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Conserved domains on  [gi|124517731|ref|NP_001074916|]
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splicing factor Cactin [Rattus norvegicus]

Protein Classification

splicing factor cactin( domain architecture ID 10563375)

splicing factor cactin plays a role in pre-mRNA splicing by facilitating excision of a subset of introns

Gene Ontology:  GO:0045087|GO:0000398|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CactinC_cactus pfam09732
Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of ...
 639-763 2.23e-92

Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain pfam10312 further upstream.


:

Pssm-ID: 401611  Cd Length: 125  Bit Score: 284.10  E-value: 2.23e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731  639 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIRKRATPEYFLEACADNRDFAILRFHAG 718
Cdd:pfam09732   1 WSDKYRPRKPRYFNRVKTGYEWNKYNQTHYDSDNPPPKVVQGYKFNIFYPDLIDKTKTPTYKIEKDPNEPDTCLIRFHAG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 124517731  719 PPYEDIAFKIVSREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 763
Cdd:pfam09732  81 PPYEDIAFRIVNKEWDYSHKRGFKSSFDRGVLQLYFNFKRSRYRR 125
Cactin_mid pfam10312
Conserved mid region of cactin; This is the conserved middle region of a family of proteins ...
 286-473 2.93e-75

Conserved mid region of cactin; This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus pfam09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localization signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.


:

Pssm-ID: 463049 [Multi-domain]  Cd Length: 186  Bit Score: 241.31  E-value: 2.93e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731  286 REKEAEHFKTWEEQEDSFHLRQAKLRSKIRIRDGRAKPIDLLAKYISAED------DDLAVEMHEPYTFLNGLTVADMED 359
Cdd:pfam10312   1 REREAEQFKEWEAKEDEFHLEQAKKRAEIRIREGRAKPIDLLAKNLRFVDperdplDDLEIELDEPYAILEGLTLEELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731  360 LLEDIQVYMELEQ-GKNVDFWRDMTTITEDEIAKLRKleasgkgpGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIE 438
Cdd:pfam10312  81 LEEDIKTYLELEKdGKNREFWNAMLVVCEDELEKLKK--------SAREGGIHSSVEADIDKILKGKTYEELEALEKQIK 152

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 124517731  439 GKIRAGGPnLDMGYWESLLQQLRAHMARARLRERH 473
Cdd:pfam10312 153 AKLRSGEP-IDVDYWESLLKKLKVYKAKARLREVH 186
 
Name Accession Description Interval E-value
CactinC_cactus pfam09732
Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of ...
 639-763 2.23e-92

Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain pfam10312 further upstream.


Pssm-ID: 401611  Cd Length: 125  Bit Score: 284.10  E-value: 2.23e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731  639 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIRKRATPEYFLEACADNRDFAILRFHAG 718
Cdd:pfam09732   1 WSDKYRPRKPRYFNRVKTGYEWNKYNQTHYDSDNPPPKVVQGYKFNIFYPDLIDKTKTPTYKIEKDPNEPDTCLIRFHAG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 124517731  719 PPYEDIAFKIVSREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 763
Cdd:pfam09732  81 PPYEDIAFRIVNKEWDYSHKRGFKSSFDRGVLQLYFNFKRSRYRR 125
CactinC_cactus smart01050
Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of ...
 639-763 5.00e-77

Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain further upstream.


Pssm-ID: 214996  Cd Length: 129  Bit Score: 243.80  E-value: 5.00e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731   639 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIRKRATPEYFLEAC----ADNRDFAILR 714
Cdd:smart01050   1 WEDKYRLRKPRYFNRVKTGYDWNKYNQTHYDNDNPPPKIVQGYKFNIFYPDLIDKGKAPRYRIESSfeieKPDDDTCLLR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 124517731   715 FHAGPPYEDIAFKIVSREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 763
Cdd:smart01050  81 FSAGPPYEDIAFKIVNREWDYSHRGGFKSSFDNGILQLQFNFKKTRYRR 129
Cactin_mid pfam10312
Conserved mid region of cactin; This is the conserved middle region of a family of proteins ...
 286-473 2.93e-75

Conserved mid region of cactin; This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus pfam09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localization signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.


