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Conserved domains on  [gi|110349997|ref|NP_001036030|]
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WD repeat and SOCS box-containing protein 1 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-147 2.35e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 2.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSHDGLHVA 85
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGH--------------TGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110349997  86 SLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQH 147
Cdd:COG2319  221 SGSADGTVRLWDLATGKLLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWdlATGELLRTLTG 286
SOCS super family cl02533
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 140-178 1.66e-21

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


The actual alignment was detected with superfamily member cd03746:

Pssm-ID: 470605  Cd Length: 40  Bit Score: 82.17  E-value: 1.66e-21
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 110349997 140 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 178
Cdd:cd03746    1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYR 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-147 2.35e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 2.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSHDGLHVA 85
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGH--------------TGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110349997  86 SLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQH 147
Cdd:COG2319  221 SGSADGTVRLWDLATGKLLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWdlATGELLRTLTG 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-146 4.65e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 4.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   1 MDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSH 79
Cdd:cd00200  122 VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLtGH--------------TGEVNSVAFSP 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110349997  80 DGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQ 146
Cdd:cd00200  188 DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvNSVAFSPDGYLLASGSEDGTIRVWdlRTGECVQTLS 258
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 140-178 1.66e-21

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 82.17  E-value: 1.66e-21
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 110349997 140 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 178
Cdd:cd03746    1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYR 39
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 136-178 2.08e-16

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 68.86  E-value: 2.08e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 110349997   136 WATPRQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 178
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-42 6.78e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 6.78e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 110349997     7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWD 42
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
7-42 8.00e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 8.00e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110349997    7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWD 42
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 141-175 1.24e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 46.00  E-value: 1.24e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 110349997  141 QVPSLQHICRMSIRRVMST---QEVQKLPVPSKILAFL 175
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKrrlGAIDKLPLPPLLKDYL 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
7-147 2.35e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 2.35e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSHDGLHVA 85
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGH--------------TGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110349997  86 SLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQH 147
Cdd:COG2319  221 SGSADGTVRLWDLATGKLLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWdlATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
7-147 1.24e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 1.24e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSHDGLHVA 85
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLtGH--------------SGAVTSVAFSPDGKLLA 178

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110349997  86 SLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQH 147
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLLRTLTGHTGavRSVAFSPDGKLLASGSADGTVRLWdlATGKLLRTLTG 244
WD40 COG2319
WD40 repeat [General function prediction only];
7-136 9.96e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 9.96e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSHDGLHVA 85
Cdd:COG2319  281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGH--------------TGAVRSVAFSPDGKTLA 346

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110349997  86 SLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 136
Cdd:COG2319  347 SGSDDGTVRLWDLATGELLRTLTGHTGavTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-146 4.65e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 4.65e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   1 MDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSH 79
Cdd:cd00200  122 VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLtGH--------------TGEVNSVAFSP 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110349997  80 DGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQ 146
Cdd:cd00200  188 DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvNSVAFSPDGYLLASGSEDGTIRVWdlRTGECVQTLS 258
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 140-178 1.66e-21

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 82.17  E-value: 1.66e-21
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 110349997 140 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 178
Cdd:cd03746    1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYR 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-136 4.04e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 4.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   5 TMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHLFP------SPT-PIFAGGANDR------ 70
Cdd:cd00200   42 ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLtGHTSYvssvafSPDgRILSSSSRDKtikvwd 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997  71 ---------------WVRAVSFSHDGLHVASLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSV 133
Cdd:cd00200  122 vetgkclttlrghtdWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGevNSVAFSPDGEKLLSSSSDGTI 201


                 ...
gi 110349997 134 YFW 136
Cdd:cd00200  202 KLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
7-146 1.93e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 1.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSHDGLHVA 85
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLtGH--------------TGAVRSVAFSPDGKTLA 136

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110349997  86 SLADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQ 146
Cdd:COG2319  137 SGSADGTVRLWDLATGKLLRTLTGHSGavTSVAFSPDGKLLASGSDDGTVRLWdlATGKLLRTLT 201
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 140-178 3.14e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 79.00  E-value: 3.14e-20
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 110349997 140 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 178
Cdd:cd03733    1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-136 2.33e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 2.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   6 MIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHLFpsptpifaggandrWVRAVSFSHDGLHV 84
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHTG--------------PVRDVAASADGTYL 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 110349997  85 ASLADDKMVRFWRIDEDCPVQVAP--LSNGLCCAFSTDGSVLAAGTHDGSVYFW 136
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTghTSYVSSVAFSPDGRILSSSSRDKTIKVW 120
WD40 COG2319
WD40 repeat [General function prediction only];
7-99 1.29e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.88  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEF-GHlfpsptpifagganDRWVRAVSFSHDGLHVA 85
Cdd:COG2319  323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLtGH--------------TGAVTSVAFSPDGRTLA 388

                         90
                 ....*....|....
gi 110349997  86 SLADDKMVRFWRID 99
Cdd:COG2319  389 SGSADGTVRLWDLA 402
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 136-178 2.08e-16

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 68.86  E-value: 2.08e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 110349997   136 WATPRQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 178
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
WD40 COG2319
WD40 repeat [General function prediction only];
7-147 2.22e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 2.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110349997   7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHNGDLLMEFGHlfpsptpifaggaNDRWVRAVSFSHDGLHVAS 86
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG-------------HTAAVLSVAFSPDGRLLAS 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110349997  87 LADDKMVRFWRIDEDCPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW--ATPRQVPSLQH 147
Cdd:COG2319   96 ASADGTVRLWDLATGLLLRTLTGHTGavRSVAFSPDGKTLASGSADGTVRLWdlATGKLLRTLTG 160
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 141-178 2.47e-10

