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Conserved domains on  [gi|115532666|ref|NP_001040848|]
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ShKT domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lipocalin_heme-bd-THAP4-like cd07828
heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar ...
 132-300 1.26e-50

heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins; Proteins in this subfamily use a beta-barrel domain to bind ferric heme. This group also includes the beta-barrel domain of human THAP domain containing 4 (THAP4). The THAP domain is found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. Arabidopsis thaliana nitrobindin may reversibly bind nitric oxide (NO) and be involved in NO transport. It also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


:

Pssm-ID: 381185  Cd Length: 150  Bit Score: 164.34  E-value: 1.26e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532666 132 LKSIAWMVGRWRseFGGKAFFPTIPKFTYGEQVDITIADNsqdthtPLLNYTAFAWDINmpdgDPTEIHSENGYIAVEYD 211
Cdd:cd07828    1 LEPLSWLLGTWR--GSGKGGYPTIKDFSYGEEITFSHDGQ------PFLNYTARTWTLD----TGKPMHRESGFLRIKPD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532666 212 KEQekeyVSLNTAMSNGFMTIEEGESGPNQVKFRLQRIGRISFshDSAVRIMFREWTLLDENRLEARLLMTTTiTRRLME 291
Cdd:cd07828   69 GNK----VELLIAHNTGLVEIEEGEVTGNTLELTTDAVARTSF--APEVTAIKRLFGLVDGNTLEYTVDMATA-GKPLTP 141


                 ....*....
gi 115532666 292 HTAVIYKKI 300
Cdd:cd07828  142 HLSARLKKV 150
ShKT smart00254
ShK toxin domain; ShK toxin domain
 80-115 1.43e-06

ShK toxin domain; ShK toxin domain


:

Pssm-ID: 214586 [Multi-domain]  Cd Length: 33  Bit Score: 43.91  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 115532666    80 CRDTDMNCAVWVAtntSDCENVELVNSHCPRTCQTC 115
Cdd:smart00254   1 CVDRHPDCAAWAK---GFCTNPFYMKSNCPKTCGFC 33
 
Name Accession Description Interval E-value
lipocalin_heme-bd-THAP4-like cd07828
heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar ...
 132-300 1.26e-50

heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins; Proteins in this subfamily use a beta-barrel domain to bind ferric heme. This group also includes the beta-barrel domain of human THAP domain containing 4 (THAP4). The THAP domain is found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. Arabidopsis thaliana nitrobindin may reversibly bind nitric oxide (NO) and be involved in NO transport. It also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381185  Cd Length: 150  Bit Score: 164.34  E-value: 1.26e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532666 132 LKSIAWMVGRWRseFGGKAFFPTIPKFTYGEQVDITIADNsqdthtPLLNYTAFAWDINmpdgDPTEIHSENGYIAVEYD 211
Cdd:cd07828    1 LEPLSWLLGTWR--GSGKGGYPTIKDFSYGEEITFSHDGQ------PFLNYTARTWTLD----TGKPMHRESGFLRIKPD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532666 212 KEQekeyVSLNTAMSNGFMTIEEGESGPNQVKFRLQRIGRISFshDSAVRIMFREWTLLDENRLEARLLMTTTiTRRLME 291
Cdd:cd07828   69 GNK----VELLIAHNTGLVEIEEGEVTGNTLELTTDAVARTSF--APEVTAIKRLFGLVDGNTLEYTVDMATA-GKPLTP 141


                 ....*....
gi 115532666 292 HTAVIYKKI 300
Cdd:cd07828  142 HLSARLKKV 150
THAP4_heme-bd pfam08768
THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals ...
 132-299 1.12e-32

THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport. This entry also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organization. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs).


Pssm-ID: 462593  Cd Length: 151  Bit Score: 118.06  E-value: 1.12e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532666  132 LKSIAWMVGRWRSEfgGKAFFPTIPKFTYGEQvdITIADNSQdthtPLLNYTAFAWdiNMPDGDPteIHSENGYIAVeyd 211
Cdd:pfam08768   2 LGPLAWLLGTWRGE--GEGGYPTIEDFTYGEE--ITFSHDGR----PFLNYTSRTW--RLDDGKP--LHRETGFWRW--- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532666  212 kEQEKEYVSLNTAMSNGFMTIEEGESGP--NQVKFRLQRIGRISFSHDsaVRIMFREWTLLDeNRLEARLLMtTTITRRL 289
Cdd:pfam08768  67 -EPGTGEVELVLAHPTGVVEIEEGTVKNggNTIELATDAIARTSFAKE--VTAGKRLYGLVD-GDLSYTVDM-ATVGGPL 141

                         170
                  ....*....|
gi 115532666  290 MEHTAVIYKK 299
Cdd:pfam08768 142 QHHLSATLKR 151
ShKT smart00254
ShK toxin domain; ShK toxin domain
 80-115 1.43e-06

ShK toxin domain; ShK toxin domain


Pssm-ID: 214586 [Multi-domain]  Cd Length: 33  Bit Score: 43.91  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 115532666    80 CRDTDMNCAVWVAtntSDCENVELVNSHCPRTCQTC 115
Cdd:smart00254   1 CVDRHPDCAAWAK---GFCTNPFYMKSNCPKTCGFC 33
ShK pfam01549
ShK domain-like; This domain of is found in several C. elegans proteins. The domain is 30 ...
 79-115 1.40e-05

ShK domain-like; This domain of is found in several C. elegans proteins. The domain is 30 amino acids long and rich in cysteine residues. There are 6 conserved cysteine positions in the domain that form three disulphide bridges. The domain is found in the potassium channel inhibitor ShK in sea anemone.


