLV----TSGLAYVRCCLNPLLYAFVGVRFRRDI 280
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
35-317 4.74e-20

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 88.28  E-value: 4.74e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd16001   1 ILLPVTYSVVFVLGLPLNGTVLWLSWcRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKViKFKDGVESCaFDLTSPDD 193
Cdd:cd16001  81 YTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYART-GSINNRTVC-YDLTSPDN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLY---LTITTFFFPLPLILVCYILILCYTWEmyqqnkdaRCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd16001 159 FGNYFPYgmvLTVTGFLIPFLIILLCYCLMIKSLIR--------SEEAAGVGKAARAKSIRTILLVCGLFALCFVPFHIT 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 271 QL------VNLQMEQPTLAFY-VGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd16001 231 RTiylfvrVYLVQDCPLLQFVsLAYKIWRPLVSFNSCINPLLYFLSGDSNRLRL 284
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
40-313 5.49e-20

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 88.51  E-value: 5.49e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFlIHQWARGGEWVFGGPLCTIITSLDTCNQ 117
Cdd:cd15390   6 VFVVMVLVAIGGNLIVIWIVLAHKRmRTVTNYFLVNLAVADLlISAFNTVF-NFTYLLYNDWPFGLFYCKFSNFVAITTV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRltRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVES----CAFDLtsPDD 193
Cdd:cd15390  85 AASVFTLMAISIDRYIAIVHPLR--PRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSertvCFIAW--PDG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 V-----LWYTLYLTITTFFFPLPLILVCYILILCYTWemyqQNKDARCCNP----SVPKQRvmKLTKMVLVLVVVFILSA 264
Cdd:cd15390 161 PnslqdFVYNIVLFVVTYFLPLIIMAVAYTRVGVELW----GSKTIGENTPrqleSVRAKR--KVVKMMIVVVVIFAICW 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 265 APYHVIQLVNLQMEQPTLAFYVGY-YLSI-CLSYASSSINPFLYILLSGNF 313
Cdd:cd15390 235 LPYHLYFILTYLYPDINSWKYIQQiYLAIyWLAMSNSMYNPIIYCWMNKRF 285
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
35-315 6.26e-20

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 87.77  E-value: 6.26e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPF-LIHQWArgGEWVFGGPLCTIITS 111
Cdd:cd15064   1 VLISVLLSLIILATILGNALVIAAILLTRKlHTPANYLIASLAVADLlVAVLVMPLsAVYELT--GRWILGQVLCDIWIS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LD-TCnqfaCSA-IM--TVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPvwvysKVIKFKDGVESCAFD 187
Cdd:cd15064  79 LDvTC----CTAsILhlCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLP-----PLFGWRTPDSEDPSE 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LTSPDDVLwYTLYLTITTFFFPLPLILVCYililcytWEMYQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPY 267
Cdd:cd15064 150 CLISQDIG-YTIFSTFGAFYIPLLLMLILY-------WKIYRAAARER------------KAAKTLGIILGAFIVCWLPF 209
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 268 HVIQLVNLQMEQPTLAFYVGYYLsICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15064 210 FLVALIVPLCSHCWIPLALKSFF-LWLGYFNSLINPLIYTFFNKDFRK 256
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
35-222 7.63e-20

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 87.92  E-value: 7.63e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRS--RKKTVPDIYICNLAVADLVHIVGMPFlihqWAR--GGEWVFGGPLCTIIT 110
Cdd:cd15188   1 VFLPVFYTLVFLLGLAGNLLLFVVLLLYvpKKKKMTEVYLLNLAVSDLLFLVTLPF----WAMyvAWHWVFGSFLCKFVS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 111 SLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTS 190
Cdd:cd15188  77 TLYTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYGG 156
                       170       180       190
                ....*....|....*....|....*....|....
gi 93277083 191 PDDV--LWYTLYLTITTFFFPLPLILVCYILILC 222
Cdd:cd15188 157 HHTIwkLVFQFQQNLLGFLFPLLAMVFFYSRIAC 190
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
35-221 2.69e-19

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 86.36  E-value: 2.69e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTI-IRSRKKTVPDIYICNLAVADLVHIVGMPFlihqWARGG--EWVFGGPLCTIITS 111
Cdd:cd15179   1 IFLPTVYSIIFLLGIVGNGLVILVMgYQKKSRTMTDKYRLHLSVADLLFVLTLPF----WAVDAaaNWYFGNFLCKAVHV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKViKFKDGVESCAFDLTSP 191
Cdd:cd15179  77 IYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKV-SELDDRYICDRIYPED 155
                       170       180       190
                ....*....|....*....|....*....|...
gi 93277083 192 DDVLWYTLYL---TITTFFFPLPLILVCYILIL 221
Cdd:cd15179 156 TFELWVVAFRfqhILVGLVLPGLVILTCYCIII 188
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
48-314 4.24e-19

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 86.09  E-value: 4.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15131  14 GVTGNLMTMLVVSKYRDmRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTILNITA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKV-----IKFKDGVESCAFDLTSPDDVLWYTLYL 201
Cdd:cd15131  94 LSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVehengTNPIDTNECKATEYAVRSGLLTIMVWV 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 202 TITTFFFPLPLILVCYILILCYTWemyQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLV---NLQME 278
Cdd:cd15131 174 SSVFFFLPVFCLTVLYSLIGRKLW---RRRRENIGPNASHRDKNNRQTVKMLAVVVFAFVLCWLPFHVGRYLfskSFEAG 250
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 93277083 279 QPTLAFYVGY--YLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15131 251 SLEIALISQYcnLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-315 4.36e-19

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 85.79  E-value: 4.36e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICStglVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQW-ARGGEWVFGGPLCTIITSL 112
Cdd:cd15204   5 VVYVLIMLVCG---VGNLLLIAVLARYKKlRTLTNLLIANLALSDfLVAVFCLPFEMDYYvVRQRSWTHGDVLCAVVNYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLtrwRTRYKT-IRINLGLWAASFILALPVWVYSKVIKFKDGVES-CAfdlts 190
Cdd:cd15204  82 RTVSLYVSTNALLVIAIDRYLVIVHPLKP---RMKRRTaCVVIALVWVVSLLLAIPSAVYSKTTPYANQGKIfCG----- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 pddVLW----------YTLYLTITTFFFPLPLILVCYILILCYTW-------EMYQQNKDARCCNPSVpkQRVMKLTKMv 253
Cdd:cd15204 154 ---QIWpvdqqayykaYYLFLFVLEFVLPVLIMTLCYLRIVRKVWfrrvpgqQTEQIRRRLRRRRRKV--RLLVVILTA- 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 93277083 254 lvlvvvFILSAAPYHVIQLVnlQMEQPTLAFYVGYYLSI-----CLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15204 228 ------FVLCWAPYYGYAIV--RDFFPTLLSKEKLNTTIfyiveALAMSNSMINTVVYVAFNNNIRK 286
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-310 4.69e-19

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 85.62  E-value: 4.69e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd15132   9 ILFVVGVTGNTMTVLIIRRYKDmRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYISEGCTYATI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWvyskvikFKDGVEScaFDLTSPDDVLW---YT 198
Cdd:cd15132  89 LHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFL-------FLVGVEQ--DNNIHPDDFSReckHT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 199 ------------LYLTITTFFFPLPLILVCYILILCYTWemyQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAP 266
Cdd:cd15132 160 pyavssgllgimIWVTTTYFFLPMLCLSFLYGFIGRKLW---KSKNDLRGPNAAARERSHRQTVRILAVVVLAFIICWLP 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 267 YHVIQLVNLQMEQPTLAFYVGYY--LSICLSYASSSINPFLYILLS 310
Cdd:cd15132 237 FHIGRILFANTEDYRTMMFSQYFniVAMQLFYLSASINPILYNLIS 282
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
35-315 7.23e-19

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 85.18  E-value: 7.23e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQwARGGEWVFGGPLCTIITSL 112
Cdd:cd14992   1 IILGVALVVIILVSVVGNFIVIAALARHKNlRGATNYFIASLAISDLlMALFCTPFNFTY-VVSLSWEYGHFLCKIVNYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDL---T 189
Cdd:cd14992  80 RTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFCcqiP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDVLWYTLY---LTITTFFFPLPLILVCYILILCYTWEMyQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAP 266
Cdd:cd14992 160 PVDNKTYEKVYfllIFVVIFVLPLIVMTLAYARISRELWFR-KVPGFSIKEVERKRLKCKRRVIKMLVCVVVLFVICWLP 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 267 YHVIQLVN--LQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd14992 239 FHLFFLLRdfFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRK 289
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
40-317 8.64e-19

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 84.99  E-value: 8.64e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLvhIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQF- 118
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDI--LVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYIYPl 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 -----ACSAIMTV-MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPD 192
Cdd:cd14978  84 antfqTASVWLTVaLTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLTI-----TTFFFPLPLILVCyILILCYTWEMYQQNKDARCCNP-----SVPKQRVMKLTKMVLVLVVVFIL 262
Cdd:cd14978 164 LRQNETYLLKYyfwlyAIFVVLLPFILLL-ILNILLIRALRKSKKRRRLLRRrrrllSRSQRRERRTTIMLIAVVIVFLI 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 93277083 263 SAAPYHVIQLVNLQMEQPTLAFYVGYYLSIC--LSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14978 243 CNLPAGILNILEAIFGESFLSPIYQLLGDISnlLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
36-274 1.07e-18

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 84.42  E-value: 1.07e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARggEWVFGGPLCTIITSLDT 114
Cdd:cd15184   2 LLPPLYSLVFIFGFVGNMLVVLILINCKKlKSMTDIYLLNLAISDLLFLLTLPFWAHYAAN--EWVFGNAMCKLLTGLYH 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfKDGVESCAFDLTSPDDV 194
Cdd:cd15184  80 IGFFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQK-EGSHYTCSPHFPPSQYQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LW---YTLYLTITTFFFPLPLILVCYILILcytwemyqqNKDARCCNPSvpkqRVMKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15184 159 FWknfQTLKMNILGLVLPLLVMIICYSGIL---------KTLLRCRNEK----KRHKAVRLIFTIMIVYFLFWAPYNIVL 225

                ...
gi 93277083 272 LVN 274
Cdd:cd15184 226 LLN 228
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
43-323 1.54e-18

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 85.84  E-value: 1.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   43 IICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQwaRGGEWVFGGPLCTIITSLDTCNQFACSA 122
Cdd:PHA02638 107 IIFILGLFGNAAIIMILFCKKIKTITDIYIFNLAISDLIFVIDFPFIIYN--EFDQWIFGDFMCKVISASYYIGFFSNMF 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  123 IMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVW--------VYSKvikfKDGVES-----CAFDLT 189
Cdd:PHA02638 185 LITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYfifeasniIFSA----QDSNETisnyqCTLIED 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  190 SPDDVLWY-----TLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVpkqrVMKLTKMVLVLVVVFILSA 264
Cdd:PHA02638 261 NEKNNISFlgrilQFEINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSI----IIICSLICWIPLNIVILFA 336
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 93277083  265 APYHVIQLVNLQMEQPTLAFYVGY--YLSICLSYASSSINPFLYILLSGNFQKRLPQIQRR 323
Cdd:PHA02638 337 TMYSFKGFNSIISEHICGFIKLGYamMLAEAISLTHCCINPLIYTLIGENFRMHLLMIFRN 397
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
41-315 1.86e-18

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 83.63  E-value: 1.86e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIhQWARGGEWVFGGPLCTIITSLDTCNQF 118
Cdd:cd15050   7 LSTISLITVILNLLVLYAVRTERKlHTVGNLYIVSLSVADLiVGAVVMPLNI-VYLLESKWILGRPVCLFWLSMDYVAST 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVW---VYSKVIKFKDGVESCAFDLTspdDVL 195
Cdd:cd15050  86 ASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILgwhHFARGGERVVLEDKCETDFH---DVT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLYLTITTFFFPLPLILVCYILILcytwemyqqnkdarccnPSVPKQRvmKLTKMVLVLVVVFILSAAPYHVIQLVnl 275
Cdd:cd15050 163 WFKVLTAILNFYIPSLLMLWFYAKIF-----------------KAVNRER--KAAKQLGFIMAAFILCWIPYFILFMV-- 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 93277083 276 QMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15050 222 IAFCKNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKK 261
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
43-317 2.09e-18

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 83.96  E-value: 2.09e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRKKTVP--DIYICNLAVADL-VHIVGMPfLIHQWARGGEWVFGGPLCTIITSLDTCNQFA 119
Cdd:cd15383   9 VLFVLSACSNLAVLWSATRNRRRKLShvRILILHLAAADLlVTFVVMP-LDAAWNVTVQWYAGDLACRLLMFLKLFAMYS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 120 CSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIrinLGL-WAASFILALPVWVYSKVIKFKDGVE--SCAFDLTSPDDvlW 196
Cdd:cd15383  88 SAFVTVVISLDRHAAILNPLAIGSARRRNRIM---LCAaWGLSALLALPQLFLFHTVTATPPVNftQCATHGSFPAH--W 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 197 ----YTLYLTITTFFFPLPLILVCYILILcytWEMYQQNK----------DARCCNPSVPKQRvMKLTKMVLVLVVVFIL 262
Cdd:cd15383 163 qetlYNMFTFFCLFLLPLLIMIFCYTRIL---LEISRRMKekkdsaknevALRSSSDNIPKAR-MRTLKMTIVIVSSFIV 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 263 SAAPYHVIQL---VNLQMEQPTLAFYVGYYLSIcLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15383 239 CWTPYYLLGLwywFSPEMLEQTVPESLSHILFL-FGLLNACLDPLIYGLFTISFRRGL 295
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
36-222 2.16e-18

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 83.18  E-value: 2.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLD 113
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVAtTRRLRTITNCYIVSLATADlLVGVLVLPLAIIRQLLG-YWPLGSHLCDFWISLD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TcnqFACSAI---MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKViKFKDGVESCAFDLTS 190
Cdd:cd15061  80 V---LLCTASilnLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSW-HGRRGLGSCYYTYDK 155
                       170       180       190
                ....*....|....*....|....*....|..
gi 93277083 191 PddvlwYTLYLTITTFFFPLPLILVCYILILC 222
Cdd:cd15061 156 G-----YRIYSSMGSFFLPLLLMLFVYLRIFR 182
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
34-317 2.37e-18

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 83.64  E-value: 2.37e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  34 TVILPsMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVG-MPFLIHQWARGGEWVFGGPLCTIITS 111
Cdd:cd15394   1 PLIIP-LYSLVVLVGVVGNYLLIYVICRTKKmHNVTNFLIGNLAFSDMLMCATcVPLTLAYAFEPRGWVFGRFMCYFVFL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTCNQFACSAIMTVMSVDRYFALVQPF--RLTRWRTRYktirINLGLWAASFILALPVWVYSKVIKFKD-GVESCA-FD 187
Cdd:cd15394  80 MQPVTVYVSVFTLTAIAVDRYYVTVYPLrrRISRRTCAY----IVAAIWLLSCGLALPAAAHTYYVEFKGlDFSICEeFW 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWE------MYQQNKDARccnpsvpKQRVMKLTKMVLVLVVVFI 261
Cdd:cd15394 156 FGQEKQRLAYACSTLLITYVLPLLAISLSYLRISVKLRNrvvpgsMTQSQAEWD-------RARRRKTFRLLVVVVVAFA 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 262 LSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSS--INPFLYILLSGNFQKRL 317
Cdd:cd15394 229 ICWLPLHIFNVIRDIDIDLIDKQYFNLIQLLCHWLAMSSacYNPFLYAWLHDSFRGEL 286
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
35-318 2.61e-18

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 83.09  E-value: 2.61e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGgEWVFGGPLCTIITSL 112
Cdd:cd15329   1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKlRTPSNYLIVSLAVSDLlVALLVMPLAIIYELSG-YWPFGEILCDVWISF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNqfaCSA-IMT--VMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPvwvysKVIKFKDGVESCAFDLT 189
Cdd:cd15329  80 DVLL---CTAsILNlcAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIP-----PLFGWKNKVNDPGVCQV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDdvLWYTLYLTITTFFFPLPLILVCYililcytWEMYQQNKdarccnpsvpkqRVMKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15329 152 SQD--FGYQIYATFGAFYIPLIVMLVLY-------YKIYRAAK------------SERKAIKTLGIIMGAFTLCWLPFFI 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 270 IQLVNLQMeQPTLAFYVGYYLSIC---LSYASSSINPFLYILLSGNFqkRLP 318
Cdd:cd15329 211 LALLRPFL-KPIKCSCIPLWLSRLflwLGYANSFLNPIIYAKFNREF--RTP 259
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
60-310 2.80e-18

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 83.29  E-value: 2.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  60 IRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPF 139
Cdd:cd15365  27 LQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPL 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 140 RLTRWRTRYKTIRINLGLWaasfilALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYIL 219
Cdd:cd15365 107 KFMHLRTIRTALSVSVAIW------LLEICFNAVILTWEDSFHESSSHTLCYDKFPLEDWQARLNLFRICLGYLLPLLII 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 220 ILCYtWEMYQqnkdARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASS 299
Cdd:cd15365 181 LFCY-WKIYQ----AVRSNQATEDQEKKKIFKLLLLITVTFVICFTPYHVVLLIRSIVEPCDCRNAKWLYTLYKITVALT 255
                       250
                ....*....|....*
gi 93277083 300 SIN----PFLYILLS 310
Cdd:cd15365 256 SLNciadPFLYCFVT 270
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
42-317 3.41e-18

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 83.16  E-value: 3.41e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  42 GIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCNQFA 119
Cdd:cd15389   8 SIIIVISLFGNSLVCHVIFKNKRmHTATNLFIVNLAVSDiLITLLNTPFTLVRFVNS-TWVFGKIMCHLSRFAQYCSVYV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 120 CSAIMTVMSVDRYFALVQPFRlTRWRTRYKTIRINLgLWAASFILALPVWVYSKVIKFKDGVES----CAFDLTSPDDVL 195
Cdd:cd15389  87 STLTLTAIALDRHRVILHPLK-PRITPCQGVVVIAI-IWIMASCLSLPHAIYQKLVEFEYSNERtrsrCLPSFPEPSDLF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WytLYLTITTF----FFPLPLILVCYILILCYTWemYQQNKDARCCNPSVPKQRVMKLT-KMVLVLVVVFILSAAP---Y 267
Cdd:cd15389 165 W--KYLDLATFilqyVLPLLIIGVAYTRVAKKLW--LRNAIGDVTTEQYVAQRRKKKKTiKMLMLVVLLFAICWLPlncY 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 268 HViqLVNLQMEQP-TLAFYVGYYLSIclsyASSSINPFLYILLSGNFQKRL 317
Cdd:cd15389 241 HV--LLSSHPIRSnSALFFAFHWLAM----SSTCYNPFIYCWLNDSFRSEL 285
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
49-310 4.21e-18

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 83.24  E-value: 4.21e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTI-IRSRKKTVPDIYICNLAVADL-VHIVG-MPFLIHQWArgGEWVFGGPLCTIITSLDTCNQFACSAIMT 125
Cdd:cd15197  15 VVGNSSVLFALwMRKAKKSRMNFFITQLAIADLcVGLINvLTDIIWRIT--VEWRAGDFACKVIRYLQVVVTYASTYVLV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VMSVDRYFALVQPFRLTRWRTRYKTIRInlGLWAASFILALPVWVYSKVIKFKDGVESCAFDLtsPDDVLWyTLYLTITT 205
Cdd:cd15197  93 ALSIDRYDAICHPMNFSQSGRQARVLIC--VAWILSALFSIPMLIIFEKTGLSNGEVQCWILW--PEPWYW-KVYMTIVA 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 206 ---FFFPLPLILVCYILILCYTW---EMYQQNKDARCCNPS---------VPKQRVmKLTKMVLVLVVVFILSAAPYHV- 269
Cdd:cd15197 168 flvFFIPATIISICYIIIVRTIWkksKIQVTINKAGLHDGSsrrsssrgiIPRAKI-KTIKMTFVIVTVFIICWSPYFVf 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 93277083 270 --IQLVNLQMEQPTLAFYVGYYLSicLSYASSSINPFLYILLS 310
Cdd:cd15197 247 dlLDVFGLLPRSKTKIAAATFIQS--LAPLNSAINPLIYCLFS 287
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
35-313 4.73e-18

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 82.79  E-value: 4.73e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIV-GMPFLIHQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15392   1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRmRTVTNYFIVNLALSDILMAVfCVPFSFIALLILQYWPFGEFMCPVVNYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLtRWRTRYKTIRInLGLWAASFILALPVWVYSKVIK---FKDGVESCAFDLT 189
Cdd:cd15392  81 QAVSVFVSAFTLVAISIDRYVAIMWPLRP-RMTKRQALLLI-AVIWIFALATALPIAITSRLFEdsnASCGQYICTESWP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWE-----MYQQNKDARCcnpsvpKQRVMKLTKMVLVLVVVFILSA 264
Cdd:cd15392 159 SDTNRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAkrtpgEAENNRDQRM------AESKRKLVKMMITVVAIFALCW 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 265 APYHVIQLVNLQMEQPTLAFYVGYYLSIC--LSYASSSINPFLYILLSGNF 313
Cdd:cd15392 233 LPLNILNLVGDHDESIYSWPYIPYLWLAAhwLAMSHCCYNPFIYCWMNAKF 283
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
43-317 7.62e-18

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 82.10  E-value: 7.62e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd15158   9 VITVFGLVGNGFALYVLIKTYRQKSAfHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVNLYCSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPvWVYSKVIKFKDGVESCaFDLTSPDDVLWYTLYL 201
Cdd:cd15158  89 YFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSP-FLMSGSHDTETNKTKC-FEPPQSNQQLTKLLVL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 202 TITTFFF----PLPLILVCYILILcytWEMYQQNKDARccnpsvpKQRVM--KLTKMVLVLVVVFILSAAPYHVIQLVNL 275
Cdd:cd15158 167 NYISLVVgfiiPFLVILICYAMII---RTLLKNTMKAR-------KQQSSrkKAIRMIIIVLLAFLVSFMPYHIQRTIHL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 276 QMEQP-------TLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15158 237 HFLSRkdstceeVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
36-315 1.01e-17

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 82.05  E-value: 1.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPF-LIHQWARggEWVFGGPLCTIITSL 112
Cdd:cd15208   2 VLIALYILVFIVGLVGNVLVCFAVWRNHHmRTVTNYFIVNLSLADfLVIIICLPAtLLVDVTE--TWFFGQVLCKIIPYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQP--FRLTRWRTRyktiRINLGLWAASFILALPVWVYSKVIKFKdgVESCAFDLTS 190
Cdd:cd15208  80 QTVSVSVSVLTLSCIALDRWYAICHPlmFKSTAKRAR----VSILIIWIVSLLIMIPQAIVMECSRVV--PLANKTILLT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVLW--------YTLYLTITTFFFPLPLILVCYILILCYTWEMyQQNKDARCCNPSVPKQRVM-------------KL 249
Cdd:cd15208 154 VCDERWsdsiyqkvYHICFFLVTYLLPLCLMILAYFQIFRKLWCR-QIPGTSSVVQRKWNKPRKSavaaeekqlrsrrKT 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 93277083 250 TKMVLVLVVVFILSAAPYHVIQL---VNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15208 233 AKMLIVVVIMFAICYLPVHLLNIlryVFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFRE 301
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
36-315 1.32e-17

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 81.92  E-value: 1.32e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIV-FTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15125   2 VIPSLYLLIITVGLLGNITLVkIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDgVESCAFDLTSP--- 191
Cdd:cd15125  82 TSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMP-DDNTTFTACIPypq 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 -DDVLWYTLYLTITTFFFPLPL-ILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMK-LTKMVLVLVVVFILSAAPYH 268
Cdd:cd15125 161 tDEMHPKIHSVLIFLVYFLIPLaIISIYYYHIAKTLIKSAHNIPGEYSEHSKRQMETRKrLAKIVLVFVGLFAFCWFPNH 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 269 VIQL---VNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15125 241 VLYMyrsFNYNEIDSSLGHMIVTLVARVLSFCNSCVNPFALYLLSESFRR 290
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
35-314 2.07e-17

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 81.01  E-value: 2.07e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIhQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15202   1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRmRTVTNYFIVNLAVADiMITLFNTPFTF-VRAVNNTWIFGLFMCHFSNFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRlTRWRTRYKTIRInLGLWAASFILALPVWVYSKVIKFKDGVES----CAFDL 188
Cdd:cd15202  80 QYCSVHVSAYTLTAIAVDRYQAIMHPLK-PRISKTKAKFII-AVIWTLALAFALPHAICSKLETFKYSEDIvrslCLEDW 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 189 TSPDDVLW--YTLYLTITTFFFPLPLILVCYILILCYTWEM-----YQQNKDARccnpSVPKQRvmKLTKMVLVLVVVFI 261
Cdd:cd15202 158 PERADLFWkyYDLALFILQYFLPLLVISFAYARVGIKLWASnmpgdATTERYFA----LRRKKK--KVIKMLMVVVVLFA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 262 LSAAPYHVIQLVNLQMEQPTLAFYVGYYLSI-CLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15202 232 LCWLPFNIYVLLLSSKPDYLIKTINAVYFAFhWLAMSSTCYNPFIYCWLNERFR 285
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
35-315 2.16e-17

