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Conserved domains on  [gi|117938301|ref|NP_001071092|]
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zinc finger protein 846 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 3.78e-25

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.05  E-value: 3.78e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301     8 VTFEDVAVDFTQEEWTLLDQAQRDLYRDVMLENYKNLIILaGSELFKRSLMSGLEQMEEL 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-496 3.26e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 106 RSNTAEKLYDSNHSGKVFNE---HPFLMTHMITHIGEKTSEDNQSGKALRKNFPHSFYKKSHAEGKMPKCVKHEKAFNQF 182
Cdd:COG5048   54 RSHTGEKPSQCSYSGCDKSFsrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 183 PNLTRQNKTHTQEKLCECKDC--WRTFLNQSSLKLHIRSHNgdkhyvcKECGKAFSNSSHLIGHGRIHSGEKPYVCKECG 260
Cdd:COG5048  134 DPQLPDLLSISNLRNNPLPGNnsSSVNTPQSNSLHPPLPAN-------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLS 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 261 KAFTQSTGLKLHIRTHSgEKPYKCKECGKAFTHS------SYLTDHTRIHSGKKPYVCMECGKAFTRSTGLILHMRIHTG 334
Cdd:COG5048  207 SSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKG 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 335 -EKPYECKECGKAFIHSSYLTKHVR--IHSGEKL--YLCKA--CGKAFTRSSGLVLHMRTHTGEKPYECK--ECGKAFN- 404
Cdd:COG5048  286 fSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSp 365

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 405 -----NSSMLSQHVRIHTgEKPYEC--KECGKAFTQSSGLSTHLRTHT--GEKACECKECGKAFARSTNLNMHMRTHTGE 475
Cdd:COG5048  366 llnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444

                        410       420
                 ....*....|....*....|.
gi 117938301 476 KPYACKECGKAFRYSTYLNVH 496
Cdd:COG5048  445 APLLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-517 8.68e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 117938301  492 YLNVHTRTHTGAKPYECKKCGKNFTQ 517
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 3.78e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.05  E-value: 3.78e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301     8 VTFEDVAVDFTQEEWTLLDQAQRDLYRDVMLENYKNLIILaGSELFKRSLMSGLEQMEEL 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-45 4.32e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.76  E-value: 4.32e-23
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 117938301    7 LVTFEDVAVDFTQEEWTLLDQAQRDLYRDVMLENYKNLI 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLV 39
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-45 1.82e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 1.82e-20
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 117938301   8 VTFEDVAVDFTQEEWTLLDQAQRDLYRDVMLENYKNLI 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-496 3.26e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 106 RSNTAEKLYDSNHSGKVFNE---HPFLMTHMITHIGEKTSEDNQSGKALRKNFPHSFYKKSHAEGKMPKCVKHEKAFNQF 182
Cdd:COG5048   54 RSHTGEKPSQCSYSGCDKSFsrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 183 PNLTRQNKTHTQEKLCECKDC--WRTFLNQSSLKLHIRSHNgdkhyvcKECGKAFSNSSHLIGHGRIHSGEKPYVCKECG 260
Cdd:COG5048  134 DPQLPDLLSISNLRNNPLPGNnsSSVNTPQSNSLHPPLPAN-------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLS 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 261 KAFTQSTGLKLHIRTHSgEKPYKCKECGKAFTHS------SYLTDHTRIHSGKKPYVCMECGKAFTRSTGLILHMRIHTG 334
Cdd:COG5048  207 SSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKG 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 335 -EKPYECKECGKAFIHSSYLTKHVR--IHSGEKL--YLCKA--CGKAFTRSSGLVLHMRTHTGEKPYECK--ECGKAFN- 404
Cdd:COG5048  286 fSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSp 365

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 405 -----NSSMLSQHVRIHTgEKPYEC--KECGKAFTQSSGLSTHLRTHT--GEKACECKECGKAFARSTNLNMHMRTHTGE 475
Cdd:COG5048  366 llnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444

