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Conserved domains on  [gi|116007522|ref|NP_001036457|]
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conundrum, isoform D [Drosophila melanogaster]

Protein Classification

rho GTPase-activating protein( domain architecture ID 10138216)

rho GTPase-activating protein (GAP) acts by converting Rho-type GTPases to an inactive GDP-bound state, similar to human Rho GAP 18 that suppresses F-actin polymerization by inhibiting Rho

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 356-576 6.41e-112

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239856  Cd Length: 216  Bit Score: 334.31  E-value: 6.41e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 356 LFGVSINALIRRDQQVTgtDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNpdnlDNLFRTA 435
Cdd:cd04391    1 LFGVPLSTLLERDQKKV--PGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEG----TFLWDQV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 436 TVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSI-DQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMN 514
Cdd:cd04391   75 KQHDAASLLKLFIRELPQPLLTVEYLPAFYSVQGLPSKkDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMN 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116007522 515 VHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVESQ 576
Cdd:cd04391  155 LWNVAMIMAPNLFPPRGKHSKDNESLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 356-576 6.41e-112

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 334.31  E-value: 6.41e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 356 LFGVSINALIRRDQQVTgtDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNpdnlDNLFRTA 435
Cdd:cd04391    1 LFGVPLSTLLERDQKKV--PGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEG----TFLWDQV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 436 TVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSI-DQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMN 514
Cdd:cd04391   75 KQHDAASLLKLFIRELPQPLLTVEYLPAFYSVQGLPSKkDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMN 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116007522 515 VHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVESQ 576
Cdd:cd04391  155 LWNVAMIMAPNLFPPRGKHSKDNESLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 380-530 2.40e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 152.31  E-value: 2.40e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522  380 PLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTfyqnpDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNE 459
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRG-----PDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFE 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116007522  460 LIQLFYQCHTLPSID-QMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR 530
Cdd:pfam00620  76 LYEEFIEAAKLPDEEeRLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPP 147
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 379-530 2.58e-34

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 128.15  E-value: 2.58e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522   379 VPLFLEKLIGELLRRGSREEGLLRIGGHKQKTellyNELESTFYQNPDnLDNLFRTATVHELSSLLKRWLRELPQPLLTN 458
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRV----KELRDAFDSGPD-PDLDLSEYDVHDVAGLLKLFLRELPEPLITY 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116007522   459 ELIQLFYQCHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR 530
Cdd:smart00324  78 ELYEEFIEAAKLEDETErLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPP 150
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 356-576 6.41e-112

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 334.31  E-value: 6.41e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 356 LFGVSINALIRRDQQVTgtDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNpdnlDNLFRTA 435
Cdd:cd04391    1 LFGVPLSTLLERDQKKV--PGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFYEG----TFLWDQV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 436 TVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSI-DQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMN 514
Cdd:cd04391   75 KQHDAASLLKLFIRELPQPLLTVEYLPAFYSVQGLPSKkDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMN 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116007522 515 VHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVESQ 576
Cdd:cd04391  155 LWNVAMIMAPNLFPPRGKHSKDNESLQEEVNMAAGCANIMRLLIRYQDLLWTVPSFLINQVR 216
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 380-530 2.40e-43

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 152.31  E-value: 2.40e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522  380 PLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTfyqnpDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNE 459
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRG-----PDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFE 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116007522  460 LIQLFYQCHTLPSID-QMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR 530
Cdd:pfam00620  76 LYEEFIEAAKLPDEEeRLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPP 147
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 380-546 3.56e-40

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 144.37  E-value: 3.56e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 380 PLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELEStfyqnpDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNE 459
Cdd:cd00159    1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDR------GEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFE 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 460 LIQLFYQCHTLPSIDQM-NALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNN 538
Cdd:cd00159   75 LYDEFIELAKIEDEEERiEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELLE 154


                 ....*...
gi 116007522 539 SIAEQVRM 546
Cdd:cd00159  155 DIKKLNEI 162
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 379-530 2.58e-34

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 128.15  E-value: 2.58e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522   379 VPLFLEKLIGELLRRGSREEGLLRIGGHKQKTellyNELESTFYQNPDnLDNLFRTATVHELSSLLKRWLRELPQPLLTN 458
Cdd:smart00324   3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRV----KELRDAFDSGPD-PDLDLSEYDVHDVAGLLKLFLRELPEPLITY 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116007522   459 ELIQLFYQCHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR 530
Cdd:smart00324  78 ELYEEFIEAAKLEDETErLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPP 150
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 357-565 9.21e-26

