|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
8-461 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 542.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 8 ADGRWAWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGG 87
Cdd:TIGR00892 12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 88 VLASLGMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLG 167
Cdd:TIGR00892 92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 168 WRGAFLIFGGILLHCCVCGALLRPVATNEVPEP---KEDPLLPPKIPTRSCLAtCVSTIRYHLAFDILRHNmGFCIYVTG 244
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKsksKEGLPPDGSTKKLSKKS-TAEKINRFLDFSLFTHR-GFLVYLSG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 245 VTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSLAAYRKYLFAVAILINGLTNLICT 324
Cdd:TIGR00892 250 NVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCG-LIAGLKWIRPHVQYLFSFALLFNGLTHLLCA 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 325 VSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSG 404
Cdd:TIGR00892 329 LAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGS 408
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 124286852 405 FLVSGSLILGVGFYAAEKKKLKqdgqakmenaTSEMTPMHDLTSEDKDSAKKQPYPE 461
Cdd:TIGR00892 409 IVVSAGLFLAIGNYINYRLLAK----------EQKAALEREGARDKKDAEGDSRESE 455
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
13-417 |
0e+00 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 517.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 13 AWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASL 92
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 93 GMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAF 172
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 173 LIFGGILLHCCVCGALLRPvatnevpepkedpllppkiptrsclatcvstiryhlafdiLRHNMGFCIYVTGVTWMNLGF 252
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP----------------------------------------FCSNTRYQIYTLGVTWMVLGF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 253 ALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVL 332
Cdd:cd17425 201 VLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAG-LLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 333 LGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLI 412
Cdd:cd17425 280 LVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALF 359
|
....*
gi 124286852 413 LGVGF 417
Cdd:cd17425 360 MGLSF 364
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
13-416 |
3.75e-108 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 325.14 E-value: 3.75e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 13 AWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASL 92
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 93 GMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAF 172
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 173 LIFGGILLHCCVCGALLRPvatnevpepkedpllppkiptrsclatcvstiryhLAFDILRhNMGFCIYVTGVTWMNLGF 252
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRP-----------------------------------LDFSVFR-DRGFVIYTIAKFIMVLGL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 253 ALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVL 332
Cdd:cd17430 205 FVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACG-VVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGGL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 333 LGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLI 412
Cdd:cd17430 284 VVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALF 363
|
....
gi 124286852 413 LGVG 416
Cdd:cd17430 364 LALG 367
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
13-413 |
2.12e-101 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 307.56 E-value: 2.12e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 13 AWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASL 92
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 93 GMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAF 172
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 173 LIFGGILLHCCVCGALLRpvatnevpepkedpllppkiptrsclatcvstiryhlafdiLRHNMGFCIYVTGVTWMNLGF 252
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-----------------------------------------LLKDPTFVLLALGVSFAMLGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 253 ALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSLaaYRKYLFAVAILINGLTNLICTVSADFRVL 332
Cdd:cd17352 200 FVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLG-LLADKPRI--GRLYLYIFTLLILGLSLLAFPLATTYVGL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 333 LGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLI 412
Cdd:cd17352 277 IVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVL 356
|
.
gi 124286852 413 L 413
Cdd:cd17352 357 L 357
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
14-416 |
2.74e-84 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 263.60 E-value: 2.74e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLG 93
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 94 MVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFL 173
Cdd:cd17427 82 MISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 174 IFGGILLHCCVCGALLRPVAtnevpepkedPLLPPKiptrsclatcvstiryhlafdilrhnmGFCIYVTGVTWMNLGFA 253
Cdd:cd17427 162 ILGGLLLNCCVAGSLMRPLG----------PLFKHR---------------------------GFLIYLSGNVIMFLGFF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 254 LPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLL 333
Cdd:cd17427 205 APIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMG-LVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGLV 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 334 GYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 413
Cdd:cd17427 284 IYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWL 363
|
...
gi 124286852 414 GVG 416
Cdd:cd17427 364 FIG 366
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
14-416 |
1.27e-69 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 225.91 E-value: 1.27e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLG 93
Cdd:cd17426 2 WAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 94 MVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFL 173
Cdd:cd17426 82 LIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 174 IFGGILLHCCVCGALLRPVAtnevPEPkedpllppkiptrsclatcvstiryHLAFDILRHNmGFCIYVTGVTWMNLGFA 253
Cdd:cd17426 162 ILGGLLLNCCVAGSLMRPIG----PKP-------------------------FLDLTLFTHR-GFLLYLSGNVIMFFGLF 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 254 LPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLL 333
Cdd:cd17426 212 APLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMG-IVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGFC 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 334 GYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 413
Cdd:cd17426 291 IYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYL 370
|
...
gi 124286852 414 GVG 416
Cdd:cd17426 371 FIG 373
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
14-413 |
2.42e-68 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 223.04 E-value: 2.42e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLG 93
Cdd:cd17423 2 WVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 94 MVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFL 173
Cdd:cd17423 82 FLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 174 IFGGILLHCCVCGALLRPVATnevpepKEDPLLPPKiptrsclatcvstiRYHLAFDI-LRHNMGFCIYVTGVTWMNLGF 252
Cdd:cd17423 162 LLSALSLHLVPCGALLRPLAL------PGDPPAPPR--------------SLSAAFGLsLLTHRAFLRYALATTLINTGY 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 253 ALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLlagrKSLAAYRK-YLFAVAILINGLTNLICTVSADFRV 331
Cdd:cd17423 222 FIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWL----ADLGPLRLlHLLVLWTALTGLSLLLLPLAKVYGS 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 332 LLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSL 411
Cdd:cd17423 298 LLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSL 377
|
..
gi 124286852 412 IL 413
Cdd:cd17423 378 IL 379
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
14-415 |
3.48e-61 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 203.83 E-value: 3.48e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLG 93
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 94 MVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFL 173
Cdd:cd17422 82 MITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 174 IFGGILLHCCVCGALLRpvatnevpepkedpllppkiptrsclatcvstiryhlafdILRhNMGFCIYVTGVTWMNLGFA 253
Cdd:cd17422 162 VVGALQLNIVVCGALLR----------------------------------------VLK-EPGFICYALFGLFATLGFF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 254 LPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLLagrkSLAAYRK-YLFAVAILINGLTNLICTVSADFRVL 332
Cdd:cd17422 201 APQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVL----NKCPIRKiYIELICVILLCVVLLLFPFAYGFWSL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 333 LGYCLVYSLSMCGVGILVFQVLM--DIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGS 410
Cdd:cd17422 277 LVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGA 356
|
....*
gi 124286852 411 LILGV 415
Cdd:cd17422 357 VFLAL 361
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
14-414 |
2.18e-53 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 183.09 E-value: 2.18e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLG 93
Cdd:cd17424 2 WMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 94 MVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFL 173
Cdd:cd17424 82 LILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 174 IFGGILLHCCVCGALLRpvatnevpepkedPLLPPkiptrsclatcvstiryhlafdilrhnmGFCIYVTGVTWMNLGFA 253
Cdd:cd17424 162 ILGGFVLNLCVCGALMR-------------FLLMP----------------------------DFLVLAVSVLFLAYGCS 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 254 LPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLL 333
Cdd:cd17424 201 PPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFG-WLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLLV 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 334 GYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 413
Cdd:cd17424 280 PFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLL 359
|
.
