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Conserved domains on  [gi|320545183|ref|NP_001036368|]
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Cadherin-N2, isoform C [Drosophila melanogaster]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182806)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1013-1198 2.61e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 123.68  E-value: 2.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1013 TRSFRGNGWAWYPPLQL-CQESHLSLEFITRVADGLILYNGPIVPpkpeetviSDFIALELEQGYPRLLIDFGSGTLELR 1091
Cdd:cd00110     1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG--------GDFLALELEDGRLVLRYDLGSGSLVLS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1092 VKTkkTLDDGVWHRLDIFWDTENVRMVVDFCRtalvsemedgtppefddnacQARGQIPPFAESLNLNQPLQLGGLYRQH 1171
Cdd:cd00110    73 SKT--PLNDGQWHSVSVERNGRSVTLSVDGER--------------------VVESGSPGGSALLNLDGPLYLGGLPEDL 130

                         170       180
                  ....*....|....*....|....*..
gi 320545183 1172 FDQTLYNwqyafsSKGFDGCIRNVIHN 1198
Cdd:cd00110   131 KSPGLPV------SPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 489-586 1.09e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 1.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  489 HIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVrSTNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGS 567
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 320545183  568 PARTATATLTVIVKDVNDN 586
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 1662-1719 1.91e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 106.47  E-value: 1.91e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320545183  1662 DKDNNAPPFDDLRNFTFEGSGSIAESLSSLASGTDDENQDFNYLQNWGPRFNALAAMY 1719
Cdd:pfam01049    2 DNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELY 59
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 41-132 1.65e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 1.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   41 YETEIDENADLQSTVLTVNAKDHNESTN--IRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEAT---RNR 115
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdggGPP 81

                          90
                  ....*....|....*..
gi 320545183  116 KNNYTTVVINVRDVNDN 132
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1265-1426 3.29e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 103.27  E-value: 3.29e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1265 PTTFKAQSYVKFALSFEPdRFSTQLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRneeqlLTLTAI 1344
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGS-----LVLSSK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1345 A-VNDGQWHVIRISRYGSAALMELDGGesrRYNESFHFTGHQWLtiDKQEGVYAGGKAEYTGIKTFEVQSDFqRSCLDDI 1423
Cdd:cd00110    75 TpLNDGQWHSVSVERNGRSVTLSVDGE---RVVESGSPGGSALL--NLDGPLYLGGLPEDLKSPGLPVSPGF-VGCIRDL 148


                  ...
gi 320545183 1424 RLD 1426
Cdd:cd00110   149 KVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-248 8.54e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 8.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  140 TYRTQITEedDRNLPKRILQVTATDGDVDRPINIVYFLTGqgidpdNPANSKFDINRTTGDIFVLKPLDRDQpngRPQWR 219
Cdd:cd11304     1 SYEVSVPE--NAPPGTVVLTVSATDPDSGENGEVTYSIVS------GNEDGLFSIDPSTGEITTAKPLDREE---QSSYT 69

                          90       100
                  ....*....|....*....|....*....
gi 320545183  220 FTVFAQDEGGEGLVGYADIQVNLKDINDN 248
Cdd:cd11304    70 LTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 256-359 1.76e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 1.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  256 IYFGNVTENGTAGSSVMTMSAVDYDDPNestNAKLIYSIEknvieEETGAPIFEIEPETGLIKTAVCcLDRERTPDYSIQ 335
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*.
gi 320545183  336 VVAMDGGG--LKGTGTASIRVKDLND 359
Cdd:cd11304    72 VTATDGGGppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 594-703 3.59e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 3.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  594 YKPTLPENVS-GKKILEVAAKDPDDrlrGNGGPFTFRLDPLASDEIkagFKVeydrrgDNENGVaiISSLRPFDREAQKS 672
Cdd:cd11304     2 YEVSVPENAPpGTVVLTVSATDPDS---GENGEVTYSIVSGNEDGL---FSI------DPSTGE--ITTAKPLDREEQSS 67

                          90       100       110
                  ....*....|....*....|....*....|.
gi 320545183  673 YAIPIEIKDNGAPAMTGTSTLTVTIGDVNDN 703
Cdd:cd11304    68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1497-1535 9.61e-11

