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Conserved domains on  [gi|114053163|ref|NP_001039872|]
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cilia- and flagella-associated protein 298 [Bos taurus]

Protein Classification

cilia- and flagella-associated protein 298( domain architecture ID 10567415)

cilia- and flagella-associated protein 298 plays a role in motile cilium function, possibly by acting on outer dynein arm assembly

Gene Ontology:  GO:0003352|GO:0060271

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CFAP298 pfam11069
Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which ...
 189-283 2.38e-56

Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization. Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26).


:

Pssm-ID: 463214  Cd Length: 95  Bit Score: 176.30  E-value: 2.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114053163  189 AQLWWAAKELRRTKKLSDYVGKNEKTKIIVKIQHRGQGAPAREPIISSEEQKQLMLYYHRRQEELKKLEENDDDSCLNSP 268
Cdd:pfam11069   1 AQLWWAGKEMQRGKKLSDYIGKNEKTKIIVKLQKKGSGAPGREPVVSEEEQKAMMAYYYRKQEELKKLEEDDDDSYLNSE 80

                          90
                  ....*....|....*
gi 114053163  269 WADNTALKRHFHGVK 283
Cdd:pfam11069  81 WADPRGLKRQLHGLN 95
 
Name Accession Description Interval E-value
CFAP298 pfam11069
Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which ...
 189-283 2.38e-56

Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization. Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26).


Pssm-ID: 463214  Cd Length: 95  Bit Score: 176.30  E-value: 2.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114053163  189 AQLWWAAKELRRTKKLSDYVGKNEKTKIIVKIQHRGQGAPAREPIISSEEQKQLMLYYHRRQEELKKLEENDDDSCLNSP 268
Cdd:pfam11069   1 AQLWWAGKEMQRGKKLSDYIGKNEKTKIIVKLQKKGSGAPGREPVVSEEEQKAMMAYYYRKQEELKKLEEDDDDSYLNSE 80

                          90
                  ....*....|....*
gi 114053163  269 WADNTALKRHFHGVK 283
Cdd:pfam11069  81 WADPRGLKRQLHGLN 95
 
Name Accession Description Interval E-value
CFAP298 pfam11069
Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which ...
 189-283 2.38e-56

Cilia- and flagella-associated protein 298; This is a eukaryotic family of proteins which includes a group of cilia- and flagella-associated protein, including Kur from zebrafish and C21orf59 from humans. Kur has been shown to play a dual role in cilia motility and polarization. Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic airway infections, male infertility, and situs abnormalities. Mutations in the C21orf59 gene cause ciliary dyskinesia, primary, 26 (CILD26).


Pssm-ID: 463214  Cd Length: 95  Bit Score: 176.30  E-value: 2.38e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114053163  189 AQLWWAAKELRRTKKLSDYVGKNEKTKIIVKIQHRGQGAPAREPIISSEEQKQLMLYYHRRQEELKKLEENDDDSCLNSP 268
Cdd:pfam11069   1 AQLWWAGKEMQRGKKLSDYIGKNEKTKIIVKLQKKGSGAPGREPVVSEEEQKAMMAYYYRKQEELKKLEEDDDDSYLNSE 80

                          90
                  ....*....|....*
gi 114053163  269 WADNTALKRHFHGVK 283
Cdd:pfam11069  81 WADPRGLKRQLHGLN 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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