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 105.23  E-value: 9.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIRRdqqvTGTDSSLVplfLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNlfrtAT 436
Cdd:cd04386    5 FGTPLEEHLKR----TGREIALP---IEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGTFSLPLDEFY----SD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 437 VHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNV 515
Cdd:cd04386   74 PHAVASALKSYLRELPDPLLTYNLYEDWVQAANKPDEDErLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSP 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 116007522 516 HNVATIMAPSMFPPRYihpsDNNSIAEQVRMAAQCCRLTNILILRGEKLF 565
Cdd:cd04386  154 SNIAIVLAPNLLWAKN----EGSLAEMAAGTSVHVVAIVELIISHADWFF 199
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 357-571 2.48e-24

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 101.29  E-value: 2.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIRRDqqvtGTDSSL--------VPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNL 428
Cdd:cd04397    1 FGVPLEILVEKF----GADSTLgvgpgklrIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVPDLS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 429 DNlfrtaTVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINL 507
Cdd:cd04397   77 KE-----NPVQLAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEErKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSF 151

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116007522 508 KDI-----NKMNVHNVATIMAPSMFPPRyihpSDNNSIAEQVRMAAqccRLTNILILRGEKLFQVPNNL 571
Cdd:cd04397  152 SHIdeetgSKMDIHNLATVITPNILYSK----TDNPNTGDEYFLAI---EAVNYLIENNEEFCEVPDEL 213
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 356-572 5.64e-22

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 94.08  E-value: 5.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 356 LFGVSINALirrdQQVTGTDSSLVPLFLEKLIGELLRRGSrEEGLLRIGGHKQKTELLYNELESTfyqnpdnlDNLFRTA 435
Cdd:cd04394    1 VFGVPLHSL----PHSTVPEYGNVPKFLVDACTFLLDHLS-TEGLFRKSGSVVRQKELKAKLEGG--------EACLSSA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 436 TVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMN-ALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMN 514
Cdd:cd04394   68 LPCDVAGLLKQFFRELPEPLLPYDLHEALLKAQELPTDEERKsATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMD 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 116007522 515 VHNVATIMAPSMFPPRYIHPSDNNSIaeQVRMAAQCCrLTNILILRGEKLFQVPNNLI 572
Cdd:cd04394  148 SSNLAVIFAPNLFQSEEGGEKMSSST--EKRLRLQAA-VVQTLIDNASNIGIVPDFIL 202
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 357-524 1.15e-21

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 92.89  E-value: 1.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIrrdqqvtgTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELEStfyqNPDNLDnlFRTAT 436
Cdd:cd04377    1 FGVSLSSLT--------SEDRSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDT----DPDSVN--LEDYP 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 437 VHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSI-DQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNV 515
Cdd:cd04377   67 IHVITSVLKQWLRELPEPLMTFELYENFLRAMELEEKqERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSA 146


                 ....*....
gi 116007522 516 HNVATIMAP 524
Cdd:cd04377  147 NALAIVFAP 155
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 367-527 1.28e-21

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 92.76  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 367 RDQQVTGTDsslVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELEStfyqnpDNLDNLFRTA--TVHELSSLL 444
Cdd:cd04385    6 EDQQLTDND---IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRK------DARSVQLREGeyTVHDVADVL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 445 KRWLRELPQPLLTNELIQLFYQCHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMA 523
Cdd:cd04385   77 KRFLRDLPDPLLTSELHAEWIEAAELENKDErIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFG 156


                 ....
gi 116007522 524 PSMF 527
Cdd:cd04385  157 PTLF 160
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 379-571 2.53e-21

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 92.50  E-value: 2.53e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 379 VPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTfyqnpdNLDNLFRTATVHELSSLLKRWLRELPQPLLTN 458
Cdd:cd04376    9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG------IDVVLDENHSVHDVAALLKEFFRDMPDPLLPR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 459 ELIQLFYQCHTLPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIII-NLKDI----------NKMNVHNVATIMAPSMF 527
Cdd:cd04376   83 ELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAeHAADSidedgqevsgNKMTSLNLATIFGPNLL 162