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 58.03  E-value: 9.61e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 320545183 1497 DRNECLDL-PCLNGATCINLEPRlrYRCICPEGYWGENCE 1535
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGS--YRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 388-483 1.03e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.11  E-value: 1.03e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    388 TVTVQDEDETNTFQYKVVPNSGFGadKFAMVRNgdgTGSLKIIQPLDYEdplQSSGFRFRIQVNDKGDDGpggsdkyHVA 467
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG--LFSIDPE---TGEITTTKPLDRE---EQPEYTLTVEATDGGGPP-------LSS 65

                            90
                    ....*....|....*.
gi 320545183    468 YSWVVVKLRDINDNVP 483
Cdd:smart00112   66 TATVTITVLDVNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 977-1010 5.24e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 320545183  977 CRT-HLCYNGGRCVETRNGPKCVaCPVGYNGPRCQ 1010
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCS-CPPGYTGRNCE 38
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1233-1259 1.04e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.04e-03
                           10        20
                   ....*....|....*....|....*..
gi 320545183  1233 CWEHGNCVASlvQAKCHCQPGWMGPGC 1259
Cdd:pfam07974    2 CSGRGTCVNQ--CGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1013-1198 2.61e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 123.68  E-value: 2.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1013 TRSFRGNGWAWYPPLQL-CQESHLSLEFITRVADGLILYNGPIVPpkpeetviSDFIALELEQGYPRLLIDFGSGTLELR 1091
Cdd:cd00110     1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG--------GDFLALELEDGRLVLRYDLGSGSLVLS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1092 VKTkkTLDDGVWHRLDIFWDTENVRMVVDFCRtalvsemedgtppefddnacQARGQIPPFAESLNLNQPLQLGGLYRQH 1171
Cdd:cd00110    73 SKT--PLNDGQWHSVSVERNGRSVTLSVDGER--------------------VVESGSPGGSALLNLDGPLYLGGLPEDL 130

                         170       180
                  ....*....|....*....|....*..
gi 320545183 1172 FDQTLYNwqyafsSKGFDGCIRNVIHN 1198
Cdd:cd00110   131 KSPGLPV------SPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 489-586 1.09e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 1.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  489 HIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVrSTNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGS 567
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 320545183  568 PARTATATLTVIVKDVNDN 586
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1039-1200 1.36e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.05  E-value: 1.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  1039 FITRVADGLILYNGPivppkpeetVISDFIALELEQGYPRLLIDFGSGTLELRVkTKKTLDDGVWHRLDIFWDTENVRMV 1118
Cdd:pfam02210    1 FRTRQPNGLLLYAGG---------GGSDFLALELVNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  1119 VDFCRtalvsemedgtppefddnacQARGQIPPFAESLNLNQPLQLGGLyrqhfdQTLYNWQYAFSSKGFDGCIRNVIHN 1198
Cdd:pfam02210   71 VDGQT--------------------VVSSLPPGESLLLNLNGPLYLGGL------PPLLLLPALPVRAGFVGCIRDVRVN 124


                   ..
gi 320545183  1199 SE 1200
Cdd:pfam02210  125 GE 126
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 1662-1719 1.91e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 106.47  E-value: 1.91e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320545183  1662 DKDNNAPPFDDLRNFTFEGSGSIAESLSSLASGTDDENQDFNYLQNWGPRFNALAAMY 1719
Cdd:pfam01049    2 DNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELY 59
LamG smart00282
Laminin G domain;
1034-1200 3.14e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.20  E-value: 3.14e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   1034 HLSLEFITRVADGLILYNGPIVPpkpeetviSDFIALELEQGYPRLLIDFGSGTLELRVKTKKtLDDGVWHRLDIFWDTE 1113
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG--------GDYLALELRDGRLVLRYDLGSGPARLTSDPTP-LNDGQWHRVAVERNGR 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   1114 NVRMVVDFCRtalvsemedgtppefddnacQARGQIPPFAESLNLNQPLQLGGLYRQHFDQTLYNwqyafsSKGFDGCIR 1193
Cdd:smart00282   72 SVTLSVDGGN--------------------RVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV------TPGFRGCIR 125


                    ....*..
gi 320545183   1194 NVIHNSE 1200
Cdd:smart00282  126 NLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 41-132 1.65e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 1.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   41 YETEIDENADLQSTVLTVNAKDHNESTN--IRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEAT---RNR 115
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdggGPP 81