gi 124286852 414 G 414
Cdd:cd17424 360 G 360
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
13-404 |
1.28e-41 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 151.90 E-value: 1.28e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 13 AWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASL 92
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 93 GMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPlLARYLLETLGWRGAF 172
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFALAP-FTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 173 LIFGGILLHCCVCGALLRPVATNevpePKEDPLlppkiptrsclatcvstiryhlafdilrhnmgFCIYVTGVTWMNLGF 252
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPIDFS----LLKDPF--------------------------------FCIYTWSFVFSQLAY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 253 ALPHIFLVPYAMHHGVDDYWAAMLMSIVGfcniFLRPMAGLLLAGRKSLAAYRKYLFAVAILI-NGLTNLICTVSADFRV 331
Cdd:cd17421 204 FIPYFHLVARARTLGIDPMDASFIISVAG----ITETVAQLASGWIADQNWIKKYHYHKAYLIlCGVTNLLAPLATTYPL 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124286852 332 LLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSG 404
Cdd:cd17421 280 LMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGG 352
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-413 |
4.61e-34 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 131.93 E-value: 4.61e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 13 AWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASL 92
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 93 GMVVSTFSGSLThLFLTAGVITGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGA 171
Cdd:COG2223 83 GLLLLALAVSYW-LLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 172 FLIFGGILLHCCVCGALLRPVATNEVPEPKEDPLLPPKIPTRSclatcvstiryhlafdilRHNMGFCIYVTGVTWMNLG 251
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRD------------------PRFWLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 252 FALphiFLVPYAM-HHGVDDYWAAMLMSIVGFCNIFLRPMAGLL---LAGRKSLAAyrkyLFAVAILINGLTNLIctvSA 327
Cdd:COG2223 224 FSS---WLPPYLVdQFGLSAATAGLLAALFALLGALGRPLGGWLsdrIGGRRVLLI----VFALMALGLLLLALA---LG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 328 DFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLV 407
Cdd:COG2223 294 SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLAL 373
|
....*.
gi 124286852 408 SGSLIL 413
Cdd:COG2223 374 VALVLT 379
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
13-401 |
4.34e-32 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 125.71 E-value: 4.34e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 13 AWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASL 92
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 93 GMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAF 172
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 173 LIFGGILLHCCVCGALLRpvatnevpepkedpllppkiptrsclatcvstiryhlafdiLRHNMGFCIYVTGVTWMNLGF 252
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-----------------------------------------LFTNKVFVAFIFWALFAYCSF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 253 ALPHIFLVPYAMHHGVDDYWAAM-LMSIVGFCNIFLRPMAGlLLAGRKSLAAYRKYLFAVAILinGLTNLICTVSADFRV 331
Cdd:cd17429 200 VIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILG-IICDLPCISVWNVFILANFTL--GVCILILPLMHTYTG 276
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 332 LLGYCLVYSLSmCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYM 401
Cdd:cd17429 277 LAIVCALIGFS-SGYFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYV 345
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-413 |
9.15e-28 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 113.91 E-value: 9.15e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 13 AWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASL 92
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 93 GMVVSTFSGSLTHLFLTAGVITGLGM-CFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGA 171
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAgTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 172 FLIFGGILLhccvcgALLRPVATNEVPEPKEDPLLPPKIPTRSCLATCVSTIRYHLAFDILRHNMGFC-IYVTGVTwmnl 250
Cdd:cd17355 161 LLVLALLAL------LVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCgFAVVGLI---- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 251 gfalphIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSlaayRKYLFAVAILINGLTNLICTVS-ADF 329
Cdd:cd17355 231 ------VHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSG-WLGDRYS----PRRLLAASYALRALGLALLLLLpFPP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 330 RVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSG 409
Cdd:cd17355 300 LALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIA 379
|
....
gi 124286852 410 SLIL 413
Cdd:cd17355 380 ALLV 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-413 |
1.40e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 113.04 E-value: 1.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 6 EQADGRWAWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMML 85
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 86 GGVLASLGMVVSTFSGSLTHLFLTAgVITGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLE 164
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 165 TLGWRGAFLIFGGILLhccvcgallrpvatnevpepkedpllppkiptrscLATCVSTIryhlafdilrhnmGFCIYVTG 244
Cdd:COG2271 160 AFGWRAAFLILGLPGL-----------------------------------LLALLRFW-------------LLALAYFL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 245 VTWMNLGFALphiFLVPYAM-HHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRksLAAYRKYLFAVAILINGLTNLIC 323
Cdd:COG2271 192 VYFALYGFLT---WLPTYLVeVRGLSLAQAGLLLSLPFLAGIVGSLLGG-WLSDR--LGRRRKLVLAIGLLLAALALLLL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 324 TVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTnNFSYVFYMSS 403
Cdd:COG2271 266 ALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLA 344
|
410
....*....|
gi 124286852 404 GFLVSGSLIL 413
Cdd:COG2271 345 ALALLAALLA 354
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
13-413 |
1.96e-27 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 113.39 E-value: 1.96e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 13 AWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASN-----SETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGG 87
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKLGdpeasFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 88 VLASLGMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLG 167
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 168 WRGAFLIFGGILLHCCVCGALLRPVATnevpePKEDPllPPKIPTRSCLATCVSTIRYHLAFDILRHNMgFCIYVTGVTW 247
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHP-----SPEDP--KSKPGRRTLHSRINLFLRKIFNVEIFKRKR-YVIWALGIPL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 248 MNLGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLLAGRKSLAayRKYLFAVAILINGLTNLICTVSA 327
Cdd:cd17420 233 ALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVK--KMYLQVLSFVSIGLMSMMIPLCN 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 328 DFRVLLGYCLVYSL-SMCGVGILVfQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFL 406
Cdd:cd17420 311 SFGILISVCLVMGLfDGCFISIMA-PIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPP 389
|
....*..