Pssm-ID: 463049 [Multi-domain]  Cd Length: 186  Bit Score: 241.31  E-value: 2.93e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731  286 REKEAEHFKTWEEQEDSFHLRQAKLRSKIRIRDGRAKPIDLLAKYISAED------DDLAVEMHEPYTFLNGLTVADMED 359
Cdd:pfam10312   1 REREAEQFKEWEAKEDEFHLEQAKKRAEIRIREGRAKPIDLLAKNLRFVDperdplDDLEIELDEPYAILEGLTLEELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731  360 LLEDIQVYMELEQ-GKNVDFWRDMTTITEDEIAKLRKleasgkgpGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIE 438
Cdd:pfam10312  81 LEEDIKTYLELEKdGKNREFWNAMLVVCEDELEKLKK--------SAREGGIHSSVEADIDKILKGKTYEELEALEKQIK 152

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 124517731  439 GKIRAGGPnLDMGYWESLLQQLRAHMARARLRERH 473
Cdd:pfam10312 153 AKLRSGEP-IDVDYWESLLKKLKVYKAKARLREVH 186
 
Name Accession Description Interval E-value
CactinC_cactus pfam09732
Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of ...
 639-763 2.23e-92

Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain pfam10312 further upstream.


Pssm-ID: 401611  Cd Length: 125  Bit Score: 284.10  E-value: 2.23e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731  639 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIRKRATPEYFLEACADNRDFAILRFHAG 718
Cdd:pfam09732   1 WSDKYRPRKPRYFNRVKTGYEWNKYNQTHYDSDNPPPKVVQGYKFNIFYPDLIDKTKTPTYKIEKDPNEPDTCLIRFHAG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 124517731  719 PPYEDIAFKIVSREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 763
Cdd:pfam09732  81 PPYEDIAFRIVNKEWDYSHKRGFKSSFDRGVLQLYFNFKRSRYRR 125
CactinC_cactus smart01050
Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of ...
 639-763 5.00e-77

Cactus-binding C-terminus of cactin protein; CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo. Most members of the family also have a Cactin_mid domain further upstream.


Pssm-ID: 214996  Cd Length: 129  Bit Score: 243.80  E-value: 5.00e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731   639 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIRKRATPEYFLEAC----ADNRDFAILR 714
Cdd:smart01050   1 WEDKYRLRKPRYFNRVKTGYDWNKYNQTHYDNDNPPPKIVQGYKFNIFYPDLIDKGKAPRYRIESSfeieKPDDDTCLLR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 124517731   715 FHAGPPYEDIAFKIVSREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 763
Cdd:smart01050  81 FSAGPPYEDIAFKIVNREWDYSHRGGFKSSFDNGILQLQFNFKKTRYRR 129
Cactin_mid pfam10312
Conserved mid region of cactin; This is the conserved middle region of a family of proteins ...
 286-473 2.93e-75

Conserved mid region of cactin; This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus pfam09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localization signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo.


Pssm-ID: 463049 [Multi-domain]  Cd Length: 186  Bit Score: 241.31  E-value: 2.93e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731  286 REKEAEHFKTWEEQEDSFHLRQAKLRSKIRIRDGRAKPIDLLAKYISAED------DDLAVEMHEPYTFLNGLTVADMED 359
Cdd:pfam10312   1 REREAEQFKEWEAKEDEFHLEQAKKRAEIRIREGRAKPIDLLAKNLRFVDperdplDDLEIELDEPYAILEGLTLEELEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124517731  360 LLEDIQVYMELEQ-GKNVDFWRDMTTITEDEIAKLRKleasgkgpGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIE 438
Cdd:pfam10312  81 LEEDIKTYLELEKdGKNREFWNAMLVVCEDELEKLKK--------SAREGGIHSSVEADIDKILKGKTYEELEALEKQIK 152

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 124517731  439 GKIRAGGPnLDMGYWESLLQQLRAHMARARLRERH 473
Cdd:pfam10312 153 AKLRSGEP-IDVDYWESLLKKLKVYKAKARLREVH 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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