                          90
                  ....*....|....*..
gi 320545183  116 KNNYTTVVINVRDVNDN 132
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1265-1426 3.29e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 103.27  E-value: 3.29e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1265 PTTFKAQSYVKFALSFEPdRFSTQLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRneeqlLTLTAI 1344
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGS-----LVLSSK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1345 A-VNDGQWHVIRISRYGSAALMELDGGesrRYNESFHFTGHQWLtiDKQEGVYAGGKAEYTGIKTFEVQSDFqRSCLDDI 1423
Cdd:cd00110    75 TpLNDGQWHSVSVERNGRSVTLSVDGE---RVVESGSPGGSALL--NLDGPLYLGGLPEDLKSPGLPVSPGF-VGCIRDL 148


                  ...
gi 320545183 1424 RLD 1426
Cdd:cd00110   149 KVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-248 8.54e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 8.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  140 TYRTQITEedDRNLPKRILQVTATDGDVDRPINIVYFLTGqgidpdNPANSKFDINRTTGDIFVLKPLDRDQpngRPQWR 219
Cdd:cd11304     1 SYEVSVPE--NAPPGTVVLTVSATDPDSGENGEVTYSIVS------GNEDGLFSIDPSTGEITTAKPLDREE---QSSYT 69

                          90       100
                  ....*....|....*....|....*....
gi 320545183  220 FTVFAQDEGGEGLVGYADIQVNLKDINDN 248
Cdd:cd11304    70 LTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 508-588 1.21e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.57  E-value: 1.21e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    508 KATDADQGGHSKVAYKIVRStNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDN 586
Cdd:smart00112    1 SATDADSGENGKVTYSILSG-NDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 320545183    587 AP 588
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 256-359 1.76e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 1.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  256 IYFGNVTENGTAGSSVMTMSAVDYDDPNestNAKLIYSIEknvieEETGAPIFEIEPETGLIKTAVCcLDRERTPDYSIQ 335
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*.
gi 320545183  336 VVAMDGGG--LKGTGTASIRVKDLND 359
Cdd:cd11304    72 VTATDGGGppLSSTATVTITVLDVND 97
LamG smart00282
Laminin G domain;
1288-1428 6.31e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 90.48  E-value: 6.31e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   1288 QLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSmrnEEQLLTLTAIAVNDGQWHVIRISRYGSAALMEL 1367
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320545183   1368 DGGESRrynESFHFTGHQWLTIDkqEGVYAGGKAEYTGIKTFEVQSDFqRSCLDDIRLDGK 1428
Cdd:smart00282   78 DGGNRV---SGESPGGLTILNLD--GPLYLGGLPEDLKLPPLPVTPGF-RGCIRNLKVNGK 132
Cadherin pfam00028
Cadherin domain;
490-580 7.25e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.90  E-value: 7.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   490 IEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVrSTNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGSP 568
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-GGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 320545183   569 ARTATATLTVIV 580
Cdd:pfam00028   80 PLSSTATVTITV 91
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1293-1428 4.16e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 87.86  E-value: 4.16e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  1293 FRTREQGGELFRVSDQHHrEYAILELRRGHLQFRYNLNSmrnEEQLLTLTAIAVNDGQWHVIRISRYGSAALMELDGGES 1372
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDLGS---GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 320545183  1373 RRYNESFHFtghqwLTIDKQEGVYAGGKAEYTGIKTFEVQSDFqRSCLDDIRLDGK 1428
Cdd:pfam02210   77 VSSLPPGES-----LLLNLNGPLYLGGLPPLLLLPALPVRAGF-VGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 61-134 8.54e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 8.54e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320545183     61 KDHNESTNIRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEAT---RNRKNNYTTVVINVRDVNDNPP 134
Cdd:smart00112    5 ADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdggGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
41-126 1.14e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 1.14e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    41 YETEIDENADLQSTVLTVNAKDHNESTN--IRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEAT---RNR 115
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATdsgGPP 80

                           90
                   ....*....|.
gi 320545183   116 KNNYTTVVINV 126
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 594-703 3.59e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 3.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  594 YKPTLPENVS-GKKILEVAAKDPDDrlrGNGGPFTFRLDPLASDEIkagFKVeydrrgDNENGVaiISSLRPFDREAQKS 672
Cdd:cd11304     2 YEVSVPENAPpGTVVLTVSATDPDS---GENGEVTYSIVSGNEDGL---FSI------DPSTGE--ITTAKPLDREEQSS 67