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 80.47  E-value: 2.16e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIgiicstgLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15053   8 LLLPLLT-------VFGNVLVIMSVFRERSlQTATNYFIVSLAVADLlVAILVMPFAVYVEVNGGKWYLGPILCDIYIAM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDgVESCAFdlTSPD 192
Cdd:cd15053  81 DVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRD-PEECRF--YNPD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 dvlwYTLYLTITTFFFPLPLILVCYILILcytwemyqqnkdarccnpsVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15053 158 ----FIIYSSISSFYIPCIVMLLLYYRIF-------------------RALRREKKATKTLAIVLGVFLFCWLPFFTLNI 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 273 VN-----LQMEQPTLAFYVgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15053 215 LNaicpkLQNQSCHVGPAL-FSLTTWLGYVNSFLNPIIYTIFNIEFRK 261
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
42-314 2.75e-17

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 80.80  E-value: 2.75e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  42 GIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMP-FLIHQWARGgEWVFGGPLCTIITSLDtcNQF 118
Cdd:cd14997   8 GVIFVVGVLGNVLVGIVVWKNKDmRTPTNIFLVNLSVADlLVLLVCMPvALVETWARE-PWLLGEFMCKLVPFVE--LTV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVM--SVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYS--KVIKFKDG--VESCafdlTSPD 192
Cdd:cd14997  85 AHASVLTILaiSFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITefKEEDFNDGtpVAVC----RTPA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLY-LTITTFFFPLPLIL--VCYILIlCYTWEMYQQNKDARCCNPSVPKQRVMK-LTKMVLVLVVVFILSAAPYH 268
Cdd:cd14997 161 DTFWKVAYiLSTIVVFFVVPLAIlsGLYSVI-CRRLVGHPALESRRADAANRHTLRSRRqVVYMLITVVVLFFVCLLPFR 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 269 VIQLVNLQMEQPTLAFY--VGYY--LSIC--LSYASSSINPFLYILLSGNFQ 314
Cdd:cd14997 240 VVTLWIIFAPDEDLQALglEGYLnlLVFCrvMVYLNSALNPILYNLMSTKFR 291
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
43-317 2.88e-17

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 80.59  E-value: 2.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFT-IIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd14988   9 VIFVVGLVENVLVIWVnWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFANMYSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPFRLtrWRTRYKTIR--INLGLWAASFILALPVWVYSKVIkfkDGVES-CAF--DLTSPDD-VL 195
Cdd:cd14988  89 FFLTCLSVDRYLTLTSSSPF--WQQHQHRIRraLCAGIWVLSAIIPLPEVVHMQLL---DGVEPmCLFlaPFETYDEwAL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCnpsvpkqrvmkltkMVLVLVVVFILSAAPYHVIQLVNL 275
Cdd:cd14988 164 AVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRHCL--------------LIYAYILVFVVCWLPYHVTLLLLT 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 276 QMEQPTL-------AFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14988 230 LHGSHISlhcnlvhFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
35-316 6.38e-17

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 79.53  E-value: 6.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15379   1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQAlSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPfrLTRW---RTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDgvESCAFDLTS 190
Cdd:cd15379  81 YTNLHGSILFLTCISVQRYLGICHP--LASWhkkKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRN--RTVCYDLSP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PD---DVLWYTLYLTITTFFFPLPLILVCYILILCYTWEmyqqnKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPY 267
Cdd:cd15379 157 PArstAYFPYGITLTRTGFLLPFAARLACYCSMATILCR-----VVIAVAVVAAPGEKRGKAARMIIVVAAVFLISFLPF 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 268 HVIQLVNLQ------MEQPTL-AFYVGYYLSICLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15379 232 HYTKTRYLQvrswdgGPCTTRqAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPR 287
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
37-317 6.51e-17

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 79.46  E-value: 6.51e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWArgGEWVFGGPLCTIITSLDTC 115
Cdd:cd15187   3 LPVLYCLLFVFGLLGNSLVIWVLVACKKlRSMTDVYLLNLAASDLLFVFSLPFQAYYLL--DQWVFGNAMCKIVSGAYYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfKDGVESCaFDLTSPDDVL 195
Cdd:cd15187  81 GFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVAS-EDGRLQC-IPFYPGQGNS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLY---LTITTFFFPLPLILVCYILILCYTWEMYQQNKdarccnpsvpkqrvMKLTKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15187 159 WKVFTnfeVNILGLLIPFSILIFCYHNILRNLRRCHNQNK--------------TKAIKLVFIVVIVFFLFWTPFNVVLF 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 273 VN-------LQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15187 225 LDslhslhiIDGCQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
41-317 6.62e-17

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 79.20  E-value: 6.62e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADLvhIVGMPFLIHQWARGGEWVFGGP--LCTIITSLDTCNQ 117
Cdd:cd15196   7 LATILVLALFGNSCVLLVLYRRRRKLSRmHLFILHLSVADL--LVALFNVLPQLIWDITYRFYGGdlLCRLVKYLQVVGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRInLGLWAASFILALP-VWVYSKVIKFkDGVESCAFDLTSPDDVLW 196
Cdd:cd15196  85 YASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMV-AIAWVLSLLLSIPqLFIFSYQEVG-SGVYDCWATFEPPWGLRA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 197 YTLYLTITTFFFPLPLILVCYILILCYTWemyqqnkdarccnpsvpkQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQ 276
Cdd:cd15196 163 YITWFTVAVFVVPLIILAFCYGRICYVVW------------------RAKIKTVKLTLVVVACYIVCWTPFFVVQMWAAW 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 93277083 277 MEQptlAFYVGYYLSICLSYAS--SSINPFLYILLSGNFQKRL 317
Cdd:cd15196 225 DPT---APIEGPAFVIIMLLASlnSCTNPWIYLAFSGNLRRAL 264
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
36-317 6.67e-17

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 79.80  E-value: 6.67e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGN--ILIVFTIIR-SRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15147   2 LFPIVYSIIFVLGLIANcyVLWVFARLYpSKKLNEIKIFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGCL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCA--FDLTS 190
Cdd:cd15147  82 FFINTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTNTVKIDSGNFTrcFEGYE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDD--VLWYTLYLTITTFFFPLPLILVCYILILCYTweMYQQNKDARccnPSVPKQRVMkltKMVLVLVVVFILSAAPYH 268
Cdd:cd15147 162 KDNskPVLIIHFIIIGLFFLVFLLILVCNLVIARTL--LSQPVQGQR---NAGVKRRAL---WMVCTVLAVFVICFVPHH 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 269 VIQ----LVNLQMEQPTL-----AFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15147 234 VVQgpwtLAVLQQWRYWDcqfrqALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRKHL 291
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
43-315 1.12e-16

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 79.05  E-value: 1.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSR-KKTVPDIYICNLAVADL-VHIVGMPFLIHQwARGGEWVFGGPLCTIITSLDTCNQFAC 120
Cdd:cd15205   9 LIFVLALFGNSLVIYVVTRKRaMRTATNIFICSLALSDLlITFFCIPFTLLQ-NISSNWLGGAFMCKMVPFVQSTAVVTS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVW-VYSKVIKFKDGVES----CAFDLTSPDDVL 195
Cdd:cd15205  88 ILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLfVQQLEVKYDFLYEKrhvcCLERWYSPTQQK 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLYLTITTFFFPLPLILVCYILILCYTW--------EMYQQNKDARCCNPSVPKQRVMkltKMVLVLVVVFILSAAPY 267
Cdd:cd15205 168 IYTTFILVILFLLPLTTMLFLYSRIGYELWikkrvgdaSVLQTIHGIEMSKISRKKKRAV---KMMVTVVLLFAVCWAPF 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 268 HVIQLV----NLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15205 245 HVVHMMieysNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKK 296
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
36-310 1.16e-16

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 78.68  E-value: 1.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTC 115
Cdd:cd15371   2 LIPAVYIIVVVLGVPSNAIILWMLFFRLRSVCTAIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFYG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD-GVESCAFDLTSPDDV 194
Cdd:cd15371  82 NMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYYLKElNITTCHDVLPECEQN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 ----LWYTLYLTITTFFFPLPLILVCYILILcytwemyqqnkdaRCCNPSvpKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15371 162 snfqFYYFISMAVFGFLIPLVITIFCYISII-------------RTLNAY--EHKWFWYVKITALVLIIFTICFAPSNVI 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 93277083 271 QLVNL--QMEQPTLAFYVGYYLSICLSYASSSINPFLYILLS 310
Cdd:cd15371 227 LIIHHfnYYYFNNDNLYSIYLIALCLGSLNSCLDPFLYFLMS 268
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
37-317 1.96e-16

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 78.22  E-value: 1.96e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTC 115
Cdd:cd15378   3 LPTMYSIEFVLGFIGNTIVILGYIFCLKNwKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNG-QWLFGDFLCKSNRYLLHA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKViKFKDGVESCAFDLTSPDDV- 194
Cdd:cd15378  82 NLYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGP-NLKDNVTKCKDYASSGDATn 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 -LWYTLYLTITTFFFPLplilvCYILILCYTWEMYQQNKDARCCNpSVPKQRVMKLTKMvlvLVVVFILSAAPYHVIQLV 273
Cdd:cd15378 161 sLIYSLFLTVTGFLIPL-----CVMCFFYYKIALFLKNRNRQLAN-ATSFEKPLTLVIL---AVVIFSVLFTPYHVMRNV 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 274 NLQMEQPTLAFY--------VGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15378 232 RIASRLDSIGVSectliiikSLYIVTRPIAFLNSVINPVFYFLMGDHFREML 283
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
35-317 2.49e-16

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 77.87  E-value: 2.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15924   1 QLFPVLYTVIFFAGILLNGLAMWIFFHIPSKSSFIIYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFdLTSPDDV 194
Cdd:cd15924  81 FTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVKKCSF-LKSELGL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTL--YLTITTFFFPLPLILVCYILILCYTWEMYQQNKDarccNPSVPKQRVmklTKMVLVLVVVFILSAAPYHVI-- 270
Cdd:cd15924 160 KWHEIvnYICQVIFWIVFLLMIVCYTAITKKVYRSYRRVFR----SSSSRRKKS---NVKIFIIVAVFFVCFVPYHFAri 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 271 -----QLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15924 233 pytlsQTRDVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
35-313 2.80e-16

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 77.43  E-value: 2.80e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIV--GMPFLIHQWARGGEWVFGGPLCTIITS 111
Cdd:cd14995   1 VVATFLVLLICGVGIVGNIMVVLVVLRTRHmRTPTNCYLVSLAVADLMVLVaaGLPNEIESLLGPDSWIYGYAGCLLITY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPvW----VYSKVIKFKDGVESCAFD 187
Cdd:cd14995  81 LQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSP-WlfllDLSIKHYGDDIVVRCGYK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LtspDDVLWYTLYLTITTFFFPLPLILVC--YILILCYTWEMYQQnkdarccnpsvpkqrvmkLTKMVLVLVVVFILSAA 265
Cdd:cd14995 160 V---SRHYYLPIYLADFVLFYVIPLLLAIvlYGLIGRILFSSRKQ------------------VTKMLAVVVVLFALLWM 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 266 PYHVIQLVNLQMEQPTLAFYVGYYLSICLsYASSSINPFLYILLSGNF 313
Cdd:cd14995 219 PYRTLVVYNSFASPPYLDLWFLLFCRTCI-YLNSAINPILYNLMSQKF 265
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
40-216 3.92e-16

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 77.88  E-value: 3.92e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQF 118
Cdd:cd15058   6 LLALIILAIVVGNLLVIIAIARTSRlQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVMSVDRYFALVQPFR----LTRWRTRY------------KTIRINLGLWAASFILALPVWVYSkvikfkdgvE 182
Cdd:cd15058  86 ASIETLCVIAVDRYIAITRPLRyqvlLTKRRARVivcvvwivsalvSFVPIMNQWWRANDPEANDCYQDP---------T 156
                       170       180       190
                ....*....|....*....|....*....|....
gi 93277083 183 SCAFDLTSPddvlwYTLYLTITTFFFPLpLILVC 216
Cdd:cd15058 157 CCDFRTNMA-----YAIASSVVSFYIPL-LIMIF 184
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
35-315 3.93e-16

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 77.73  E-value: 3.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIhQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15048   1 IVLAVLISVLILVTVIGNLLVILAFIKDKKlRTVSNFFLLNLAVADFlVGLVSMPFYI-PYTLTGKWPFGKVFCKAWLVV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCnqfACSA-IMTVM--SVDRYFALVQPfrlTRWRTRyKTIRINLGLWAASFILALpvWVYSKVIKFKDGVESCAFDLT 189
Cdd:cd15048  80 DYT---LCTAsALTIVliSLDRYLSVTKA---VKYRAK-QTKRRTVLLMALVWILAF--LLYGPAIIGWDLWTGYSIVPT 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDV-LWYTLYLTITT----FFFPLPLILVCYILILCYTWEMYQ-------QNKDARCCNPSVPKQ-------RVMKLT 250
Cdd:cd15048 151 GDCEVeFFDHFYFTFITsvleFFIPFISVSFFNLLIYLNIRKRSRrrplrsvPILPASQNPSRARSQreqvklrRDRKAA 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 251 KMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15048 231 KSLAILVLVFLICWAPYTILTIIRSFCSGSCVDSYL-YEFTFWLLWTNSAINPFLYAACHPRFRK 294
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
37-315 5.02e-16

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 76.90  E-value: 5.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDT 114
Cdd:cd15323   3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPqNLFLVSLASADiLVATLVMPFSLANELMG-YWYFGQVWCNIYLALDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CnqFACSAI--MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPvwvysKVIKFKDGVESCAFDLTSPD 192
Cdd:cd15323  82 L--FCTSSIvhLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFP-----PLISMYRDPEGDVYPQCKLN 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLTITTFFFPlplilvCYILILCYTwEMYQqnkdarccnpsVPKQRVMKLTKMVLVLVVVFILSAAP----YH 268
Cdd:cd15323 155 DETWYILSSCIGSFFAP------CLIMILVYI-RIYR-----------VAKAREKRFTFVLAVVMGVFVVCWFPfffsYS 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 269 VIQLVNLQMEQPTLAFYVGYYLSIClsyaSSSINPFLYILLSGNFQK 315
Cdd:cd15323 217 LYGICREACEVPEPLFKFFFWIGYC----NSSLNPVIYTIFNQDFRR 259
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
35-274 5.64e-16

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 76.71  E-value: 5.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgeWVFGGPLCTIITSLD 113
Cdd:cd15181   1 VFIPLAYSLVFLLGVVGNGLVLTILLRRRRsRRTTENYLLHLALADLLLLLTFPFSVVESIAG--WVFGTFLCKLVGAIH 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRtRYKTIRIN-LGLWAASFILALPVWVYSKVIKFKDG-VESCAF--DLT 189
Cdd:cd15181  79 KLNFYCSSLLLACISVDRYLAIVHAIHSYRHR-RLRSVHLTcGSIWLVCFLLSLPNLVFLEVETSTNAnRTSCSFhqYGI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDVLWYTLYLTITTFFFpLPLILVCYililCYTWEMYQQNKDARccnpSVPKQRVMKLTkmvLVLVVVFILSAAPYHV 269
Cdd:cd15181 158 HESNWWLTSRFLYHVVGFF-LPLLIMGY----CYATIVVTLCQSSR----RLQKQKAIRVA---ILVTLVFCLCWLPYNI 225

                ....*
gi 93277083 270 IQLVN 274
Cdd:cd15181 226 VIFLD 230
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
36-315 5.69e-16

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 77.01  E-value: 5.69e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPD-IYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15201   2 VLPPVLILEFVLGLLGNGLALWIFCFHLKSWKSStVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAasFILALPVWVYSKVIKFKDG----VESCAFDLTS 190
Cdd:cd15201  82 MNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWL--LTIAMTVYLLTKKHLFPRGnatqCESFNICTGT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVLWYTlYLTITTFFFPLPLILVCyilILCYTWEMYQQNKDArccnpsvpKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15201 160 DSSSNWHE-AMFLLEFFLPLAIILYC---SVRIIWQLRGRQLDR--------HAKIKRAVQFIMVVAIVFIICFLPSNVT 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 271 QLVNL-----------QMEQPTLAFYVgyylSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15201 228 RIAIWilkhtsnedcqYYRSVDLAFYI----TISFTYFNSMLDPVVYYFSSPSFKN 279
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
41-317 6.06e-16

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 76.98  E-value: 6.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVH--IVGMPFLIHQwARGGEWVFGGPLCTIITSLDTCNQ 117
Cdd:cd15337   7 IAIVGILGVIGNLLVIYLFSKTKSlRTPSNMFIINLAISDFGFsaVNGFPLKTIS-SFNKKWIWGKVACELYGFAGGIFG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILAL-PVWVYSKVIkfKDGVE-SCAFDLTSPD-DV 194
Cdd:cd15337  86 FMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIpPFFGWGRYV--PEGFQtSCTFDYLSRDlNN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFFPLPLILVCYILILcytWEMYQQNKDARCCNPSVP----------KQRVMKLTKMVLVLVVVFILSA 264
Cdd:cd15337 164 RLFILGLFIFGFLCPLLIIIFCYVNII---RAVRNHEKEMTQTAKSGMgkdtekndarKKAEIRIAKVAIILISLFLLSW 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 265 APYHVIQLvnlqMEQPTLAFYVGYYLS---ICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15337 241 TPYAVVAL----LGQFGPAYWITPYVSelpVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
40-317 6.61e-16

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 76.74  E-value: 6.61e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADLVhiVGMPFLIHQWARGGEWVFGGP--LCTIITSLDTCN 116
Cdd:cd15388   6 VLAIIFACALLSNSLVLLVLWRRRKQLARmHVFMLHLCIADLV--VAFFQVLPQLVWDITDRFRGPdvLCRLVKYLQVVG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 117 QFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGlWAASFILALP-VWVYSKViKFKDGVESCAFDLTSPDDVL 195
Cdd:cd15388  84 MFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVA-WAISLILSLPqVFIFSKV-EVAPGVYECWACFIEPWGLK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLYLTITTFFFPLPLILVCYILIlCYTWEMYQQNKDARCCNPSVPKQR--------------VMKLTKMVLVLVVVFI 261
Cdd:cd15388 162 AYVTWITLVVFVLPTLIITVCQVLI-FKEIHINIYLKSQIIVAVVKKKQLlssrassvaevskaMIKTVKMTLVIVLVYV 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 93277083 262 LSAAPYHVIQLVNL-QMEQPTLAfyVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15388 241 LCWAPFFLVQLWSVwDPKAPTEG--ATFTILMLLASLNSCTNPWIYMAFSSSVSKEL 295
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
35-272 6.77e-16

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 76.71  E-value: 6.77e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgeWVFGGPLCTIITSLD 113
Cdd:cd15176   1 LFLPVFYTIALVVGLAGNSLVVAIYAYYKKlKTKTDVYILNLAVADLLLLFTLPFWAADAVNG--WVLGTAMCKITSALY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPfrLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAF---DLTS 190
Cdd:cd15176  79 TMNFSCGMQFLACISVDRYVAITKA--TSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVfppSLVT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVLWYTLYLTItTFFFPLPLILVCYililcytWEMYQQNKDArccnPSVPKQRVMKLtkmVLVLVVVFILSAAPYHVI 270
Cdd:cd15176 157 SAKATIQILEVLL-GFVLPFLVMVFCY-------SRVARALSRT----PNVKKSRALKV---LLAVVGVFIVTQLPYNVV 221

                ..
gi 93277083 271 QL 272
Cdd:cd15176 222 KF 223
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-314 8.66e-16

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 76.80  E-value: 8.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC 120
Cdd:cd15133   9 LIFVVGVVGNVLTCLVIARHKAmRTPTNYYLFSLAVSDLlVLLLGMPLELYELWQNYPFLLGSGGCYFKTFLFETVCLAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFdLTSPDDVLWYTLY 200
Cdd:cd15133  89 ILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGVPASAQ-CTVRKPQAIYNMI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 201 LTITTF-FFPLPLILVCYILILCYTWEMYQQNKDARC---------CNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15133 168 PQHTGHlFFVLPMAVISVLYLLMALRLARERGLDATGagskigtrtGQLLQHPRTRAQVTKMLFILVVVFAICWAPFHID 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 271 QLVNLQMEQPT----LAFYVGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15133 248 RLMWSFISDWTdnlhEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFR 295
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
35-317 1.14e-15

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 75.98  E-value: 1.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15969   1 IVFPVLYLIIFIGSILLNGLAVWIFFHIRNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVLFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFdLTSPDDV 194
Cdd:cd15969  81 ASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTEDNIHDCSK-LKSPLGV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTL--YLTITTFFFPLPLILVCYILILCYtweMYQQNKDARCC--NPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15969 160 KWHTAvsYINICIFVAVLVILIVCYISISRY---IYKSSKQFISSssRTRKHNQSIRVVVAVFFVCFLPYHLCRIPFTFS 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 271 QLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15969 237 QLDKILDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSFSQRL 283
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
36-317 1.49e-15

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 75.68  E-value: 1.49e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIhQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15183   2 LLPPLYSLVFIIGVVGNVLVVLVLIQHKRlRNMTSIYLFNLAISDLVFLFTLPFWI-DYKLKDDWIFGDAMCKFLSGFYY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKViKFKDGVESCAFDLTSPDDV 194
Cdd:cd15183  81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKS-QWEFTHHTCSAHFPRKSLI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLY-LTITTFFFPLPLIlvcyILILCYTWEMYQQNKDarccnpsvPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLV 273
Cdd:cd15183 160 RWKRFQaLKLNLLGLILPLL----VMIICYTGIINILLRR--------PNEKKAKAVRLIFVITLLFFLLWTPYNLAAFV 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 274 N-----------LQMEQPTLAFYVgyylSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15183 228 SafqdvlftpscEQSQQLDLALQV----TEVIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
43-317 1.84e-15

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 75.39  E-value: 1.84e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADL-VHIVGMPFLIHQwARGGEWVFGGPLCTIITSldTCNQFAC 120
Cdd:cd15074   9 VIGILSTLGNGTVLFVLYRRRSKLKPaELLTVNLAVSDLgISVFGYPLAIIS-AFAHRWLFGDIGCVFYGF--CGFLFGC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAIMT--VMSVDRYFALVQPfRLTRWRTRYKTIRINLGLWA-ASFILALPVWVYSKVIKFKDGVeSCAFDLTSPDDVLW- 196
Cdd:cd15074  86 CSINTltAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLyALFWAVAPLVGWGSYGPEPFGT-SCSIDWTGASASVGg 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 197 --YTLYLTITTFFFPLPLILVCYILILcytWEMyqQNKDARCCNPSVPKQRV----MKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15074 164 msYIISIFIFCYLLPVLIIVFSYVKII---RKV--KSSRKRVAGFDSRSKRQhkieRKVTKVAVLICAGFLIAWTPYAVV 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 271 QL---VNLQMEQPTLAFYVGyylsiCLSYASSSI-NPFLYILLSGNFQKRL 317
Cdd:cd15074 239 SMwsaFGSPDSVPILASILP-----ALFAKSSCMyNPIIYLLFSSKFRQDL 284
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
36-317 1.91e-15

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 75.25  E-value: 1.91e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHqWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15185   2 FLPPLYSLVFIVGLLGNVVVVVILIKYRRlRIMTNIYLLNLAISDLLFLFTLPFWIH-YVRWNNWVFGHGMCKLLSGFYY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfKDGVESCAFDLTSPDDV 194
Cdd:cd15185  81 LGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQE-LFEEFLCSPLYPEDTED 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LW---YTLYLTITTFFFPLPLILVCYILILcytwemyqqNKDARCcnpsvPKQRVMKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15185 160 SWkrfHALRMNIFGLALPLLIMVICYTGII---------KTLLRC-----PSKKKYKAIRLIFVIMVVFFIFWTPYNLVL 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 93277083 272 LVNL-----------QMEQPTLAFYVgyylSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15185 226 LLSAfqsiffetdceRSKHLDLAMQV----TEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
42-314 2.22e-15

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 75.35  E-value: 2.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  42 GIICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC 120
Cdd:cd16003   8 GFVVAVAVFGNLIVIWIILaHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAIMTVMSVDRYFALVQPFRLtrwRTRYKTIRINLG-LWAASFILALPVWVYSKvIKFKDGVESCAFDLT-SPDDVLWYT 198
Cdd:cd16003  88 IYSMTAIAVDRYMAIIDPLKP---RLSATATKVVIGsIWILAFLLAFPQCLYSK-TKVMPGRTLCFVAWPgGPDQHFTYH 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 199 LYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRvmKLTKMVLVLVVVFILSAAPYHVIQLVNLQME 278
Cdd:cd16003 164 IIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYHEQLRAKR--KVVKMMIIVVLTFAICWLPYHIYFIVTGLYQ 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 93277083 279 QPTLAFYVG--YYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd16003 242 QLNRWKYIQqvYLASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
35-315 2.32e-15

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 74.69  E-value: 2.32e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIIcstglVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITSL 112
Cdd:cd15059   6 IVSVVILLII-----VGNVLVIVAVLTSRKlRAPQNWFLVSLAVADiLVGLLIMPFSLVNELMG-YWYFGSVWCEIWLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTcnqFACSA-IMTV--MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSK-VIKFKDGVESCAFdl 188
Cdd:cd15059  80 DV---LFCTAsIVNLcaISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKdEQPWHGAEPQCEL-- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 189 tspDDVLWYTLYLTITTFFFPLPLILVCYILILcytwemyqqnkdarccnpSVPKQRVMKLTKMVLVLVVVFILSAAPY- 267
Cdd:cd15059 155 ---SDDPGYVLFSSIGSFYIPLLIMIIVYARIY------------------RAAKRKERRFTLVLGVVMGAFVLCWLPFf 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 268 --HVIQLVNLQMEQPTLAFYVGYYLSIClsyaSSSINPFLYILLSGNFQK 315
Cdd:cd15059 214 ftYPLVVVCKTCGVPELLFKFFFWLGYC----NSALNPVIYTIFNKDFRR 259
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
35-317 3.17e-15

