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Conserved domains on  [gi|221329993|ref|NP_001036466|]
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uncharacterized protein Dmel_CG14464, isoform C [Drosophila melanogaster]

Protein Classification

ARF7EP_C superfamily-containing protein( domain architecture ID 142817)

ARF7EP_C superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARF7EP_C super family cl20830
ARF7 effector protein C-terminus; This family represents the C-terminus of the ARF7 effector ...
 18-103 6.58e-24

ARF7 effector protein C-terminus; This family represents the C-terminus of the ARF7 effector protein (ARF7EP). ARF7EP interacts with ADP-ribosylation factor-like protein 14 and unconventional myosin-Ie and through this interaction controls movement of MHC-II-containing vesicles along the actin cytoskeleton in dendritic cells. It contains a conserved CXCXXXXCXXCXXXCXXCXXXXCXXXCXC motif in it's C-terminal half.


The actual alignment was detected with superfamily member pfam14949:

Pssm-ID: 464395  Cd Length: 102  Bit Score: 87.72  E-value: 6.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329993   18 RHRKKGVSNEYSNYLDSENKKKgrkkcqnSAYDEYGNIRSNGLDICDCMNQECDGCWYNCRSCGSTRCGPQCRSNRKFFY 97
Cdd:pfam14949  24 SRREKRKLARKVNKRPNRNKKS-------KHYDENGKLISNGKDLCDCLDEECPGCHYPCPKCGSRKCGPECRCNRKWMY 96


                  ....*.
gi 221329993   98 EDITYD 103
Cdd:pfam14949  97 ESIEVE 102
 
Name Accession Description Interval E-value
ARF7EP_C pfam14949
ARF7 effector protein C-terminus; This family represents the C-terminus of the ARF7 effector ...
 18-103 6.58e-24

ARF7 effector protein C-terminus; This family represents the C-terminus of the ARF7 effector protein (ARF7EP). ARF7EP interacts with ADP-ribosylation factor-like protein 14 and unconventional myosin-Ie and through this interaction controls movement of MHC-II-containing vesicles along the actin cytoskeleton in dendritic cells. It contains a conserved CXCXXXXCXXCXXXCXXCXXXXCXXXCXC motif in it's C-terminal half.


Pssm-ID: 464395  Cd Length: 102  Bit Score: 87.72  E-value: 6.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329993   18 RHRKKGVSNEYSNYLDSENKKKgrkkcqnSAYDEYGNIRSNGLDICDCMNQECDGCWYNCRSCGSTRCGPQCRSNRKFFY 97
Cdd:pfam14949  24 SRREKRKLARKVNKRPNRNKKS-------KHYDENGKLISNGKDLCDCLDEECPGCHYPCPKCGSRKCGPECRCNRKWMY 96


                  ....*.
gi 221329993   98 EDITYD 103
Cdd:pfam14949  97 ESIEVE 102
 
Name Accession Description Interval E-value
ARF7EP_C pfam14949
ARF7 effector protein C-terminus; This family represents the C-terminus of the ARF7 effector ...
 18-103 6.58e-24

ARF7 effector protein C-terminus; This family represents the C-terminus of the ARF7 effector protein (ARF7EP). ARF7EP interacts with ADP-ribosylation factor-like protein 14 and unconventional myosin-Ie and through this interaction controls movement of MHC-II-containing vesicles along the actin cytoskeleton in dendritic cells. It contains a conserved CXCXXXXCXXCXXXCXXCXXXXCXXXCXC motif in it's C-terminal half.


Pssm-ID: 464395  Cd Length: 102  Bit Score: 87.72  E-value: 6.58e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221329993   18 RHRKKGVSNEYSNYLDSENKKKgrkkcqnSAYDEYGNIRSNGLDICDCMNQECDGCWYNCRSCGSTRCGPQCRSNRKFFY 97
Cdd:pfam14949  24 SRREKRKLARKVNKRPNRNKKS-------KHYDENGKLISNGKDLCDCLDEECPGCHYPCPKCGSRKCGPECRCNRKWMY 96


                  ....*.
gi 221329993   98 EDITYD 103
Cdd:pfam14949  97 ESIEVE 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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