                          90       100       110
                  ....*....|....*....|....*....|.
gi 320545183  673 YAIPIEIKDNGAPAMTGTSTLTVTIGDVNDN 703
Cdd:cd11304    68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-250 9.46e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 9.46e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    161 TATDGDVDRPINIVYFLTGqgidpdNPANSKFDINRTTGDIFVLKPLDRDQpngRPQWRFTVFAQDEGGEGLVGYADIQV 240
Cdd:smart00112    1 SATDADSGENGKVTYSILS------GNDDGLFSIDPETGEITTTKPLDREE---QPEYTLTVEATDGGGPPLSSTATVTI 71

                            90
                    ....*....|
gi 320545183    241 NLKDINDNAP 250
Cdd:smart00112   72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 275-362 4.29e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.69  E-value: 4.29e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    275 SAVDYDDPNestNAKLIYSIEknvieEETGAPIFEIEPETGLIKTAVCcLDRERTPDYSIQVVAMDGGG--LKGTGTASI 352
Cdd:smart00112    1 SATDADSGE---NGKVTYSIL-----SGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGppLSSTATVTI 71

                            90
                    ....*....|
gi 320545183    353 RVKDLNDMPP 362
Cdd:smart00112   72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
257-355 4.64e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 4.64e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   257 YFGNVTENGTAGSSVMTMSAVDYDDPnesTNAKLIYSIeknvIEEETGaPIFEIEPETGLIKTAVCcLDRERTPDYSIQV 336
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG---PNGRIFYSI----LGGGPG-GNFRIDPDTGDISTTKP-LDRESIGEYELTV 71

                           90
                   ....*....|....*....
gi 320545183   337 VAMDGGGLKGTGTASIRVK 355
Cdd:pfam00028   72 EATDSGGPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 612-703 5.19e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 5.19e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    612 AKDPDDrlrGNGGPFTFRLDPLASDEIkagFKVeydrrgDNENGvaIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTS 691
Cdd:smart00112    2 ATDADS---GENGKVTYSILSGNDDGL---FSI------DPETG--EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTA 67

                            90
                    ....*....|..
gi 320545183    692 TLTVTIGDVNDN 703
Cdd:smart00112   68 TVTITVLDVNDN 79
Cadherin pfam00028
Cadherin domain;
141-242 3.10e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 3.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   141 YRTQITEedDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPdnpansKFDINRTTGDIFVLKPLDRDQpngRPQWRF 220
Cdd:pfam00028    1 YSASVPE--NAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG------NFRIDPDTGDISTTKPLDRES---IGEYEL 69

                           90       100
                   ....*....|....*....|..
gi 320545183   221 TVFAQDEGGEGLVGYADIQVNL 242
Cdd:pfam00028   70 TVEATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
597-697 2.82e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 2.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   597 TLPENV-SGKKILEVAAKDPDDRLrgNGGPFTFrldpLASDEIKAGFKVEYDrrgdneNGVaiISSLRPFDREAQKSYAI 675
Cdd:pfam00028    4 SVPENApVGTEVLTVTATDPDLGP--NGRIFYS----ILGGGPGGNFRIDPD------TGD--ISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|..
gi 320545183   676 PIEIKDNGAPAMTGTSTLTVTI 697
Cdd:pfam00028   70 TVEATDSGGPPLSSTATVTITV 91
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1497-1535 9.61e-11

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 58.03  E-value: 9.61e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 320545183 1497 DRNECLDL-PCLNGATCINLEPRlrYRCICPEGYWGENCE 1535
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGS--YRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1497-1535 4.92e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 53.40  E-value: 4.92e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 320545183   1497 DRNECLDL-PCLNGATCINLEPrlRYRCICPEGYW-GENCE 1535
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVG--SYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1501-1533 4.05e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 47.76  E-value: 4.05e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 320545183  1501 CLDLPCLNGATCINLEPrlRYRCICPEGYWGEN 1533
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG--GYTCICPEGYTGKR 31
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 388-483 1.03e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.11  E-value: 1.03e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    388 TVTVQDEDETNTFQYKVVPNSGFGadKFAMVRNgdgTGSLKIIQPLDYEdplQSSGFRFRIQVNDKGDDGpggsdkyHVA 467
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG--LFSIDPE---TGEITTTKPLDRE---EQPEYTLTVEATDGGGPP-------LSS 65