                        410       420
                 ....*....|....*....|.
gi 117938301 476 KPYACKECGKAFRYSTYLNVH 496
Cdd:COG5048  445 APLLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-489 1.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.81e-05
                          10        20
                  ....*....|....*....|....*.
gi 117938301  464 NLNMHMRTHTGEKPYACKECGKAFRY 489
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 253-300 7.39e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.86  E-value: 7.39e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 117938301 253 PYVCKECGKAFTQSTGLKLHIRThsGEKPYKCKECGKAFTHSSYLTDH 300
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDH 118
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-517 8.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 117938301  492 YLNVHTRTHTGAKPYECKKCGKNFTQ 517
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 3.78e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 98.05  E-value: 3.78e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301     8 VTFEDVAVDFTQEEWTLLDQAQRDLYRDVMLENYKNLIILaGSELFKRSLMSGLEQMEEL 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-45 4.32e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.76  E-value: 4.32e-23
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 117938301    7 LVTFEDVAVDFTQEEWTLLDQAQRDLYRDVMLENYKNLI 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLV 39
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-45 1.82e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 84.14  E-value: 1.82e-20
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 117938301   8 VTFEDVAVDFTQEEWTLLDQAQRDLYRDVMLENYKNLI 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
106-496 3.26e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 106 RSNTAEKLYDSNHSGKVFNE---HPFLMTHMITHIGEKTSEDNQSGKALRKNFPHSFYKKSHAEGKMPKCVKHEKAFNQF 182
Cdd:COG5048   54 RSHTGEKPSQCSYSGCDKSFsrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 183 PNLTRQNKTHTQEKLCECKDC--WRTFLNQSSLKLHIRSHNgdkhyvcKECGKAFSNSSHLIGHGRIHSGEKPYVCKECG 260
Cdd:COG5048  134 DPQLPDLLSISNLRNNPLPGNnsSSVNTPQSNSLHPPLPAN-------SLSKDPSSNLSLLISSNVSTSIPSSSENSPLS 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 261 KAFTQSTGLKLHIRTHSgEKPYKCKECGKAFTHS------SYLTDHTRIHSGKKPYVCMECGKAFTRSTGLILHMRIHTG 334
Cdd:COG5048  207 SSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSllsqspSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKG 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 335 -EKPYECKECGKAFIHSSYLTKHVR--IHSGEKL--YLCKA--CGKAFTRSSGLVLHMRTHTGEKPYECK--ECGKAFN- 404
Cdd:COG5048  286 fSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSp 365

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 405 -----NSSMLSQHVRIHTgEKPYEC--KECGKAFTQSSGLSTHLRTHT--GEKACECKECGKAFARSTNLNMHMRTHTGE 475
Cdd:COG5048  366 llnnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444

                        410       420
                 ....*....|....*....|.
gi 117938301 476 KPYACKECGKAFRYSTYLNVH 496
Cdd:COG5048  445 APLLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-527 8.48e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 8.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 208 LNQSSLKLHIRSHNGDKHYVCKECGKAFSNSSHLIGHGRIHSGEKPYVCKECGKAFTQSTGLKL--HIRTHSGE------ 279
Cdd:COG5048   16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNpsdlns 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 280 -----------------------KPYKCKECGKAFTHSSYLTDHTRIHS---GKKPYVCMECGKAFTRSTGLILHMRIHT 333
Cdd:COG5048   96 kslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISnlrNNPLPGNNSSSVNTPQSNSLHPPLPANS 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 334 gekpyeckECGKAFIHSSYLTKHVRIHSGEKLYLCKACGKAFTRSSGLVLHMRTHTgEKPYECKECGKAFNNSSMLSQHV 413
Cdd:COG5048  176 --------LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPS 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 414 RIHTGEKPYECKECG------KAFTQSSGLSTHLRTHTG-EKACECKECGKAFARSTNLNMHMRT--HTGE--KPYACKE 482
Cdd:COG5048  247 SLSSSDSSSSASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPY 326