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 116007522 528 ppRYIHPSDNNSIAEQVRMA--AQCCRLTNILILRGEKLFQVPNNL 571
Cdd:cd04376  163 --HKQKSGEREFVQASLRIEesTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 380-574 1.76e-20

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 90.21  E-value: 1.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 380 PLFLE------KLIgELLRRGSREEGLLRIGGHKQKTELLYNELEStfyQNPDNLDNlfRTATVHELSSLLKRWLRELPQ 453
Cdd:cd04392    4 PLTEEgiaqiyQLI-EYLEKNLRVEGLFRKPGNSARQQELRDLLNS---GTDLDLES--GGFHAHDCATVLKGFLGELPE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 454 PLLTN----------ELIQLFYQCHTLPSID---QMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVAT 520
Cdd:cd04392   78 PLLTHahypahlqiaDLCQFDEKGNKTSAPDkerLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLAL 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 116007522 521 IMAPSMFPPRYIHPSDnnsiaeqvrMAAQCCRLTNI---LILRGEKLFQVPNNLIVE 574
Cdd:cd04392  158 LFTPHLICPRNLTPED---------LHENAQKLNSIvtfMIKHSQKLFKAPAYLRED 205
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 357-528 4.54e-19

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 85.53  E-value: 4.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIRRDQqvtgtdsSLVPLFLEKLIGELLRRGSREEGLLRIGGhkqkTELLYNELESTFYQNPDNLDNLFRT-- 434
Cdd:cd04398    1 FGVPLEDLILREG-------DNVPNIVYQCIQAIENFGLNLEGIYRLSG----NVSRVNKLKELFDKDPLNVLLISPEdy 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 435 -ATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINK 512
Cdd:cd04398   70 eSDIHSVASLLKLFFRELPEPLLTKALSREFIEAAKIEDeSRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNR 149

                        170
                 ....*....|....*.
gi 116007522 513 MNVHNVATIMAPSMFP 528
Cdd:cd04398  150 MSVNNLAIIWGPTLMN 165
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 357-549 2.23e-18

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 83.82  E-value: 2.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIRRDqqvtgtdSSLVPLFLEKLIGELLRRGSREEGLLRIGGhkQKTELlyNELESTFYQNPDNLDNLFRTAT 436
Cdd:cd04387    1 FGVKISTVTKRE-------RSKVPYIVRQCVEEVERRGMEEVGIYRISG--VATDI--QALKAAFDTNNKDVSVMLSEMD 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 437 VHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLP-SIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNV 515
Cdd:cd04387   70 VNAIAGTLKLYFRELPEPLFTDELYPNFAEGIALSdPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSL 149

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 116007522 516 HNVATIMAPSMFPP---RYIHPSDNNSIAEQVRMAAQ 549
Cdd:cd04387  150 HNLATVFGPTLLRPsekESKIPTNTMTDSWSLEVMSQ 186
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 382-526 8.12e-18

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 82.02  E-value: 8.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 382 FLEKligellRRGSREEGLLRIGGH----KQKTELLYNELESTFYQNPDNLDnlfrtatVHELSSLLKRWLRELPQPLLT 457
Cdd:cd04400   32 YLDK------NRAIYEEGIFRLSGSasviKQLKERFNTEYDVDLFSSSLYPD-------VHTVAGLLKLYLRELPTLILG 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116007522 458 NELIQLFYQCHTLPSiDQMNALSILCHL---LPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSM 526
Cdd:cd04400   99 GELHNDFKRLVEENH-DRSQRALELKDLvsqLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNVCIVFSPTL 169
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 357-527 8.59e-18

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 81.58  E-value: 8.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIrrdqqvtgTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELEStfyqNPDN--LDNLfrt 434
Cdd:cd04407    1 FGVRVGSLT--------SNKTSVPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQA----DPENvkLENY--- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 435 aTVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSI-DQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKM 513
Cdd:cd04407   66 -PIHAITGLLKQWLRELPEPLMTFAQYNDFLRAVELPEKqEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRM 144

                        170
                 ....*....|....
gi 116007522 514 NVHNVATIMAPSMF 527
Cdd:cd04407  145 SPNALAIVFAPCLL 158
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 357-530 1.50e-17