                            90
                    ....*....|....*.
gi 320545183    468 YSWVVVKLRDINDNVP 483
Cdd:smart00112   66 TATVTITVLDVNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 977-1010 5.24e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 320545183  977 CRT-HLCYNGGRCVETRNGPKCVaCPVGYNGPRCQ 1010
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCS-CPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 977-1008 2.61e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 2.61e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 320545183   977 CRTHLCYNGGRCVETRNGPKCvACPVGYNGPR 1008
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTC-ICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
980-1010 8.38e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 8.38e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 320545183    980 HLCYNGGRCVETRNGPKCVaCPVGY-NGPRCQ 1010
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCE-CPPGYtDGRNCE 39
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1233-1259 1.04e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.04e-03
                           10        20
                   ....*....|....*....|....*..
gi 320545183  1233 CWEHGNCVASlvQAKCHCQPGWMGPGC 1259
Cdd:pfam07974    2 CSGRGTCVNQ--CGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1013-1198 2.61e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 123.68  E-value: 2.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1013 TRSFRGNGWAWYPPLQL-CQESHLSLEFITRVADGLILYNGPIVPpkpeetviSDFIALELEQGYPRLLIDFGSGTLELR 1091
Cdd:cd00110     1 GVSFSGSSYVRLPTLPApRTRLSISFSFRTTSPNGLLLYAGSQNG--------GDFLALELEDGRLVLRYDLGSGSLVLS 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1092 VKTkkTLDDGVWHRLDIFWDTENVRMVVDFCRtalvsemedgtppefddnacQARGQIPPFAESLNLNQPLQLGGLYRQH 1171
Cdd:cd00110    73 SKT--PLNDGQWHSVSVERNGRSVTLSVDGER--------------------VVESGSPGGSALLNLDGPLYLGGLPEDL 130

                         170       180
                  ....*....|....*....|....*..
gi 320545183 1172 FDQTLYNwqyafsSKGFDGCIRNVIHN 1198
Cdd:cd00110   131 KSPGLPV------SPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 489-586 1.09e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 1.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  489 HIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVrSTNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGS 567
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 320545183  568 PARTATATLTVIVKDVNDN 586
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1039-1200 1.36e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 109.05  E-value: 1.36e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  1039 FITRVADGLILYNGPivppkpeetVISDFIALELEQGYPRLLIDFGSGTLELRVkTKKTLDDGVWHRLDIFWDTENVRMV 1118
Cdd:pfam02210    1 FRTRQPNGLLLYAGG---------GGSDFLALELVNGRLVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  1119 VDFCRtalvsemedgtppefddnacQARGQIPPFAESLNLNQPLQLGGLyrqhfdQTLYNWQYAFSSKGFDGCIRNVIHN 1198
Cdd:pfam02210   71 VDGQT--------------------VVSSLPPGESLLLNLNGPLYLGGL------PPLLLLPALPVRAGFVGCIRDVRVN 124


                   ..
gi 320545183  1199 SE 1200
Cdd:pfam02210  125 GE 126
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 1662-1719 1.91e-27

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 106.47  E-value: 1.91e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 320545183  1662 DKDNNAPPFDDLRNFTFEGSGSIAESLSSLASGTDDENQDFNYLQNWGPRFNALAAMY 1719
Cdd:pfam01049    2 DNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELY 59
LamG smart00282
Laminin G domain;
1034-1200 3.14e-27

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 108.20  E-value: 3.14e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   1034 HLSLEFITRVADGLILYNGPIVPpkpeetviSDFIALELEQGYPRLLIDFGSGTLELRVKTKKtLDDGVWHRLDIFWDTE 1113
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG--------GDYLALELRDGRLVLRYDLGSGPARLTSDPTP-LNDGQWHRVAVERNGR 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   1114 NVRMVVDFCRtalvsemedgtppefddnacQARGQIPPFAESLNLNQPLQLGGLYRQHFDQTLYNwqyafsSKGFDGCIR 1193
Cdd:smart00282   72 SVTLSVDGGN--------------------RVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPV------TPGFRGCIR 125


                    ....*..
gi 320545183   1194 NVIHNSE 1200
Cdd:smart00282  126 NLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 41-132 1.65e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.09  E-value: 1.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   41 YETEIDENADLQSTVLTVNAKDHNESTN--IRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEAT---RNR 115
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdggGPP 81