gi 124286852 407 VSGSLIL 413
Cdd:cd17420 390 LIGSSLL 396
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
11-420 |
1.08e-26 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 111.12 E-value: 1.08e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 11 RWAWVVLLSSLVTQALTLGFP-TCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVL 89
Cdd:COG2807 13 RAGRWLLLLAIVLVALNLRPAiTSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 90 ASLGMVVSTFSGSLTHLFLTAGVItGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWR 169
Cdd:COG2807 93 LAAGLLLRSLAPSVALLLAGTALI-GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 170 GAFLIFGGILLhccVCGALLRPVATNEVPEPKEDPLLPPKIPT-RSCLATCVSTIryhlafdilrhnMGFCiyvtgvtwm 248
Cdd:COG2807 172 GALAVWALLAL---LALLLWLPLLRRRPAAAAAAPAAASLRSLwRSPLAWLLTLF------------FGLQ--------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 249 NLGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLLAGRKslaayRKYLFAVAILINGLTNLICTVSAD 328
Cdd:COG2807 228 SLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLG-----DRRPLLLLLGLLGLAGLLGLLLAP 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 329 FRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCG-VTSLISPPLAGLLLDKTNNFSYVFYMSSGFLV 407
Cdd:COG2807 303 GSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGyLLAALGPLLVGALHDATGSWTAALLLLAALAV 382
|
410
....*....|...
gi 124286852 408 sgsLILGVGFYAA 420
Cdd:COG2807 383 ---LMLVAGLLAG 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-413 |
3.15e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 103.66 E-value: 3.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 34 IGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLtAGVI 113
Cdd:cd06174 15 ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL-GRFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 114 TGLGMCFSFQSSITVVGLYFV-RRRPLANALASMGLSMGVTLWPLLARYLLE--TLGWRGAFLIFGGILLHCCVCGALLR 190
Cdd:cd06174 94 LGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 191 PVATNEVPEPKEdpllppkiptrsclatCVSTIRYHLAFDILRHNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDD 270
Cdd:cd06174 174 PDPPESARAKNE----------------EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 271 YW-AAMLMSIVGFCNIFLRPMAGLLLagrkSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGIL 349
Cdd:cd06174 238 VAvAGLLLSLFGLAGALGSLLLGLLS----DRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124286852 350 VFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 413
Cdd:cd06174 314 SFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
14-413 |
5.08e-24 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 102.97 E-value: 5.08e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLG 93
Cdd:cd17428 2 WVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 94 MVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFL 173
Cdd:cd17428 82 LMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 174 IFGGILLHCCVCGALLRpvatnevpepkedpLLPPKIPTRSCLATcvstiryhLAFDIlrhnmgfciyvtgvtwmnlGFA 253
Cdd:cd17428 162 IVGALALNLLACGSLMR--------------LFKNRVFSALFIAI--------LLFDI-------------------GAF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 254 LPHIFLVPYAMHHGVDDYWAAM-LMSIVGFCNIFLRPMAGLLLAGR--KSLaayrkYLFAVAILINGLTNLICTVSADFR 330
Cdd:cd17428 201 PPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKwvNSL-----YLYVLTLIGMGAALLAIPFAKSYL 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 331 VLLGYCLVYSLsMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGS 410
Cdd:cd17428 276 TLAVLSAILGF-LSGNWSIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGG 354
|
...
gi 124286852 411 LIL 413
Cdd:cd17428 355 FLL 357
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
14-413 |
1.00e-22 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 99.48 E-value: 1.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSE-----TSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGV 88
Cdd:cd17464 2 WVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSKDDAqmrfkTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 89 LASLGMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGW 168
Cdd:cd17464 82 VGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 169 RGAFLIFGGILLHCCVCGALLRPVATNevPEPKEDPLLPPKIPTRSCLatcvstiryhLAFDILRhNMGFCIYVTGVTWM 248
Cdd:cd17464 162 FNTLRVLCIFMFVLFLAGFTYKPLVPM--KKDKEGKKRKFKCPPLKKI----------FNFNIWK-STGYRIWAFGIPAA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 249 NLGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNiflrpMAGLLLAGRKS---LAAYRKYLFAVAILINGLTNLICTV 325
Cdd:cd17464 229 LFGYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITS-----GIGRLIFGRVAdyiPGVKKVYLQVSSFFFIGLMSMMIPL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 326 SADFRVLLGYCLVYSL-SMCGVGILVfQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSG 404
Cdd:cd17464 304 CHVFGGLIAVCLFMGLfDGCFISIMA-PIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGV 382
|
....*....
gi 124286852 405 FLVSGSLIL 413
Cdd:cd17464 383 PPIIGGIIL 391
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-382 |
1.08e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 98.64 E-value: 1.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 34 IGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLThLFLTAGVI 113
Cdd:pfam07690 16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW-LLLVLRVL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 114 TGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPV 192
Cdd:pfam07690 95 QGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 193 ATNEVPEPKEDPLLPPKIPTRsclatcvstiryhlafdILRHNMGFCIYVTGVTWMNLGFALPhIFLVPYAMHHGVDDYW 272
Cdd:pfam07690 175 PESKRPKPAEEARLSLIVAWK-----------------ALLRDPVLWLLLALLLFGFAFFGLL-TYLPLYQEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 273 AAMLMSIVGFCNIFLRPMAGLLLagRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQ 352
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLS--DRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNA 314
|
330 340 350
....*....|....*....|....*....|
gi 124286852 353 VLMDIVPMDRFPSALGLFTILCGVTSLISP 382
Cdd:pfam07690 315 LVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-378 |
2.00e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 92.34 E-value: 2.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 7 QADGRWAWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLG 86
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 87 GVLASLGMVVSTFSGSLTHLFLtAGVITGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLET 165
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 166 LGWRGAFLIFGGILLHCCVCGALLRPVATNEVPEPKEDPLLPpkiptrsclatcvstiryhlafdiLRHNMGFCIYVTGV 245
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------------------------LLRRPRLLLLLLLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 246 TWMNLGFALPHIFLVPYAMH-HGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSlaayRKYLFAVAILINGLTNLICT 324
Cdd:COG2814 217 FLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAG-RLADRFG----RRRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 124286852 325 VSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTS 378
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
14-416 |
6.77e-19 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 88.24 E-value: 6.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLG 93
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 94 MVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFL 173
Cdd:cd17314 82 YTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 174 IFGGILLHCCVCGALLRPVATNEVPEPKEdpllPPKIPTRSCLATCVSTIRYHLAFDILRHNM-GFCIYVTGVTWMNLGF 252
Cdd:cd17314 162 ILGILAAIVLSVVSLLGFKEPPDNQARLH----VQKKKTQTMGEIFRDKVFWILFIAIFLVLIgGFLFIANMASLVRSLQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 253 ALPHIFLVPyamhhgvddywaamLMSIVGFCNIFLRPMAGLLLAGRKSlaayRKYLFAVAILINGLT---NLICTVSADF 329
Cdd:cd17314 238 LDAPSFVTK--------------LMSIYGLFNAFGRLLWGIVADFFGG----RLSTLSILLTILGLGlcaFLFLLKMTPV 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 330 RVLLGYCLVYsLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSG 409
Cdd:cd17314 300 GLVLTGSLLG-FSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLA 378
|
....*..
gi 124286852 410 SLILGVG 416
Cdd:cd17314 379 SAILLAV 385
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
13-412 |
1.63e-18 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 86.90 E-value: 1.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 13 AWVVLLSSLVTQaLTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASL 92
Cdd:cd17353 2 RWLVLLGAVLMH-LILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 93 GMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAF 172
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 173 LIFGGI-LLHCCVCGALLRPVATNEVPEPKEDPLLPPKIPTRSCLAT-CVSTIRYHLAfdilrhnmgFCIYVTGVTWMNL 250
Cdd:cd17353 161 LILGIIfLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPReMLRTPTFWLL---------WLMFFLNATAGLM 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 251 GFAlphiFLVPYAMH-HGVDDYWAAMLMSIVGFCNIFLRPMAGLL--LAGRKslaayRKYLFAVAILINGLTNLICTVSA 327
Cdd:cd17353 232 LIG----QAKPIGQEfAGLDAGIAALAVSILSIFNGGGRPFWGWLsdKIGRK-----NTLSIAFLIQGVAMFLLPFIGSV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 328 DFRVLLGYCLVYSlsmCGVGI--LVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGlLLDKTNNFSYVFYMSSGF 405
Cdd:cd17353 303 AVLFVLGVALIGF---CYGGGfaLFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAAL 378
|
....*..
gi 124286852 406 LVSGSLI 412
Cdd:cd17353 379 SLVALAL 385
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
14-180 |
2.16e-16 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 80.61 E-value: 2.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRDF-----QASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGV 88
Cdd:cd17465 2 WVVVFAATWCNGSIFGIQNSFGILYVMLLNEQedqkdQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 89 LASLGMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGW 168
Cdd:cd17465 82 VAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGL 161
|
170
....*....|..
gi 124286852 169 RGAFLIFGGILL 180
Cdd:cd17465 162 AHTFQVLSLFMF 173
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
72-413 |
3.21e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 70.68 E-value: 3.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 72 ILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLTAgVITGLGMCFSFQSSITVVG-LYFVRRRPLANALASMGLSM 150
Cdd:cd17325 53 RLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMALIAdIAPPEERGRAMGIFSSAIGL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 151 GVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPvatNEVPEPKEDPLLPPKIPTRsclatcvstiryhLAFD 230
Cdd:cd17325 132 GFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP---EPRPPPNKRAVSAARLRSG-------------LRLL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 231 ILRHNMGFCIYVTGVTWMNLGFALPhiFLVPYAMHH-GVDDYWAAMLMSIVGFCNIFLRPMAGLLlAGRKSlaayRKYLF 309
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEP--FLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKL-SDRIG----RKPLI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 310 AVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLL 389
Cdd:cd17325 269 LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
|
330 340
....*....|....*....|....
gi 124286852 390 DkTNNFSYVFYMSSGFLVSGSLIL 413
Cdd:cd17325 349 D-AFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
34-413 |
1.33e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.64 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 34 IGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLtagVI 113
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLV---LL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 114 TGLGMCFS-FQSSIT--VVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLr 190
Cdd:cd17475 92 FLVGAGYGsVQPGGGraIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLF- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 191 pvatneVPEPKEDPLLPPKIPTRsclatcVSTIRYHLAFDILRHnmgfcIYVTGVTWMNLGFALpHIFLVPYAM-HHGVD 269
Cdd:cd17475 171 ------YREPPAASAATESASTL------LRSLKEVLRNRDVWL-----IAIAGALLVAPQFAL-LTFLLLFLHdHLGLS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 270 DYWAAMLMSIVGFCNIFLRPMAGL----LLAGRkslaaYRKYLFAVAILINGLTNLI--CTVSADFRVLLGYCLVYSLSM 343
Cdd:cd17475 233 VVAAGALLAVAQLGGALGRIGLGRvsdrVFGGR-----RRPVLVITAAIAAAALLVLslLSPGTPLWLLVLLLILLGLFA 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 344 CGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 413
Cdd:cd17475 308 IGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
69-412 |
2.39e-10 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 61.94 E-value: 2.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 69 LCSILVKHFGCRVtMMLGGVLAS----LGMVVSTFSGSLTHLFLTAGVITGLGMCFSfqsSITVVGLYFVRRRPLANALA 144
Cdd:cd06180 53 LASFLRRRGRARR-LIRGGLLLTvlllAAMALTSGFAALLALRFLAGAASAFVFVFG---SNLVLHHATAAGRGHLIGLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 145 SMGLSMGVTLWPLLARYLL-ETLGWRGAFLIFGGILLhccVCGALLRPVATNEVPEPKEDPLLPPKIPTRscLATCVSTI 223
Cdd:cd06180 129 FAGVGLGIALSGLLVPAGLgGGLSWRAGWLALALLSA---VLLLLSFLLLRRGPSAPTEASAAESAPGLN--RPLWRLAL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 224 RYHLAfdilrhNMGFCIYVTgvtwmnlgfalphiFLVPYAMHHGVDDYWAAMLMSIVGFCNIFlrpmaGLLLAGRKSLAA 303
Cdd:cd06180 204 AYGLF------GFGYIITAT--------------FLPLIARETGAGSLLAGLLWSLFGLAAVP-----SCFLWGALSDRW 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 304 YRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRfPSALGLFTILCGVTSLISPP 383
Cdd:cd06180 259 GTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAA-PRALALMTASFGVGQILGPL 337
|
330 340
....*....|....*....|....*....
gi 124286852 384 LAGLLLDKTNNFSYVFYMSSGFLVSGSLI 412
Cdd:cd06180 338 LAGWLADATGGFAPALILAAAALVVAALL 366
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
73-412 |
1.27e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.53 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 73 LVKHFGCRVTMMLGGVLASLGMVVSTFSGSLThLFLTAGVITGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMG 151
Cdd:cd17489 54 LLDRFGRKRLLLIGLLIFALATLLYLLATSVA-LLLVLRLIHGIGWGAFTTAAATLVADIIpPSRRGEGIGYYGLATTLA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 152 VTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATNEVPEPKEDPLLPPKIPTRSCLATCVSTIryhLAFdi 231
Cdd:cd17489 133 MALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILF---LAS-- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 232 lrhnMGFCIYVTgvtwmnlgfalphiFLVPYAMHHGVDDywAAMLMSIVGFCNIFLRPMAGLLlagrkSLAAYRKYLFAV 311
Cdd:cd17489 208 ----IAYGAIST--------------FLPLYAAERGISN--AGLFFTVYAIALLLSRPFSGKL-----SDRKGPKTVIIP 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 312 AILINGLTNLICTVSADFRVLLGYCLVYSLsMCGVGILVFQVLM-DIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLD 390
Cdd:cd17489 263 GLLLLALGLLLLSFAGSPWMLLLAAVLYGL-GFGLLFPALQALAvDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE 341
|
330 340
....*....|....*....|..