Pssm-ID: 426319  Cd Length: 37  Bit Score: 41.23  E-value: 1.40e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 115532666   79 KCRDTDMNCAVWVATNTSDCENVELVNSHCPRTCQTC 115
Cdd:pfam01549   1 SCVDPHSDCASWAALGCTSPFYQDFMKENCPKTCGFC 37
 
Name Accession Description Interval E-value
lipocalin_heme-bd-THAP4-like cd07828
heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar ...
 132-300 1.26e-50

heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins; Proteins in this subfamily use a beta-barrel domain to bind ferric heme. This group also includes the beta-barrel domain of human THAP domain containing 4 (THAP4). The THAP domain is found in proteins involved in transcriptional regulation, cell-cycle control, apoptosis and chromatin modification. Arabidopsis thaliana nitrobindin may reversibly bind nitric oxide (NO) and be involved in NO transport. It also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. This group belongs to the lipocalin/cytosolic fatty-acid binding protein family which have a large beta-barrel ligand-binding cavity. Lipocalins are mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules, as well as membrane bound-receptors. They participate in processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty-acid binding proteins, also bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381185  Cd Length: 150  Bit Score: 164.34  E-value: 1.26e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532666 132 LKSIAWMVGRWRseFGGKAFFPTIPKFTYGEQVDITIADNsqdthtPLLNYTAFAWDINmpdgDPTEIHSENGYIAVEYD 211
Cdd:cd07828    1 LEPLSWLLGTWR--GSGKGGYPTIKDFSYGEEITFSHDGQ------PFLNYTARTWTLD----TGKPMHRESGFLRIKPD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532666 212 KEQekeyVSLNTAMSNGFMTIEEGESGPNQVKFRLQRIGRISFshDSAVRIMFREWTLLDENRLEARLLMTTTiTRRLME 291
Cdd:cd07828   69 GNK----VELLIAHNTGLVEIEEGEVTGNTLELTTDAVARTSF--APEVTAIKRLFGLVDGNTLEYTVDMATA-GKPLTP 141


                 ....*....
gi 115532666 292 HTAVIYKKI 300
Cdd:cd07828  142 HLSARLKKV 150
THAP4_heme-bd pfam08768
THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals ...
 132-299 1.12e-32

THAP4-like, heme-binding beta-barrel domain; This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport. This entry also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology. Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organization. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs).


Pssm-ID: 462593  Cd Length: 151  Bit Score: 118.06  E-value: 1.12e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532666  132 LKSIAWMVGRWRSEfgGKAFFPTIPKFTYGEQvdITIADNSQdthtPLLNYTAFAWdiNMPDGDPteIHSENGYIAVeyd 211
Cdd:pfam08768   2 LGPLAWLLGTWRGE--GEGGYPTIEDFTYGEE--ITFSHDGR----PFLNYTSRTW--RLDDGKP--LHRETGFWRW--- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532666  212 kEQEKEYVSLNTAMSNGFMTIEEGESGP--NQVKFRLQRIGRISFSHDsaVRIMFREWTLLDeNRLEARLLMtTTITRRL 289
Cdd:pfam08768  67 -EPGTGEVELVLAHPTGVVEIEEGTVKNggNTIELATDAIARTSFAKE--VTAGKRLYGLVD-GDLSYTVDM-ATVGGPL 141

                         170
                  ....*....|
gi 115532666  290 MEHTAVIYKK 299
Cdd:pfam08768 142 QHHLSATLKR 151
ShKT smart00254
ShK toxin domain; ShK toxin domain
 80-115 1.43e-06

ShK toxin domain; ShK toxin domain


Pssm-ID: 214586 [Multi-domain]  Cd Length: 33  Bit Score: 43.91  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 115532666    80 CRDTDMNCAVWVAtntSDCENVELVNSHCPRTCQTC 115
Cdd:smart00254   1 CVDRHPDCAAWAK---GFCTNPFYMKSNCPKTCGFC 33
ShK pfam01549
ShK domain-like; This domain of is found in several C. elegans proteins. The domain is 30 ...
 79-115 1.40e-05

ShK domain-like; This domain of is found in several C. elegans proteins. The domain is 30 amino acids long and rich in cysteine residues. There are 6 conserved cysteine positions in the domain that form three disulphide bridges. The domain is found in the potassium channel inhibitor ShK in sea anemone.


Pssm-ID: 426319  Cd Length: 37  Bit Score: 41.23  E-value: 1.40e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 115532666   79 KCRDTDMNCAVWVATNTSDCENVELVNSHCPRTCQTC 115
Cdd:pfam01549   1 SCVDPHSDCASWAALGCTSPFYQDFMKENCPKTCGFC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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