                          90
                  ....*....|....*..
gi 320545183  116 KNNYTTVVINVRDVNDN 132
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1265-1426 3.29e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 103.27  E-value: 3.29e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1265 PTTFKAQSYVKFALSFEPdRFSTQLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRneeqlLTLTAI 1344
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGS-----LVLSSK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183 1345 A-VNDGQWHVIRISRYGSAALMELDGGesrRYNESFHFTGHQWLtiDKQEGVYAGGKAEYTGIKTFEVQSDFqRSCLDDI 1423
Cdd:cd00110    75 TpLNDGQWHSVSVERNGRSVTLSVDGE---RVVESGSPGGSALL--NLDGPLYLGGLPEDLKSPGLPVSPGF-VGCIRDL 148


                  ...
gi 320545183 1424 RLD 1426
Cdd:cd00110   149 KVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-248 8.54e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 8.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  140 TYRTQITEedDRNLPKRILQVTATDGDVDRPINIVYFLTGqgidpdNPANSKFDINRTTGDIFVLKPLDRDQpngRPQWR 219
Cdd:cd11304     1 SYEVSVPE--NAPPGTVVLTVSATDPDSGENGEVTYSIVS------GNEDGLFSIDPSTGEITTAKPLDREE---QSSYT 69

                          90       100
                  ....*....|....*....|....*....
gi 320545183  220 FTVFAQDEGGEGLVGYADIQVNLKDINDN 248
Cdd:cd11304    70 LTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 508-588 1.21e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.57  E-value: 1.21e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    508 KATDADQGGHSKVAYKIVRStNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDN 586
Cdd:smart00112    1 SATDADSGENGKVTYSILSG-NDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 320545183    587 AP 588
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 256-359 1.76e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 1.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  256 IYFGNVTENGTAGSSVMTMSAVDYDDPNestNAKLIYSIEknvieEETGAPIFEIEPETGLIKTAVCcLDRERTPDYSIQ 335
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE---NGEVTYSIV-----SGNEDGLFSIDPSTGEITTAKP-LDREEQSSYTLT 71

                          90       100
                  ....*....|....*....|....*.
gi 320545183  336 VVAMDGGG--LKGTGTASIRVKDLND 359
Cdd:cd11304    72 VTATDGGGppLSSTATVTITVLDVND 97
LamG smart00282
Laminin G domain;
1288-1428 6.31e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 90.48  E-value: 6.31e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   1288 QLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSmrnEEQLLTLTAIAVNDGQWHVIRISRYGSAALMEL 1367
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGS---GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 320545183   1368 DGGESRrynESFHFTGHQWLTIDkqEGVYAGGKAEYTGIKTFEVQSDFqRSCLDDIRLDGK 1428
Cdd:smart00282   78 DGGNRV---SGESPGGLTILNLD--GPLYLGGLPEDLKLPPLPVTPGF-RGCIRNLKVNGK 132
Cadherin pfam00028
Cadherin domain;
490-580 7.25e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.90  E-value: 7.25e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   490 IEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVrSTNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGSP 568
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-GGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 320545183   569 ARTATATLTVIV 580
Cdd:pfam00028   80 PLSSTATVTITV 91
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1293-1428 4.16e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 87.86  E-value: 4.16e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  1293 FRTREQGGELFRVSDQHHrEYAILELRRGHLQFRYNLNSmrnEEQLLTLTAIAVNDGQWHVIRISRYGSAALMELDGGES 1372
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDLGS---GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTV 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 320545183  1373 RRYNESFHFtghqwLTIDKQEGVYAGGKAEYTGIKTFEVQSDFqRSCLDDIRLDGK 1428
Cdd:pfam02210   77 VSSLPPGES-----LLLNLNGPLYLGGLPPLLLLPALPVRAGF-VGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 61-134 8.54e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 8.54e-20
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 320545183     61 KDHNESTNIRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEAT---RNRKNNYTTVVINVRDVNDNPP 134
Cdd:smart00112    5 ADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdggGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
41-126 1.14e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 1.14e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    41 YETEIDENADLQSTVLTVNAKDHNESTN--IRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEAT---RNR 115
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNgrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATdsgGPP 80

                           90
                   ....*....|.
gi 320545183   116 KNNYTTVVINV 126
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 594-703 3.59e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 3.59e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  594 YKPTLPENVS-GKKILEVAAKDPDDrlrGNGGPFTFRLDPLASDEIkagFKVeydrrgDNENGVaiISSLRPFDREAQKS 672
Cdd:cd11304     2 YEVSVPENAPpGTVVLTVSATDPDS---GENGEVTYSIVSGNEDGL---FSI------DPSTGE--ITTAKPLDREEQSS 67