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 74.74  E-value: 3.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15161   1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPsNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWR-TRYKTIrINLGLWAASFILALPVWVYSKVIKFkDGVESCA---FDLT 189
Cdd:cd15161  81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIRkPLYAHV-VCGFLWVIVTVAMAPLLVSPQTVEV-NNTTVCLqlyREKA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPddvlwYTLYLTITTFFFPLPLILVCYILILcytWEMYQQNKDARccnpsVPKQRVMkltKMVLVLVVVFILSAAPYHV 269
Cdd:cd15161 159 SR-----GALVSLAVAFTIPFVTTVTCYLLII---RSLRTGKREEK-----PLKDKAI---KMIILVLTIFLICFVPYHI 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 270 IQLV-NLQMEQPTL------AFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15161 223 SRYIyILSHNGAGAscssrrGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
43-315 4.31e-15

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 74.81  E-value: 4.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVAD-LVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC 120
Cdd:cd15358   9 LIFVVGAVGNGLTCIVILRHKVMRTPtNYYLFSLAVSDlLVLLLGMPLELYEMWSNYPFLLGAGGCYFKTLLFETVCFAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALP-------VWVYSKVIKFKDGVESCAfdLTSPDD 193
Cdd:cd15358  89 ILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPntslhgiFQLTVPCRGPVPDSATCM--LVKPRW 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VlwYTLYLTITT---FFFPLPLILVCYILI-LCYTWEMYQQNKDARC---------CNPSVPKQRVMKLTKMVLVLVVVF 260
Cdd:cd15358 167 M--YNLIIQITTllfFFLPMGTISVLYLLIgLQLKREKMLLVLEAKGskagdsyqhRRIQQEKRRRRQVTKMLFVLVVVF 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 93277083 261 ILSAAPYHVIQLVNLQMEQPT----LAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15358 245 GICWAPFHTDRLMWSFISQWTgelhLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFRE 303
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
35-317 4.35e-15

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 74.45  E-value: 4.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPD-IYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15374   1 ILLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTtVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfKDGVESCaFDLTSPDD 193
Cdd:cd15374  81 YANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSR-KDNITLC-HDTTRPEE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLYLT-ITTFFFPLP--LILVCYILIlcyTWEMYQQNKDARCCNPSVPKQRVMKLTKMvlvLVVVFILSAAPYHVI 270
Cdd:cd15374 159 FDHYVHYSSaVMVLLFGIPclVIVVCYGLM---ARRLCKPRVGSSRQQGPSSKKRSLKTIIM---VLTVFAICFVPFHIT 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 93277083 271 QLVN-----LQMEQPTL-AFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15374 233 RTLYyvarlLKADCDTLnIINVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
39-310 5.03e-15

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 74.00  E-value: 5.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  39 SMIGIICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQ 117
Cdd:cd14964   3 IILSLLTCLGLLGNLLVLLSLVRLRKRpRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYGAN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIkfkdgVESCAFDLTSPDDVLWY 197
Cdd:cd14964  83 LASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAI-----PRYNTLTGSCYLICTTI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 198 TLYLTITTFFFPLPLILVCYILI-LCYTWEMYQQNKDARCCNPSVPKqrvMKLTKMVLVLVVVFILSAAPYHVIQLVNLQ 276
Cdd:cd14964 158 YLTWGFLLVSFLLPLVAFLVIFSrIVLRLRRRVRAIRSAASLNTDKN---LKATKSLLILVITFLLCWLPFSIVFILHAL 234
                       250       260       270
                ....*....|....*....|....*....|....
gi 93277083 277 MEQPTLAFYVgYYLSICLSYASSSINPFLYILLS 310
Cdd:cd14964 235 VAAGQGLNLL-SILANLLAVLASTLNPFIYCLGN 267
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
43-219 6.25e-15

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 73.50  E-value: 6.25e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTcnqFAC 120
Cdd:cd15052   9 LLVIATIGGNILVCLAISLEKRlQNVTNYFLMSLAIADlLVGLLVMPLSILTELFGGVWPLPLVLCLLWVTLDV---LFC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAI---MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYS---KVIKFKDGveSCAfdLTSPDdv 194
Cdd:cd15052  86 TASimhLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGiidTTNVLNNG--TCV--LFNPN-- 159
                       170       180
                ....*....|....*....|....*
gi 93277083 195 lwYTLYLTITTFFFPLPLILVCYIL 219
Cdd:cd15052 160 --FVIYGSIVAFFIPLLIMVVTYAL 182
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
35-315 6.40e-15

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 73.52  E-value: 6.40e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15298   1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQlQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVES--CAFDLTSP 191
Cdd:cd15298  81 YVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDnqCFIQFLSN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLWYTlylTITTFFFPLPLILVCYILIlcytwemyqqnkdarccnpSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15298 161 PAVTFGT---AIAAFYLPVVIMTVLYIHI-------------------SLASARERKVTRTIFAILLAFILTWTPYNVMV 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 272 LVNLQMEQ--PTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15298 219 LVNTFCQSciPDTVWSIGYW----LCYVNSTINPACYALCNATFKK 260
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
35-315 7.44e-15

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 73.46  E-value: 7.44e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTI-IRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd17790   1 VLIVITTGILSLVTVTGNLLVLISFkVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRT-RYKTIRINLGlWAASFILALPVWVYSKVIKFKDGVES--CAFDLTS 190
Cdd:cd17790  81 YVASNASVMNLLIISFDRYFSITRPLTYRAKRTpRRAAIMIGLA-WLISFVLWAPAILFWQYLVGERTVLAgqCYIQFLS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVLWYTlylTITTFFFPLPLILVCYililcytWEMYQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd17790 160 QPIITFGT---AIAAFYLPVTIMIILY-------WRIYRETIKEK------------KAARTLSAILLAFILTWTPYNIM 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 271 QLVNLQMEQ--PTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd17790 218 VLVSTFCKDcvPKTLWELGYW----LCYVNSTVNPMCYALCNKSFRD 260
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
43-317 7.99e-15

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 73.67  E-value: 7.99e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIR-SRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd15153   9 IIFIPGLLANSAALWVLCRfISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQH-TWPFGRFLCLLCFYLKYLNMYASI 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPFRLTRWRTRYKtIRINLGLWAASFILALPvWVYSKVIKFKDGVESCAFDL--TSPDDVLWYTL 199
Cdd:cd15153  88 CFLTCISIQRCFFLLHPFKARDWKRRYD-VGISAAVWIVVGLACLP-FPLLRSKSLSNNNRSCFADLgmKKLNFGAAIAM 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 200 YLTITTFFFPLPLILVCYIlilcyTWEMYQQNKDARCCNPSVPKQRvmKLTKMVLVLVVVFILSAAPYH--------VIQ 271
Cdd:cd15153 166 MTVAELFGFVIPLFIIAWC-----TWKTENSLRQRNKQQQSTSEKQ--KALRMVRMCAAVFFICFAPYHinflfylmVSE 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 272 LV--NLQMEQPTLAFYVgyyLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15153 239 SIitNCEVSQVILQFHP---ISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
39-311 1.04e-14

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 73.70  E-value: 1.04e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  39 SMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADLVhiVGMPFLIHQWARGGEWVFGGP--LCTIITSLDTC 115
Cdd:cd15385   5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRmHLFIKHLSLADLV--VAFFQVLPQLCWDITYRFYGPdfLCRIVKHLQVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRInLGLWAASFILALPVWVYSKVIKFK--DGVESCAFDLTSPDD 193
Cdd:cd15385  83 GMFASTYMLVMMTADRYIAICHPLKTLQQPTKRSYLMI-GSAWALSFILSTPQYFIFSLSEIEngSGVYDCWANFIVPWG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLYLTITTFFFPLPLILVCYILILCYTWE------MYQQNKDAR---CCNPSVPKQRVM-----KLTKMVLVLVVV 259
Cdd:cd15385 162 IKAYITWITISIFVVPVIILLTCYGFICYNIWRnikcktRRGLSDNALkniLLAVCVSSVKTIsrakiRTVKMTFVIVLA 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 260 FILSAAPYHVIQL--VNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSG 311
Cdd:cd15385 242 YIVCWAPFFTIQMwsVWDQNFPWDESENTAVTITALLASLNSCCNPWIYMFFSG 295
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
43-315 1.14e-14

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 72.68  E-value: 1.14e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVH-IVGMPFLIHQWARGgEWVFGGPLCTIITSLdtcnQFAC 120
Cdd:cd15210   9 VFMVVGVPGNLLTVLALLRSKKlRTRTNAFIINLSISDLLFcAFNLPLAASTFLHQ-AWIHGETLCRVFPLL----RYGL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAI----MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVW-VYSKVIKFKDGVESCAF--DLTSPDd 193
Cdd:cd15210  84 VAVslltLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWlGIWGRFGLDPKVCSCSIlrDKKGRS- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 vlwYTLYLTITTFFFPLPLILVCYILilcytwemyqqNKDarccnpsvpkqrvMKLTKMVLVLVVVFILSAAPYHVIQLV 273
Cdd:cd15210 163 ---PKTFLFVFGFVLPCLVIIICYAR-----------RED-------------RRLTRMMLVIFLCFLVCYLPITLVNVF 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 93277083 274 NLQMEQPTLafyvgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15210 216 DDEVAPPVL-----HIIAYVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
36-315 1.29e-14

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 72.77  E-value: 1.29e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYlRTVTNYFIVSLAVADlLVGSIVMPFSILHEMTGGYWLFGRDWCDVWHSFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALP--VWvYSKVIKFKDGVESCAFdltsP 191
Cdd:cd15067  81 VLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPaiAW-WRAVDPGPSPPNQCLF----T 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLwYTLYLTITTFFFPLPLILVCYililcytWEMYQqnkdarccnpSVPKQRvmKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15067 156 DDSG-YLIFSSCVSFYIPLVVMLFTY-------YRIYR----------AAAKEQ--KAAKTLGIVMGVFILCWLPFFVTN 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 272 LV-----NLQMEQPTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15067 216 ILigfcpSNCVSNPDILFPLVTW----LGYINSGMNPIIYACSSRDFRR 260
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
48-317 2.54e-14

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 72.26  E-value: 2.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTI-IRSRKKTVPDIYICNLAVADLVHIVGMPFLIHqWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15155  14 GLITNCASLFVFcFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIF-YNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLTC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSkVIKFKDGVESCaFDLTSPDDVLWY----TLYLT 202
Cdd:cd15155  93 ISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFS-TTNVSNTSTTC-FEGFSKSIWKTYlskiTIFIE 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 203 ITTFFFPLPLILVCYILILcytwemYQQNKDARCCNPSVPKQRVMkltKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTL 282
Cdd:cd15155 171 VVGFIIPLLLNLTCSSLVL------RTLRKPATLSQIGTNKEKVL---KMILVHVAIFVVCFVPYNSILFLYALVRSQAI 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 93277083 283 A-------FYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15155 242 AncgverfARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
74-315 2.86e-14

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 72.05  E-value: 2.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  74 NLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRI 153
Cdd:cd15922  41 NLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKL 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 154 NLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDV-LWYTLYLTITTFFFPLPLILVCYILILCYTWEMyqqnk 232
Cdd:cd15922 121 CLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIHQSELSLLyFVWNFVLLILGFLLPFGVSLTCYALLGASIAKM----- 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 233 darccNPSVPKQRVMKLT--KMVLVLVVVFILSAAPYHVIQ----LVNLQMEQPTLAFY---VGYYLSICLSYASSSINP 303
Cdd:cd15922 196 -----NSNNARGRAMKAKslQMIGISLVIFIICFVPLHVTRtvgvVVKLFYPESCTLLHkveVAYYISWVLTGVNCCLDP 270
                       250
                ....*....|..
gi 93277083 304 FLYILLSGNFQK 315
Cdd:cd15922 271 LLYCFASEKFRK 282
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
35-315 3.12e-14

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 71.51  E-value: 3.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITSL 112
Cdd:cd15322   1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPqNLFLVSLASADiLVATLVIPFSLANEVMG-YWYFGKVWCEIYLAL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCnqFACSAI--MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPvwvysKVIKFKDGVESCAFDLTS 190
Cdd:cd15322  80 DVL--FCTSSIvhLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP-----PLITIEKKSGQPEGPICK 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVLWYTLYLTITTFFFPlplilvCYILILCYTwEMYQqnkdarccnpsVPKQRVMKLTKMVLVLVVVFILSAAP---- 266
Cdd:cd15322 153 INDEKWYIISSCIGSFFAP------CLIMVLVYI-RIYQ-----------IAKNREKRFTFVLAVVIGVFVICWFPffft 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 267 YHVIQLVNLQMEQPTLAFYVGYylsiclSYASSSINPFLYILLSGNFQK 315
Cdd:cd15322 215 YTLTAVCDCSVPETLFKFFFWF------GYCNSSLNPVIYTIFNHDFRR 257
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
48-317 3.79e-14

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 71.74  E-value: 3.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVM 127
Cdd:cd15120  14 GLVVNGLYLWVLGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMFTSVFLLTAI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 128 SVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLT------SPDDVLWYT-LY 200
Cdd:cd15120  94 SLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQNNYAlstnweSAEVQASRQwIH 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 201 LTITTFFFPLPLILVCYILILCYTwEMYQQNKDARCCNPSVPkqrvmklTKMVLVLVVVFILSAAPYHVIQLVNLQMEQP 280
Cdd:cd15120 174 VAMFVFRFLLGFLLPFLIITFCYV-RMALKMKERGLARSSKP-------FKVMFTAVVSFFVCWLPYHLHSGLVLTRGRP 245
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 93277083 281 TLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15120 246 PSLTDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
38-308 4.20e-14

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 71.36  E-value: 4.20e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  38 PSMIGIICSTGLVGNILIVFTI-IRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCN 116
Cdd:cd15366   4 PTLYIIVIVLGLPTNCLALWAAyLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 117 QFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLW 196
Cdd:cd15366  84 IYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFRDRYNHTFCFEKYPMEDWVAW 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 197 YTLYLTITTFFFPLPLILVCYILILcytwemyqqnkDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVN-- 274
Cdd:cd15366 164 MNLYRVFVGFLFPWVLMLFSYRGIL-----------RAVRGNVSTEQQEKAKIKRLALSLIAIVLLCFAPYHVLLLSRsv 232
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 93277083 275 LQMEQP-----TLAFYVGYYLSICLSYASSSINPFLYIL 308
Cdd:cd15366 233 VYLGKPcdcgfEERVFTAYHVSLALTSLNCVADPILYCL 271
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
50-315 4.44e-14

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 71.20  E-value: 4.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  50 VGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPfLIHQWARGGEWVFGGPLCTIITSLDTCnqfACSA-IMTV 126
Cdd:cd15049  16 GGNILVILSFRVNRQlRTVNNYFLLSLACADLiIGLVSMN-LYTVYLVMGYWPLGPLLCDLWLALDYV---ASNAsVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 M--SVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVE--SCAFD-LTSPddvlWYTLYL 201
Cdd:cd15049  92 LliSFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQYFVGERTVPdgQCYIQfLDDP----AITFGT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 202 TITTFFFPLPLILVCYililcytWEMYQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYHVIQLVN--LQMEQ 279
Cdd:cd15049 168 AIAAFYLPVLVMTILY-------WRIYRETARER------------KAARTLSAILLAFIITWTPYNILVLVStfCAKCI 228
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 93277083 280 PTLAFYVGYYLsiClsYASSSINPFLYILLSGNFQK 315
Cdd:cd15049 229 PDTLWSFGYWL--C--YINSTINPFCYALCNKTFRK 260
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
35-314 6.20e-14

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 70.75  E-value: 6.20e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15299   4 VLIAFLTGILALVTIIGNILVIVSFKVNKQlKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSID 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRyKTIRINLGL-WAASFILALPVWVYSKVIKFKDGV--ESCAFDLTS 190
Cdd:cd15299  84 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTT-KRAGVMIGLaWVISFVLWAPAILFWQYFVGKRTVppDECFIQFLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVLWYTlylTITTFFFPLPLILVCYililcytWEMYQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15299 163 EPIITFGT---AIAAFYLPVTIMTILY-------WRIYKETIKEK------------KAAQTLSAILLAFIITWTPYNIM 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 271 QLVNLQMEQ--PTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15299 221 VLVNTFCDSciPKTYWNLGYW----LCYINSTVNPVCYALCNKTFR 262
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
35-306 7.99e-14

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 70.92  E-value: 7.99e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK--KTVPDIYICNLAVADL-VHIVGMPFLIHQWArGGEWVFGGpLCTIITS 111
Cdd:cd15057   1 IITGCILYLLVLLTLLGNALVIAAVLRFRHlrSKVTNYFIVSLAVSDLlVAILVMPWAAVNEV-AGYWPFGS-FCDVWVS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPVWVYSKVIKFKDGVESCAFDLTS 190
Cdd:cd15057  79 FDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISfIPVQLGWHRADDTSEALALYADPCQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVL--WYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQ-----NKDARCCNPSVPKQ----RVMKLTKMVLVLVVV 259
Cdd:cd15057 159 CDSSLnrTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRRiaaleRAAQESTNPDSSLRsslrRETKALKTLSIIMGV 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 260 FILSAAPYHVIQLVN----LQMEQPTLAFYVGYYLSICLSYASSSINPFLY 306
Cdd:cd15057 239 FVCCWLPFFILNCVLpfcdLRTAQFPCVPDTTFIVFVWLGWANSSLNPIIY 289
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
36-306 1.30e-13

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 70.30  E-value: 1.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICstgLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGeWVFGGPLCTIITSLDT 114
Cdd:cd15079   5 FIYIFLGIVS---LLGNGLVIYIFSTTKSlRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEG-WALGPLGCQIYAFLGS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CnqFACSAIMT--VMSVDRYFALVQPFRLTRWrTRYKTIRINLGLWAASFILALP----VW-VYSKvikfkDG-VESCAF 186
Cdd:cd15079  81 L--SGIGSIWTnaAIAYDRYNVIVKPLNGNPL-TRGKALLLILFIWLYALPWALLpllfGWgRYVP-----EGfLTSCSF 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 187 D-LTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTW----EMYQQNK----DARCCNPSVPKQRV-MKLTKMVLVL 256
Cdd:cd15079 153 DyLTRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAVFahekALREQAKkmnvVSLRSNADANKQSAeIRIAKVALTN 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 257 VVVFILSAAPYHVIQLVNLQMEQPTLAFYVGyYLSICLSYASSSINPFLY 306
Cdd:cd15079 233 VFLWFIAWTPYAVVALIGAFGNQSLLTPLVS-MIPALFAKTAACYNPIVY 281
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
40-312 1.37e-13

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 70.22  E-value: 1.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILI-VFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGE-WVFGGPLCTIITSLDTCNQ 117
Cdd:cd15198   6 FLGVILVAGVAGNTTVlCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLGDrWMAGDVACRLLKLLQASAR 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRlTRWRTRyktiRINLGLWAASFILALP-VWVY-----SKVIKFKDGVESCA--FDLT 189
Cdd:cd15198  86 GASANLVVLLALDRHQAIRAPLG-QPLRAW----KLAALGWLLALLLALPqAYVFrvdfpDDPASAWPGHTLCRgiFAPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARC-------------CNPSVPKQRVMKLtKMVLVL 256
Cdd:cd15198 161 PRWHLQVYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKpwkkpskshlratAPSALPRAKVKTL-KMTLVI 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 257 VVVFILSAAPYHVIQLV----NLQMEQPTLAFYVGyylsiCLSYASSSINPFLYILLSGN 312
Cdd:cd15198 240 ALLFVGCSLPYFIAELAaafgSGDWEPEKVAAALG-----VMAVANSATNPFVFLFFNAG 294
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
48-317 1.55e-13

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 69.79  E-value: 1.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRS-RKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd14987  14 GLLANSVVVWVNLQAkRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSINLFGSIFFLTC 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDlTSPDDVLW-----YTLYL 201
Cdd:cd14987  94 MSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNETYCRS-FYPEESFKewligMELVS 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 202 TITTFFFPLPLILVCYILIlcytwemyqqnkdARCCNPSVPKQRVMKlTKMVLVLVVVFILSAAPYHVIQLV-------- 273
Cdd:cd14987 173 IVLGFVIPFPIIAVFYFLL-------------ARAISASSDQERKSS-RKIIFSYVVVFLVCWLPYHTVVLLdilsflhl 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 274 ---NLQMEQptlAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14987 239 ipfSCQLEN---FLYAALHVTQCFSLVHCCVNPILYSFINRNYRYEL 282
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
43-315 1.56e-13

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 69.95  E-value: 1.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGN-ILI-VFTIIRSRKkTVPDIYICNLAVADLVHIVG-MPFLIHQWARGGeWVFGGPLCTIITSLDTCNQFA 119
Cdd:cd15123   9 VIISVGILGNaILIkVFFKIKSMQ-TVPNIFITSLAFGDLLLLLTcVPVDATRYIADT-WLFGRIGCKLLSFIQLTSVGV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 120 CSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVL---- 195
Cdd:cd15123  87 SVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTTFEACAPYPVSekil 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 --WYTLYLTITTFFFPLPLILVCYILIlcyTWEMYQQNKDARCCNPSVPKQRV---MKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15123 167 qeIHSLLCFLVFYIIPLSIISVYYFLI---ARTLYKSTFNMPAEEHSHARKQIesrKRVAKTVLVLVALFAFCWLPNHIL 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 271 QLVNLQMEQ----PTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15123 244 YLYRSFTYHtsvdSSAFHLIATIFSRVLAFSNSCVNPFALYWLSKSFRQ 292
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
48-269 1.57e-13

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 69.67  E-value: 1.57e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNIL-IVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHqwARGGEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15165  14 GLLLNLMaLWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMH--SSKKQWPLGRTLCSFLESLYFVNMYGSILIIVC 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPvwVYSKVIKFKDGVeSCAFDLTSPDDVLWYTLYLTITTF 206
Cdd:cd15165  92 ISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIP--IYSFHDKPTNNT-RCFHGFSNKTWSKKVIVVVEEFGF 168
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 93277083 207 FFPLPLILVCYILILcytwemyQQNKDARccNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15165 169 LIPMAVMVFCSVQII-------RTLLDMR--RPEQPKVKQNKSVKIVLSNLVVFLVCFTPYHL 222
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
35-316 1.72e-13

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 69.80  E-value: 1.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGN--ILIVFTIiRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15200   1 AFLAPVLGIEFVLGLVGNgiALFIFCF-HRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFR-LTRWRTRyKTIRINLGLWAASFILALPVWVYSKVikfKDGVESCAFDL-TS 190
Cdd:cd15200  80 LSMNRTASIVFLTAIALNRYLKVVHPHHqLSKASVG-CAAKVAAGLWILILLLNIHLLLLDHV---QSNSTCLSYDHgTD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVLWYTLYLTITTFFFPLPLILVCYILILCytweMYQQNKDARCCNPsvpkQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15200 156 PSASDRWHRILFFLEFFLPLGIILFCIFSIIL----TLKQRKLAKQAGP----QRAVKVLAVIVLVYTVCFLPSILFALA 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 271 QLVNLQMEQPTLAFYVG--YYLSICLSYASSSINPFLYILLSGNFQKR 316
Cdd:cd15200 228 SLVAFKVSQCRSLDLCTqlFHGSLAFTYLNSALDPVLYCFSSPSFLNQ 275
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
35-315 2.30e-13

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 69.44  E-value: 2.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITSL 112
Cdd:cd15056   1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQlRKKTNYFVVSLAVADlLVAVLVMPFGAIELVNN-RWIYGETFCLVRTSL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD--------GVESC 184
Cdd:cd15056  80 DVLLTTASIMHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFISFLPIMQGWNHIGIEDliafncasGSTSC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 185 AFDLTSPddvlwYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQ---------NKDARCCNPSVPKQRVMKLTKMVLV 255
Cdd:cd15056 160 VFMVNKP-----FAIICSTVAFYIPALLMVLAYYRIYVAAREQAHQirslqragsSNHEADQHRNSRMRTETKAAKTLGI 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 93277083 256 LVVVFILSAAPYHVIQLVNlqmeqPTLAFYVGYYL---SICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15056 235 IMGCFCVCWAPFFVTNIVD-----PFIGYRVPYLLwtaFLWLGYINSGLNPFLYAFFNKSFRR 292
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
48-315 2.73e-13

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 69.08  E-value: 2.73e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIhQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMT 125
Cdd:cd15399  14 GVVGNSLVIYVVIKFKNmRTVTNFFIANLAVADLmVNTLCLPFTL-VYTLLDEWKFGAVLCHLVPYAQALAVHVSTVTLT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VMSVDRYFALVqpFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSK--VIKFKDGVESCAFDLTSPDDVLWY-TLY-L 201
Cdd:cd15399  93 VIALDRHRCIV--YHLESKISKKISFLIIGLTWAASALLASPLAIFREysVIEISPDFKIQACSEKWPNGTLNDgTIYsV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 202 TITTFFFPLPLILVCYILILCYTwemyqqnKDARCCNPSVPK----QRVMKLTKMVLVLVVVFILSAAPYHVIQLVN--- 274
Cdd:cd15399 171 SMLLIQYVLPLAIISYAYIRIWT-------KLKNHVSPGGGNdhyhQRRRKTTKMLVCVVVVFAVSWLPFHAFQLASdid 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 93277083 275 ---LQMEQPTLAFYVGYYLSICLSYAsssiNPFLYILLSGNFQK 315
Cdd:cd15399 244 skvLDLKEYKLIYTIFHVIAMCSTFA----NPLLYGWMNNNYRT 283
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
35-315 3.99e-13

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 68.45  E-value: 3.99e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15297   1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHlQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVE--SCAFDLTSP 191
Cdd:cd15297  81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRTVPegECYIQFFSN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLWYTlylTITTFFFPLPLILVCYililcytWEMyqqnkdarccnpSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15297 161 AAVTFGT---AIAAFYLPVIIMTVLY-------WQI------------SRASSREKKVTRTILAILLAFIITWTPYNVMV 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 272 LVNLQMEQ--PTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15297 219 LINTFCASciPNTVWTIGYW----LCYINSTINPACYALCNATFKK 260
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
51-315 4.61e-13

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 68.07  E-value: 4.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  51 GNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMS 128
Cdd:cd15310  17 GNVLVCMAVLRERAlQTTTNYLVVSLAVADLlVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 129 VDRYFALVQPFRLTRWRTRYKTIRINL---GLWAASFILALPVwvyskVIKFKDGVESCAFDLTSPDdvlwYTLYLTITT 205
Cdd:cd15310  97 IDRYTAVVMPVHYQHGTGQSSCRRVSLmitAVWVLAFAVSCPL-----LFGFNTTGDPTVCSISNPD----FVIYSSVVS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 206 FFFPLPLILVCYILILCYTwemyqqnkdarccnpsvpkQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFY 285
Cdd:cd15310 168 FYLPFGVTLLVYVRIYVVL-------------------LREKKATQMLAIVLGAFIVCWLPFFLTHILNTHCQACHVPPE 228
                       250       260       270
                ....*....|....*....|....*....|
gi 93277083 286 VgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15310 229 L-YSATTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
35-315 5.19e-13

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 68.13  E-value: 5.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTI-IRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15300   1 ITIAAVTAVVSLITIVGNVLVMISFkVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRyKTIRINLGL-WAASFILALPV---WVYSkVIKFKDGVESCAFDLT 189
Cdd:cd15300  81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTP-KRAGIMIGLaWLISFILWAPPilcWQYF-VGKRTVPERECQIQFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDVLWYTlylTITTFFFPLPLILVCYILIlcytwemYQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYHV 269
Cdd:cd15300 159 SEPTITFGT---AIAAFYIPVSVMTILYCRI-------YKETIKER------------KAAQTLSAILLAFIITWTPYNI 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 270 IQLVNLQMEQ--PTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15300 217 MVLVSTFCSDciPLTLWHLGYW----LCYVNSTVNPMCYALCNKTFRK 260
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
30-315 7.16e-13

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 67.64  E-value: 7.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  30 SVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCT 107
Cdd:cd15321   2 SVQATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPqNLFLVSLAAADiLVATLIIPFSLANELMG-YWYFRKTWCE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 108 IITSLDTCnqFACSAI--MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYskviKFKDGVESCA 185
Cdd:cd15321  81 IYLALDVL--FCTSSIvhLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIY----KGKQKDEQGG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 186 FDLTSPDDVLWYTLYLTITTFFFPlplilvCYILILCYTwEMYQqnkdarccnpsVPKQRVMKLTKMVLVLVVVFILSAA 265
Cdd:cd15321 155 LPQCKLNEEAWYILSSSIGSFFAP------CLIMILVYL-RIYL-----------IAKNREKRFTFVLAVVIGVFVLCWF 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 266 PYHViqLVNLQMEQPTLAFYVG--YYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15321 217 PFFF--SYSLGAICPELCKVPHslFQFFFWIGYCNSSLNPVIYTIFNQDFRR 266
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
51-317 7.56e-13

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 67.93  E-value: 7.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  51 GNILIVFTIIRSRK-KTVPDIYICNLAVADLVH-IVGMPFLIHQwARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMS 128
Cdd:cd15391  17 GNYSVIVVFYDGRRsRTDLNYYLINLAVSDLIMaLFCMPFTFTQ-IMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIG 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 129 VDRYFALVQPFRltRWRTRYKTIRINLGLWAASFIL-ALPVWVYSKVIKFKDGVESCAFDLTSPDDVLW---YTLYLTIT 204
Cdd:cd15391  96 IDRFFAVIFPLR--SRHTKSRTKCIIASIWAISFSLsSVQLFAGRTQRYGQYSEGRVLCGESWPGPDTSrsaYTVFVMLL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 205 TFFFPLPLILVCYILILCYTWEM-----------YQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYHVIQLV 273
Cdd:cd15391 174 TYIIPLLILTSTYGYVGFRLWNRtapgnadkgrdDMQIKSKR------------KVIKMLVFVVLMFGICWLPLHLFNLV 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 274 N-----LQMEQPTLAFYVgYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15391 242 QdfstvFRNMPQHTTRLI-YGACHWIAMSNSFVNPIIYLFMNDSFRSIL 289
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
36-315 7.98e-13

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 67.83  E-value: 7.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIV-GMPFLIHQwARGGEWVFGGPLCTIITSLD 113
Cdd:cd14977   2 VIMSLSLVIFAVGIIGNLMVLCIVCTNYYmRSVPNILIASLALGDLLLLLlCVPLNAYN-LLTKDWLFGDVMCKLVPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD----GVESCAFDLT 189
Cdd:cd14977  81 VTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSldnsSLTVCIMKPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDVLWYTLYLT-ITTFFFPLPL--ILVCYILILCytwEMYQQNKDARCCNPSVPKQRvMKLTKMVLVLVVVFILSAAP 266
Cdd:cd14977 161 TPFAETYPKARSWwLFGCYFCLPLafTAVCYLLMAR---TLIRAAKEYTRGTKKHMKQR-RQLAKTVLCLVLVFAFCWLP 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 267 YHVIQLVNLQME-----QPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd14977 237 EHISNILRATLYnevliDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRR 290
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
43-268 9.15e-13

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 67.48  E-value: 9.15e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRS-RKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd15154   9 LLFPVGLLLNAVALWVFVRYlRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANH-YWPFGNFLCQFSGSIFQMNMYGSC 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKV--IKFKDGVESCAFDLTSPDD---VLW 196
Cdd:cd15154  88 LFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSsdCLLHGEKVYRCFESFSDNDwkgLLP 167
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 93277083 197 YTLYLTITTFFFPLPLILVCYILILcytWEMYQQNkdarccnpSVPKQRVMKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15154 168 LVVLAEILGFLLPLAAVLYCSCRIF---VELCRTQ--------EPQQGRRRKTVRLLLVNLVIFLICFVPYN 228
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
40-317 9.31e-13

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 67.53  E-value: 9.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPF-LIHQWArgGEWVFGGPLCTIITSLDTCN 116
Cdd:cd15979   6 LYSVIFLLSVFGNMLIIVVLGLNKRlRTVTNSFLLSLALSDLmLAVFCMPFtLIPNLM--GTFIFGEVICKAVAYLMGVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 117 QFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG----VESCAFDLTSPD 192
Cdd:cd15979  84 VSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGdrprGHQCRHAWPSAQ 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 -DVLWYTLYLTItTFFFPLPLILVCYILILCytwEMYQQnkdarccnpSVPKQRVMkltKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15979 164 vRQAWYVLLLLI-LFFIPGVVMIVAYGLISR---ELYRG---------LLAKKRVI---RMLVVIVAMFFLCWLPIFSAN 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 272 LVNLQMEQPTLAFYVGYYLSIC--LSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15979 228 TWRAFDPLSAHRALSGAPISFIhlLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
48-315 1.08e-12

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 67.56  E-value: 1.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRK----KTVPDIYICNLAVADL-VHIVGMPFLIHQ--WARGgEWVFGGPLCTIITSLDTCNQFAC 120
Cdd:cd15355  14 GTVGNSITLYTLARKKSlqhlQSTVHYHLASLALSDLlILLLAMPVELYNfiWVHH-PWAFGDAACRGYYFLRDACTYAT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVW-----VYSKVIKFKDGVESCAFDLTSPDDVL 195
Cdd:cd15355  93 ALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMLftmgeQNRSGTHPGGLICTPIVDTSTLKVVI 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLYLtitTFFFPLPLILVCYILILCYTWEMYQQ-NKDARCC---------NPSVPKQRVMKL---TKMVLVLVVVFIL 262
Cdd:cd15355 173 QVNAFL---SFLFPMLVISVLNTLIANQLTVMVNQaEQENQVCtiggqrtvlSVSMEPGRVQSLrhgVLVLRAVVIAFVV 249
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 93277083 263 SAAPYHVIQLV-----NLQMEQPTLAFYVGYY-LSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15355 250 CWLPYHVRRLMfcyvsDEQWTTFLYDFYHYFYmLTNVLFYVSSAINPILYNLVSANFRQ 308
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
37-317 1.14e-12

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 67.16  E-value: 1.14e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGewVFGGPLCTIITSLDTC 115
Cdd:cd15171   3 VPQLCSAVFLVGLLDNGLVVFILVKYKGlKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGG--SLGNPTCKVLVALSSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGL-WAASFILALPVWVYSKViKFKDGVESCAFDLT---SP 191
Cdd:cd15171  81 GLHSEALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVLaWLTAFLVTLPEFVFYKP-QMDSQKSKCAFSRPhflPA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLW---YTLYLTITTFFFPLPLILVCYIlilcytwemyQQNKDARccnpsvPKQRVMKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15171 160 EETFWkyfLTLKMNIVVLVFPLLVFIICCV----------QLRKTQR------FRERQRDLSKLVFAIMVVFLLMWAPYN 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 269 VI-------QLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15171 224 IAlflsafkEHFSLRDCKSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
70-312 1.20e-12

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 67.10  E-value: 1.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  70 IYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYK 149
Cdd:cd15367  37 IYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKA 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 150 TIRINLGLWAASFILALPVWVYSKVIKFKDGVESC--AFDLTSPDDVLWYtlYLTITTFFFPLPLILVCYILILcytwem 227
Cdd:cd15367 117 ATLVSTVIWLKELMTCVFFFLHGEISKDKENHSVCfeHYPIKAWEHNINY--YRFYAGFLFPIFLLSFSYCRIL------ 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 228 yqqnkdaRCCNPSVPKQRVMK--LTKMVLVLVVVFILSAAPYHVIQLVNLQMEQP---TLAFYVGYYLSICLSYASSSIN 302
Cdd:cd15367 189 -------RAVRKSHGTQKSQKiqIKRLVLSTVVIFLVCFGPYHILLLVRSVFERDcnfAEGIFNYYHFSLLLTSFNCVAD 261
                       250
                ....*....|
gi 93277083 303 PFLYILLSGN 312
Cdd:cd15367 262 PVLYCFASES 271
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
48-315 1.33e-12

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 67.62  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   48 GLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWArgGEWVFGGPLCTIITSLDTCNQFACSAIMTVM 127
Cdd:PHA02834  42 GLIGNVLVIAVLIVKRFMFVVDVYLFNIAMSDLMLVFSFPFIIHNDL--NEWIFGEFMCKLVLGVYFVGFFSNMFFVTLI 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  128 SVDRYFALVQPFRLtRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFkDGVESCAFDLTSPDDVLWYTLYLTITTFF 207
Cdd:PHA02834 120 SIDRYILVVNATKI-KNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNT-DNLKQCIFNDYHENFSWSAFFNFEINIFG 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  208 FPLPLIlvcyILILCYTWEMYQQnKDARCCNPSVPKQRVMKLTKMVLVLVVVF--ILSAAPYHVIQLVNLQMEQPTLAFY 285
Cdd:PHA02834 198 IVIPLI----ILIYCYSKILYTL-KNCKNKNKTRSIKIILTVVTFTVVFWVPFniVLFINSLQSVGLIDIGCYHFKKIVY 272
                        250       260       270
                 ....*....|....*....|....*....|
gi 93277083  286 VGYYLSIcLSYASSSINPFLYILLSGNFQK 315
Cdd:PHA02834 273 SIDIAEL-ISFVHCCVNPIIYAFVGKNFKK 301
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
35-315 1.34e-12

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 67.28  E-value: 1.34e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK----KTVPDIYICNLAVADL-VHIVGMPFLIHQ--WARGgEWVFGGPLCT 107
Cdd:cd15130   1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSlqslQSTVRYHLGSLALSDLlILLLAMPVELYNfiWVHH-PWAFGDAGCR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 108 IITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPV-WVYSKVIKFKDGVESCAF 186
Cdd:cd15130  80 GYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMlFTMGLQNESDDGTHPGGL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 187 DLTSPDDVLWYTLYLTITTFF-FPLPLILVCYIlilcytwEMYQQNKDARCCNPSVPKQRVMkltkmvlvlVVVFILSAA 265
Cdd:cd15130 160 VCTPIVDTATLKVVIQVNTFMsFLFPMLVTSIL-------NTVIANKLVQALRRGVLVLRAV---------VIAFVVCWL 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 266 PYHVIQLV-----NLQMEQPTLAFYVGYY-LSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15130 224 PYHVRRLMfcyisDEQWTTFLFDFYHYFYmLTNALFYVSSAINPILYNLVSANFRQ 279
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
48-222 1.76e-12

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 66.71  E-value: 1.76e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARggEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15923  14 GLLLNILALWVFCwRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRR--ESAGLQKLCNFVLSLYYINMYVSIFTITA 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVyskvikFKDGVESC-AFDLTSPDDVLWYTLYLTITT 205
Cdd:cd15923  92 ISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFL------LDSSNEKTmCFQRTKQTESLKVFLLLEIFG 165
                       170
                ....*....|....*..
gi 93277083 206 FFFPLPLILVCYILILC 222
Cdd:cd15923 166 FLLPLIIMTFCSARVIH 182
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
35-317 2.03e-12

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 66.85  E-value: 2.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIV--FTIIRSrKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15124   1 YAIPTVYGIIILIGLIGNITLIkiFCTVKS-MRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSP- 191
Cdd:cd15124  80 QLTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYDKSTNKTFVSCAPy 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 --DDVLWYTLYLTITTFFF---PLPLILVCYILIlcytwemyQQNKDARCCNPSVP-----KQRV---MKLTKMVLVLVV 258
Cdd:cd15124 160 phSNELHPKIHSMASFLIFyviPLSIISVYYYFI--------AKNLIRSAYNLPVEgnvhvRRQIesrKRLAKTVLVFVG 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 93277083 259 VFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSIC---LSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15124 232 LFAFCWLPNHIIYLYRSYHYSEVDTSMLHFVSSICariLAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
50-313 2.92e-12

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 66.36  E-value: 2.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  50 VGNILIVFTIIRSRKK-TVPDIYICNLAVADLVhiVGMPFLIHQWARGGEWVFGGP--LCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15386  16 AGNLAVLLAMYRMRRKmSRMHLFVLHLALTDLV--VALFQVLPQLIWEITYRFQGPdlLCRAVKYLQVLSMFASTYMLIM 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINlGLWAASFILALP-VWVYS-KVIKFKDGVESCAFDLTSPDDVLWYTLYLTIT 204
Cdd:cd15386  94 MTVDRYIAVCHPLRTLQQPSRQAYLMIG-ATWLLSCILSLPqVFIFSlREVDQGSGVLDCWADFGFPWGAKAYITWTTLS 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 205 TFFFPLPLILVCYILIlCY------TWEMYQQNKDARCCNPSVPKQRV----------MKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15386 173 IFVLPVAILIVCYSLI-CYeicknlKGKTQTSRSEGGGWRTQGMPSRVssvrtisrakIRTVKMTFVIVLAYIACWAPFF 251
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 269 VIQL-----VNLQMEQPTlafYVGYYLSICLSYASSSINPFLYILLSGNF 313
Cdd:cd15386 252 SVQMwsvwdENAPDEDSS---DFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
35-315 3.06e-12

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 65.68  E-value: 3.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIY-ICNLAVADLV-HIVGMPFLIHQWARGgEWVFGGPLCTIITSL 112
Cdd:cd15326   1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYfIVNLAIADLLlSFTVLPFSATLEILG-YWVFGRIFCDIWAAV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVEsCAFDlTSPd 192
Cdd:cd15326  80 DVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKV-CEIT-EEP- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 dvlWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDArccnpsvpkqrvmkltKMVLVLVVVFILSAAPYHV--- 269
Cdd:cd15326 157 ---FYALFSSLGSFYIPLIVILVMYCRVYIVALKFSREKKAA----------------KTLGIVVGMFILCWLPFFIalp 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 270 IQLVNLQMEQPTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15326 218 LGSLFSHLKPPETLFKIIFW----LGYFNSCLNPIIYPCSSKEFKR 259
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
35-306 3.90e-12

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 65.74  E-value: 3.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICStglVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFlihqwarggewvfggplcTIITSL 112
Cdd:cd14968   4 IVLEVLIAVLSV---LGNVLVIWAVKLNRAlRTVTNYFIVSLAVADiLVGALAIPL------------------AILISL 62
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQF-AC------------SAIMTVM--SVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILAL-PVW-VYSKVI 175
Cdd:cd14968  63 GLPTNFhGClfmaclvlvltqSSIFSLLaiAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLtPMFgWNNGAP 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 176 ---KFKDGVESCAFDLTSPDDVLWYTLYltITTFFFPLPLILVCYILILCYTWEMYQQNKDARC-CNPSVPKQRVMKLTK 251
Cdd:cd14968 143 lesGCGEGGIQCLFEEVIPMDYMVYFNF--FACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRsRRSRSTLQKEVKAAK 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 252 MVLVLVVVFILSAAPYHVIQLVNL---QMEQPTLAFYVGyylsICLSYASSSINPFLY 306
Cdd:cd14968 221 SLAIILFLFALCWLPLHIINCITLfcpECKVPKILTYIA----ILLSHANSAVNPIVY 274
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
35-170 3.95e-12

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 65.87  E-value: 3.95e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNI--LIVFTIIRSRKKTVpDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15148   1 LPLAVFYSLIFLFGLVGNLlaLWVFLFIHRKRNSV-RIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGNL 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWV 170
Cdd:cd15148  80 FYMNMYISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIV 137
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
40-315 4.84e-12

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 65.24  E-value: 4.84e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWArGGEWVFGGPLCTIITSLDTCNQ 117
Cdd:cd15008   5 VFGVLWLVSVFGNSLVCLVIHRSRRtQSTTNYFVVSMACADLlLSVASAPFVLLQFT-SGRWTLGSAMCKLVRYFQYLTP 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFIlalpvwvySKVIKFKDGVES--CAFDLTSPDDVL 195
Cdd:cd15008  84 GVQIYVLLSICVDRFYTIVYPLSFKVSREKAKKMIAASWLFDAAFV--------SPALFFYGSNWGphCNFFLPDSWDGA 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVmKLTKMVLVLVVVFILSAAPYHVIQLVNL 275
Cdd:cd15008 156 AYAIIHLLVGFLVPSILIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKV-KTIKMFLMLNSMFLLSWLPFYVVQLWHP 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 93277083 276 Q---MEQPTLAFyvgyyLSIC-LSYASSSINPFLYILLSGNFQK 315
Cdd:cd15008 235 ResdYRQSSLVF-----LAVTwISFSSSASKPTLYSVYNANFRR 273
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
39-220 5.20e-12

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 65.14  E-value: 5.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  39 SMIGIICSTgLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIhQWARGGEWVFGGPLCTIITsldTCN 116
Cdd:cd15060   6 LLSVIIAFT-IVGNILVILSVFTYRPlRIVQNFFIVSLAVADLaVAIFVLPLNV-AYFLLGKWLFGIHLCQMWL---TCD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 117 QFACSAI---MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPvwvysKVIKFKDGVEScaFDLTSPDD 193
Cdd:cd15060  81 ILCCTASilnLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVP-----PLIGWNDWPEN--FTETTPCT 153
                       170       180       190
                ....*....|....*....|....*....|
gi 93277083 194 VL---WYTLYLTITTFFFPLPLILVCYILI 220
Cdd:cd15060 154 LTeekGYVIYSSSGSFFIPLLIMTIVYVKI 183
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
35-314 5.40e-12

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 65.21  E-value: 5.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIhQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15063   1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKlRTVTNLFIVSLACADLlVGTLVLPFSA-VNEVLDVWIFGHTWCQIWLAV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSK----VIKFKDGVESCAFDL 188
Cdd:cd15063  80 DVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNdgkdGIMDYSGSSSLPCTC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 189 TSPDDVLwYTLYLTITTFFFPLPLILVCYililcytWEMYqqnkdarccnpsVPKQRVMKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15063 160 ELTNGRG-YVIYSALGSFYIPMLVMLFFY-------FRIY------------RAARMETKAAKTVAIIVGCFIFCWLPFF 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 269 VIQLVNLQMEQ--PTLAFYVGYYLSIClsyaSSSINPFLYILLSGNFQ 314
Cdd:cd15063 220 TVYLVRAFCEDciPPLLFSVFFWLGYC----NSALNPCIYALFSRDFR 263
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
49-317 5.69e-12

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 65.16  E-value: 5.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRK-KTVPDIYICNLAVADLvhIVGMpFLIHQWAR---GGEWVFGGPLCTIITSLDTCNQFACSAIM 124
Cdd:cd15012  14 FFGNLLVILVVTSHRRmRTITNFFLANLAVADL--CVGI-FCVLQNLSiylIPSWPFGEVLCRMYQFVHSLSYTASIGIL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 125 TVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG-----VESCAFDLTSPDDVLWYTL 199
Cdd:cd15012  91 VVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTqdgqeEEICVLDREMFNSKLYDTI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 200 YLtITTFFFPLPLILVCYILILCYTWEmyqqnkdarccNPSVPKQRvmKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEq 279
Cdd:cd15012 171 NF-IVWYLIPLLIMTVLYSKISIVLWK-----------SSSIEARR--KVVRLLVAVVVSFALCNLPYHARKMWQYWSE- 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 93277083 280 PTLAF----YVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15012 236 PYRCDsnwnALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
38-245 8.78e-12

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 64.57  E-value: 8.78e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  38 PSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIY---ICNLAVADLV-HIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd14981   4 PAPPALMFVFGVLGNLLALIVLARSSKSHKWSVFyrlVAGLAITDLLgILLTSPVVLAVYASNFEWDGGQPLCDYFGFMM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPVWVYSKVIKFKDGvESCAFDLTS-- 190
Cdd:cd14981  84 SFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIAsLPLLGLGSYVLQYPG-TWCFLDFYSkn 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 191 PDDVLWytLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQR 245
Cdd:cd14981 163 TGDAAY--AYLYSILGLLILLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQK 215
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
52-315 1.42e-11

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 63.81  E-value: 1.42e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  52 NILIVFTIIRSRKKTVPDIY-ICNLAVAD-LVHIVGMPFLIhQWARGGEWVFGGPLCTIITSLD----TCNQFACSAImt 125
Cdd:cd15334  18 NSLVITAIIVTRKLHHPANYlICSLAVTDfLVAVLVMPFSI-MYIVKETWIMGQVVCDIWLSVDitccTCSILHLSAI-- 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 vmSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDgvESCAFDltspDDVLWYTLYLTITT 205
Cdd:cd15334  95 --ALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSRE--DECIIK----HDHIVFTIYSTFGA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 206 FFFPLPLILVCYililcytWEMYQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFY 285
Cdd:cd15334 167 FYIPLALILILY-------YKIYRAATRER------------KAATTLGLILGAFVICWLPFFVKEVIVNTCDSCYISEE 227
                       250       260       270
                ....*....|....*....|....*....|
gi 93277083 286 VGYYLSiCLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15334 228 MSNFLT-WLGYINSLINPLIYTIFNEDFKK 256
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
35-317 1.69e-11

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 64.07  E-value: 1.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15150   1 VIFPLLYTVLFIVGLTMNGLAMRVFFQIPSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVIFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFdLTSPDDV 194
Cdd:cd15150  81 FTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILTNRQPTPKNVKKCSL-LKSEFGL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTL--YLTITTFFFPLPLILVCYILIlcyTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFI---LSAAPYHV 269
Cdd:cd15150 160 VWHEIvnYICQVIFWVNFLIVIVCYTLI---TKELYKSYKRTRGVGKVSRKKVNVKVFIIIAVFFICFVpfhFARIPYTL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 270 IQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15150 237 SQTRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSL 284
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
35-315 2.04e-11

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 63.37  E-value: 2.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15325   1 IVLGVILGGFILFGVLGNILVILSVACHRHlQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILAL-PVWVYSKVIKFKDGVesCAFDlTSPD 192
Cdd:cd15325  81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIgPLFGWKEPAPEDETI--CQIT-EEPG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 dvlwYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDArccnpsvpkqrvmkltKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15325 158 ----YALFSALGSFYLPLAIILVMYCRVYVVALKFSREKKAA----------------KTLGIVVGCFVLCWLPFFLVMP 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 273 VNL---QMEQPTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15325 218 IGSifpAYKPSDTVFKITFW----LGYFNSCINPIIYPCSSQEFKK 259
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
35-315 2.41e-11

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 63.34  E-value: 2.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVAD-LVHIVGMPFLIhQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15055   1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPtNLLLLSLAVADfLVGLLVMPFSM-IRSIETCWYFGDTFCKLHSSL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRL-TRWRTRYKTIRINLGlWAASFILALPVwVYSK-VIKFKDGVESCAFDLTS 190
Cdd:cd15055  80 DYILTSASIFNLVLIAIDRYVAVCDPLLYpTKITIRRVKICICLC-WFVSALYSSVL-LYDNlNQPGLIRYNSCYGECVV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDVLWYTLyLTITTFFFPLPLILVCYILI-LCYTWEM-----YQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSA 264
Cdd:cd15055 158 VVNFIWGVV-DLVLTFILPCTVMIVLYMRIfVVARSQArairsHTAQVSLEGSSKKVSKKSERKAAKTLGIVVGVFLLCW 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 265 APYHVIQLVNLQMEQPTLAFYVgyylSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15055 237 LPYYIVSLVDPYISTPSSVFDV----LIWLGYFNSCLNPLIYALFYPWFRK 283
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-314 2.43e-11

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 63.32  E-value: 2.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd16004   9 LIVLVAVTGNATVIWIILAHRRmRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFVSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPF--RLTRWRTRYktirINLGLWAASFILALPVWVYSkVIKFKDGVESCAFDLtsPDDV----- 194
Cdd:cd16004  89 YSMTAIAADRYMAIIHPFkpRLSAGSTKV----VIAGIWLVALALAFPQCFYS-TVTMDQGRTKCIVAW--PGDSggkhq 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRvMKLTKMVLVLVVVFILSAAPYHV-IQLV 273
Cdd:cd16004 162 LTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHGAYHRQLQAK-KKFVKTMVVVVVTFAICWLPYHLyFILG 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 93277083 274 NLQMEQPTLAFYVGYYLSI-CLSYASSSINPFLYILLSGNFQ 314
Cdd:cd16004 241 SFNEDIYCQKYIQQVYLAIfWLAMSSTMYNPIIYCCLNQRFR 282
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
35-317 3.15e-11

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 63.03  E-value: 3.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKK--TVPDIYICNLAVADLvhIVGMPFLI---------HQWARGGEWVFGG 103
Cdd:cd14980   1 ISLRIFIWIIGILALIGNILVIIWHISSKKKkkKVPKLLIINLAIADF--LMGIYLLIiaiadqyyrGRYAQYSEEWLRS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 104 PLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRyKTIRINLGLWAASFILA-LPVWVYSKVIKFKDGVE 182
Cdd:cd14980  79 PPCLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYK-SAKIILILGWLFSIIFAaIPILYSINQPGDNRLYG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 183 SCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVC--YILILCYtweMYQQNKDARccnpSVPKQRVMKLTKMVLVLVVVF 260
Cdd:cd14980 158 YSSICMPSNVSNPYYRGWLIAYLLLTFIAWIIICilYILIFIS---VRKSRKSAR----RSSSKRDKRIAIRLALILITD 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 93277083 261 ILSAAPYHVIQLVNLqMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14980 231 LICWLPYYIVIFSGL-LTSTEIDIHVLQFIAILALPLNSAINPYLYTLTTPTFKRDF 286
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
35-314 3.55e-11

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 62.97  E-value: 3.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIIcstGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIV-GMPF-LIHQWARggEWVFGGPLCTIITS 111
Cdd:cd15978   4 ILLYSLIFLL---SVLGNSLIIAVLIRNKRmRTVTNIFLLSLAVSDLMLCLfCMPFtLIPNLLK--DFIFGSAVCKTATY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCA--FDLT 189
Cdd:cd15978  79 FMGISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGnmCRLL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 190 SPDDVL---WYTlYLTITTFFFPLPLILVCYILILCytwEMYQQNKDArccnpsVPKQRVMKltkMVLVLVVVFILSAAP 266
Cdd:cd15978 159 WPNDVTqqsWYI-FLLLILFLIPGIVMMTAYGLISL---ELYRGIKFL------MAKKRVIR---MLIVIVILFFLCWTP 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 267 YHVIQLVNLQMEQPTLAFYVGYYLSIC--LSYASSSINPFLYILLSGNFQ 314
Cdd:cd15978 226 IFSANAWRAFDTRSADRLLSGAPISFIhlLSYTSACVNPIIYCFMNKRFR 275
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
35-317 4.68e-11

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 62.49  E-value: 4.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVF-TIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15364   1 IFLVVVYSVVFALGFPANCLTLWlTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKviKFKDGVESCAFDLTSPDD 193
Cdd:cd15364  81 FCNIYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMRE--GQTEGSHTCFETLQMDTQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYtlYLTITTFFFPLPLIlvcyilILCYTWEMYQQNKDArccNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLV 273
Cdd:cd15364 159 VAGF--YYARFCIGFAIPLA------ILIFTNYRIFRSIQT---STSLTPHQKAKVKYLAIAVIVIFLICFAPYHLVLLV 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 274 N----LQMEQPTLAF----YVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15364 228 RaiafSLYPNGMCGFeeriYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
49-317 5.36e-11

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 62.09  E-value: 5.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSR--KKTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGGEwVFGGPLCTIITSLDTCNQFACSAIMT 125
Cdd:cd15219  14 LLSNLLVLLCFLYSAelRKQVPGIFLLNLSFCNlLLTVLNMPFTLLGVVRNRQ-PFGDGFCQAVGFLETFLTSNAMLSMA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VMSVDRYFALVQPFRLTRwRTRYKTIRINLGL-WAASFILALPVWVYSKViKFKDGVESCAFDLTSPDDVLWYTLYlTIT 204
Cdd:cd15219  93 ALSIDRWIAVVFPLSYTS-KMRYRDAALMVGYsWLHSLTFSLVALFLSWL-GYSSLYASCTLHLPREEERRRFAVF-TAF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 205 TFFFPLPLILVCyiliLCYTWEMYQQNKdarccnpsvpkqRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPtlaf 284
Cdd:cd15219 170 FHAFTFLLSLLV----LCVTYLKVLKVR------------RRQRATKKISIFIGTFVLCFAPYVITRLVELLPFVT---- 229
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 93277083 285 yVGYY---LSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15219 230 -INRYwgiVSKCLTYSKAASDPFVYSLLRQQYRKVL 264
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
35-317 5.58e-11

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 62.51  E-value: 5.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIR-SRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd14996   1 VALPIIYSFLFVTGVFGNLLSLWVFLTkISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANFFG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 T----CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTI----------------RINLGLWAASFILALPVWVYSK 173
Cdd:cd14996  81 TlvihVSMCVSILILSWIAISRYATLMKHDSATQKQSCYEKIfyghflkrfrqpkfarYLCIYIWGVVLCIIIPVVVYYS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 174 VIKF-KDGVESCAFDLTSPDDVLWYTLYLTITTFFFplplilVCYILILCYTWEMYQQNKDARCCNPSVPKQRV-MKLTK 251
Cdd:cd14996 161 VREAdEDGESLCYNRQVELGAKGSQIAGLIATTFFF------LFFLVVLLSYYSFVNHLRRIQKNTCISEKDLIyRSVKR 234
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 93277083 252 MVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSI-----CLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14996 235 NILIIQALLVVCFLPYHIFKPVFYVLHQREDCQQLNYLIETkniltCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
35-315 6.01e-11

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 62.12  E-value: 6.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTI-IRSRKKTVPDIYICNLAVADLVHIVGMPFLI--HQWArggewvfgGPL--CTII 109
Cdd:cd15920   1 VTLPVMYSIICIVGLLSNTLALWVFfLRQQRETSISVYMRNLALADLLLVLCLPFRVayQNTA--------GPLsfCKIV 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 110 TSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYS--------KVIKFKD-G 180
Cdd:cd15920  73 GAFFYLNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFESrnegpcdnKCFHFRSkG 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 181 VESCAFDLTspddvlwytlylTITTFFFPLPLILVCYILILCYTWEMY-----QQNKDArccnpsvpKQRVMKLTkmvLV 255
Cdd:cd15920 153 LTAGGINLT------------AVVIFYILSLLFLYFYAKISHKLYKVSlgnaqQQIKKA--------SKRAIIKT---FI 209
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 93277083 256 LVVVFILSAAPYHVIQL--VNLQME-------QPTLafYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15920 210 VLAIFIVCFVPYHIVRVpyVLAQIDvisslpwKQTL--HIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
49-320 6.63e-11

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 62.28  E-value: 6.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCnqFACSAIMTV 126
Cdd:cd15307  15 AAGNILVCLAIAWERRlQNVTNYFLMSLAITDLmVAVLVMPLGILTLVKG-HFPLSSEHCLTWICLDVL--FCTASIMHL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 --MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVwvyskVIKFKDGVESCAFDLTSPDDVLWYTLYLTIT 204
Cdd:cd15307  92 ctISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPL-----SLMYSKDHASVLVNGTCQIPDPVYKLVGSIV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 205 TFFFPLPLILVCYililCYTWEMYQQNKDARCCNPSVPKqrvmKLTKMVLVLVVVFILSAAPYHVIQ-LVNLQMEQPTLA 283
Cdd:cd15307 167 CFYIPLGVMLLTY----CLTVRLLARQRSRHGRIIRLEQ----KATKVLGVVFFTFVILWSPFFVLNlLPTVCAECEERI 238
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 93277083 284 FYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQI 320
Cdd:cd15307 239 SHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKV 275
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
35-317 6.88e-11

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 61.68  E-value: 6.88e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15302   1 ILLALITAILSIITVIGNILVLLSFYVDRNiRQPSNYFIASLAVSDlLIGLESMPFYTVYVLNGDYWPLGWVLCDLWLSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLW---AASFILALPVWVY--SKVIKFKDGVESCAFd 187
Cdd:cd15302  81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWiipALLFFISIFGWQYftGQGRSLPEGECYVQF- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LTSPddvlWYTLYLTITTFFFPLPLILVCYililcytWEMYQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPY 267
Cdd:cd15302 160 MTDP----YFNMGMYIGYYWTTLIVMLILY-------AGIYRAANRAR------------KALRTITFILGAFVICWTPY 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 268 HVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15302 217 HILATIYGFCEAPPCVNETLYTISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
39-314 7.07e-11

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 62.12  E-value: 7.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  39 SMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQ 117
Cdd:cd15199   5 SLLILEFGLGLPGNAIALWTFIFRLKVWKPyAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSLSR 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFkdgvESCafDLTSPDDVLWY 197
Cdd:cd15199  85 GVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQPKNF----TEC--NSFSPKDDEDF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 198 TLYLTITTFFF----PLPLILVCYILILcytwemYQQNKDARCCNPSVPKQRVMKL-TKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15199 159 SDTWQEAVFFLqfllPFGLIVFCTVRII------RRLKKRLRDVGKQPKLQRAMALvTSVVVVFGFCFLPCFLARVLMLI 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 93277083 273 VNLQMEQPTLAFYVGYY-LSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15199 233 FQNKESCNALNIAVHTYdVTMCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
40-315 9.56e-11

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 61.83  E-value: 9.56e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICstgLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGeWVFGGPLCTIITSLDTCNQ 117
Cdd:cd15980   9 LIFLLC---MMGNGVVCFIVLRSKHmRTVTNLFILNLAISDLlVGIFCMPTTLLDNIIAG-WPFGSTVCKMSGMVQGISV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRlTRWRTRYKTIRINLgLWAASFILALPVWVYSKVIKFKDG------------VESCA 185
Cdd:cd15980  85 SASVFTLVAIAVDRFRCIVYPFK-QKLTISTAVVIIVI-IWVLAIAIMCPSAVMLHVQEEKNYrvvlgsqnktspVYWCR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 186 FDLTSPDDVLWYTLYLTITTFFFPLPLILVCY--ILILCYTWEMYQQNKDARCCNPSVPKQRvMKLTKMVLVLVVVFILS 263
Cdd:cd15980 163 EDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYarIGITLFKTAMPHTGKHNQEQRHVVSRKK-QKVIKMLLIVALLFILS 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 264 AAPYHVIQL----VNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15980 242 WLPLWTLMMlsdyANLSPNQLQIINIYIYPFAHWLAFFNSSVNPIIYGFFNENFRR 297
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
41-168 1.29e-10

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 60.85  E-value: 1.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQwARGGEWVFGGPLCTIITSLDTCnqF 118
Cdd:cd15066   6 MTLIILAAIFGNLLVIISVMRHRKlRVITNYFVVSLAMADmLVALCAMTFNASV-EITGRWMFGYFMCDVWNSLDVY--F 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 93277083 119 ACSAIMTV--MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPV 168
Cdd:cd15066  83 STASILHLccISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISfLPI 135
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-314 1.36e-10

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 61.03  E-value: 1.36e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd16002   9 VIVVVSVVGNIIVMWIILaHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPFRLTRWRTRYKTIrINLgLWAASFILALPVWVYSKVIKFKDGVeSCAFDLTSPDDVLWYTLY- 200
Cdd:cd16002  89 YSMTAIALDRYMAIIHPLQPRLSATATKVV-ICV-IWVLAFLLAFPQGYYSDTEEMPGRV-VCYVEWPEHEERKYETVYh 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 201 --LTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRvmKLTKMVLVLVVVFILSAAPYHVIQLvnLQME 278
Cdd:cd16002 166 vcVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQVSAKR--KVVKMMIVVVCTFAICWLPYHIYFL--LQYF 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 93277083 279 QPTL---AFYVGYYLSIC-LSYASSSINPFLYILLSGNFQ 314
Cdd:cd16002 242 HPELyeqKFIQQVYLAIMwLAMSSTMYNPIIYCCLNDRFR 281
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
43-317 1.40e-10

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 61.28  E-value: 1.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNIL---IVFTIIRSRKKTVpdIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCNQFA 119
Cdd:cd15152   9 VILIPGLIGNVLalwVFYAYVKETKRAV--IFMINLAIADLLQVLSLPLRIFYYLNK-SWPFGKFLCMFCFYLKYVNMYA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 120 CSAIMTVMSVDRYFALVQPFRLTRWRTRYKtIRINLGLWAASFILALPvwvYSKVIKFKDGVESCAF------DLTSPDD 193
Cdd:cd15152  86 SIYFLVCISVRRCLYLIYPFRYNDCKRKCD-VYISIAGWLVVCVGCLP---FPLLRQSQDTNPTCCFadlplrNVGLTTS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLyLTITTFFFPLPLILVCyililcyTWEMYQQNKDARCCNPSVPKQRvmKLTKMVLVLVVVFILSAAPYHVI--- 270
Cdd:cd15152 162 VIMLTI-AELTGFVTPLLIVLYC-------SWKTVMSLREKTPVLQDLGEKK--KALKMILTCAVVFLICFAPYHISfpl 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 271 -------QLVNLQMEQPTLAFYVgyyLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15152 232 dflvksnKIKSCTARKVILIFHP---VALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
36-315 1.50e-10

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 60.99  E-value: 1.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICST-GLVGNILIVFTI-IRSRKKTVPDIYICNLAVADL-VHIVGMPfLIHQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15301   1 VLIVIVAAVLSLvTVGGNVMVMISFkIDKQLQTISNYFLFSLAVADFaIGVISMP-LFTVYTALGYWPLGYEVCDTWLAI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILaLPVWVYSKVI---KFKDGVESC--AFD 187
Cdd:cd15301  80 DYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLL-WPPWIYSWPYiegKRTVPAGTCyiQFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LTSPddvlWYTLYLTITTFFFPLPLILVCYililcytWEMYQQNKDARccnpsvpKQRVMKLTKMVLVLVVVFILSAAPY 267
Cdd:cd15301 159 ETNP----YVTFGTALAAFYVPVTIMCILY-------WRIWRETKKRQ-------KKQESKAAKTLSAILLAFIVTWTPY 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 268 HVIQLVN----LQMEQPTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15301 221 NVLVLIKaffpCSDTIPTELWDFSYY----LCYINSTINPLCYALCNAAFRR 268
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-311 1.56e-10

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 60.99  E-value: 1.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  39 SMIGIICSTGLVGNILIVFTIIRSR-KKTVPDIYICNLAVADLVHIVG--MPFLIHQWArggeWVFGGP--LCTIITSLD 113
Cdd:cd15387   5 TVLALILFLALTGNICVLLAIHTTRhKHSRMYFFMKHLSIADLVVAVFqvLPQLIWDIT----FRFYGPdfLCRLVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIrinLGLWAASFILALP-VWVYSkVIKFKDGVESCAFDLTSPD 192
Cdd:cd15387  81 VVGMFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYV---LFSWLLSLVFSIPqVHIFS-LREVGNGVYDCWADFIQPW 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQ-QNKDARCCNPSVPKQRVMKLT----------------KMVLV 255
Cdd:cd15387 157 GPKAYITWITLSVYIIPVLILSVCYGLISFKIWQNVKlKTRRETKTPLSSAASGGAALArvssvkliskakirtvKMTFV 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 93277083 256 LVVVFILSAAPYHVIQLVNL-QMEQPTLAFyvGYYLSICLSYASSSINPFLYILLSG 311
Cdd:cd15387 237 IVLAYIVCWTPFFFVQMWSVwDPNAPKEAS--PFIIAMLLASLNSCCNPWIYMFFTG 291
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
40-314 1.65e-10

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 60.71  E-value: 1.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRKKTVPDIY-ICNLAVAD-LVHIVGMPFLIhQWARGGEWVFGGPLCTIITSLD-TCn 116
Cdd:cd15335   6 TLALITILTTVLNSAVIAAICTTKKLHQPANYlICSLAVTDfLVAVLVMPLSI-TYIVMDTWTLGYFICEIWLSVDmTC- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 117 qFACSAI-MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVwVYSKVIKFKDGVESCAFDltspDDVL 195
Cdd:cd15335  84 -CTCSILhLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPP-LFWRNHHDANIPSQCIIQ----HDHV 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLYLTITTFFFPLPLILVCYililcytWEMYQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYHVIQLVnL 275
Cdd:cd15335 158 IYTIYSTFGAFYIPLTLILILY-------YRIYHAASRER------------KAARILGLILGAFILSWLPFFIKELI-V 217
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 93277083 276 QMEQPTLAFYVGYYLSiCLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15335 218 GLSVMTVSPEVADFLT-WLGYVNSLVNPLLYTSFNEDFK 255
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
40-314 1.84e-10

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 60.64  E-value: 1.84e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCNQF 118
Cdd:cd15156   6 VFSMVFVLGLIANCVAIYIFMCTLKvRNETTTYMINLAISDLLFVFTLPFRIFYFVQR-NWPFGDLLCKISVTLFYTNMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALP-VWVYSKVIKFKDGVESCAFDLTSPDdvlWY 197
Cdd:cd15156  85 GSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPaSFFQSTNNQLNNNSETCFENFSSKT---WK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 198 T------LYLTITTFFFPLPLILVCYILILcytwemYQQNKDARCCNPSVPKQRVMkltKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15156 162 TylskivIFIEIVGFFIPLILNVTCSTMVL------KTLRRPNTLSRSKLNKKKVL---KMIFVHLFIFCFCFIPYNVNL 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 272 LVNLQMEQPTL-------AFYVGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15156 233 VLYSLVRTQTFkncsvvaAVRTMYPITLCIAVSNCCFDPIVYYFTSETIQ 282
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
41-247 2.48e-10

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 60.44  E-value: 2.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICS----TGLVGNILI---VFTIIRSRKKTvpDIYICNLAVADL-VHIVGMPFLIHQwARGGEWVFGGPLCTIITSL 112
Cdd:cd15065   2 IGIFLSliivLAIFGNVLVclaIFTDRRLRKKS--NLFIVSLAVADLlVALLVMTFAVVN-DLLGYWLFGETFCNIWISF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPV---WVYSKVIKFKD------GVE 182
Cdd:cd15065  79 DVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISfLPIhlgWHRLSQDEIKGlnhasnPKP 158
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 183 SCAFDLTSPddvlwYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVM 247
Cdd:cd15065 159 SCALDLNPT-----YAVVSSLISFYIPCLVMLLIYSRLYLYARKHVVNIKSQKLPSESGSKFQVP 218
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
35-315 2.78e-10

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 60.19  E-value: 2.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIY-ICNLAVAD-LVHIVGMPFLIhQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15333   5 ISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYlIASLAVTDlLVSILVMPISI-VYTVTGTWTLGQVVCDIWLSS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 D-TCnqfaCSAI---MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKViKFKDGVESCAFDl 188
Cdd:cd15333  84 DiTC----CTASilhLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQA-KAEEEVSECVVN- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 189 tspDDVLWYTLYLTITTFFFPLPLILVCYILILCytwemyqqnkDARCcnpsvpkqRVMKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15333 158 ---TDHILYTVYSTVGAFYIPTLLLIALYGRIYV----------EARA--------RERKATKTLGIILGAFIVCWLPFF 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 269 VIQLV-----NLQMEQPTLAFYVGYylsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15333 217 IISLVlpickDACWFHLAIFDFFTW-----LGYLNSLINPIIYTMSNEDFKQ 263
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
48-317 2.81e-10

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 60.52  E-value: 2.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRKKT-VPDIYICNLAVAD-LVHIVGMPFLIhQWARGGEWVFGGPLCTIiTSLDTCNQFACSAIMT 125
Cdd:cd15397  14 GLLGNICLICVIARQKEKTnVTNILIANLSFSDiLVCLVCLPFTV-VYTLMDYWIFGEVLCKM-TPFIQCMSVTVSILSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VM-SVDRYFALVQPfrlTRWRTRYKTIRINLGL-WAASFILALPVWVY-----------SKVIKFKDGVESCAFDLTSPD 192
Cdd:cd15397  92 VLiALERHQLIINP---TGWKPSVSQAYLAVVViWMLACFISLPFLAFhiltdepyknlSHFFAPLADKAVCTESWPSEH 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DVLWYTLYLTITTFFFPLPLILVCYILIlcytWEMYQQNKDA--RCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15397 169 HKLAYTTWLLLFQYCLPLLFILVCYLRI----YLRLRRRKDMleRRGEYNRRAGHSKRINVMLVSLVAAFALCWLPLNVF 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 271 QLVNLQMEQPTLAFYVGYYLSIC--LSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15397 245 NAIADWNHEAIPHCQHNLIFSLChlAAMASTCVNPIIYGFLNSNFKKEV 293
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
35-313 3.66e-10

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 59.58  E-value: 3.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15328   1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTfHRVPHNLVASMAVSDvLVAALVMPLSLVHELSGRRWQLGRSLCQVWISF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTrWRTRYKTIRINLGL-WAASFILALPVWVYSKVIKFKDGVESCAFDlTSP 191
Cdd:cd15328  81 DVLCCTASIWNVTAIALDRYWSITRHLEYT-LRTRRRISNVMIALtWALSAVISLAPLLFGWGETYSEDSEECQVS-QEP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DdvlwYTLYLTITTFFFPLPLILVCYililcytWEMYQqnkdarccnpsvPKQRVMKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15328 159 S----YTVFSTFGAFYLPLCVVLFVY-------WKIYK------------AAQKEKRAALMVGILIGVFVLCWIPFFLTE 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 93277083 272 LVNLQMEQPTLAFYVGYYLsiCLSYASSSINPFLYILLSGNF 313
Cdd:cd15328 216 LISPLCSCDIPPIWKSIFL--WLGYSNSFFNPLIYTAFNKNY 255
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
40-314 3.88e-10

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 59.56  E-value: 3.88e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCnq 117
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKlQNATNYFLMSLAIADmLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVL-- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTV--MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVY-----SKVikFKDGveSCafdLTS 190
Cdd:cd15304  84 FSTASIMHLcaISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFglqddSKV--FKEG--SC---LLA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 191 PDDvlwYTLYLTITTFFFPLPLILVCYILilcyTWEMYQQnkdarccnpSVPKQRvmKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15304 157 DEN---FVLIGSFVAFFIPLTIMVITYFL----TIKSLQQ---------SISNEQ--KASKVLGIVFFLFVVMWCPFFIT 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 271 QLVNLQMEQPTLAFYVGYYLSI--CLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15304 219 NVMAVICKESCNEVVIGGLLNVfvWIGYLSSAVNPLVYTLFNKTYR 264
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
35-319 5.04e-10

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 59.19  E-value: 5.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWvFGGPLCTIITSLDT 114
Cdd:cd14973   1 LVIFSLTVLLSLCGLVGNGLVLWLLGFRIKRNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSL-PGFALCRLLATLMF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAfdltspddv 194
Cdd:cd14973  80 FSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLESYFCGFLFWKFNESACR--------- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 lwYTLYLTITTFFFPLPLILVCYILILCYTwemyqqnkdarCCNPSVPKQRvmKLTKMVLVLVVVFILSAAPYHVIQLvn 274
Cdd:cd14973 151 --TFNFLSALLFLLLFLVMCVSSLTLLIRV-----------QCSSQRRPPT--RLYVVILLTVLVFLLCGLPLGIYWF-- 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 93277083 275 LQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQ 319
Cdd:cd14973 214 LLLWFSNYLFHTFHPISDLLSCVNSSANPIIYFFVGSLRGRRLRE 258
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
35-314 6.97e-10

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 58.84  E-value: 6.97e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15330   1 IITSLFLGTLILCAIFGNACVVAAIALERSlQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRT-RYKTIRINLgLWAASFILALPVWVYSKVIKFKDGVESCAFdltSPD 192
Cdd:cd15330  81 VLCCTSSILHLCAIALDRYWAITDPIDYVNKRTpRRAAVLISL-TWLIGFSISIPPMLGWRTPEDRSDPDACTI---SKD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 DvlWYTLYLTITTFFFPLPLILVCYILILcytwemyqqnKDArccnpsvpkQRVMKLTKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15330 157 P--GYTIYSTFGAFYIPLILMLVLYGRIF----------KAA---------ARERKTVKTLGIIMGTFILCWLPFFIVAL 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 273 V----NLQMEQPTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15330 216 VlpfcESTCHMPELLGAIINW----LGYSNSLLNPIIYAYFNKDFQ 257
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
40-272 7.57e-10

