NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|115533356|ref|NP_001041200|]
View 

F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 17778750)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; similar to Caenorhabditis elegans F-box domain-containing protein

Gene Ontology:  GO:0000209|GO:0031146|GO:0019005|GO:0005515
PubMed:  10581972|31898225

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 136-270 2.93e-25

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 98.03  E-value: 2.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533356  136 DVFVSTIPLILKSAKSLHVKEVEFrSGWSIEEMAQMLQCI--EKVEGIEIHKPGPLD---ALVPLDQWKMAKSVIA-LDK 209
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISL-SGLSFSEVASILPYFdaGTLEEIELSSESDEDqfeEIVELEQWKNAKSLKIeGSS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115533356  210 QSLLDIGNIFHLHQFKLQLVRISREELVKIRDVLLKSTNFEYGIIYLVEHTTENIGTLFNP 270
Cdd:pfam01827  80 LSSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDP 140
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 8-51 6.02e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438921  Cd Length: 46  Bit Score: 48.25  E-value: 6.02e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 115533356   8 LNSMPLEIIHEILSKLIPIQRLVIRKVSCNFRYIID-EYFGIKEL 51
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDnQDPGFKKI 45
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 136-270 2.93e-25

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 98.03  E-value: 2.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533356  136 DVFVSTIPLILKSAKSLHVKEVEFrSGWSIEEMAQMLQCI--EKVEGIEIHKPGPLD---ALVPLDQWKMAKSVIA-LDK 209
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISL-SGLSFSEVASILPYFdaGTLEEIELSSESDEDqfeEIVELEQWKNAKSLKIeGSS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115533356  210 QSLLDIGNIFHLHQFKLQLVRISREELVKIRDVLLKSTNFEYGIIYLVEHTTENIGTLFNP 270
Cdd:pfam01827  80 LSSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDP 140
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 8-51 6.02e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 48.25  E-value: 6.02e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 115533356   8 LNSMPLEIIHEILSKLIPIQRLVIRKVSCNFRYIID-EYFGIKEL 51
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDnQDPGFKKI 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
11-49 8.99e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 8.99e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 115533356    11 MPLEIIHEILSKLIPIQRLVIRKVSCNFRYIID-EYFGIK 49
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDsHDFWFK 40
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 8-43 9.99e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.06  E-value: 9.99e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 115533356    8 LNSMPLEIIHEILSKLIPIQRLVIRKVSCNFRYIID 43
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 136-270 2.93e-25

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 98.03  E-value: 2.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533356  136 DVFVSTIPLILKSAKSLHVKEVEFrSGWSIEEMAQMLQCI--EKVEGIEIHKPGPLD---ALVPLDQWKMAKSVIA-LDK 209
Cdd:pfam01827   1 EKIIESFLNILKSKKCLHVKEISL-SGLSFSEVASILPYFdaGTLEEIELSSESDEDqfeEIVELEQWKNAKSLKIeGSS 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115533356  210 QSLLDIGNIFHLHQFKLQLVRISREELVKIRDVLLKSTNFEYGIIYLVEHTTENIGTLFNP 270
Cdd:pfam01827  80 LSSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDP 140
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 8-51 6.02e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 48.25  E-value: 6.02e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 115533356   8 LNSMPLEIIHEILSKLIPIQRLVIRKVSCNFRYIID-EYFGIKEL 51
Cdd:cd22150    1 LSDLPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDnQDPGFKKI 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
11-49 8.99e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 8.99e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 115533356    11 MPLEIIHEILSKLIPIQRLVIRKVSCNFRYIID-EYFGIK 49
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDsHDFWFK 40
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 8-43 9.99e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.06  E-value: 9.99e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 115533356    8 LNSMPLEIIHEILSKLIPIQRLVIRKVSCNFRYIID 43
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH