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Conserved domains on  [gi|94818790|ref|NP_001035546|]
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rhomboid domain-containing protein 2 isoform a [Homo sapiens]

Protein Classification

rhomboid family protein( domain architecture ID 10483871)

rhomboid family protein may be an intramembrane serine protease that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchors, or an inactive rhomboid protein that lacks the conserved active sites and has no peptidase activity

CATH:  1.20.1540.10
Gene Ontology:  GO:0016020
MEROPS:  S54
PubMed:  24099005|22035660|26527717|12620104
SCOP:  4000471

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 54-204 1.60e-26

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


:

Pssm-ID: 426384  Cd Length: 147  Bit Score: 103.07  E-value: 1.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94818790    54 ALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTVGTVRHCFFTVIFAIFSAIIFLSFEAVSslsklgevEDAR 133
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLS--------TPSV 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 94818790   134 GFTPVAFAMLGVTTVRSRMRRALVFGMVV-PSVLVPWLLLGASWLI---PQTSFLSNVCGLSIGLAYGLTYCYSI 204
Cdd:pfam01694  73 GASGAIFGLLGALLVLGPRNRILLFGLIGaLLALLLFILLNLVLGLlpgNGVSNLAHLGGLLVGLLLGFILLRRP 147
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 54-204 1.60e-26

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 103.07  E-value: 1.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94818790    54 ALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTVGTVRHCFFTVIFAIFSAIIFLSFEAVSslsklgevEDAR 133
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLS--------TPSV 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 94818790   134 GFTPVAFAMLGVTTVRSRMRRALVFGMVV-PSVLVPWLLLGASWLI---PQTSFLSNVCGLSIGLAYGLTYCYSI 204
Cdd:pfam01694  73 GASGAIFGLLGALLVLGPRNRILLFGLIGaLLALLLFILLNLVLGLlpgNGVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 18-200 3.57e-08

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 52.94  E-value: 3.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94818790  18 PSATFFTALLSLLVSGprLFLLQQPLAPSGLTLKSEALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTVGTV 97
Cdd:COG0705   3 PPVTLALIALNVLVFL--LQLLLGGELLNWLALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94818790  98 RHCFFTVIFAIFSAIIFLSFEAVSSLSKLGevedARGftpVAFAMLGVTTVRSRMRRALVFGMVVPS--VLVPWLLLGAS 175
Cdd:COG0705  81 RFLLLYLLSGLGGGLLQLLFSPGSGYPLVG----ASG---AIFGLLGALLVLGPRRRVLLLFIPIPAllFLLVWLLLGLL 153

                       170       180
                ....*....|....*....|....*...
gi 94818790 176 WLIPQTSFLSN---VCGLSIGLAYGLTY 200
Cdd:COG0705 154 FGLLGGGGIAWeahLGGLLAGLLLALLL 181
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 54-204 1.60e-26

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 103.07  E-value: 1.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94818790    54 ALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTVGTVRHCFFTVIFAIFSAIIFLSFEAVSslsklgevEDAR 133
Cdd:pfam01694   1 PVQPGQLWRLITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYLFSPLS--------TPSV 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 94818790   134 GFTPVAFAMLGVTTVRSRMRRALVFGMVV-PSVLVPWLLLGASWLI---PQTSFLSNVCGLSIGLAYGLTYCYSI 204
Cdd:pfam01694  73 GASGAIFGLLGALLVLGPRNRILLFGLIGaLLALLLFILLNLVLGLlpgNGVSNLAHLGGLLVGLLLGFILLRRP 147
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 18-200 3.57e-08

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 52.94  E-value: 3.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94818790  18 PSATFFTALLSLLVSGprLFLLQQPLAPSGLTLKSEALRNWQVYRLVTYIFVYENPISLLCGAIIIWRFAGNFERTVGTV 97
Cdd:COG0705   3 PPVTLALIALNVLVFL--LQLLLGGELLNWLALVPARLLLGELWRLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94818790  98 RHCFFTVIFAIFSAIIFLSFEAVSSLSKLGevedARGftpVAFAMLGVTTVRSRMRRALVFGMVVPS--VLVPWLLLGAS 175
Cdd:COG0705  81 RFLLLYLLSGLGGGLLQLLFSPGSGYPLVG----ASG---AIFGLLGALLVLGPRRRVLLLFIPIPAllFLLVWLLLGLL 153

                       170       180
                ....*....|....*....|....*...
gi 94818790 176 WLIPQTSFLSN---VCGLSIGLAYGLTY 200
Cdd:COG0705 154 FGLLGGGGIAWeahLGGLLAGLLLALLL 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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