gi 124286852 391 KTnNFSYVFYMSSGFLVSGSLI 412
Cdd:cd17489 342 LF-GYRAMFLLAAVVVLLALVL 362
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-413 |
1.38e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 59.51 E-value: 1.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 32 TCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHlFLTAG 111
Cdd:cd17319 20 VNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS-LYVLR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 112 VITGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGIllhccvcGALLR 190
Cdd:cd17319 99 FLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLL-------GLLLA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 191 PVATnevpepkedpLLPPKIPTRSCLATCVSTIRYHLAF---DILRHNMGFciyvtgvTWMNLGFALPHIFLVpyamhhg 267
Cdd:cd17319 172 VLWW----------FYLRQVWGLALGYFGINYALYGLLTwlpTYLKQARGF-------SLKQVGLLAAIPFLA------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 268 vddywAAMLMSIVGFCNIFLRPMAglllagRKSLAAYRKYLFAVAILINGLTNlictvSADFRVLLgyclvysLSMCGVG 347
Cdd:cd17319 228 -----GAIGMILGGRLSDRLLRGA------RRLVIIIGLLLAAVGLLLAYLTT-----SPVVAVIL-------LSLAGFG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124286852 348 ILVFQVLMDIVPMDRFP-----SALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 413
Cdd:cd17319 285 IGAASPVFWSLPADLLPgeaaaTAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
39-412 |
1.96e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.10 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 39 TDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLtAGVITGLGM 118
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLL-ARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 119 CFSFQSSITVVGLYFV-RRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLhcCVCGALLRPVatnev 197
Cdd:cd17324 102 GGFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL--LAALLLWRLL----- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 198 pepkedPLLPPKIPTRSCLatcVSTIRYHLAFDILRHnmgfcIYVTGVTWMNLGFALpHIFLVPYAMH-HGVDDYWAAML 276
Cdd:cd17324 175 ------PSLPPKKPGSLGL---LSSLLLLLRNPRLRL-----AYLITFLLFGGFFAL-YTYLAPFLTDvPGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 277 MSIVGFCNIFlrpmaGLLLAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMD 356
Cdd:cd17324 240 LLLFGVAGVV-----GSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 124286852 357 IVPMDR-FPSALGLFTILCGVTslISPPLAGLLLDKTnNFSYVFYMSSGFLVSGSLI 412
Cdd:cd17324 315 LAPEARgLASSLYLAAYNLGGA--LGAALGGLVLDHG-GWAGVGWVGAALLLLALLL 368
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
4-297 |
4.27e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.51 E-value: 4.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 4 ALEQADGRWAWVVLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTM 83
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 84 MLGGVLASLGMVVSTFSGSLThLFLTAGVITGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYL 162
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPE-LLIAARALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 163 LETLGWRGAFLIfggillhcCVCGALLRPVATNEVPEPKEDPLLPPKIPTRSCLATcVSTIRYHLAFDILRHNMGFCIYV 242
Cdd:COG0477 162 VAALGWRWIFLI--------NAPLGLLALVLRLRLPESRGLLLALLALALAALLLA-ALALALLALLLLLLLLLLALLAL 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 124286852 243 TGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLLAG 297
Cdd:COG0477 233 LLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
67-415 |
7.05e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 7.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 67 GPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLTAGVItGLGMCFSFQSSITVVGLYFV-RRRPLANALAS 145
Cdd:cd17473 52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALL-GIGVAGIMTLATALIGDYFEgEERAKMLGLQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 146 MGLSMGVTLWPLLARYLLEtLGWRGAFLIFG-GILLHCCVCgALLRPVATNEVPEPKEDPLLPPKIPTRSCLATCVSTIr 224
Cdd:cd17473 131 AAMSLGGVVFLLLGGALAE-IGWRAPFLVYLlALPVLILVL-LFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAF- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 225 yhlafdilrhnMGFCIYVTGVTwmNLGFALPHIFLVPYAMhhgvddywAAMLMSIVGFCNiflrpMAGLLLAGRKSLAAY 304
Cdd:cd17473 208 -----------LAMLLFYVIPI--QLPFLLQERGGGSAAL--------IGLALAIASLAG-----AIGALLFGRLKRRLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 305 RKYLFAVAILINGLTNLICTVSADFRVLLGYCLVyslSMCGVGIL---VFQVLMDIVPMDRFPSALGLFTILCGVTSLIS 381
Cdd:cd17473 262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAIL---AGLGFGLLlptLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLS 338
|
330 340 350
....*....|....*....|....*....|....
gi 124286852 382 PPLAGLLLDKTNNFSYVFYMSSGFLVSGSLILGV 415
Cdd:cd17473 339 PLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
26-180 |
1.69e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.40 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 26 LTLGFPTCI-GVFFTDLQRDFQASNSETSWFPSI--LGAMVhgGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGS 102
Cdd:COG0738 18 FLWGFATALwGPLIPALKDAFGLSDAQAGLLLFAffLGYLL--ASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 103 LThLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLL---ETLGWRGAFLIFGGIL 179
Cdd:COG0738 96 YP-LLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLIllgLSLSWHLPYLILAVLL 174
|
.
gi 124286852 180 L 180
Cdd:COG0738 175 L 175
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
248-413 |
1.00e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.82 E-value: 1.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 248 MNLGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLlAGRKSlaayRKYLFAVAILINGLTNLICTVSA 327
Cdd:COG2814 22 SGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRL-ADRFG----RRRVLLLGLLLFALGSLLCALAP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 328 DFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDkTNNFSYVFYMSSGFLV 407
Cdd:COG2814 97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFGWRWVFLVNAVLAL 175
|
....*.