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 58.98  E-value: 7.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIIcstGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGeWVFGGPLCTIITSLDTCNQ 117
Cdd:cd15073   9 VAGII---STISNGIVLVTFVKFRElRTPTNALIINLAVTDLgVSIIGYPFSAASDLHGS-WKFGYAGCQWYAFLNIFFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVeSCAFDLTSPDDV-LW 196
Cdd:cd15073  85 MASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGA-TCTINWRKNDSSfVS 163
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 197 YTLYLTITTFFFPLPLILVCYILILCYtweMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15073 164 YTMSVIVVNFIVPLAVMFYCYYNVSRF---VKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPYSIVCL 236
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
47-315 8.23e-10

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 58.81  E-value: 8.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  47 TGLVGNILIVFTIIRS-RKKTVP-DIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIM 124
Cdd:cd15170  13 IGLPANLLAFYTFIRKvRRKPTPiDILLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFIFFSTIYISTLFL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 125 TVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKD---GVESCAFDLTSPDD---VLWYT 198
Cdd:cd15170  93 TAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFSHCSIVYIVEYHIDSENtsvTNNSRCYDNFTPEQlkiLLPVR 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 199 LYLTITTFFFPLPLILVCYILILcytWEMYqqnkdarcCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVN-LQM 277
Cdd:cd15170 173 LELFLVLFCIPFLITCFCYINFI---RILS--------SLPHISRQRKQRAIGLAVATLLNFIVCFAPYNISHVVGfIQR 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 93277083 278 EQPTLAFYVgyylsICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15170 242 KSPEWRMYA-----LLLSTLNACLDPIIFYFSSSAVRR 274
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
37-315 1.27e-09

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 58.38  E-value: 1.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGlvGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15305   5 LLILIIIILTIG--GNILVIMAVSLEKKlQNATNFFLMSLAVADmLVGILVMPVSLIAILYDYAWPLPRYLCPIWISLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CnqFACSAIMTV--MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVY-----SKVikFKDGveSCAfd 187
Cdd:cd15305  83 L--FSTASIMHLcaISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVIglqddEKV--FVNG--TCV-- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LTSPDdvlwYTLYLTITTFFFPLPLILVCYililCYTWEMYQQNKdarccnpSVPKQRvmKLTKMVLVLVVVFILSAAPY 267
Cdd:cd15305 155 LNDEN----FVLIGSFVAFFIPLIIMVITY----CLTIQVLQRQQ-------AINNER--RASKVLGIVFFLFLIMWCPF 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 268 HVIQLVNLQMEQPTLAFYVGYYLS--ICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15305 218 FITNILSVLCKEACDQKLMEELLNvfVWVGYVSSGINPLVYTLFNKTYRR 267
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
41-315 1.30e-09

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 58.00  E-value: 1.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLV-HIVGMPFLIHQWARGGeWVFGGPLCTIITSLDTCNQF 118
Cdd:cd15327   7 LAIFILMAIVGNILVILSVACNRHlQTVTNYFIVNLAIADLLlSTTVLPFSATLEVLGF-WAFGRVFCDIWAAVDVLCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALpvwvySKVIKFKDGVESCAfDLTSPDDVLWYT 198
Cdd:cd15327  86 ASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISI-----GPLLGWKEPPPPDE-SICSITEEPGYA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 199 LYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDArccnpsvpkqrvmkltKMVLVLVVVFILSAAPYH-VIQLVNL-- 275
Cdd:cd15327 160 LFSSLFSFYLPLMVILVMYFRVYVVALKFSREKKAA----------------KTLAIVVGVFILCWFPFFfVLPLGSFfp 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 93277083 276 QMEQPTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15327 224 ALKPSEMVFKVIFW----LGYFNSCVNPIIYPCSSKEFKR 259
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
43-220 1.44e-09

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 58.48  E-value: 1.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTgLVGNILIVFTIIRSR--KKTVPDIYICNLAVADL-VHIVGMPF-LIHQWArgGEWVFGGpLCTIITSLDTCNQF 118
Cdd:cd15320  11 LILST-LLGNTLVCAAVIRFRhlRSKVTNFFVISLAVSDLlVAVLVMPWkAVAEIA--GFWPFGS-FCNIWVAFDIMCST 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPV---WVYSKVIKFKDG-VESCAFDLTSPDD 193
Cdd:cd15320  87 ASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfIPVqlnWHKAKPTSFLDLnASLRDLTMDNCDS 166
                       170       180
                ....*....|....*....|....*....
gi 93277083 194 VL--WYTLYLTITTFFFPLPLILVCYILI 220
Cdd:cd15320 167 SLnrTYAISSSLISFYIPVAIMIVTYTRI 195
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
50-220 1.80e-09

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 57.86  E-value: 1.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  50 VGNILIVFTIIRSRK-KTVPDIYICNLAVADLVH-IVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVM 127
Cdd:cd15212  16 LGNCAVIGVIVKHRQlRTVTNAFILSLSLSDLLTaLLCLPFAFLTLFSRPGWLFGDRLCLANGFFNACFGIVSTLTMTLI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 128 SVDRYFALVQPFRLTRWRTRykTIRINLGLWAASFILALPVWVYSKVIKF--KDGVESCAFDLTSPDDVLW--YTLYLTI 203
Cdd:cd15212  96 SFDRYYAIVRQPQGKIGRRR--ALQLLAAAWLTALGFSLPWYLLASAPEYyeKLGFYHCLYVLHSGPSRLGaaYSSVLIV 173
                       170
                ....*....|....*..
gi 93277083 204 TTFFFPLPLILVCYILI 220
Cdd:cd15212 174 LCYLLPFALMCFCHYNI 190
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
41-217 1.89e-09

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 58.24  E-value: 1.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVH-IVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQF 118
Cdd:cd15005   7 LGLILCVSLAGNLLFSVLIVRDRSlHRAPYYFLLDLCLADGLRsLACFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTS--PDDVLW 196
Cdd:cd15005  87 HSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTFIREEDQCTFEHRSykANDTLG 166
                       170       180
                ....*....|....*....|....
gi 93277083 197 YTLYLTI---TTFFFPLPLILVCY 217
Cdd:cd15005 167 FMLVLAVviaATHLVYLKLLIFLR 190
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
42-314 3.27e-09

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 56.72  E-value: 3.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  42 GIICSTGLVGNILIVFTI-IRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFggplCTIITSLDTCNQFAC 120
Cdd:cd15163   8 TLIFLVGIVLNSLALYVFcFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMYYSAGNCLT----CSFVHIFSYFVNMYC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAI-MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPvwVYSKVIKFKdgvESCAFDLtspddvlwytL 199
Cdd:cd15163  84 SILfLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFS--ILTTAIKFA---SCCLSKL----------F 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 200 YLTITTFFFPLPLILVCYILILCYTWE--MYQQNKDARccnpsvpkqrvMKLTKMVLVLVVVFILSAAPYHVIQ-LVNLQ 276
Cdd:cd15163 149 ALTVFEFFLPLLIITFFTIRIMCALSRpgLMHQSRERR-----------MRAVQLLITVLIIFMICFTPFHVRQvAVAFN 217
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 93277083 277 MEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15163 218 PDIPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
35-313 3.38e-09

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 56.59  E-value: 3.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPF-LIHQWArgGEWVFGGPLCTIITS 111
Cdd:cd15331   1 VLTSIILGLLILATIIGNVFVIAAILLERSlQGVSNYLILSLAVADLmVAVLVMPLsAVYEVS--QHWFLGPEVCDMWIS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTcnqFACSAI---MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLgLWAASFILALPVWVYSKVIKFKDGVESCAFDL 188
Cdd:cd15331  79 MDV---LCCTASilhLVAIALDRYWAVTNIDYIRRRTAKRILIMIAV-VWFVSLIISIAPLFGWKDEDDLDRVLKTGVCL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 189 TSPDdvLWYTLYLTITTFFFPLPLILVCYililcytWEMYQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15331 155 ISQD--YGYTIFSTVGAFYVPLLLMIIIY-------WKIYQAAKRER------------KAARTLAIITGAFVVCWLPFF 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 93277083 269 VIQLVnLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNF 313
Cdd:cd15331 214 LVALV-MPFCGAWQISRFLESFFLWLGYFNSLLNPIIYTIFSPDF 257
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
49-306 3.40e-09

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 57.00  E-value: 3.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRKK--TVPDIYICNLAVADLVHIVGMPFLI-HQWARGGEW----VFGGPLCTIITSldtcnqfaCS 121
Cdd:cd15104  14 ITGNLLVIVALLKLIRKkdTKSNCFLLNLAIADFLVGLAIPGLAtDELLSDGENtqkvLCLLRMCFVITS--------CA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 A-IMTVM--SVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKvIKFKDGVESCAFDLTSPDDVLwyt 198
Cdd:cd15104  86 AsVLSLAaiAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQ-FQQTSYKGKCSFFAAFHPRVL--- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 199 LYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRV----MKLTKMVLVLVVVFILSAAPYHVIQLVN 274
Cdd:cd15104 162 LVLSCMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHPRRtlsdFKAARTVAVLIGCFLLSWLPFQITGLVQ 241
                       250       260       270
                ....*....|....*....|....*....|..
gi 93277083 275 LQMEQPTLAFYVGYYLSIcLSYASSSINPFLY 306
Cdd:cd15104 242 ALCDECKLYDVLEDYLWL-LGLCNSLLNPWIY 272
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
48-317 3.49e-09

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 56.76  E-value: 3.49e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVHIVGMpfLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd14989  14 GFIGNILILVVNLSFREKmTIPDLYFVNLAVADLILVADS--LIEVFNLNEKYYDIAVLCTFMSLFLQINMYSSIFFLTW 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTiRINLGL-WAASFILALPVWVYSKViKFKDGVESCAFDLTspdDVLWYTLYLtitT 205
Cdd:cd14989  92 MSFDRYIALAKVMKSSPLRTMQHA-RLSCGLiWMASISATLLPFTAVQA-QHTGEVHFCFADVR---EIQWLEVTL---G 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 206 FFFPLPLILVCYILILcytwEMYQQNKDARCCNPsvpkqRVMKLTKMVLVLVVVFILSAAPYHV-IQLVNLQMEQPTLAF 284
Cdd:cd14989 164 FIIPFSIIGLCYSLIV----RVLVRAQKHRRLRP-----RRQKALRMILVVVLVFFICWLPENVfISIQLLQGTQEPSES 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 93277083 285 Y----------VGYYLSIClSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14989 235 YdesfrhnhplTGHIVNLA-AFSNSCLNPLIYSFLGETFRDKL 276
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
49-314 5.19e-09

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 56.38  E-value: 5.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRK-KTVPDIYICNLAVADLV-HIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15308  15 IAGNVLVCLSVCTERAlKTTTNYFIVSLAVADLLlALLVLPLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGvESCAFDLTSpddvlwYTLYLTITTF 206
Cdd:cd15308  95 ISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDP-AVCKLEDNN------YVVYSSVCSF 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 207 FFPLPLILVCYililcytWEMYQQNKDARccnpsvpkqrvmKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQ----PTL 282
Cdd:cd15308 168 FIPCPVMLVLY-------CAMFRGLGRER------------KAMRVLPVVVGAFLFCWTPFFVVHITRALCEScsipPQL 228
                       250       260       270
                ....*....|....*....|....*....|..
gi 93277083 283 AFYVGYylsicLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15308 229 ISIVTW-----LGYVNSALNPVIYTVFNAEFR 255
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
44-221 5.41e-09

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 56.37  E-value: 5.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  44 ICSTGLVGNI--LIVFTIIRSRKKTVpDIYICNLAVADLVHIVGMPFLIHQWARgGEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd15166  10 IFIIGLFVNItaLWVFSCTTKKRTTV-TVYMMNVALVDLIFILSLPFRMVYYAK-DEWPFGDYFCRILGALTVFYPSIAL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESC--AFDLTSPDDVlwYTL 199
Cdd:cd15166  88 WLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYEDPDKASNFTTClkMLDIIHLKEV--NVL 165
                       170       180
                ....*....|....*....|....
gi 93277083 200 YLTITTFFFPLPLILV--CYILIL 221
Cdd:cd15166 166 NFTRLIFFFLIPLFIMigCYLVII 189
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
40-315 5.78e-09

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 56.03  E-value: 5.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCnq 117
Cdd:cd15324   6 VVVVIILVTIVGNVLVVVAVFTSRALRAPqNLFLVSLASADiLVATLVIPFSLANEVMG-YWYFGSTWCAFYLALDVL-- 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAI--MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKvikfKDGVESCAFDLTspddvl 195
Cdd:cd15324  83 FCTSSIvhLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTK----HDEWECLLNDET------ 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLYLTITTFFFPlplilvCYILILCYtwemyqqnkdarCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNL 275
Cdd:cd15324 153 WYILSSCTVSFFAP------GLIMILVY------------CKIYRVAKMREKRFTFVLAVVMGVFVLCWFPFFFTYSLHA 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 93277083 276 QMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15324 215 VCRKRCGIPDALFNLFFWIGYCNSSVNPIIYTIFNRDFRK 254
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
51-217 5.87e-09

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 56.41  E-value: 5.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  51 GNILIVFTIIR-SRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSV 129
Cdd:cd15957  17 GNVLVITAIAKfERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 130 DRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPVWVYSKVIKFKDGV-----ESCAFDLTSPDdvlwYTLYLTI 203
Cdd:cd15957  97 DRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSfLPIQMHWYRATHQEAIncyaeETCCDFFTNQA----YAIASSI 172
                       170
                ....*....|....
gi 93277083 204 TTFFFPLPLILVCY 217
Cdd:cd15957 173 VSFYVPLVIMVFVY 186
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
41-222 9.82e-09

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 55.35  E-value: 9.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILI--VFTIiRSRKKTVPDIYICNLAVADLVHIVGMPFLIH-QWARggewVFGGPLCTIITSLDTCNQ 117
Cdd:cd15164   7 YIPILFFGLLFNVLAlwVFCC-KMKKWTETRVYMINLAVADCCLLFSLPFVLYfLKHS----WPDDELCLVLQSIYFINR 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILalpvwVYSKVIKFKDGVESCaFDLTSPDDVLWy 197
Cdd:cd15164  82 YMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVLVIIS-----VSLRLAWEEQEENFC-FGKTSTRPSKR- 154
                       170       180
                ....*....|....*....|....*
gi 93277083 198 TLYLTITTFFFPLPLILVCYILILC 222
Cdd:cd15164 155 TLIFSLLGFFIPLIILSFCSIQVIR 179
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
39-315 1.02e-08

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 55.51  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  39 SMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVHIVGMP--FLIHQWARggEWVFGGPLCTIITSLDTC 115
Cdd:cd15000   4 SMFLPVVLFGIFGNFVLLYILASNRSlRTPTNLLIGNMALADLLTLLVCPwmFLVHDFFQ--NYVLGSVGCKLEGFLEGS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRlTRWRTRYKTIRINLgLWAASFILALPVWVYS--KVIKFKDGVESCAFDLTSPDD 193
Cdd:cd15000  82 LLLASVLALCAVSYDRLTAIVLPSE-ARLTKRGAKIVIVI-TWIVGLLLALPLAIYRsyRERQWKNFLETYCAENTQVLP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLyLTITTFFfPLPLILVCYILIlcytweMYQQNKDARCC----NPSVP--KQRVMkltKMVLVLVVVFILSAAPY 267
Cdd:cd15000 160 IYWHVI-ITVLVWL-PLGIMLICYSAI------FWKLDKYERRVlrreHPSVVryKKKAA---KTLFIVLITFVVCRIPF 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 268 HVIQLVNLQM-------EQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15000 229 TALIFYRYKLvpndntqNSVSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFRK 283
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
49-218 1.04e-08

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 55.68  E-value: 1.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRS-RKKTVPDIYICNLAVADLVH-IVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15958  15 VAGNVLVIVAIGRTqRLQTLTNLFITSLACADLVMgLLVVPFGATLVVRG-RWLYGSFFCELWTSVDVLCVTASIETLCV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPVWVY------SKVIKFKDGVESCAFDLTSPddvlwYTL 199
Cdd:cd15958  94 IAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSfLPIMMHwwrdedDQALKCYEDPGCCDFVTNRA-----YAI 168
                       170
                ....*....|....*....
gi 93277083 200 YLTITTFFFPLPLILVCYI 218
Cdd:cd15958 169 ASSIISFYIPLLIMIFVYL 187
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
35-315 1.32e-08

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 55.19  E-value: 1.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVhivgMPFLIHQWARG----GEWVFGGPLCTII 109
Cdd:cd15062   1 IVVGVALGAFILFAIGGNLLVILSVACNRHlRTPTHYFIVNLAVADLL----LSFTVLPFSATlevlGYWAFGRIFCDVW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 110 TSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILAL-PVWVYSKVIKFKD---GVESCA 185
Cdd:cd15062  77 AAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIgPLLGWKEPAPADEqacGVNEEP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 186 FdltspddvlwYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDArccnpsvpkqrvmkltKMVLVLVVVFILSAA 265
Cdd:cd15062 157 G----------YVLFSSLGSFYLPLAIILVMYCRVYVVAFKFSREKKAA----------------KTLGIVVGAFVLCWF 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 93277083 266 PYHVIQLVNL---QMEQPTLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15062 211 PFFVVLPLGSlfsTLKPPEPVFKVVFW----LGYFNSCLNPIIYPCSSREFKR 259
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
36-317 2.02e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 54.51  E-value: 2.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNIL-IVFTIIRSRKKTVPDIYICNLAVADLvhIVGMPFLI----------------HQWARGGe 98
Cdd:cd15137   2 VLRVFIWVVGIIALLGNLFvLIWRLKYKEENKVHSFLIKNLAIADF--LMGVYLLIiasvdlyyrgvyikhdEEWRSSW- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  99 wvfggpLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRyKTIRINLGLWAASFILA-LPVWVYSKVIKF 177
Cdd:cd15137  79 ------LCTFAGFLATLSSEVSVLILTLITLDRFICIVFPFSGRRLGLR-RAIIVLACIWLIGLLLAvLPLLPWDYFGNF 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 178 --KDGVesC-AFDLTSPDDVLW-YTLYLTITTFFFPLPLILVCYILilcytweMYQQNKDARCCNPSVPKQRVMKLTKMV 253
Cdd:cd15137 152 ygRSGV--ClPLHITDERPAGWeYSVFVFLGLNFLAFVFILLSYIA-------MFISIRRTRKAAASRKSKRDMAVAKRF 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 93277083 254 LVLVVVFILSAAPYHVIQLVNL---QMEQPTLAFYVGYYLSIclsyaSSSINPFLYILLSGNFQKRL 317
Cdd:cd15137 223 FLIVLTDFLCWIPIIVIGILALsgvPIPGEVYAWVAVFVLPI-----NSALNPILYTLSTPKFRKKL 284
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
51-219 2.38e-08

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 54.45  E-value: 2.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  51 GNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCnqFACSAIMTV-- 126
Cdd:cd15306  17 GNILVILAVSLEKKlQYATNYFLMSLAVADLlVGLFVMPIALLTILFEAMWPLPLVLCPIWLFLDVL--FSTASIMHLca 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVysKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTF 206
Cdd:cd15306  95 ISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPI--KGIETDVDNPNNITCVLTKERFGDFILFGSLAAF 172
                       170
                ....*....|...
gi 93277083 207 FFPLPLILVCYIL 219
Cdd:cd15306 173 FTPLAIMIVTYFL 185
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
49-220 2.40e-08

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 54.58  E-value: 2.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSR--KKTVPDIYICNLAVADL-VHIVGMPF-LIHQWArgGEWVFGGpLCTIITSLDTCNQFACSAIM 124
Cdd:cd15319  15 LLGNILVCAAVVRFRhlRSKVTNIFIVSLAVSDLfVALLVMPWkAVAEVA--GYWPFGA-FCDVWVAFDIMCSTASILNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 125 TVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPV-----------WVYSKVIKFKDGV-ESCAFDLTSP 191
Cdd:cd15319  92 CVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISfIPVqlnwhkdsgddWVGLHNSSISRQVeENCDSSLNRT 171
                       170       180
                ....*....|....*....|....*....
gi 93277083 192 ddvlwYTLYLTITTFFFPLPLILVCYILI 220
Cdd:cd15319 172 -----YAISSSLISFYIPVAIMIVTYTRI 195
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
49-315 4.03e-08

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 53.76  E-value: 4.03e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGeWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15401  15 VLGNLLVILSVLRNKKlRNAGNIFVVSLSVADLvVAVYPYPLILLAIFHNG-WTLGNIHCQISGFLMGLSVIGSVFNITA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWvYSKVIKFKDGVESCAFDLTSPDDvlwYTLYLTITTF 206
Cdd:cd15401  94 IAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNF-FVGSLQYDPRIYSCTFAQTVSSS---YTITVVVVHF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 207 FFPLPLILVCYILIlcytWEMYQQNKDaRCCNPSVPKQRVMKLtKMVLVLVVVFILSA---APYHVIQL---VNLQMEQP 280
Cdd:cd15401 170 IVPLSIVTFCYLRI----WVLVIQVKH-RVRQDSKQKLKANDI-RNFLTMFVVFVLFAvcwGPLNFIGLavaINPLKVAP 243
                       250       260       270
                ....*....|....*....|....*....|....*
gi 93277083 281 TLAFYVgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15401 244 KIPEWL-FVLSYFMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
41-306 4.05e-08

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 53.98  E-value: 4.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIRSRKKTVPdIY--ICNLAVADL-VHIVGMPFLIhQWARGGEWVFGGPLCTIITSLDTCNQ 117
Cdd:cd15384   7 LAVMFVISFIGNLLTIIQIYRLRRSRRT-IYslLLHLAIADLlVTFFCIPSEA-IWAYTVAWLAGNTMCKLVKYLQVFGL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPfrLTRWRTRYKTIRINLGLWAASFILALPvwvysKVIKFKDGVESCAFDLTSPDDVLWY 197
Cdd:cd15384  85 YLSTYITVLISLDRCVAILYP--MKRNQAPERVRRMVTVAWILSPIFSIP-----QAVIFHVERGPFVEDFHQCVTYGFY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 198 T------LYLTITTFF-FPLPLI--LVCYILI---LCYTWEMYQQNKDARCcNPSVPKQRVM-----KLTKMVLVLVVVF 260
Cdd:cd15384 158 TaewqeqLYNMLSLVFmFPIPLVimVTCYVLIfitLSKSSRDFQGLEIYTR-NRGPNRQRLFhkakvKSLRMSAVIVTAF 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 261 ILSAAPYHVIQLVNLQMEQPTLAFYVGYYLsICLSYASSSINPFLY 306
Cdd:cd15384 237 ILCWTPYYVIMIWFLFFNPYPLNDILFDVI-FFFGMSNSCVNPLIY 281
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
34-221 4.86e-08

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 53.14  E-value: 4.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  34 TVILPSMIGIicstGLVGNiLIVFTIIRSRK--KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIIT 110
Cdd:cd15213   4 AILMILMIFV----GFLGN-SIVCLIVYQKPamRSAINLLLANLAFSDiMLSLVCMPFAAVTIITG-RWIFGDIFCRISA 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 111 SLDTCNQFACSAIMTVMSVDRYFALVQpfRLTRWRTRYKTIRInLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTS 190
Cdd:cd15213  78 MLYWFFVLEGVAILLIISVDRYLIIVQ--RQDKLNPHRAKILI-AVSWVLSFCVSFPPLVGWGKYEFPPRAPQCVLGYTE 154
                       170       180       190
                ....*....|....*....|....*....|.
gi 93277083 191 PDDVLWYTLYLTITTFFFPLPLILVCYILIL 221
Cdd:cd15213 155 SPADRIYVVLLLVAVFFIPFLIMLYSYFCIL 185
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
35-317 5.61e-08

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 53.25  E-value: 5.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDT 114
Cdd:cd15151   1 VVFPVLYTVLFLVGLILNSVAAWIFFHIPSTSTFIVYLKNTLVADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVVFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAfDLTSPDDV 194
Cdd:cd15151  81 ITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPATPISVKKCA-SLKSPLGL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFF--PLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15151 160 KWHEVVNYICQFIFwgVFALMVLFYTIISKKVYESYKKSRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFVRVPYTLSQT 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 93277083 273 VNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15151 240 GKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
49-315 6.23e-08

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 52.98  E-value: 6.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRK-KTVPDIYICNLAVADLV-HIVGMPFLIHQWARGGeWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15402  15 ILGNLLVILSVYRNKKlRNAGNIFVVSLAVADLVvAIYPYPLVLTSIFHNG-WNLGYLHCQISGFLMGLSVIGSIFNITG 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVwVYSKVIKFKDGVESCAFDLTSPDDvlwYTLYLTITTF 206
Cdd:cd15402  94 IAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPN-LFVGSLQYDPRIYSCTFAQSVSSA---YTIAVVFFHF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 207 FFPLPLILVCYILILCYTWEMYQQNKDARccNPSVPKQRVMKLTKMvLVLVVVFILSAAPYHVIQL-VNLQMEQ-----P 280
Cdd:cd15402 170 ILPIIIVTFCYLRIWILVIQVRRRVKPDN--KPKLKPHDFRNFVTM-FVVFVLFAVCWAPLNFIGLaVAVDPETivpriP 246
                       250       260       270
                ....*....|....*....|....*....|....*
gi 93277083 281 TLAFYVGYYlsicLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15402 247 EWLFVASYY----MAYFNSCLNAIIYGLLNQNFRR 277
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
51-218 6.73e-08