                          90       100       110
                  ....*....|....*....|....*....|.
gi 320545183  673 YAIPIEIKDNGAPAMTGTSTLTVTIGDVNDN 703
Cdd:cd11304    68 YTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 161-250 9.46e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 9.46e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    161 TATDGDVDRPINIVYFLTGqgidpdNPANSKFDINRTTGDIFVLKPLDRDQpngRPQWRFTVFAQDEGGEGLVGYADIQV 240
Cdd:smart00112    1 SATDADSGENGKVTYSILS------GNDDGLFSIDPETGEITTTKPLDREE---QPEYTLTVEATDGGGPPLSSTATVTI 71

                            90
                    ....*....|
gi 320545183    241 NLKDINDNAP 250
Cdd:smart00112   72 TVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 275-362 4.29e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.69  E-value: 4.29e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    275 SAVDYDDPNestNAKLIYSIEknvieEETGAPIFEIEPETGLIKTAVCcLDRERTPDYSIQVVAMDGGG--LKGTGTASI 352
Cdd:smart00112    1 SATDADSGE---NGKVTYSIL-----SGNDDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGppLSSTATVTI 71

                            90
                    ....*....|
gi 320545183    353 RVKDLNDMPP 362
Cdd:smart00112   72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
257-355 4.64e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 4.64e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   257 YFGNVTENGTAGSSVMTMSAVDYDDPnesTNAKLIYSIeknvIEEETGaPIFEIEPETGLIKTAVCcLDRERTPDYSIQV 336
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG---PNGRIFYSI----LGGGPG-GNFRIDPDTGDISTTKP-LDRESIGEYELTV 71

                           90
                   ....*....|....*....
gi 320545183   337 VAMDGGGLKGTGTASIRVK 355
Cdd:pfam00028   72 EATDSGGPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 612-703 5.19e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 5.19e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    612 AKDPDDrlrGNGGPFTFRLDPLASDEIkagFKVeydrrgDNENGvaIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTS 691
Cdd:smart00112    2 ATDADS---GENGKVTYSILSGNDDGL---FSI------DPETG--EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTA 67

                            90
                    ....*....|..
gi 320545183    692 TLTVTIGDVNDN 703
Cdd:smart00112   68 TVTITVLDVNDN 79
Cadherin pfam00028
Cadherin domain;
141-242 3.10e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 3.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   141 YRTQITEedDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPdnpansKFDINRTTGDIFVLKPLDRDQpngRPQWRF 220
Cdd:pfam00028    1 YSASVPE--NAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG------NFRIDPDTGDISTTKPLDRES---IGEYEL 69

                           90       100
                   ....*....|....*....|..
gi 320545183   221 TVFAQDEGGEGLVGYADIQVNL 242
Cdd:pfam00028   70 TVEATDSGGPPLSSTATVTITV 91
Laminin_G_1 pfam00054
Laminin G domain;
1039-1203 1.73e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 63.49  E-value: 1.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  1039 FITRVADGLILYNGPIVPPkpeetvisDFIALELEQGYPRLLIDFGSGTLELRVKTKktLDDGVWHRLDIFWDTENVRMV 1118
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTER--------DFLALELRDGRLEVSYDLGSGAAVVRSGDK--LNDGKWHSVELERNGRSGTLS 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  1119 VDFCRTaLVSEMEDGTppefddnacqargqippfAESLNLNQPLQLGGLYRqhfdQTLYNWQYAfSSKGFDGCIRNVIHN 1198
Cdd:pfam00054   71 VDGEAR-PTGESPLGA------------------TTDLDVDGPLYVGGLPS----LGVKKRRLA-ISPSFDGCIRDVIVN 126


                   ....*
gi 320545183  1199 SEHYD 1203
Cdd:pfam00054  127 GKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1293-1376 2.78e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 62.72  E-value: 2.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  1293 FRTREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRneeqLLTLTAIAVNDGQWHVIRISRYGSAALMELDGGES 1372
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGA----AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEAR 76


