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Conserved domains on  [gi|124249113|ref|NP_001074280|]
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Splunc6 precursor [Mus musculus]

Protein Classification

LBP/BPI/CETP family protein( domain architecture ID 1919)

LBP (lipopolysaccharide-binding protein)/BPI (bactericidal permeability-increasing protein)/CETP (cholesteryl ester transfer protein) family protein similar to Mesocricetus auratus cholesteryl ester transfer protein and Equus burchellii antiquorum latherin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BPI super family cl00188
BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / ...
 204-349 5.03e-03

BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


The actual alignment was detected with superfamily member cd00264:

Pssm-ID: 412206  Cd Length: 208  Bit Score: 37.75  E-value: 5.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249113 204 VQLSWKVLASSDFE-----IKFQTKLTINFPGILSFLSGSTVDVDIEIPLQL---QQMEPGQMSFSVKSCRAVFTGIQVN 275
Cdd:cd00264   57 LQLKILSLSSPTLKlspkgLDLSQSVSIELFVTWPASDGGNPLFSLEVEISAslqLSVDPGRLTLSLSLCSSTVELLSSN 136

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124249113 276 SGVISKMMESMLKwslnISLPNMLCPVARFWFYIINQQLAILQNIASLGMPEDSNLLDTKQPMLYERTYTMDFK 349
Cdd:cd00264  137 IGGFGNFIVSLLQ----KVLNTILCPVVLPALNSKLRSGLPLLPVPPVPSPAGVDYSLTAEPVLSASFLLLDAD 206
 
Name Accession Description Interval E-value
BPI cd00264
BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / ...
 204-349 5.03e-03

BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


Pssm-ID: 238164  Cd Length: 208  Bit Score: 37.75  E-value: 5.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249113 204 VQLSWKVLASSDFE-----IKFQTKLTINFPGILSFLSGSTVDVDIEIPLQL---QQMEPGQMSFSVKSCRAVFTGIQVN 275
Cdd:cd00264   57 LQLKILSLSSPTLKlspkgLDLSQSVSIELFVTWPASDGGNPLFSLEVEISAslqLSVDPGRLTLSLSLCSSTVELLSSN 136

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124249113 276 SGVISKMMESMLKwslnISLPNMLCPVARFWFYIINQQLAILQNIASLGMPEDSNLLDTKQPMLYERTYTMDFK 349
Cdd:cd00264  137 IGGFGNFIVSLLQ----KVLNTILCPVVLPALNSKLRSGLPLLPVPPVPSPAGVDYSLTAEPVLSASFLLLDAD 206
 
Name Accession Description Interval E-value
BPI cd00264
BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / ...
 204-349 5.03e-03

BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


Pssm-ID: 238164  Cd Length: 208  Bit Score: 37.75  E-value: 5.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124249113 204 VQLSWKVLASSDFE-----IKFQTKLTINFPGILSFLSGSTVDVDIEIPLQL---QQMEPGQMSFSVKSCRAVFTGIQVN 275
Cdd:cd00264   57 LQLKILSLSSPTLKlspkgLDLSQSVSIELFVTWPASDGGNPLFSLEVEISAslqLSVDPGRLTLSLSLCSSTVELLSSN 136

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124249113 276 SGVISKMMESMLKwslnISLPNMLCPVARFWFYIINQQLAILQNIASLGMPEDSNLLDTKQPMLYERTYTMDFK 349
Cdd:cd00264  137 IGGFGNFIVSLLQ----KVLNTILCPVVLPALNSKLRSGLPLLPVPPVPSPAGVDYSLTAEPVLSASFLLLDAD 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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