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Conserved domains on  [gi|127139277|ref|NP_001076015|]
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stefin A-like protein [Mus musculus]

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-91 1.66e-24

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 88.16  E-value: 1.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127139277   4 GGVSEASRATPEIQKIADKVRPQLEAKT-NKKYEKFEAVEYKTQAVAGENIFIKMDVGHGCFI-HIKVFNGPTGKDN--Y 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80

                         90
                 ....*....|..
gi 127139277  80 ELHGYQTDKTKD 91
Cdd:pfam00031 81 GLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-91 1.66e-24

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 88.16  E-value: 1.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127139277   4 GGVSEASRATPEIQKIADKVRPQLEAKT-NKKYEKFEAVEYKTQAVAGENIFIKMDVGHGCFI-HIKVFNGPTGKDN--Y 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80

                         90
                 ....*....|..
gi 127139277  80 ELHGYQTDKTKD 91
Cdd:pfam00031 81 GLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-62 1.60e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 65.91  E-value: 1.60e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127139277     1 MSLGGVSEASRATPEIQKIADKVRPQLEAKTNKKYE--KFEAVEYKTQAVAGENIFIKMDVGHG 62
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGET 64
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-86 5.33e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 51.71  E-value: 5.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127139277   4 GGVSEASRATPEIQKIADKVRPQLEAKTNKKY-EKFEAVEYKTQAVAGENIFIKMDVGHGcfIHIKVFNGPTGKDNYELH 82
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGDT--NCKKSSVPLDCPDCKLLE 78


                 ....
gi 127139277  83 GYQT 86
Cdd:cd00042   79 EGKK 82
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-91 1.66e-24

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 88.16  E-value: 1.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127139277   4 GGVSEASRATPEIQKIADKVRPQLEAKT-NKKYEKFEAVEYKTQAVAGENIFIKMDVGHGCFI-HIKVFNGPTGKDN--Y 79
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPLLDEkwL 80

                         90
                 ....*....|..
gi 127139277  80 ELHGYQTDKTKD 91
Cdd:pfam00031 81 GLCSAQVYKVPW 92
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-62 1.60e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 65.91  E-value: 1.60e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 127139277     1 MSLGGVSEASRATPEIQKIADKVRPQLEAKTNKKYE--KFEAVEYKTQAVAGENIFIKMDVGHG 62
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGET 64
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-86 5.33e-10

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 51.71  E-value: 5.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 127139277   4 GGVSEASRATPEIQKIADKVRPQLEAKTNKKY-EKFEAVEYKTQAVAGENIFIKMDVGHGcfIHIKVFNGPTGKDNYELH 82
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGDT--NCKKSSVPLDCPDCKLLE 78


                 ....
gi 127139277  83 GYQT 86
Cdd:cd00042   79 EGKK 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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