                   ....
gi 320545183  1373 RRYN 1376
Cdd:pfam00054   77 PTGE 80
Cadherin pfam00028
Cadherin domain;
597-697 2.82e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 2.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183   597 TLPENV-SGKKILEVAAKDPDDRLrgNGGPFTFrldpLASDEIKAGFKVEYDrrgdneNGVaiISSLRPFDREAQKSYAI 675
Cdd:pfam00028    4 SVPENApVGTEVLTVTATDPDLGP--NGRIFYS----ILGGGPGGNFRIDPD------TGD--ISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|..
gi 320545183   676 PIEIKDNGAPAMTGTSTLTVTI 697
Cdd:pfam00028   70 TVEATDSGGPPLSSTATVTITV 91
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1497-1535 9.61e-11

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 58.03  E-value: 9.61e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 320545183 1497 DRNECLDL-PCLNGATCINLEPRlrYRCICPEGYWGENCE 1535
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGS--YRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1497-1535 4.92e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 53.40  E-value: 4.92e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 320545183   1497 DRNECLDL-PCLNGATCINLEPrlRYRCICPEGYW-GENCE 1535
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVG--SYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1501-1533 4.05e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 47.76  E-value: 4.05e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 320545183  1501 CLDLPCLNGATCINLEPrlRYRCICPEGYWGEN 1533
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG--GYTCICPEGYTGKR 31
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 388-483 1.03e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 48.11  E-value: 1.03e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183    388 TVTVQDEDETNTFQYKVVPNSGFGadKFAMVRNgdgTGSLKIIQPLDYEdplQSSGFRFRIQVNDKGDDGpggsdkyHVA 467
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG--LFSIDPE---TGEITTTKPLDRE---EQPEYTLTVEATDGGGPP-------LSS 65

                            90
                    ....*....|....*.
gi 320545183    468 YSWVVVKLRDINDNVP 483
Cdd:smart00112   66 TATVTITVLDVNDNAP 81
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1500-1535 2.30e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 45.93  E-value: 2.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 320545183 1500 ECLDL-PCLNGATCINLEPRlrYRCICPEGYWGE-NCE 1535
Cdd:cd00053     1 ECAASnPCSNGGTCVNTPGS--YRCVCPPGYTGDrSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 977-1010 5.24e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 320545183  977 CRT-HLCYNGGRCVETRNGPKCVaCPVGYNGPRCQ 1010
Cdd:cd00054     5 CASgNPCQNGGTCVNTVGSYRCS-CPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 977-1008 2.61e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.76  E-value: 2.61e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 320545183   977 CRTHLCYNGGRCVETRNGPKCvACPVGYNGPR 1008
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTC-ICPEGYTGKR 31
EGF smart00181
Epidermal growth factor-like domain;
1500-1535 7.10e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.65  E-value: 7.10e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 320545183   1500 ECLDL-PCLNGaTCINLEPRlrYRCICPEGYWG-ENCE 1535
Cdd:smart00181    1 ECASGgPCSNG-TCINTPGS--YTCSCPPGYTGdKRCE 35
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1506-1529 7.95e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.47  E-value: 7.95e-04
                           10        20
                   ....*....|....*....|....
gi 320545183  1506 CLNGATCINLEPRlrYRCICPEGY 1529
Cdd:pfam12661    1 CQNGGTCVDGVNG--YKCQCPPGY 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
980-1010 8.38e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 8.38e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 320545183    980 HLCYNGGRCVETRNGPKCVaCPVGY-NGPRCQ 1010
Cdd:smart00179    9 NPCQNGGTCVNTVGSYRCE-CPPGYtDGRNCE 39
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1233-1259 1.04e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.10  E-value: 1.04e-03
                           10        20
                   ....*....|....*....|....*..
gi 320545183  1233 CWEHGNCVASlvQAKCHCQPGWMGPGC 1259
Cdd:pfam07974    2 CSGRGTCVNQ--CGKCVCDSGYQGATC 26
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 490-586 1.69e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 39.63  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320545183  490 IEVSIYEDTKVGTILEQFKAtdaDQGGHSKVAYKIVRSTNRKR-QFAISDR--GAVSIQRPLDRETQDRHHIQILAIDDG 566
Cdd:cd00031     2 PDGSAVEGRSRGSFRVSIPT---DLIASSGEIIKISAAGKEALpSWLHWEPhsGILEGLEKLDREDKGVHYISVSAASLG 78

                          90       100
                  ....*....|....*....|
gi 320545183  567 SPARTATATLTVIVKDVNDN 586
Cdd:cd00031    79 ANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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