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 81.74  E-value: 1.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIRRDQQvtgtdSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELEST---FYQNPDNLDNlfr 433
Cdd:cd04379    1 FGVPLSRLVEREGE-----SRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNsaaVELSEELYPD--- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 434 tatVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQM-----NALSILcHLLPPENRNTLRSLLSFFNIIINLK 508
Cdd:cd04379   73 ---INVITGVLKDYLRELPEPLITPQLYEMVLEALAVALPNDVqtnthLTLSII-DCLPLSAKATLLLLLDHLSLVLSNS 148

                        170       180
                 ....*....|....*....|..
gi 116007522 509 DINKMNVHNVATIMAPSMFPPR 530
Cdd:cd04379  149 ERNKMTPQNLAVCFGPVLMFCS 170
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 378-565 2.44e-17

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 80.56  E-value: 2.44e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 378 LVPLFLEKLIGELLRRGSREEGLLRIGGHKQktelLYNELESTF--YQNPdnldnLFRTAT-VHELSSLLKRWLRELPQP 454
Cdd:cd04390   21 LVPILVEQCVDFIREHGLKEEGLFRLPGQAN----LVKQLQDAFdaGERP-----SFDSDTdVHTVASLLKLYLRELPEP 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 455 LLTNELIQLFYQCHTLPSIDQ-------MNALSILchllPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMF 527
Cdd:cd04390   92 VIPWAQYEDFLSCAQLLSKDEekglgelMKQVSIL----PKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNIL 167

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 116007522 528 PPRYIHPsdnnsiAEQVRMAAQCCRLTNILILRGEKLF 565
Cdd:cd04390  168 RPKVEDP------ATIMEGTPQIQQLMTVMISKHEPLF 199
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 356-527 2.72e-17

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 80.20  E-value: 2.72e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 356 LFGVSINALIRRDQQVTGtdsslVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNpdnldnLFRTA 435
Cdd:cd04393    2 VFGVPLQELQQAGQPENG-----VPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVD------LSKEA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 436 TVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMNA--LSILCHLLPPENRNTLRSLLSFFNIIINLKDINKM 513
Cdd:cd04393   71 DVCSAASLLRLFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGrkLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRM 150

                        170
                 ....*....|....
gi 116007522 514 NVHNVATIMAPSMF 527
Cdd:cd04393  151 TAENLAAVFGPDVF 164
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 357-530 5.92e-17

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 79.30  E-value: 5.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIRRdqqvtGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQ---KTELLYNELESTFYQNPDNldnlfr 433
Cdd:cd04404    6 FGVSLQFLKEK-----NPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQvvkEVQQKYNMGEPVDFDQYED------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 434 tatVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKM 513
Cdd:cd04404   75 ---VHLPAVILKTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKM 151

                        170
                 ....*....|....*..
gi 116007522 514 NVHNVATIMAPSMFPPR 530
Cdd:cd04404  152 TNSNLAVVFGPNLLWAK 168
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 353-527 1.79e-16

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 78.61  E-value: 1.79e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 353 EGNLFGVSINALIRRdqqvTGtdsSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTfyqnPDNLdnLF 432
Cdd:cd04375    1 DKNVFGVPLLVNLQR----TG---QPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESS----TDNV--NY 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 433 RTATVHELSSLLKRWLRELPQPLLTNELIQLFYQ-CHTLPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDIN 511
Cdd:cd04375   68 DGQQAYDVADMLKQYFRDLPEPLLTNKLSETFIAiFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQEN 147

                        170
                 ....*....|....*.
gi 116007522 512 KMNVHNVATIMAPSMF 527
Cdd:cd04375  148 QMTATNLAVCLAPSLF 163
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 357-526 2.19e-15

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 74.78  E-value: 2.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIRRDQQVTGTDsslVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELL---YNELESTfyqnpdNLDNLfr 433
Cdd:cd04381    1 FGASLSLAVERSRCHDGID---LPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELkaaYNRRESP------NLEEY-- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 434 taTVHELSSLLKRWLRELPQPLLTNELIQLFYQ-CHTLPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINK 512
Cdd:cd04381   70 --EPPTVASLLKQYLRELPEPLLTKELMPRFEEaCGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETK 147