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 117938301 483 --CGKAFRYSTYLNVHTRTHTGAKPYECK--KCGKNFTQSSALAKHLRT 527
Cdd:COG5048  327 slCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSL 375
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-481 6.13e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 6.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 171 KCVKHEKAFNQFPNLTRQNKTHTQEKLCECKDCWRT--FLNQSSLKLHIRSHNGDKHYVC--KECGKAFSNSSHLIGHGR 246
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLNskSLPLSNSKASSSSLSSSS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 247 IHSgekPYVCKECGKAFTQSTGLKLHI----RTHSGEKPYK-CKECGKAFTHSSYLTDHTRIHSGKKPYvcmecgkafTR 321
Cdd:COG5048  115 SNS---NDNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLPgNNSSSVNTPQSNSLHPPLPANSLSKDP---------SS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 322 STGLILHMRIHTGEK-PYECKECGKAFIHSSYLTKHVRIHSgEKLYLCKACGKAFTRSSGLVLHMRTHTGEKPYECKECG 400
Cdd:COG5048  183 NLSLLISSNVSTSIPsSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 401 KAFNNSSMLSQHVRIHTGE-------KPYECKECGKAFTQSSGLSTHLRT--HTGE--KACECKE--CGKAFARSTNLNM 467
Cdd:COG5048  262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330
                 ....*....|....
gi 117938301 468 HMRTHTGEKPYACK 481
Cdd:COG5048  342 HILLHTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-489 1.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.81e-05
                          10        20
                  ....*....|....*....|....*.
gi 117938301  464 NLNMHMRTHTGEKPYACKECGKAFRY 489
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-433 4.46e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.46e-05
                          10        20
                  ....*....|....*....|....*.
gi 117938301  408 MLSQHVRIHTGEKPYECKECGKAFTQ 433
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
381-405 7.88e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 7.88e-05
                          10        20
                  ....*....|....*....|....*
gi 117938301  381 LVLHMRTHTGEKPYECKECGKAFNN 405
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-293 8.78e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 8.78e-05
                          10        20
                  ....*....|....*....|....*
gi 117938301  269 LKLHIRTHSGEKPYKCKECGKAFTH 293
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 250-328 8.81e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 8.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 250 GEKPYVCK--ECGKAFTQSTGLKLHiRTHSGEKPykckecgkaFTHSSYLTDHTRIHSGK-KPYVCMECGKAFTRSTGLI 326
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQ---------KLHENPSPEKMNIFSAKdKPYRCEVCDKRYKNLNGLK 415


                 ..
gi 117938301 327 LH 328
Cdd:COG5189  416 YH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 198-277 1.21e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 198 CECKDCWRTFLNQSSLKLHiRSHNgdkhyvckECGKAFSNSSHLIGHGRIHSGEKPYVCKECGKAFTQSTGLKLHiRTHS 277
Cdd:COG5189  352 CPVEGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-349 1.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.58e-04
                          10        20
                  ....*....|....*....|....*
gi 117938301  325 LILHMRIHTGEKPYECKECGKAFIH 349
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 253-300 7.39e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.86  E-value: 7.39e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 117938301 253 PYVCKECGKAFTQSTGLKLHIRThsGEKPYKCKECGKAFTHSSYLTDH 300
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRY--TEHSKVCPVCGKEFRNTDSTLDH 118
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
99-312 1.54e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301  99 PNGVQLERSNTAEKLYDSNHSGKVFNEHP-------FLMTHMITHIGEKTSEDNQSGKALRKNFPHSFYKKSHAEGKMPK 171
Cdd:COG5048  212 PSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqspssLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIK 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938301 172 CVKHEKAFNQFPNLTRQNKT--HTQEKL----CECKDCWRTFLNQSSLKLHIRSHNGDKHYVCK--ECGKAFSNSSHLIG 243
Cdd:COG5048  292 SKQCNISFSRSSPLTRHLRSvnHSGESLkpfsCPYSLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEP 371

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117938301 244 HGRIH-----SGEKPYVC--KECGKAFTQSTGLKLHIRTHSGEKP--YKCKECGKAFTHSSYLTDHTRIHSGKKPYVC 312
Cdd:COG5048  372 PQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-321 2.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 117938301  296 YLTDHTRIHSGKKPYVCMECGKAFTR 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 282-304 3.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.86e-03
                          10        20
                  ....*....|....*....|...
gi 117938301  282 YKCKECGKAFTHSSYLTDHTRIH 304
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 338-360 4.65e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.65e-03
                          10        20
                  ....*....|....*....|...
gi 117938301  338 YECKECGKAFIHSSYLTKHVRIH 360
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 422-444 5.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.95e-03
                          10        20
                  ....*....|....*....|...
gi 117938301  422 YECKECGKAFTQSSGLSTHLRTH 444
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 254-276 6.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.76e-03
                          10        20
                  ....*....|....*....|...
gi 117938301  254 YVCKECGKAFTQSTGLKLHIRTH 276
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 450-472 7.60e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.60e-03
                          10        20
                  ....*....|....*....|...
gi 117938301  450 CECKECGKAFARSTNLNMHMRTH 472
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-237 8.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 117938301  212 SLKLHIRSHNGDKHYVCKECGKAFSN 237
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
492-517 8.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.68e-03
                          10        20
                  ....*....|....*....|....*.
gi 117938301  492 YLNVHTRTHTGAKPYECKKCGKNFTQ 517
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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