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 53.37  E-value: 6.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  51 GNILIVFTIIRS-RKKTVPDIYICNLAVADLVhivgMPFLI----HQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMT 125
Cdd:cd15959  17 GNLLVIVAIAKTpRLQTMTNVFVTSLACADLV----MGLLVvppgATILLTGHWPLGTTVCELWTSVDVLCVTASIETLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAAS-FILALPV---W----VYSKVIKFKDGVESCAFDLTSPddvlwY 197
Cdd:cd15959  93 AIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISaAISFLPImnqWwrdgADEEAQRCYDNPRCCDFVTNMP-----Y 167
                       170       180
                ....*....|....*....|.
gi 93277083 198 TLYLTITTFFFPLPLILVCYI 218
Cdd:cd15959 168 AIVSSTVSFYVPLLVMIFVYV 188
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
43-322 7.23e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 53.06  E-value: 7.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRKKTVPD-IYICNLAVADLVhiVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd14972   7 VLGVFIVVENSLVLAAIIKNRRLHKPMyILIANLAAADLL--AGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 122 AI-MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPVWVYSKVIKFKdgvESCAfDLTSPDDvlwYTL 199
Cdd:cd14972  85 AYsLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAlLPVLGWNCVLCDQ---ESCS-PLGPGLP---KSY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 200 YLTITTFFF-PLPLILVCYILILCYTW----EMYQQNKDARCCNPSVPkqrvMKLTKMVLVLVVVFILSAAPYHVIQLVN 274
Cdd:cd14972 158 LVLILVFFFiALVIIVFLYVRIFWCLWrhanAIAARQEAAVPAQPSTS----RKLAKTVVIVLGVFLVCWLPLLILLVLD 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 93277083 275 LQMEQPTLAFYVGYYLSICLSYaSSSINPFLYILlsgnfqkRLPQIQR 322
Cdd:cd14972 234 VLCPSVCDIQAVFYYFLVLALL-NSAINPIIYAF-------RLKEMRR 273
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
40-273 7.44e-08

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 52.92  E-value: 7.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVHIV-GMPFLIHQwARGGEWVFGGPLCTIITSLDTCNQ 117
Cdd:cd15215   5 LIVIFLCASLFGNIVLLLVFQRKPQLlQVANRFIFNLLVADLLQTVlVMPWVIAT-SVPLFWPLDSHLCTALVVLMHLFA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAfdltspddVLW- 196
Cdd:cd15215  84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDERNALCS--------VIWg 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 197 ----YTLYLTITTFFFPLPLILVCYILILCYTWEMYQqnkdarccnpsvpkqrvMKLTKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15215 156 ssysYTILSVVSSFVLPVIIMLACYSMVFRAARRCYH-----------------CKAAKVIFIIIFSYVLSMGPYSFLSV 218

                .
gi 93277083 273 V 273
Cdd:cd15215 219 L 219
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
35-306 1.57e-07

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 51.86  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIY-ICNLAVAD-LVHIVGMPFLIhqwARGGE--WVFGGPLCTIIT 110
Cdd:cd15314   1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYlILSLAVADlLVGGLVMPPSM---VRSVEtcWYFGDLFCKIHS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 111 SLD----TCNQFACSAImtvmSVDRYFALVQPFrltRWRTRYkTIRINLGL----WAASFILA-----LPVWVYSKVIKF 177
Cdd:cd15314  78 SFDitlcTASILNLCFI----SIDRYYAVCQPL---LYRSKI-TVRVVLVMilisWSVSALVGfgiifLELNIKGIYYNH 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 178 KDGVESCAFDLTSPDDVLWytlylTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLV 257
Cdd:cd15314 150 VACEGGCLVFFSKVSSVVG-----SVFSFYIPAVIMLCIYLKIFLVAQRQARSIQSARTKSGASSSKMERKATKTLAIVM 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 93277083 258 VVFILSAAPYHVIQLVN--LQMEQPTLAFYVgyylSICLSYASSSINPFLY 306
Cdd:cd15314 225 GVFLLCWTPFFLCNIIDpfINYSIPPVLIEV----LNWLGYSNSTLNPFIY 271
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
43-223 1.98e-07

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 51.45  E-value: 1.98e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLvhIVGMPFLI------------HQWARggEWVFGGpLCTII 109
Cdd:cd15136   9 FVFLLALVGNIIVLLVLLTSRTKlTVPRFLMCNLAFADF--CMGIYLGLlaivdaktlgeyYNYAI--DWQTGA-GCKTA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 110 TSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWV----YSKvikfkdgVESC- 184
Cdd:cd15136  84 GFLAVFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVgvssYSK-------TSICl 156
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 93277083 185 AFDLTSPDDVLWYTLYLTITTFFFplPLILVCYILILCY 223
Cdd:cd15136 157 PFETETPVSKAYVIFLLLFNGLAF--LIICGCYIKIYLS 193
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
35-221 3.73e-07

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 50.57  E-value: 3.73e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQwARGGEWVFGGPLCTIITSL 112
Cdd:cd15054   1 GWVAAFLCLIILLTVAGNSLLILLIFTQRSlRNTSNYFLVSLFMSDLmVGLVVMPPAMLN-ALYGRWVLARDFCPIWYAF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTcnqFACSAI---MTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALP----------VWVYSKVIKFKD 179
Cdd:cd15054  80 DV---MCCSASilnLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLpielgwhelgHERTLPNLTSGT 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 93277083 180 GVESCAFDLTSPddvlwYTLYLTITTFFFPLPLILVCYILIL 221
Cdd:cd15054 157 VEGQCRLLVSLP-----YALVASCLTFFLPSGAICFTYCRIL 193
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
40-315 6.65e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 50.04  E-value: 6.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTgLVGNILIVFTIIRSRKKTVP-DIYICNLAVAD-LVHIVGMPFLIHQWARGGeWVFGGPLCTIITSLDTCNQ 117
Cdd:cd15312   7 MAGAILLT-VFGNLMVIISISHFKQLHSPtNFLILSLAITDfLLGFLVMPYSMVRSVESC-WYFGDLFCKIHSSLDMMLS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVwVYSKVikFKDGVE----------SCAFD 187
Cdd:cd15312  85 TTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGV-VFSEV--NLEGIEdyvalvsctgSCVLI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LtspdDVLWYTLYLTItTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPS-----VPKQRVMKLTKMVLVLVVVFIL 262
Cdd:cd15312 162 F----NKLWGVIASLI-AFFIPGTVMIGIYIKIFFVARKHAKVINNRPSVTKGdsknkLSKKKERKAAKTLSIVMGVFLL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 93277083 263 SAAPYHVIQLVNlqmeqPTLAF---YVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15312 237 CWLPFFVATLID-----PFLNFstpVDLFDALVWLGYFNSTCNPLIYGFFYPWFQK 287
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
43-317 8.89e-07

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 49.83  E-value: 8.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRS-RKKTVPDIYICNLAVAD-LVHIVGMPFLIhQWARGGEWVFGGPLCTIiTSLDTCNQFAC 120
Cdd:cd15396   9 VVTIVGLFGNLCLITIIKKQkEEHNVTNILIANLSLSDvLVCVMCIPFTA-VYTLMDHWIFGETMCKL-TSFVQSVSVSV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAIMTVM-SVDRYFALVQPfrlTRWRTRYKTIRINLGL-WAASFILALPVWVYSKVIK------------FKDGVeSCAF 186
Cdd:cd15396  87 SIFSLVLiAIERYQLIVNP---RGWKPSASHAYWGIVLiWLFSLMISIPFLIFHQLTDepfrnlsshsdfYKDKV-VCIE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 187 DLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRvmKLTKMVLVLVVVFILSAAP 266
Cdd:cd15396 163 AWPSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNSKIDRMRENESRLSENK--RINTMLISIVVTFAACWLP 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 93277083 267 YHVIQLVNLQMEQPTLAFYVGYYLSIC--LSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15396 241 LNIFNVVFDWNHEVLMSCHHNLVFTLChlVAMVSTCINPIFYGFLNKNFQKDL 293
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
35-315 1.08e-06

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 49.48  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK----KTVPDIYICNLAVAD-LVHIVGMPFLIHQ--WARGgEWVFGGPLCT 107
Cdd:cd15356   1 VLFTAVYALIWALGAAGNALTIHLVLKKRSlrglQGTVHYHLVSLALSDlLILLISVPIELYNfvWFHY-PWVFGDLVCR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 108 IITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVyskVIKFKDGVEScAFD 187
Cdd:cd15356  80 GYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAF---IMGQKYELET-ADG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMyqqnkdaRCCNPSVPKQRVMKLT-KMVLVLVVVFILSAAP 266
Cdd:cd15356 156 EPEPSSRVCTVLVSRATLKVFIQVNAFVSFVLPLALIAFL-------NGVTVSHLRIQSLQHSvQVLRAIVIAYVICWLP 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 267 YHVIQLVNLQM-----EQPTLAFYVGYY-LSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15356 229 YHARRLMFCYVpddawTDSLYNFYHYFYmLTNTLFYVSSAVNPLLYNVVSSSFRK 283
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
47-314 1.43e-06

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 49.06  E-value: 1.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  47 TGLVGNILIVFTIIRSRKKTVPDIYI-CNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMT 125
Cdd:cd15080  13 LGFPINFLTLYVTVQHKKLRTPLNYIlLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWSLV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKfkDGVE-SCAFDLTSPDDVLW---YTLYL 201
Cdd:cd15080  93 VLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIP--EGMQcSCGIDYYTLKPEVNnesFVIYM 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 202 TITTFFFPLPLILVCYILILCYTWEMYQQNKDarccnpSVPKQRVMK-LTKMVLVLVVVFILSAAPYHVIQLVnLQMEQP 280
Cdd:cd15080 171 FVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQE------SATTQKAEKeVTRMVIIMVIAFLICWVPYASVAFY-IFTHQG 243
                       250       260       270
                ....*....|....*....|....*....|....
gi 93277083 281 TLAFYVGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15080 244 SDFGPIFMTIPAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
34-170 1.65e-06

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 48.64  E-value: 1.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  34 TVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLD 113
Cdd:cd14994   1 TYSLIFLYSVVLIGGVIGVILMSFLLVKMNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYASK-TWKFGMPLCKMVSAMI 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWV 170
Cdd:cd14994  80 HIHMHLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFV 136
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
51-315 1.68e-06

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 48.49  E-value: 1.68e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  51 GNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCNQFACSAIMTVMS 128
Cdd:cd15309  17 GNVLVCMAVSREKAlQTTTNYLIVSLAVADLlVATLVMPWVVYLEVVG-EWRFSRIHCDIFVTLDVMMCTASILNLCAIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 129 VDRYFALVQPFRL-TRWRTRYKTIRINLGLWAASFILALPVwvyskVIKFKDGVESCAFdLTSPDdvlwYTLYLTITTFF 207
Cdd:cd15309  96 IDRYTAVAMPMLYnTRYSSKRRVTVMISVVWVLSFAISCPL-----LFGLNNTDQNECI-IANPA----FVVYSSIVSFY 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 208 FPLPLILVCYILILcytwemyqqnkdarccnpsVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYvg 287
Cdd:cd15309 166 VPFIVTLLVYVQIY-------------------IVLQKEKKATQMLAIVLGVFIICWLPFFITHILNMHCDCNIPPAL-- 224
                       250       260
                ....*....|....*....|....*...
gi 93277083 288 YYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15309 225 YSAFTWLGYVNSAVNPIIYTTFNIEFRK 252
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
49-315 2.04e-06

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 48.67  E-value: 2.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMP-FLIHQWARGgeWVFGGPLCTIITSLDTCNQFACSAIMT 125
Cdd:cd15981  15 MVGNGLVCFIVLKNRQmRTVTNMFILNLAVSDlLVGIFCMPtTLVDNLITG--WPFDNAMCKMSGLVQGMSVSASVFTLV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VMSVDRYFALVQPFRlTRWRTRYKTIRINLgLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLW--------- 196
Cdd:cd15981  93 AIAVERFRCIVHPFR-QKLTLRKAIVTIVI-IWVLALIIMCPSAVTLTVTREEHHFMVDDYNNSYPLYSCWeawpdtemr 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 197 --YTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPK--QRVMKLTKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15981 171 kiYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRGSQGEEEEGRRvsKRKIKVINMLIIVALFFTLSWLPLWTLML 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 273 VN--LQMEQPTLAFYVGYYLSIC--LSYASSSINPFLYILLSGNFQK 315
Cdd:cd15981 251 LTdyGHLSEDQLNLVTVYVFPFAhwLAFFNSSVNPIIYGYFNENFRR 297
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
35-221 2.35e-06

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 48.30  E-value: 2.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTII-RSRKKTVPDIYICNLAVAD-LVHIVGMPFLIHQwARGGEWVFGGPLCTIITSL 112
Cdd:cd15404   1 VILSAVMIFILLVSFLGNFVVCLMVYqKAAMRSAINILLASLAFADmMLAVLNMPFALVT-IITTRWIFGDAFCRVSAMF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQpfRLTRWRTRYKTIRINLGlWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPD 192
Cdd:cd15404  80 FWLFVMEGVAILLIISIDRFLIIVQ--KQDKLNPYRAKVLIAVS-WAVSFCVAFPLAVGSPDLQIPSRAPQCVFGYTTNP 156
                       170       180
                ....*....|....*....|....*....
gi 93277083 193 DVLWYTLYLTITTFFFPLPLILVCYILIL 221
Cdd:cd15404 157 GYQAYVILIMLIFFFIPFMVMLYSFMGIL 185
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
48-317 2.58e-06

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 48.27  E-value: 2.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIhQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMT 125
Cdd:cd15395  14 GVSGNLALIIIILKQKEmHNVTNILIVNLSFSDLlMTIMCLPFTF-VYTLMDHWVFGEAMCKLNSMVQCISITVSIFSLV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VMSVDRYFALVQPfRLTRWRTRYKTIRINLgLWAASFILALPVWVYSKVIK--FKD---------GVESCAFDLTSPDDV 194
Cdd:cd15395  93 LIAIERHQLIINP-RGWRPNNRHAYVGIAV-IWVLAVLTSLPFLIFQVLTDepFKNvnvsldaykGKYVCLDQFPSDTIR 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFFPLPLILVCYILIlcYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVN 274
Cdd:cd15395 171 LSYTTCLLVLQYFGPLCFIFICYLKI--YIRLKRRNNMMDKMRDNKYRSSETKRINIMLISIVVAFAVCWLPLNIFNAVF 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 93277083 275 LQMEQPTLAFYVGYYLSICLSYA--SSSINPFLYILLSGNFQKRL 317
Cdd:cd15395 249 DWNHEAIATCNHNLLFLICHLTAmiSTCVNPIFYGFLNKNFQRDL 293
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
49-315 3.00e-06

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 48.24  E-value: 3.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRK-KTVPDIYICNLAVADL-VHIVGMPFLIHQWARGGeWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15209  15 VLGNLLVILSVLRNKKlRNAGNIFVVSLSVADLvVAIYPYPLILHAIFHNG-WTLGQLHCQASGFIMGLSVIGSIFNITA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWvYSKVIKFKDGVESCAFDLTSPDdvlWYTLYLTITTF 206
Cdd:cd15209  94 IAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNF-FIGSLQYDPRIYSCTFAQTVST---VYTITVVVIHF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 207 FFPLPLILVCYILIlcytWEMYQQNKD--ARCCNPSVPKQRVMKLTKMvLVLVVVFILSAAPYHVIQL---VNLQMEQPT 281
Cdd:cd15209 170 LLPLLIVSFCYLRI----WVLVLQVRQrvKPDQRPKLKPADVRNFLTM-FVVFVLFAVCWAPLNFIGLavaINPKEMAPK 244
                       250       260       270
                ....*....|....*....|....*....|....
gi 93277083 282 LAFYVgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15209 245 IPEWL-FVASYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
44-306 4.46e-06

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 47.62  E-value: 4.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  44 ICSTGLVGNILIVFTI-IRSRKKTVPDIYICNLAVAD-LVHIVGMPFLIhqwarggewVFGGPLCTiitSLDTCNQFAC- 120
Cdd:cd15068  10 IAVLAILGNVLVCWAVwLNSNLQNVTNYFVVSLAAADiAVGVLAIPFAI---------TISTGFCA---ACHGCLFIACf 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 ------SAIMTVMSV--DRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILAL-PVWVYSKVIKFK----------DGV 181
Cdd:cd15068  78 vlvltqSSIFSLLAIaiDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLtPMLGWNNCGQPKegknhsqgcgEGQ 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 182 ESCAFDLTSPDDVLWYtlYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPK--QRVMKLTKMVLVLVVV 259
Cdd:cd15068 158 VACLFEDVVPMNYMVY--FNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARStlQKEVHAAKSLAIIVGL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 260 FILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLY 306
Cdd:cd15068 236 FALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIY 282
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
49-315 5.52e-06

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 47.15  E-value: 5.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVhIVGMPF-LIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTV 126
Cdd:cd15400  15 ILGNLLVIISVFRNRKlRNSGNVFVVSLALADLV-VALYPYpLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITG 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 127 MSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWvYSKVIKFKDGVESCAFDLTSPDdvlWYTLYLTITTF 206
Cdd:cd15400  94 IAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNF-FVGSLEYDPRIYSCTFVQTASS---SYTIAVVVIHF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 207 FFPLPLILVCYILILCYTWEMYQQNKDARccNPSVPKQRVMKLTKMvLVLVVVFILSAAPYHVIQL---VNLQMEQPTLA 283
Cdd:cd15400 170 IVPITVVSFCYLRIWVLVIQVRRKVKSES--KPRLKPSDFRNFLTM-FVVFVIFAICWAPLNLIGLavaINPQEMAPKVP 246
                       250       260       270
                ....*....|....*....|....*....|..
gi 93277083 284 FYVgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15400 247 EWL-FVVSYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
41-203 6.81e-06

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 47.33  E-value: 6.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVH-IVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQF 118
Cdd:cd15218   7 LGFIIGVSVVGNLLISILLVKDKTlHRAPYYFLLDLCCSDILRsAICFPFVFTSVKNGSTWTYGTLTCKVIAFLGVLSCF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTS--PDDVLW 196
Cdd:cd15218  87 HTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREEDQCTFQHRSfrANDSLG 166

                ....*..
gi 93277083 197 YTLYLTI 203
Cdd:cd15218 167 FMLLLAL 173
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
35-320 6.83e-06

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 46.74  E-value: 6.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIhQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15295   1 VVLLFLMSLLALVIVLGNALVIIAFVVDKNlRHRSNYFFLNLAISDfFVGAISIPLYI-PYTLTNRWDFGRGLCVFWLVI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTR-YKTIRINLGLWAASFILALPVWVYSKviKFKDGVESCAFDLTSP 191
Cdd:cd15295  80 DYLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVHGPAILVSD--SWKTEDGECEPEFFSN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 ddvlWYtlYLTITTFF-FPLPLILVCYILILCYtWEMYQqnkdarccnpsvpKQRVMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15295 158 ----WY--ILAITSVLeFLVPVILVAYFNTQIY-WSLWK-------------RLRDRKLAKSLAIILGTFAICWAPYSLF 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 93277083 271 QLVNLQMEQPTLAFYvgYYLSICLSYASSSINPFLYILLSGNFQKRLPQI 320
Cdd:cd15295 218 TIIRAACEKHRGSPW--YNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKI 265
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
41-317 7.25e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 46.78  E-value: 7.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLV----GNILIVFTIIRSRKKTVP-DIYICNLAVADLvhIVGMPFLIHQWARGGE--WVFGGPLCTIITSLD 113
Cdd:cd15318   3 IYLACAIGMLiivlGNLFVVVTVSHFKALHTPtNFLLLSLALADM--LLGLTVLPFSTIRSVEscWYFGDSFCRLHTCLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRL-TRWRTRYKTIRINLGlWAASFILAlPVWVYSKVIKFKDG--------VESC 184
Cdd:cd15318  81 TLFCLTSIFHLCFISIDRHCAICDPLLYpSKFTIRVACIFIAAG-WLVPTVYT-SVFLYTKAVEEGLAelltsvpcVGSC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 185 AFDLTSpddvLWYtlYLTITTFFFPlplilvCYILILCYTWEMYQQNKDARCCNPSV-----PKQRVMKLTKMVLVLVVV 259
Cdd:cd15318 159 QLLYNK----LWG--WLNFPVFFIP------CLIMIGLYVKIFIVAKRQARAIASLLsdtngASKRERKAAKTLGIAVGV 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 260 FILSAAPYHVIQLVN--LQMEQPTLAFYVgyylSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15318 227 YLLCWLPFTIDTMVDslLNFITPPLLFDI----IIWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
47-235 8.72e-06

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 46.51  E-value: 8.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  47 TGLVGNILIVFTIIRSRKKTVP-DIYICNLAVADLV-HIVGMP-FLIHQWARGGEWVFGGPLCTI--ITSLdtcnqFAC- 120
Cdd:cd15221  13 VALLGNSLLLFVIVTERSLHEPmYLFLSMLAVTDLLlSTTTVPkMLAIFWFGAGEISFDGCLTQMffVHFV-----FVTe 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKF------------KDGVESCAFDL 188
Cdd:cd15221  88 SAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYcghnviphtyceHMGIARLACAD 167
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 93277083 189 TSPDdvLWYTLYLTITTFFFPLPLILVCYILILCYTWEMyqQNKDAR 235
Cdd:cd15221 168 ITVN--IWYGLTVALLTVGLDVVLIAVSYALILRAVFRL--PSKDAR 210
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
40-206 1.30e-05

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 46.48  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRK-KTVPDIYICNLAVADLVH-IVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQ 117
Cdd:cd15217   6 LLGLIICVSLAGNLIVSLLVLKDRAlHKAPYYFLLDLCLADTIRsAVCFPFVLVSIRNGSAWTYSVLSCKIVAFMAVLFC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFD--LTSPDDVL 195
Cdd:cd15217  86 FHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKFIREEDQCIFEhrYFKANDTL 165
                       170
                ....*....|.
gi 93277083 196 WYTLYLTITTF 206
Cdd:cd15217 166 GFMLMLAVLIV 176
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
48-314 2.93e-05

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 45.23  E-value: 2.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSR-KKTVPDIYICNLAVADLVHIV-GMPFLIHQWArGGEWVFGGPLCTIITSLDTCNQFACSAIMT 125
Cdd:cd15976  14 GIIGNSTLLRIIYKNKcMRNGPNILIASLALGDLLHIIiDIPINVYKLL-AEDWPFGVEMCKLVPFIQKASVGITVLSLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VMSVDRYFALVQPFRL-TRWRTRYKTIRINLgLWAASFILALPvwvyskvikfkdgvESCAFDLTSPD---DVLWYTLYL 201
Cdd:cd15976  93 ALSIDRYRAVASWSRIkGIGVPKWTAVEIVL-IWVVSIILAVP--------------EAIGFDMITMDykgELLRICLLH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 202 TITT-----------------FFFPLPLIL--VCYILILCytwEMYQQNKDARCCNPSVPKQRvMKLTKMVLVLVVVFIL 262
Cdd:cd15976 158 PIQKtafmqfyktakdwwlfsFYFCLPLACtaVFYTLMTC---EMLRKKNGMQIALNDHLKQR-REVAKTVFCLVLVFAL 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 263 SAAPYHVIQLVNLQMEQPTLA--------FYVGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15976 234 CWLPLHLSRILKLTIYDEKDPnrcellsfFLVLDYIGINMASLNSCINPIALYLVSKRFK 293
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
40-314 3.34e-05

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 44.90  E-value: 3.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  40 MIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIIT-SLDTCNQF 118
Cdd:cd15081  19 MIFVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGfTVSVCGIT 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAiMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVikFKDGVE-SCAFDLTSPDD---V 194
Cdd:cd15081  99 GLWS-LTIISWERWVVVCKPFGNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRY--WPHGLKtSCGPDVFSGSSdpgV 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 195 LWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDarccnpSVPKQRVMK-LTKMVLVLVVVFILSAAPYHVIQLv 273
Cdd:cd15081 176 QSYMIVLMITCCIIPLAIIILCYLQVWLAIRAVAQQQKE------SESTQKAEKeVSRMVVVMIFAYCFCWGPYTFFAC- 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 93277083 274 nLQMEQPTLAFY-VGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15081 249 -FAAANPGYAFHpLAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
34-306 3.75e-05

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 44.84  E-value: 3.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  34 TVILPSMIGIicstGLVGNILIVFTII-RSRKKTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITS 111
Cdd:cd15403   4 AIVMILMIAI----GFLGNAIVCLIVYqKPAMRSAINLLLATLAFSDiMLSLLCMPFTAVTIITV-DWHFGAHFCRISAM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 112 LDTCNQFACSAIMTVMSVDRYFALVQpfRLTRWRTRYKTIRInLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSP 191
Cdd:cd15403  79 LYWFFVLEGVAILLIISVDRFLIIVQ--RQDKLNPHRAKVMI-AISWVLSFCISFPSVVGWTLVEVPARAPQCVLGYTES 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLWYTLYLTITTFFFPLPLILVCYILILCYTWE---MYQQNKDARCCNPsVPKQRVMKL-------------TKMVLV 255
Cdd:cd15403 156 PADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRnavRIHNHADSLCLSQ-VSKLGLMGLqrphqmnvdmsfkTRAFTT 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 256 LVVVFI---LSAAPYHVIQLVNLQMEQptlaFYVG---YYLSIC---LSYASSSINPFLY 306
Cdd:cd15403 235 ILILFVgfsLCWLPHTVFSLLSVFSRR----FYYSssfYPISTCvlwLSYLKSVFNPVIY 290
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
35-314 4.76e-05