                        170
                 ....*....|....
gi 116007522 513 MNVHNVATIMAPSM 526
Cdd:cd04381  148 MNIQNISIVLSPTV 161
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 365-565 2.28e-15

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 74.74  E-value: 2.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 365 IRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELeSTFYQNPDNLDNLFRTatVHELSSLL 444
Cdd:cd04395    4 VPLDDCPPSSENPYVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEEL-NRGGFDIDLQDPRWRD--VNVVSSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 445 KRWLRELPQPLLTNELIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMA 523
Cdd:cd04395   81 KSFFRKLPEPLFTNELYPDFIEANRIEDpVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFG 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 116007522 524 PSMfppryIHPSDNNSIAEQVRMAAQcCRLTNILILRGEKLF 565
Cdd:cd04395  161 PTL-----VRTSDDNMETMVTHMPDQ-CKIVETLIQHYDWFF 196
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 357-529 1.20e-14

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 72.42  E-value: 1.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIRRDQqvtgtdsSLVPLFLEKLIGELLRRGSREEGLLRIGGHK---QKTELLYNELESTFYQNPDNLDnlfr 433
Cdd:cd04403    1 FGCHLEALCQREN-------STVPKFVRLCIEAVEKRGLDVDGIYRVSGNLaviQKLRFAVDHDEKLDLDDSKWED---- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 434 tatVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLP-SIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINK 512
Cdd:cd04403   70 ---IHVITGALKLFFRELPEPLFPYSLFNDFVAAIKLSdYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNR 146

                        170
                 ....*....|....*..
gi 116007522 513 MNVHNVATIMAPSMFPP 529
Cdd:cd04403  147 MTTQNLAIVFGPTLLRP 163
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 372-545 2.06e-14

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 71.94  E-value: 2.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 372 TGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGhkqkTELLYNELESTFYQ---NPD--NLDnlfrtatVHELSSLLKR 446
Cdd:cd04382   10 DPSTSPMIPALIVHCVNEIEARGLTEEGLYRVSG----SEREVKALKEKFLRgktVPNlsKVD-------IHVICGCLKD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 447 WLRELPQPLLTNELIQLFYQCHTLPSIDQMN-ALSILCHLLPPENRNTLRSLLSFFNIIINLKDiNKMNVHNVATIMAPS 525
Cdd:cd04382   79 FLRSLKEPLITFALWKEFMEAAEILDEDNSRaALYQAISELPQPNRDTLAFLILHLQRVAQSPE-CKMDINNLARVFGPT 157

                        170       180
                 ....*....|....*....|
gi 116007522 526 MFPPRYIHPSDNNSIAEQVR 545
Cdd:cd04382  158 IVGYSVPNPDPMTILQDTVR 177
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 380-565 8.09e-13

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 67.54  E-value: 8.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 380 PLFLEKLIGELLRRGSREEGLLRIGGHKQKTEllynELESTFYQNPDNLDnlfRTATVHE----LSSLLKRWLRELPQPL 455
Cdd:cd04372   17 PMVVDMCIREIEARGLQSEGLYRVSGFAEEIE----DVKMAFDRDGEKAD---ISATVYPdinvITGALKLYFRDLPIPV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 456 LTNELIQLFYQCHTLPSID-QMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMfppryIHP 534
Cdd:cd04372   90 ITYDTYPKFIDAAKISNPDeRLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTL-----MRP 164

                        170       180       190
                 ....*....|....*....|....*....|.
gi 116007522 535 SDNNSIAEQVRMAAQcCRLTNILILRGEKLF 565
Cdd:cd04372  165 PEDSALTTLNDMRYQ-ILIVQLLITNEDVLF 194
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 379-530 1.48e-12

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 67.06  E-value: 1.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 379 VPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELEstfyqNPDNLDNLfRTATVHELSSLLKRWLRELPQPLLT- 457
Cdd:cd04378   16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFE-----NGKDLVEL-SELSPHDISSVLKLFLRQLPEPLILf 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 458 ---NELIQLFYQCHTLPSIDQMNALSI-----------LCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMA 523
Cdd:cd04378   90 rlyNDFIALAKEIQRDTEEDKAPNTPIevnriirklkdLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNLGIVFG 169


                 ....*..
gi 116007522 524 PSMFPPR 530
Cdd:cd04378  170 PTLIRPR 176
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 374-529 2.39e-11

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 62.86  E-value: 2.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 374 TDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTEllynELESTFYQNpDNLDNLFRTATVHELSSLLKRWLRELPQ 453
Cdd:cd04373   10 TSEKPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLD----SLQKQFDQD-HNLDLVSKDFTVNAVAGALKSFFSELPD 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116007522 454 PLLTNELIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPP 529
Cdd:cd04373   85 PLIPYSMHLELVEAAKINDrEQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPTLMRP 161
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 382-530 4.65e-11

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 62.41  E-value: 4.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 382 FLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELI 461
Cdd:cd04374   31 FVRKCIEAVETRGINEQGLYRVVGVNSKVQKLLSLGLDPKTSTPGDVDLDNSEWEIKTITSALKTYLRNLPEPLMTYELH 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 462 QLFYQCHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR 530
Cdd:cd04374  111 NDFINAAKSENLESrVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQ 180
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 390-558 6.82e-11

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 61.93  E-value: 6.82e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 390 LLRRGSREEGLLRIGGHKQKTELLYNELEStfyQNPDNLDNLfrtaTVHELSSLLKRWLRELPQPLLTNELIQLFyqcht 469
Cdd:cd04402   26 LYQKGPSTEGIFRRSANAKACKELKEKLNS---GVEVDLKAE----PVLLLASVLKDFLRNIPGSLLSSDLYEEW----- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 470 LPSIDQ------MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMfppryIHPSDnnSIAEQ 543
Cdd:cd04402   94 MSALDQeneeekIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSL-----LWPPA--SSELQ 166

                        170
                 ....*....|....*
gi 116007522 544 VRMAAQCCRLTNILI 558
Cdd:cd04402  167 NEDLKKVTSLVQFLI 181
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 379-530 2.05e-10

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 60.98  E-value: 2.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 379 VPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELEstfyqNPDNLDNLfRTATVHELSSLLKRWLRELPQPL--- 455
Cdd:cd04409   16 IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFE-----NGKDLVEL-SELSPHDISNVLKLYLRQLPEPLilf 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 456 -LTNELIQLFYQCHTLPSIDQMNALS-------------ILCHL------LPPENRNTLRSLLSFFNIIINLKDINKMNV 515
Cdd:cd04409   90 rLYNEFIGLAKESQHVNETQEAKKNSdkkwpnmctelnrILLKSkdllrqLPAPNYNTLQFLIVHLHRVSEQAEENKMSA 169

                        170
                 ....*....|....*
gi 116007522 516 HNVATIMAPSMFPPR 530
Cdd:cd04409  170 SNLGIIFGPTLIRPR 184
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 379-524 6.23e-10

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 58.94  E-value: 6.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 379 VPLFLEKLIGELLR-RGSREEGLLRIGGHKQKTELLYNELESTFYQNpDNLDNlfrtatVHELSSLLKRWLRELPQPLLT 457
Cdd:cd04389   21 LPWILTFLSEKVLAlGGFQTEGIFRVPGDIDEVNELKLRVDQWDYPL-SGLED------PHVPASLLKLWLRELEEPLIP 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116007522 458 NEliqlFYQCHTLPSIDQMNALSILcHLLPPENRNTLRSLLSFFNIIINLKDI--NKMNVHNVATIMAP 524
Cdd:cd04389   94 DA----LYQQCISASEDPDKAVEIV-QKLPIINRLVLCYLINFLQVFAQPENVahTKMDVSNLAMVFAP 157
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 357-527 2.18e-09

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 57.32  E-value: 2.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIRRDQQVtgtdsslvPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFyqNPDNLDNLfrtaT 436
Cdd:cd04406    1 FGVELSRLTSEDRSV--------PLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDA--NSVNLDDY----N 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 437 VHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNV 515
Cdd:cd04406   67 IHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERREtVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSA 146

                        170
                 ....*....|..
gi 116007522 516 HNVATIMAPSMF 527
Cdd:cd04406  147 NALAIVFAPCIL 158
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 357-527 2.99e-09