gi 124286852 408 SGSLIL 413
Cdd:COG2814 176 LALLLL 181
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
28-174 |
3.63e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 52.63 E-value: 3.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 28 LGFPTCIGVFFTDLQRDFQASnSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLThLF 107
Cdd:cd06179 11 LFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVN-ML 88
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124286852 108 LTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLET--LGWRGAFLI 174
Cdd:cd06179 89 IGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEAnaAGWRWIFYI 157
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-191 |
4.74e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.79 E-value: 4.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFftdLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFG--CRVTMMLGGVLAS 91
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTY---LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 92 LGMVVSTFSGSLThLFLTAGVITGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRG 170
Cdd:COG2271 260 LALLLLALLPSPA-LAIALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 124286852 171 AFLIFGGILLHCCVCGALLRP 191
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-180 |
9.14e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.66 E-value: 9.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 34 IGVFFTDLQRDFQASNSETSWFPSI--LGAMVhgGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLtHLFLTAG 111
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAalFGMAI--GALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSV-LQLALLR 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 112 VITGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILL 180
Cdd:cd17365 95 FLTGLGLGAAMPNAITLVSEYApARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPL 164
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
32-190 |
2.08e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.88 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 32 TCIGVFFTDLQRDFQASNSETSW----FPSILGAMVhgggPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLThLF 107
Cdd:cd17503 13 TIVNVALPTIMGDLGASLDTVQWvitsYLLALAIMI----PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLA-SL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 108 LTAGVITGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCG 186
Cdd:cd17503 88 IIFRILQGFGGGVLIPLAQTILLRIYpPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA 167
|
....
gi 124286852 187 ALLR 190
Cdd:cd17503 168 PLLD 171
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-180 |
2.11e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.88 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 16 VLLSSLVTQALTLGFPTCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMV 95
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 96 VSTFSGSLTHLFLTAgVITGLGMCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLI 174
Cdd:cd17325 281 LLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVpPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
....*.
gi 124286852 175 FGGILL 180
Cdd:cd17325 360 AAALLL 365
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
83-413 |
3.75e-06 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 48.91 E-value: 3.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 83 MMLGGVLASLGMVVSTFSGSLTHLFLTAGVITGLGMCFSfqsSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLArYL 162
Cdd:pfam06779 66 GLLATVLLLLAMAATSSFWAVLLIRFLAGVASAAVMIFG---SSLILGHATAARRAFVGALLFAGVGIGIALSGLLV-PL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 163 LETLGWRGAFLIFGGILLhCCVCGALLRPVATNEVPEPKEDPLLPPKIPTRScLATCVSTIRYHLAfdilrhNMGFCIYV 242
Cdd:pfam06779 142 GLQLGLGGSSLWYGAGVL-SAVLTLAVFPLLPRRAPRHASAPAPAAKPLQRS-LPLWILTLAYGLA------GFGYIITA 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 243 TgvtwmnlgfalphiFLVPYAMHHGVDDYWAAMLMSIVGfcnifLRPMAGLLLAGRKSLAAYRKYLFAVAILINGLTNLI 322
Cdd:pfam06779 214 T--------------FLPAMARDGFGGPAAAALFWSLFG-----LAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 323 CTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRfPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMS 402
Cdd:pfam06779 275 SLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAP-RRLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLA 353
|
330
....*....|.
gi 124286852 403 SGFLVSGSLIL 413
Cdd:pfam06779 354 AAALVLAALIV 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
38-413 |
4.14e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 48.72 E-value: 4.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 38 FTDLQRDFQASNSETSW------FPSILGAMVHGggplcsILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLThLFLTAG 111
Cdd:cd17474 22 LPAIAEALGASPAQVGLlitaftLPAAVLMPVAG------VLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA-LLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 112 VITGLGMCFSFQSSITVVG-LYFVRRRPLANALASMGLSMGVTLWPLLARYLLeTLGWRGAFLIFGGILLHCCVCGALLr 190
Cdd:cd17474 95 ALQGIGAAGLGPLALTLIGdLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFL- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 191 pvatneVPEPKEDPLLPPKIPTRSclatcvstiryhlAFDILRHNMGFCIYVTGVTWMNLGFALphIFLVPY--AMHHGV 268
Cdd:cd17474 173 ------LPEPKEKAKSSSATKLRD-------------LKKALRGRGLLTFLVSAFLYFFLYFAF--LTYLPFllELLYGI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 269 DDYWAAMLMSIVGFCNIFLRPMAGLLLAGRKSlaayRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGI 348
Cdd:cd17474 232 SPIIIGLLFAGWSVLLALGSLFVGRLLKKRFG----ARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLP 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124286852 349 LVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLdKTNNFSYVFYMSSGFLVSGSLIL 413
Cdd:cd17474 308 LLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL-EIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
84-419 |
5.43e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 5.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 84 MLGGVLASLGMVVSTFSGSLTHLFLTAgVITGLGMCFSFQSSITVVGLYfVRRRPL--ANALASMGLSMGVTLWPLLARY 161
Cdd:cd06173 73 LRALLAAVLALLALLGSLSLWLLLVLA-FLLGIASAFFGPARQALLPEL-VPKEQLvrANALNSLATQLARIIGPALGGL 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 162 LLETLGWRGAFLIFGGILLHCCVCGALLRPVATNEVPEPKEDPLLppkiptrsclatcvstiRYHLAFDILRHNMGFCIY 241
Cdd:cd06173 151 LVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLR-----------------DLREGLRYLRRSPLLRLL 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 242 VTGVTWMNLGFALPHIFLVPYAMHH-GVDDYWAAMLMSIVGFCNIflrpmAGLLLAGRKSLAAYRKYLFAVAILINGLTN 320
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGAL-----LGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 321 LICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNnfsyvfy 400
Cdd:cd06173 289 LVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG------- 361
|
330
....*....|....*....
gi 124286852 401 MSSGFLVSGSLILGVGFYA 419
Cdd:cd06173 362 LSAVFLLAGALLLLAALLL 380
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
238-413 |
7.23e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.92 E-value: 7.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 238 FCIYVTGVTWMNLGFAlPHIFLVPYAMHHGVDDYWAAMLMSIVgfcNIFLRPMAglLLAGRKSLAAYRKYLFAVAILING 317
Cdd:cd17370 202 FWLYLLAVALFALGNF-SFAFLILRAQELGLSAALIPLLYALF---NLVYALAA--YPAGRLSDRIGRKKLLILGYLSLA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 318 LTNLICTVSADFRVLLGYCLVYslsmcGVGILVFQVLM-----DIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKT 392
Cdd:cd17370 276 LAYLGFALGSSLWLLLLGFILW-----GLYMGAQESIEraavaDLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI 350
|
170 180
....*....|....*....|.