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 44.38  E-value: 4.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIY-ICNLAVADLvhivgmpflihqwargGEWVFGGPLCTIITSLD 113
Cdd:cd15075   1 TILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYaLVNLAVADL----------------GTTVFGGLLSVVTNAVG 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQ--------------FACSAIMTV--MSVDRYFALVQPFRLTRWRTRYKTIRINLGlWAASFILALPVWVYSKVIKF 177
Cdd:cd15075  65 YFNLgrvgcvlegfavafFGIAALCTVavIAVDRLFVVCKPLGTLTFQTRHALAGIASS-WLWSLIWNTPPLFGWGSYQL 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 178 KDGVESCAFDLTS--PDDVLWYTLYLTITtFFFPLPLILVCYILILcytWEMYQQNKDARCCNPSVPKQRvMKLTKMVLV 255
Cdd:cd15075 144 EGVMTSCAPDWYSrdPVNVSYILCYFSFC-FAIPFAIILVSYGYLL---WTLRQVAKLGVAEGGSTAKAE-VQVARMVVV 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 93277083 256 LVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGyYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15075 219 MVMAFLLCWLPYAAFALTVVSKPDVYINPLIA-TVPMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
35-315 6.19e-05

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 44.01  E-value: 6.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFT-IIRSRKKTVPDIYICNLAVAD-LVHIVGMPFLIhQWARGGEWVFGGPLCTIITSL 112
Cdd:cd15296   1 VILAVLMALLVVATVLGNALVILAfVVDSSLRTQGNFFFLNLAISDfLVGGFCIPLYI-PYVLTGRWKFGRGLCKLWLVV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 113 DTCNQFACSAIMTVMSVDRYFALVQP--FRLTRWRTRYKTIRInLGLWAASFIL---ALPVWVY-SKVIKFKDGVESCAF 186
Cdd:cd15296  80 DYLLCTASVFNIVLISYDRFLSVTRAvsYRAQKGMTRQAVLKM-VLVWVLAFLLygpAIISWEYiAGGSIIPEGECYAEF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 187 DLTspddvlWYTLyLTITTFFFPLPLILVCYILILCYTwemyqqNKDARCCNPSvpkqRVMKLTKMVLVLVVVFILSAAP 266
Cdd:cd15296 159 FYN------WYFL-MTASTLEFFTPFISVTYFNLSIYL------NIQKRRFRLS----RDKKVAKSLAIIVCVFGLCWAP 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 267 YHVIQLVNLQMEQPTLAFYVgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15296 222 YTLLMIIRAACHGHCVPDYW-YETSFWLLWVNSAINPVLYPLCHMSFRR 269
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
43-339 9.02e-05

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 44.03  E-value: 9.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   43 IICSTGLVGNILIVFTII---RSRKKTVPDIYICNLAVADLVHIVGMPFLI--HQWARGGEwVFGGPLCTIITSLDTCNQ 117
Cdd:PHA03235  41 LIISVGGPLNLIVLVTQLlanRVHGFSTPTLYMTNLYLANLLTVFVLPFIMlsNQGLLSGS-VAGCKFASLLYYASCTVG 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  118 FACSAIMtvmSVDRYFALVQpfRLTRWRTRYKTIRINLGL-WAASFILALPVWVYSKVIKFKD------GVESC----AF 186
Cdd:PHA03235 120 FATVALI---AADRYRVIHQ--RTRARSSAYRSTYKILGLtWFASLICSGPAPVYTTVVAHDDvdpeapGYETCviyfRA 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  187 DLTSPDDVLWYTLyltITTFFFPLPLILVCYIlilcYTWeMYQQNKDARCcnpsvpKQRVMKLTkMVLVLVVVFILSAAP 266
Cdd:PHA03235 195 DQVKTVLSTFKVL---LTLVWGIAPVVMMTWF----YTF-FYRTLKRASY------KKRSRTLT-FVCILLLSFLCLQTP 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  267 YHVIQLVN--------LQMEQPTLAFYVGYyLSICLSYASSSINPFLYILLSGNFQKRLPQ------IQRRATEKEINNM 332
Cdd:PHA03235 260 FVAIMIFDsyatliwpSDCEHINLRDAVST-LSRLVPNLHCLLNPILYAFLGNDFLKRFRQcfrgelFSRRAFLRSRQKC 338

                 ....*..
gi 93277083  333 GNTLKSH 339
Cdd:PHA03235 339 GATAIST 345
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
47-166 9.83e-05

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 43.21  E-value: 9.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  47 TGLVGNILIVFTIIRS---RKKtvpdIYICNLAVADLV-HIVGMPF-LIHQWARGGEWVFGGPLCTIITSLDTCNQFACS 121
Cdd:cd15220  12 TALVGNTAVMVVIAKTphlRKF----AFVCHLCVVDLLaALLLMPLgILSSSPFFLGVVFGEAECRVYIFLSVCLVSASI 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 93277083 122 AIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILAL 166
Cdd:cd15220  88 LTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGL 132
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
43-314 1.01e-04

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 43.31  E-value: 1.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSR-KKTVPDIYICNLAVADLVHIV-GMPFLIHQWArGGEWVF-----GGPLCTIITSLDTC 115
Cdd:cd15975   9 IIFIVGMVGNATLLRIIYQNKcMRNGPNALIASLALGDLIYIViDIPINVYKLL-AQKWPFddssfGVFLCKLVPFLQKA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFK---DGVESCAFDLTSPD 192
Cdd:cd15975  88 SVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPEAIGFVMVPFEyngEQYRTCMLNATTKF 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 193 D---VLWYTLYLTITTFFFPLPLILVCYILILCytwEM-YQQNKDARCCNPSVPKQRvMKLTKMVLVLVVVFILSAAPYH 268
Cdd:cd15975 168 MnfyVDAKDWWLFGFYFCVPLACTAIFYTLMTC---EMlNRRKGSLRIALSEHLKQR-REVAKTVFCLVVIFALCWFPLH 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 269 VIQLVNLQMEQPT-------LAFY-VGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15975 244 LSRILKKTVYNENdprrcelLSFLlVMDYISINLATMNSCINPIALYFVSKKFK 297
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
43-218 1.10e-04

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 43.19  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTII-RSRKKTVPD-IYICNLAVADLVHIVGMPFLIHQWARGGeWVFGGPLCTIITSLDTCNQFAC 120
Cdd:cd14983   9 LTILLGLPSNLLALYAFVnRARLRLTPNvIYMINLCLSDLVFILSLPIKIVEALSSA-WTLPAVLCPLYNLAHFSTLYAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAAS-------FILALPVwVYSKVIKFKDGVESC--AFDLTSP 191
Cdd:cd14983  88 TCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVifhvtlvFILETSG-GTLDINTPVGNSSTCyeNFTPEQL 166
                       170       180
                ....*....|....*....|....*..
gi 93277083 192 DDVLWYTLYLTITTFFFPLPLILVCYI 218
Cdd:cd14983 167 ALLAPVRLELSLVLFFLPLAITAFCYV 193
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
43-306 1.15e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 43.38  E-value: 1.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTI-IRSRKKTVPDIYICNLAVADL-VHIVGMPFLIhqwarggewVFGGPLCTiitSLDTCNQFAC 120
Cdd:cd15069   9 IIAALSVAGNVLVCAAVgTNSTLQTPTNYFLVSLAAADVaVGLFAIPFAI---------TISLGFCT---DFHSCLFLAC 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 121 -------SAIMTVMSV--DRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILAL-PVWVYSKVIKFKDGVE-------- 182
Cdd:cd15069  77 fvlvltqSSIFSLLAVavDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLtPFLGWNKAMSATNNSTnpadhgtn 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 183 ------SCAFDLTSPddvLWYTLYLtitTFF----FPLPLILVCYILILCYTWEMYQQNKDARccNPSVPKQRVMKLTKM 252
Cdd:cd15069 157 hsccliSCLFENVVP---MSYMVYF---NFFgcvlPPLLIMLVIYIKIFLVACRQLQRTELMD--HSRTTLQREIHAAKS 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 253 VLVLVVVFILSAAPYHVIQLVNL-QMEQPTLAFYVGYYLSICLSYASSSINPFLY 306
Cdd:cd15069 229 LAIIVGIFALCWLPVHILNCITLfQPEFSKSKPKWAMNVAILLSHANSVVNPIVY 283
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
49-315 1.40e-04

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 42.97  E-value: 1.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  49 LVGNILIVFTIIRSRKK-TVPDIYICNLAVADLVhiVGMPFLI----------HQWARGGEWVfGGPLCTIITSLDTCNQ 117
Cdd:cd15964  15 ILGNVFVLLILLTSHYKlTVPRFLMCNLAFADFC--MGIYLLLiasvdlhtrsEYYNHAIDWQ-TGPGCNTAGFFTVFAS 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 118 FACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPVWVYSKVIKfkdgVESC-AFDLTSPDDVL 195
Cdd:cd15964  92 ELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLAlLPLVGVSSYAK----VSIClPMDTETPLAQA 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 W--YTLYLTITTFFfplpLILVCYILILCYTWemyqqnkdarccNPSV-PKQRVMKLTKMVLVLVVVFILSAAP--YHVI 270
Cdd:cd15964 168 YivFVLMLNIIAFV----IICACYIKIYITVR------------NPQYkSGDKDTKIAKRMAVLIFTDFICMAPisFYAL 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 93277083 271 QLVnlqMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15964 232 SAI---LNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFRR 273
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
35-315 1.93e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 42.54  E-value: 1.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTIIRSRKKTVP-DIYICNLAVAD-LVHIVGMPFlihQWARGGE--WVFGGPLCTIIT 110
Cdd:cd15316   1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPtNFLIASLACADfLVGVTVMPF---STVRSVEscWYFGESFCTFHT 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 111 SLDTCNQFACSAIMTVMSVDRYFALVQPFrltRWRTRYkTIRINLGLWAASFILALpvwVYSKVIKF----KDGVE---- 182
Cdd:cd15316  78 CCDVSFCYASLFHLCFISVDRYIAVTDPL---VYPTKF-TVSVSGICISVSWIFSL---TYSFSVFYtgvnDDGLEelvn 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 183 --SCAFDLTSPDDVLWytLYLTITTFFFPLPLILVCYILILCYT------WEMYQQNKDARCCNPSVP-KQRVMKLTKMV 253
Cdd:cd15316 151 alNCVGGCQIILNQNW--VLVDFLLFFIPTFAMIILYGKIFLVAkqqarkIEMTSSKAESSSESYKDRvARRERKAAKTL 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 93277083 254 LVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYvgYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15316 229 GITVIAFLVSWLPYLIDVLIDAFMNFITPPYI--YEICCWCAYYNSAMNPLIYALFYPWFRK 288
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
36-317 2.40e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 42.09  E-value: 2.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIY-ICNLAVAD-LVHIVGMPFLIHQWARGgeWVFGGPLCTIITSLd 113
Cdd:cd15082  15 VLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYiIVNLSVADfLVSLTGGTISFLTNARG--YFFLGVWACVLEGF- 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAI--MTVMSVDRYFALVQPFRLTRWRTRYKTIRInLGLWAASFILALPV---WVYSKVIKFKDGVESCAFDL 188
Cdd:cd15082  92 AVTFFGIVALwsLAVLAFERFFVICRPLGNIRLQGKHAALGL-LFVWTFSFIWTIPPvlgWSSYTVSKIGTTCEPNWYSG 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 189 TSPDDVlwYTLYLTITTFFFPLPLILVCYILILCYTWEMyqQNKDARCCNPSVPKQRVmklTKMVLVLVVVFILSAAPYH 268
Cdd:cd15082 171 NMHDHT--YIITFFTTCFILPLGVIFVSYGKLLQKLRKV--SNTQGRLGNARKPERQV---TRMVVVMIVAFMVCWTPYA 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 269 VIQLV-----NLQMEqPTLAFYVGYYlsiclSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15082 244 AFSILvtahpTIHLD-PRLAAIPAFF-----SKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
43-163 5.86e-04

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 41.09  E-value: 5.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSRKKTVPD-IYICNLAVADLVHI-VGMPFLIHQ-WARGGEWVFGGplCtiITSLDTCNQFA 119
Cdd:cd15232   9 FLYAAALTGNSLIILAISTSPKLHTPMyFFLVNLSLVDIICTsTVVPKLLQNlLTERKTISFGG--C--MAQLYFFTWSL 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 93277083 120 CSAIM--TVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFI 163
Cdd:cd15232  85 GSELLllTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGML 130
7TM_GPCR_Srv pfam10323
Serpentine type 7TM GPCR chemoreceptor Srv; Chemoreception is mediated in Caenorhabditis ...
125-315 1.99e-03

Serpentine type 7TM GPCR chemoreceptor Srv; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srv is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370977  Cd Length: 283  Bit Score: 39.53  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   125 TVMSVDRYFALVQP-FRLTRWRTRYKTIRINLGLWAASFILALPVwVYSKVIKFkDGVESCAFdLTSPDDVLWYTLylti 203
Cdd:pfam10323  94 SLLSTNRYLAICFPiSRLTKIWQSARLWKIILIYWLPGLLISLVV-LKNTDIYY-DNEENMPV-VADKDVIQRFTL---- 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083   204 TTFFFplpLILVCYILILCY--TWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAApYHVIQLVNLQMEQPT 281
Cdd:pfam10323 167 IALIF---VFVTCIYCIIAYgaLFFVIRKKNNKNSQTKSKSLKREVRLAFQVFILVLAFLIILI-FYILSNYFSQTLNTD 242
                         170       180       190
                  ....*....|....*....|....*....|....
gi 93277083   282 LAFYVGYYLSIcLSYASSSINPFLYILLSGNFQK 315
Cdd:pfam10323 243 PIFYLRALYPI-ASGLLSYINPYLLLIFNRDLRK 275
7tmA_GPR146 cd14990
G protein-coupled receptor 146, member of the class A family of seven-transmembrane G ...
43-317 2.76e-03

G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR146 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. The endogenous ligand for GPR146 is not known. It has been suggested that GPR146 may be a part of the C-peptide signaling complex. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320121  Cd Length: 280  Bit Score: 38.99  E-value: 2.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IIC-STGLVGNILIVFTIIRSRKK-TVPDIYICNLAVADLV-------HIVGMPFLihQWARggeWVFGGPLCTIITSLD 113
Cdd:cd14990   8 IICfPVGLCYNALLVLVNLYNKASmTMPDVYFVNMAIAGLVlnavapvQLLGPDNT--RWPL---WNSNNEVYITLLILF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPfrLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAF--DLTSP 191
Cdd:cd14990  83 NVSSLVSMYSTTLLSLDYYIERALP--RTYMSSVYNTKHVCGFIWGGAVLTSFSSLLFYICSHVSTKIIECSKmqNKEAA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 192 DDVLWYTLYLTittfffPLPLILVCYILILCYTWEMYQQNKDARCCNPSVpkQRVMKLTkmvlvLVVVFILsAAPYHVIQ 271
Cdd:cd14990 161 DAIMVFIGYVV------PALAVLYALVLILRIRKEATPLDQDSGRLDPSA--HRLLLAT-----VCTQFLL-WTPYYMIL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 272 LVNLQMEQPTL---AFYVGYY-----LSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd14990 227 LVHTVQASRGKkvdAGYLRVFhflkgLSKLLAFSSSFVVPLLYRYMNKNFSSKL 280
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
35-316 3.68e-03

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 38.58  E-value: 3.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  35 VILPSMIGIICSTGLVGNILIVFTI-IRSRKKTVpDIYICNLAVADLV----HIVGMPFLIHQwarggewvFGGPL--CT 107
Cdd:cd15106   1 LSLTFLTCIISLVGLTGNAVVLWLLgFRMRRNAF-SVYILNLAAADFLflccHIIDSLLRLIN--------IFHIIsiPK 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 108 IITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYskvikfkdgvesCAFD 187
Cdd:cd15106  72 ILTNVMTFPYFAGLSMLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSILEWKF------------CGFL 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 188 LTSPDDVLWYTLYLTITTFFFPLPLI-----LVCYILILCytwemyqqnkdarccnpsvpKQRVMKLTKM---VLVLVVV 259
Cdd:cd15106 140 FSGADSHWCQTFDFITTAWLIFLFVVlcgssLALLVRILC--------------------GSRKMPLTRLyvtILLTVLV 199
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 93277083 260 FILSAAPYHVIQLVNLQMEQPTLAFYVGYYL-SICLSYASSSINPFLYILLsGNFQKR 316
Cdd:cd15106 200 FLLCGLPFGIQWFLLLWIHIDLEVLFCHVYLvSVVLSCLNSSANPIIYFFV-GSFRQR 256
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-314 4.42e-03

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 38.27  E-value: 4.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  43 IICSTGLVGNILIVFTIIRSR-KKTVPDIYICNLAVADLVHIV-GMP-----FLIHQWARGGEwVFGGPLCTIITSLDTC 115
Cdd:cd15128   9 LIFIVGIIGNSTLLRIIYQNKcMRNGPNALIASLALGDLLYIViDLPinvykLLAMDWPFGDQ-PFGQFLCKLVPFIQKA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 116 NQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVl 195
Cdd:cd15128  88 SVGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFNYKGVTLRTCLLRPETS- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 196 WYTLYLT-----ITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRvMKLTKMVLVLVVVFILSAAPYHVI 270
Cdd:cd15128 167 FMKFYIDvkdwwLFGFYFCLPLVCTAIFYTLMTCEMLRKRNGMLRIALNEHLKQR-REVAKTVFCLVVIFALCWLPLHLS 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 93277083 271 QLVNLQMEQPT-------LAF-YVGYYLSICLSYASSSINPFLYILLSGNFQ 314
Cdd:cd15128 246 RILKLTVYDQNdpnrcelLSFlLVLDYFGINLATLNSCINPIALYFVSRKFK 297
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
37-317 5.23e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 38.30  E-value: 5.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYI-CNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDT 114
Cdd:cd15084  13 VAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYIlVNLAVADlLVTLFGSSVSFSNNIVG-FFVFGKTMCEFEGFMVS 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLgLWAASFILALP-VWVYSKVIKFKDGVESCAFDLTSPDD 193
Cdd:cd15084  92 LTGIVGLWSLAILAFERYLVICKPMGDFRFQQRHAVSGCAF-TWGWSLLWTSPpLFGWSSYVPEGLRTSCGPNWYTGGTN 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCcnpsvpKQRVMK-LTKMVLVLVVVFILSAAPYHVIQL 272
Cdd:cd15084 171 NNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESET------TQRAEKeVTRMVIAMVMAFLICWLPYATFAM 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 93277083 273 VNLQME----QPTLAFYVGYYlsiclSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15084 245 VVATNKdvviQPTLASLPSYF-----SKTATVYNPIIYVFMNKQFRSCL 288
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
34-174 6.61e-03

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 37.86  E-value: 6.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  34 TVILPSMIGIIcstGLVGNILIVFTIIRSR---KKTVPDIYICNLAVADLVHIV-GMPFLIHQWARGgEWVFGGPLCTII 109
Cdd:cd15142   3 PPTIPAVMFIF---GVVGNLIAIVVLCKSRkeqKETTFYTLVCGLAVTDLLGTClASPVTIATYLKG-RWPGGQPLCEYF 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 93277083 110 TSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRyKTIRINLGLWAASFIL--ALPVWVYSKV 174
Cdd:cd15142  79 SFILLFFSLSGLSIICAMSIERYLAINHAYFYNHYVDK-RLAGLTLFAIYASNILfcALPSMGLGKS 144
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
48-216 7.11e-03

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 37.83  E-value: 7.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  48 GLVGNILIVFTIIRSRK-KTVPDIYICNLAVAD-LVHIVGMPFLIHQWARgGEWVFGGPLCTIITSLDTCNQFACSAIMT 125
Cdd:cd15398  14 GFLGNLLILTALTKKWKqKTIINFLIGNLAFSDiLVVLFCSPFTLTCVLL-DQWIFGEVMCHIVPFLQCVSVMVSTLMLM 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 126 VMSVDRYFALVQPfrLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLW----YTLYL 201
Cdd:cd15398  93 SIAIVRYHMIKHP--LSNHLTANHGYFLLGTVWTLGFTICSPLPVFHKIVDLSETFNLESLKNKYLCIESWpsdsYRIAF 170
                       170
                ....*....|....*
gi 93277083 202 TITTFFFPLPLILVC 216
Cdd:cd15398 171 TISLLFVQYILPLVC 185
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
36-317 7.60e-03

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 37.52  E-value: 7.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILI--VFTIIRSRKKTVpdIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLD 113
Cdd:cd15149   2 VIPVFYSLVFIVGILLNGVNfwIFFYVPSNKSFI--VYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVIF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 114 TCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAfDLTSPDD 193
Cdd:cd15149  80 YLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSFHEANYTKCA-RLKSELG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 194 VLWY--TLYLTITTFFFPLPLILVCYILIlcyTWEMYQQNKDARCCNPSVPKqrvmKLTKMVLVLVVVFILSAAPYHVIQ 271
Cdd:cd15149 159 IQWHkaSNYICVSIFWVVFLLLIIFYVAI---SRKIYKSNQKFRRNSTNMKA----KSSRNIFSILFVFFVCFVPYHALR 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 93277083 272 L--------VNLQMEQPTLAFYVGYYlSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15149 232 IpytlsqtgADYSCQSKTILYYMKEF-TLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
37-317 8.38e-03

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 37.50  E-value: 8.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  37 LPSMIGIICSTGLVGNILIVFTIIR-SRKKTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGGeWVFGGPLCTIITSLDT 114
Cdd:cd15078   3 LALLIATIGFLGVCNNLLVLILYYKfKRLRTPTNLLLVNISLSDlLVSLLGVTFTFMSCVRGR-WVFDVAGCVWDGFSNS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 115 CNQFACSAIMTVMSVDRYFALVQPfrltrwrtryKTIRINLGLWAASFIlalpvWVYS-----------KVIKFKDGVES 183
Cdd:cd15078  82 LFGIVSIMTLTVLAYERYIRVVHA----------KVVNFSWSWRAITYI-----WLYSlawtgapllgwNRYTLEVHGLG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 184 CAFDLTSPD-DVLWYTLYLTITTFFFPLPLILVCYILILcYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFIL 262
Cdd:cd15078 147 CSFDWKSKDpNDTSFVLLFFLGCLVVPLGIMAYCYGHIL-YEIRMLRSVEDLQTFQVIKILKYEKKVAKMCLLMISTFLI 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 93277083 263 SAAPYHVIQLVNL----QMEQPTLAFyvgyyLSICLSYASSSINPFLYILLSGNFQKRL 317
Cdd:cd15078 226 CWMPYAVVSLLVTsgysKLVTPTIAI-----IPSLFAKSSTAYNPVIYIFMIRKFRQCL 279
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
41-221 8.39e-03

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 37.23  E-value: 8.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  41 IGIICSTGLVGNILIVFTIIR-SRKKTVPDIYICNLAVAD-LVHIVGMPFLIHQWARGgEWVFGGPLCTIITSLDTCNQF 118
Cdd:cd15214   6 IIIIAILICLGNLVIVVTLYKkSYLLTLSNKFVFSLTLSNlLLSVLVLPFVVTSSIRR-EWIFGVVWCNFSALLYLLISS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 119 ACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCafdLTSPDDVLWYT 198
Cdd:cd15214  85 ASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFDRFKWMC---VAAWHKEAGYT 161
                       170       180
                ....*....|....*....|...
gi 93277083 199 LYLTITTFFFPLPLILVCYILIL 221
Cdd:cd15214 162 AFWQVWCALLPFVVMLVCYGFIF 184
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
36-315 9.16e-03

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 37.15  E-value: 9.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  36 ILPSMIGIICSTGLVGNILIVFTIIRSRKK-TVPDIYICNLAVAD--------LVHIVGMPFLIHQWARGGEWVFGGPlC 106
Cdd:cd15359   2 FLRVLIWFINILAIAGNLIVLFVLLTSRYKlTVPRFLMCNLSFADfcmglyllLIASVDSQTKSQYYNHAIDWQTGSG-C 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 107 TIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILA-LPVWVYSKVIKfkdgVESC- 184
Cdd:cd15359  81 STAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAvLPLVGVSNYMK----VSICl 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083 185 AFDLTSPDDVLW--YTLYLTITTFFfplpLILVCYILILCYTW--EMYQQNKDARCCNpsvpKQRVMKLTKMVLVLVVVF 260
Cdd:cd15359 157 PMDIETLLSQAYilLILVLNVIAFL----VICACYIKIYLAVQnpELVAKNKDTKIAK----RMAILIFTDFTCMAPISF 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 261 ILSAAPYHViqlvnlqmeqPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQK 315
Cdd:cd15359 229 FAISAAFKV----------PLITVTNSKILLVLFYPINSCANPFLYAIFTKAFRR 273
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
38-166 9.73e-03

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 37.49  E-value: 9.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 93277083  38 PSMIGIICSTGLVGNILIVFTIIRSRKKTVPD------IYICNLAVADLVHI-VGMPFLIHQWARGGEWVFGGPLCTIit 110
Cdd:cd15143   4 VWFSTIFSAIGLASNLFAFIVLVKSSRKTKSRsrssflIFLCGLVVTDFLGLlVTGTIVISFHLTNFNWRVVDPDCYL-- 81
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 93277083 111 sldtCNQFACSAIM---------TVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILAL 166
Cdd:cd15143  82 ----CNFMGLSMVFyglcplllgATMAVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFLLGL 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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