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 57.74  E-value: 2.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 357 FGVSINALIR---------RDQQVTGT--DSSLVPLF----LEKLIGELLRRGSREEGLLRIGGHKQKTELLYNE-LEST 420
Cdd:cd04380   13 FGSSLETLIRlpdpgirnlIDQLELGDnpDYSEVPLSipkeIWRLVDYLYTRGLAQEGLFEEPGLPSEPGELLAEiRDAL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 421 FYQNPDNLdnlfrTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMNALSILchlLPPENRNTLRSLLSF 500
Cdd:cd04380   93 DTGSPFNS-----PGSAESVAEALLLFLESLPDPIIPYSLYERLLEAVANNEEDKRQVIRIS---LPPVHRNVFVYLCSF 164

                        170       180
                 ....*....|....*....|....*..
gi 116007522 501 FNIIINLKDINKMNVHNVATIMAPSMF 527
Cdd:cd04380  165 LRELLSESADRGLDENTLATIFGRVLL 191
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 379-529 4.69e-09

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 56.75  E-value: 4.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 379 VPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELEstfyqNPDNLDNLfRTATVHELSSLLKRWLRELPQPLLT- 457
Cdd:cd04408   16 VPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFE-----NGRDLVDL-SGHSPHDITSVLKHFLKELPEPVLPf 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 458 ---NELIQLFYQCHTLPS------------IDQMNALsiLCHlLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIM 522
Cdd:cd04408   90 qlyDDFIALAKELQRDSEkaaespsiveniIRSLKEL--LGR-LPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLGIVF 166


                 ....*..
gi 116007522 523 APSMFPP 529
Cdd:cd04408  167 GPTLLRP 173
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 364-528 1.81e-08

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 54.73  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 364 LIRRDQQVTGTDSS-LVPLFLEKLIGELLRRGSREEGLLRIGGhkqkTELLYNELESTFYQNPDNLDNLFRTATVHELSS 442
Cdd:cd04383    2 LFNGSLEEYIQDSGqAIPLVVESCIRFINLYGLQHQGIFRVSG----SQVEVNDIKNAFERGEDPLADDQNDHDINSVAG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 443 LLKRWLRELPQPLLTNELIQLFYQCHTLPSI-DQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATI 521
Cdd:cd04383   78 VLKLYFRGLENPLFPKERFEDLMSCVKLENPtERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAIC 157


                 ....*..
gi 116007522 522 MAPSMFP 528
Cdd:cd04383  158 FGPTLMP 164
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 398-536 1.03e-07

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 53.18  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 398 EGLLRIGGHKQKTEllynELESTFYQNPD---NLDNLfrTATVHELSSLLKRWLRELPQPLLTNELIQLF---------- 464
Cdd:cd04396   51 EGIFRVAGSSKRIR----ELQLIFSTPPDygkSFDWD--GYTVHDAASVLRRYLNNLPEPLVPLDLYEEFrnplrkrpri 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 465 -----YQCHTLPSIDQMNALS---ILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPpryiHPSD 536
Cdd:cd04396  125 lqymkGRINEPLNTDIDQAIKeyrDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILS----HPDH 200
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 379-532 2.26e-07

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 51.73  E-value: 2.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 379 VPLFLEKlIGELLRRGSREEGLLRIGGHKQKTELLYNELESTfyQNPDnLDNLFRTATVHELSSLLKRWLRELPQPLLTN 458
Cdd:cd04384   18 VPQVLKS-CTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSE--QIPD-LTKDVYIQDIHSVSSLCKLYFRELPNPLLTY 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116007522 459 ELIQLFYQCHTLPSID-QMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYI 532
Cdd:cd04384   94 QLYEKFSEAVSAASDEeRLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAPNLLRSKQI 168
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 380-539 3.56e-05

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 45.25  E-value: 3.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 380 PLFLEKLIGELLRRGSREEGLLRIGGHKQKTELlynelESTFYQNPDNLDnlFRTATVHELSSLLKRWLRELPQPLLT-- 457
Cdd:cd04388   16 PPLLIKLVEAIEKKGLESSTLYRTQSSSSLTEL-----RQILDCDAASVD--LEQFDVAALADALKRYLLDLPNPVIPap 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116007522 458 --NELIQLFYQCHTLPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFppRYIHPS 535
Cdd:cd04388   89 vySEMISRAQEVQSSDEYAQLLRKLIRSPNLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLLF--RFQPAS 166


                 ....
gi 116007522 536 DNNS 539
Cdd:cd04388  167 SDSP 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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