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Conserved domains on  [gi|124486733|ref|NP_001074542|]
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centrosomal protein of 76 kDa isoform 1 [Mus musculus]

Protein Classification

centrosomal protein of 76 kDa( domain architecture ID 10634911)

centrosomal protein of 76 kDa (CEP76) that during interphase is involved in regulation of centriole duplication, and that during mitosis is involved in suppressing the aberrant activation and ectopic aggregation of cytoplasmic serine/threonine-protein kinase PLK1, a regulator of mitotic progression; contains a CEP76 C2 domain; contains a region with similarity to a transglutaminase-like domain

Gene Symbol:  cep76
Gene Ontology:  GO:0046599|GO:0005813
PubMed:  19460342

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CEP76-C2 pfam15627
CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ...
 99-258 7.66e-90

CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the new C2 domain that is contained by ciliary CEP76 proteins.


:

Pssm-ID: 464781  Cd Length: 157  Bit Score: 276.14  E-value: 7.66e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486733   99 TNVDPTRRYLYLQVLGGKAFLEHLQEPEPLPGQICSTFTLCLHYRNQRFRSKPVPCACEPDFHDGFLLEVHREslgDGTR 178
Cdd:pfam15627   1 ALIDPRRRYLYLRVLGGKAFLDHLQEPEPLPGQVCSTFTLHLHFRGQRFRSKPVPCACEPDFREGFLLELPTE---AGSA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486733  179 MADSTTMLSISDPIHMVLIKTDIFGETTLVASYFLEWRSVLGSENGVTNLTVELMGVGTESKVSVGILNIKLEMYPPLSQ 258
Cdd:pfam15627  78 MADATDLLSISDPIHLVLIKTDTAGETTLLSSHFLEWRRVLCSPNGKTGLTVELRGVGAEAKVPAGILDLQLELLPRKRT 157
Transglut_core super family cl17362
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 374-411 5.51e-03

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


The actual alignment was detected with superfamily member pfam01841:

Pssm-ID: 450180 [Multi-domain]  Cd Length: 108  Bit Score: 37.00  E-value: 5.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 124486733  374 KGDCEDHANLLCSLLLGYGLEAFVCVGTKA------KGAPHAWV 411
Cdd:pfam01841  51 KGDCEDFASLFVALLRALGIPARYVTGYLRgpdtvrGGDAHAWV 94
 
Name Accession Description Interval E-value
CEP76-C2 pfam15627
CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ...
 99-258 7.66e-90

CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the new C2 domain that is contained by ciliary CEP76 proteins.


Pssm-ID: 464781  Cd Length: 157  Bit Score: 276.14  E-value: 7.66e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486733   99 TNVDPTRRYLYLQVLGGKAFLEHLQEPEPLPGQICSTFTLCLHYRNQRFRSKPVPCACEPDFHDGFLLEVHREslgDGTR 178
Cdd:pfam15627   1 ALIDPRRRYLYLRVLGGKAFLDHLQEPEPLPGQVCSTFTLHLHFRGQRFRSKPVPCACEPDFREGFLLELPTE---AGSA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486733  179 MADSTTMLSISDPIHMVLIKTDIFGETTLVASYFLEWRSVLGSENGVTNLTVELMGVGTESKVSVGILNIKLEMYPPLSQ 258
Cdd:pfam15627  78 MADATDLLSISDPIHLVLIKTDTAGETTLLSSHFLEWRRVLCSPNGKTGLTVELRGVGAEAKVPAGILDLQLELLPRKRT 157
Transglut_core pfam01841
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 374-411 5.51e-03

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


Pssm-ID: 376628 [Multi-domain]  Cd Length: 108  Bit Score: 37.00  E-value: 5.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 124486733  374 KGDCEDHANLLCSLLLGYGLEAFVCVGTKA------KGAPHAWV 411
Cdd:pfam01841  51 KGDCEDFASLFVALLRALGIPARYVTGYLRgpdtvrGGDAHAWV 94
 
Name Accession Description Interval E-value
CEP76-C2 pfam15627
CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ...
 99-258 7.66e-90

CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the new C2 domain that is contained by ciliary CEP76 proteins.


Pssm-ID: 464781  Cd Length: 157  Bit Score: 276.14  E-value: 7.66e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486733   99 TNVDPTRRYLYLQVLGGKAFLEHLQEPEPLPGQICSTFTLCLHYRNQRFRSKPVPCACEPDFHDGFLLEVHREslgDGTR 178
Cdd:pfam15627   1 ALIDPRRRYLYLRVLGGKAFLDHLQEPEPLPGQVCSTFTLHLHFRGQRFRSKPVPCACEPDFREGFLLELPTE---AGSA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486733  179 MADSTTMLSISDPIHMVLIKTDIFGETTLVASYFLEWRSVLGSENGVTNLTVELMGVGTESKVSVGILNIKLEMYPPLSQ 258
Cdd:pfam15627  78 MADATDLLSISDPIHLVLIKTDTAGETTLLSSHFLEWRRVLCSPNGKTGLTVELRGVGAEAKVPAGILDLQLELLPRKRT 157
Transglut_core pfam01841
Transglutaminase-like superfamily; This family includes animal transglutaminases and other ...
 374-411 5.51e-03

Transglutaminase-like superfamily; This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.


Pssm-ID: 376628 [Multi-domain]  Cd Length: 108  Bit Score: 37.00  E-value: 5.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 124486733  374 KGDCEDHANLLCSLLLGYGLEAFVCVGTKA------KGAPHAWV 411
Cdd:pfam01841  51 KGDCEDFASLFVALLRALGIPARYVTGYLRgpdtvrGGDAHAWV 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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