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 53.24  E-value: 2.47e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 110349997 141 QVPSLQHICRMSIRRVM---STQEVQKLPVPSKILAFLSYR 178
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 140-178 1.79e-09

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 51.05  E-value: 1.79e-09
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 110349997 140 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 178
Cdd:cd03745    1 RVLPSLRHLCRKALRHFLTTYQVLALPIPKKMKEFLTYR 39
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 141-178 2.25e-09

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 50.67  E-value: 2.25e-09
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 110349997 141 QVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSYR 178
Cdd:cd03717    2 SVRSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-42 6.78e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 6.78e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 110349997     7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWD 42
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 143-178 7.29e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 46.25  E-value: 7.29e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 110349997   143 PSLQHICRMSIRRVMSTqeVQKLPVPSKILAFLSYR 178
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--IDKLPLPPRLKDYLLYY 34
WD40 pfam00400
WD domain, G-beta repeat;
7-42 8.00e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 8.00e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 110349997    7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWD 42
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 140-178 8.90e-08

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 46.33  E-value: 8.90e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 110349997 140 RQVPSLQHICRMSIRRVM---STQEVQKLPVPSKILAFLSYR 178
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLgrrRLELIKKLPLPPRLKDYLLYE 42
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 141-175 1.24e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 46.00  E-value: 1.24e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 110349997  141 QVPSLQHICRMSIRRVMST---QEVQKLPVPSKILAFL 175
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKrrlGAIDKLPLPPLLKDYL 38
WD40 COG2319
WD40 repeat [General function prediction only];
7-45 1.44e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.91  E-value: 1.44e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 110349997   7 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWDPHN 45
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
SOCS_SOCS7 cd03741
SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the ...
 140-177 1.61e-06

SOCS (suppressors of cytokine signaling) box of SOCS7-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS7 is important in the functioning of neuronal cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239710  Cd Length: 49  Bit Score: 43.16  E-value: 1.61e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 110349997 140 RQVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFLSY 177
Cdd:cd03741    1 KNVQSLQHLCRFVIRKLVRRDHIPALPLPRRLIDYLRE 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 13-42 3.96e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.83  E-value: 3.96e-06
                          10        20        30
                  ....*....|....*....|....*....|.
gi 110349997   13 HHHDVVAC-DFSPDGALLATASYDTRVYVWD 42
Cdd:pfam20426 122 QHKDVVSCvAVTSDGSILATGSYDTTVMVWE 152
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 143-178 1.05e-05

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 40.99  E-value: 1.05e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 110349997 143 PSLQHICRMSIRRVmsTQEVQKLPVPSKILAFLS-YR 178
Cdd:cd03736    4 PSLQHLCRITINKC--TRQIQELPLPTRLKDYLTeYT 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-42 1.42e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 1.42e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 110349997   1 MDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYVWD 42
Cdd:cd00200  248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 141-175 6.33e-05

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 38.94  E-value: 6.33e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 110349997 141 QVPSLQHICRMSIRRVMSTQEVQKLPVPSKILAFL 175
Cdd:cd03740    2 QVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYL 36
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 142-175 1.07e-04

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 38.02  E-value: 1.07e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 110349997 142 VPSLQHICRMSIRRVmsTQEVQKLPVPSKILAFL 175
Cdd:cd03734    3 ARSLQHLCRLVINRL--VTDVDCLPLPRRMADYL 34
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 138-178 1.14e-04

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 38.23  E-value: 1.14e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 110349997 138 TPRqvpSLQHICRMSIRRVMSTQEVQ---KLPVPSKILAFLSYR 178
Cdd:cd03729    2 TPL---SLQQLCRINLRKALGTRALEkiaKLNIPNRIIDYLSYN 42
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 144-178 3.75e-04

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 37.12  E-value: 3.75e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 110349997 144 SLQHICRMSIRRVMSTQEVQ------KLPVPSKILAFLSYR 178
Cdd:cd03731    5 PLKHLCRLKIRKLMGLQKLQqpssmkKLPLPPALKRYILYK 45
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 138-175 9.58e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 35.88  E-value: 9.58e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 110349997 138 TPRqvpSLQHICRMSIRRVMSTQ---EVQKLPVPSKILAFL 175
Cdd:cd03723    2 TPR---SLQHLCRCAIRKLLGSRchkLVPQLSLPTSLKNYL 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 83-160 2.76e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 37.36  E-value: 2.76e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 110349997   83 HVASLADDKMVRFWRIDEDCpvqVAplsnglCCAFSTDGSVLAAGTHDGSVYFWATPRQvpslqhicRMSIRRVMSTQ 160
Cdd:pfam20426 107 QVISLNDGRMVQSIRQHKDV---VS------CVAVTSDGSILATGSYDTTVMVWEVLRG--------RSSEKRSRNTQ 167
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 142-177 4.19e-03

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 34.00  E-value: 4.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 110349997 142 VPSLQHICRMSIR------RVMSTQEVQKLPVPSKILAFLSY 177
Cdd:cd03722    3 VPSLTHLCRLEIRsslkseRLRSDSFICQLPLPRSLQDYLLY 44
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 103-136 4.51e-03

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 36.66  E-value: 4.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 110349997  103 PVQVAPLSNGL----------CCAFSTDGSVLAAGTHDGSVYFW 136
Cdd:pfam16529 170 PLQPAALESGYieieehsllvDAAFSPDGTALATASLDGEVKFF 213
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 113-136 4.83e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.44  E-value: 4.83e-03
                           10        20
                   ....*....|....*....|....
gi 110349997   113 LCCAFSTDGSVLAAGTHDGSVYFW 136
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 67-96 7.60e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.05  E-value: 7.60e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 110349997    67 ANDRWVRAVSFSHDGLHVASLADDKMVRFW 96
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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