gi 124286852 393 nNFSYVFYMSSGFLVSGSLIL 413
Cdd:cd17370 351 -SPSAAFLFSAVLALIALLLL 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
40-180 |
1.38e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.17 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 40 DLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLThLFLTAGVITGLGMC 119
Cdd:cd17321 21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA-FLIAARALQGIGAA 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124286852 120 FSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILL 180
Cdd:cd17321 100 AIMPASLALIAATFpGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
250-413 |
2.46e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 2.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 250 LGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLLAGRKslaayRKYLFAVAILINGLTNLICTVSADF 329
Cdd:cd17489 10 LSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFG-----RKRLLLIGLLIFALATLLYLLATSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 330 RVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLaGLLLDKTNNFSYVFYMSSGFLVSG 409
Cdd:cd17489 85 ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL-GLFLYQHLGFAVLFIVAAVLALLA 163
|
....
gi 124286852 410 SLIL 413
Cdd:cd17489 164 LLLV 167
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
14-180 |
2.55e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.45 E-value: 2.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRDfqaSNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLG 93
Cdd:cd17329 203 LLFLLASFLISLIYFQLESTLPVYVVEILGL---GESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIG 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 94 MVVSTFSGSLTHLFLTAGVIT-GLGMCFSFQSSItVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAF 172
Cdd:cd17329 280 FAVLAFANTLAVLILAMIVLTlGEMLVFPAVQTL-VAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
|
....*...
gi 124286852 173 LIFGGILL 180
Cdd:cd17329 359 LILAALGL 366
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
34-414 |
3.95e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 45.69 E-value: 3.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 34 IGVFFTDLQRDFQASNSE----TSWFpsILGAMVhgGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLT 109
Cdd:cd17328 18 IAGVLPDIQSDFLIDDSLagllQTVF--IISYMV--LSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 110 -AGVITGLGMCFSFqsSITVVGLYFVR-RRPLANALASMGLSMGVTLWPLLARYL-LETLGWRGAFLIFGGILLhccVCG 186
Cdd:cd17328 94 rALVGIGEASYSPI--APTIIADLFPKeKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGV---LLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 187 ALLRPVatneVPEPK---EDPLLPPKIPTRSCLATCVSTIRyHLAFdiLRHNMGFCIYVtgVTWMNLGFALPHIFLVPYA 263
Cdd:cd17328 169 ILLLLF----VREPPrgaAEGGVMAKSTATSFLADLKALAK-NPSF--ILSTLGFTAVS--FVTGALAFWAPTFFLRAFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 264 MHHGVDDYWAAMLMSIVGFCNIFLRPMAGLL--LAGRKSLAAYrKYLFAVAILINGLTNLICTVSADFRVLLGYCLVY-- 339
Cdd:cd17328 240 VGDLSSADVGLIFGAITCIAGVLGVLLGGILadRLRRKTPRAD-PLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFlg 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 340 SLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSL-ISPPLAGLLLDKTNN-----------FSYVFYMSSGFLV 407
Cdd:cd17328 319 EFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDaGSPYLIGLISDLLRQnkdsplaeaasLQYALLLCSFVLV 398
|
....*..
gi 124286852 408 SGSLILG 414
Cdd:cd17328 399 LGGFFFL 405
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
248-412 |
4.58e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.64 E-value: 4.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 248 MNLGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSlaayRKYLFAVAILINGLTNLICTVSA 327
Cdd:cd17325 8 DMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAG-RLSDRFG----RKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 328 DFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTnNFSYVFYMSSGFLV 407
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALAL 161
|
....*
gi 124286852 408 SGSLI 412
Cdd:cd17325 162 LALVL 166
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
53-191 |
4.98e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.02 E-value: 4.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 53 SWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLtAGVITGLGMCFSFQSSITVVG-L 131
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII-ARFLQGFGAAFALVAGAALIAdI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 132 YFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRP 191
Cdd:TIGR00880 80 YPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
17-180 |
5.86e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.00 E-value: 5.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 17 LLSSLVTQALTLGFPtciGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVV 96
Cdd:cd17333 1 LYISFFSNGLTDALL---GILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 97 STFSGSLThLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLET-LGWRGAFLIF 175
Cdd:cd17333 78 IFATPSIY-LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLII 156
|
....*
gi 124286852 176 GGILL 180
Cdd:cd17333 157 GLIYL 161
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
83-439 |
1.24e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.12 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 83 MMLGGVLASLGMVV--STFSGSLTHLFLTAGVI-TGLGMCFSFqSSITVVGLYFV-----RRRPLANALASMGLSMGVTL 154
Cdd:COG2211 84 ILIGAIPLALSFVLlfTAPDLSPTGKLIYALVTyLLLGLAYTL-VNIPYSALGAEltpdyEERTRLSSWRFAFAGLGGLL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 155 WPLLARYLLETL------GWRGAFLIFGGIllhcCVCGALLRPVATNEVPEPKEdpllpPKIPTRSclatcvstiryhlA 228
Cdd:COG2211 163 ASVLPPPLVAAFggdaalGYRLTALIFAVL----GLLAFLLTFFGTKERPVPEE-----EKVSLKE-------------S 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 229 FDILRHNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHH-GVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGRKSlaayRKY 307
Cdd:COG2211 221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWP-RLAKRFG----KKK 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 308 LFAVAILINGLTNLICTVS--ADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPS-------ALGLFTILCGVTS 378
Cdd:COG2211 296 AFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFAIKLGQ 375
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124286852 379 LISPPLAGLLLD-------KTNNFSYVFYMSSGFLVSGSLILGVGFYAAEKKKLKQDGQAKMENATSE 439
Cdd:COG2211 376 ALAGALAGLLLAlfgyvagAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAA 443
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
43-175 |
4.11e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 42.18 E-value: 4.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 43 RDFQASNSETSWFpsiLGAMVhgGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLThLFLTAGVITGLGMCFSF 122
Cdd:cd17317 23 RDWLVALVQTIFF---LGVLI--GSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE-LFLVLRFLVGVTSAGIF 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124286852 123 QSSItVVGLYFV--RRRPLANALASMGLSMGVTLWPLLA------RYLLETLGWRGAFLIF 175
Cdd:cd17317 97 TVGF-VLGMEIVgpKYRSFVGILFGLFWALGYMLLALLAylirdwRWLQLAISLPGLLFLL 156
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-154 |
4.41e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.27 E-value: 4.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 11 RWAWVVLLSSLVTQALTLGFPTCIGVFFTDLqrdFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLA 90
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEV---LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124286852 91 SLGMVVSTFSGSLTHLFLTAGVITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTL 154
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
14-190 |
6.62e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 6.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 14 WVVLLSSLVTQALTLGFPTCIGVFFTDLQRdfqASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLG 93
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPFLLQERGG---GSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 94 MVVSTFSGSLThLFLTAGVITGLGMCFSF-QSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYL-LETLGWRGA 171
Cdd:cd17473 277 FLLLALASGLW-VVLLGAILAGLGFGLLLpTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLvNLTGGLSGA 355
|
170
....*....|....*....
gi 124286852 172 FLIFGGILLHCCVCGALLR 190
Cdd:cd17473 356 FLILGVLALVLAIVLLLLR 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
55-180 |
8.53e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 8.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 55 FPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLtAGVITGLGmCFSFQSSITVVGLYFV 134
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL-AAVLYGLG-FGLLFPALQALAVDLV 309
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 124286852 135 R--RRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILL 180
Cdd:cd17489 310 PphRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVL 357
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
66-179 |
1.01e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.61 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 66 GGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLtAGVITGLGMCFSFQSSIT-VVGLYFVRRRPLANALA 144
Cdd:PRK03893 71 GGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFI-ARLVIGMGMAGEYGSSATyVIESWPKHLRNKASGFL 149
|
90 100 110
....*....|....*....|....*....|....*
gi 124286852 145 SMGLSMGVTLWPLLARYLLETLGWRGAFLIfgGIL 179
Cdd:PRK03893 150 ISGFSIGAVVAAQVYSLVVPVWGWRALFFI--GIL 182
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
236-413 |
1.07e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 236 MGFCIYVTGVTWMNLGFALPHIFLVpyamHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLlagrkSLAAYRKYLFAVAILI 315
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAE----DLGISPTEIGLLLTLFSLGYALAQPLAGRL-----SDRFGRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 316 NGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTnNF 395
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GW 150
|
170
....*....|....*...
gi 124286852 396 SYVFYMSSGFLVSGSLIL 413
Cdd:pfam07690 151 RAAFLILAILSLLAAVLL 168
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
66-412 |
1.14e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.00 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 66 GGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLTAgVITGLGMCFSFQSSIT-VVGLYFVRRRPLANALA 144
Cdd:cd17477 47 GSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLR-FVMGIGLAGLFVVSESwLNALATNENRGRVLGLY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 145 SMGLSMGVTLWPLLARyLLETLGWRgAFLIFGGILLHCCVCGALLRPVATNEVPEPKEDPLLPPKIPTRSCLATCVStir 224
Cdd:cd17477 126 STVLGLGFALGPLLLA-LVGTAGAL-PFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVA--- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 225 yhlafdilrhnmgfciyvtgvtwmnlGFAL--PHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLlAGRKSla 302
Cdd:cd17477 201 --------------------------GFLEgaFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWL-ADRFD-- 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 303 aYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISP 382
Cdd:cd17477 252 -RRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGP 330
|
330 340 350
....*....|....*....|....*....|
gi 124286852 383 PLAGLLLDKTNNFSYVFYMSSGFLVSGSLI 412
Cdd:cd17477 331 LLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
32-296 |
1.91e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 32 TCIGVFFTDLQRDFQASNSETSWFPSILGAMVHGGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGslTHLFLTAG 111
Cdd:cd17339 16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGG--IALLFLGT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 112 VITGLGMCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETL--GWRGAFLIFGgilLHCCVCGALL 189
Cdd:cd17339 94 ALAGAGIAVGNVLLPSLIKRDFPRRVGLMTGLYTTSMNLGAALASGLSVPLAQALggGWRGALAIWA---LPALLALLIW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 190 RPVATNEVPEPKEDPLLPPKIPTRSCLATCV-------STIRYHLAF---DILRHNmGFCIYVTG--VTWMNLgFALPHI 257
Cdd:cd17339 171 LPQLRRRKRAAAAAAPLTKISVWRSPLAWQVtlfmglqSLLFYTLMAwlpTILIDA-GLSAATAGwlLSLFQL-VGIPAS 248
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 124286852 258 FLVPYAMHHGVDDYWAAM---LMSIVGFCNIFLRPMAGLLLA 296
Cdd:cd17339 249 LLVPILATRLKNQRPIVVllaVLFIIGVLGLLFAPTALALLW 290
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
58-200 |
2.86e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 40.03 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 58 ILGAMVHG--GGPLCSilvkHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLfLTAGVITGLGMCFSFQSSITVVGLYF-V 134
Cdd:TIGR00895 62 LIGMAFGAlfFGPLAD----RIGRRRVLLWSILLFSVFTLLCALATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYApK 136
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124286852 135 RRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIfGGILlhccvcGALLRPVATNEVPEP 200
Cdd:TIGR00895 137 RFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV-GGIA------PLLLLLLLMRFLPES 195
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
66-428 |
3.55e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 39.53 E-value: 3.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 66 GGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLTAgVITGLGMCFSFQSSITvvglYFVRRRP-----LA 140
Cdd:PRK12307 69 GGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSR-FIVGMGMAGEYACAST----YAVESWPkhlksKA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 141 NALASMGLSMGVTLWPLLARYLLETLGWRGAFLIfgGILLHCCVCGALLRPVATNEVPEPKEDPLLPPKIPTRSCLATCV 220
Cdd:PRK12307 144 SAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV--GLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSM 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 221 STI--RYHLAFDILRHNMGFCIYvtGVTWMNLGfalphiFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGlLLAGR 298
Cdd:PRK12307 222 KGLfnRAQFPLTLCVFIVLFSIF--GANWPIFG------LLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWG-LCADR 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 299 KSLaayrKYLFAVAILINGLtnLICT---VSADFRVLLGYCLV-YSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILc 374
Cdd:PRK12307 293 IGL----KKTFSIGLLMSFL--FIFPlfrIPQDNYLLLGACLFgLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNL- 365
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 124286852 375 GVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLvSGSLILGVGFYAAEKKKLKQD 428
Cdd:PRK12307 366 AATSGTFNSMAATWLGITMGLGAALTFIVAFW-TATILLIIGLSIPDRLKARRE 418
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
65-206 |
5.88e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 5.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 65 GGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLTHLFLTAgVITGLGMCFSFQSSITVVG-LYFVRRRPLANAL 143
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL-VLTGFGGGLFEPASEAMIAdVTTPENRTRAFSL 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124286852 144 ASMGLSMGVTLWPLLARYLLEtLGWRGAFLIFGGILLHCCVCGALLRPVATNEVPEPKEDPLL 206
Cdd:cd17329 129 LYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEIL 190
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
59-180 |
6.64e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 6.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124286852 59 LGAMVhgGGPLCSILVKHFGCRVTMMLGGVLASLGMVVSTFSGSLThLFLTAGVITGLGMCFSFQSSITVVGLYF-VRRR 137
Cdd:cd06173 255 VGALL--GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLW-LLLAALFLLGLAGGLFNVPLNTLLQLRVpDELR 331
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 124286852 138 PLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILL 180
Cdd:cd06173 332 GRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLL 374
|
|
| |
