BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840  158 NHPDYFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIhHTDSQINIETIENMM 237
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFM-YTGKLISEENVDDLL 84

                          90       100
                  ....*....|....*....|.
gi 133901840  238 VLADLFLIDCLMCCCEKILIK 258
Cdd:pfam00651  85 AAADKLQIPSLVDKCEEFLIK 105

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840  158 NHPDYFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIhHTDSQINIETIENMM 237
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFM-YTGKLISEENVDDLL 84

                          90       100
                  ....*....|....*....|.
gi 133901840  238 VLADLFLIDCLMCCCEKILIK 258
Cdd:pfam00651  85 AAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 163 FDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADL 242
Cdd:cd18251   24 FDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAACQ 103

                         90
                 ....*....|..
gi 133901840 243 FLI-DCLMCCCE 253
Cdd:cd18251  104 LQIpEVIGFCCD 115

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840  158 NHPDYFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIhHTDSQINIETIENMM 237
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFM-YTGKLISEENVDDLL 84

                          90       100
                  ....*....|....*....|.
gi 133901840  238 VLADLFLIDCLMCCCEKILIK 258
Cdd:pfam00651  85 AAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 163 FDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADL 242
Cdd:cd18251   24 FDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAACQ 103

                         90
                 ....*....|..
gi 133901840 243 FLI-DCLMCCCE 253
Cdd:cd18251  104 LQIpEVIGFCCD 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 158 NHPDYFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQE--AVEIPGVKYDDVIQFLNFIHHTDSQINIETIEN 235
Cdd:cd18245   10 EEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGStyKIELEGISVEVMEEILDYIYTGQIKLSEDNIQD 89

                         90
                 ....*....|....*....
gi 133901840 236 MMVLAD-LFLIDCLMCCCE 253
Cdd:cd18245   90 IVQAADlLLMTDLKDLCCE 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 153 LDFSTNHPDYFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIET 232
Cdd:cd18298    3 LRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPED 82

                         90       100
                 ....*....|....*....|....
gi 133901840 233 IENMMVLADLFLIDCLMCCCEKIL 256
Cdd:cd18298   83 AIGLLDLANSYCEERLKKLCEDII 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 133901840 165 GVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHH 223
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYG 59

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 161 DYFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLA 240
Cdd:cd18256   19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAA 98

                         90       100
                 ....*....|....*....|....
gi 133901840 241 DLF-LIDCLMCCCEKILIKADSVN 263
Cdd:cd18256   99 DMLqLTEVVEICCEFLKGQLHPSN 122

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 158 NHPDYFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIhHTDSQINIETIENM- 236
Cdd:cd18300    5 NKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYL-YTDQAPILEDGDCVg 83

                         90       100
                 ....*....|....*....|...
gi 133901840 237 -MVLADLFLIDCLMCCCEKILIK 258
Cdd:cd18300   84 lIVLANRLCLPRLVALCEQYIVK 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 150 RKMLDFsTNHPDYFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQIN 229
Cdd:cd18336    8 RKMENY-LQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELK 86

                         90       100
                 ....*....|....*....|....*....
gi 133901840 230 IETIENMMVLADLFLIDCLMCCCEKILIK 258
Cdd:cd18336   87 EDTIESLLAAACLLQLSQVIDVCCNFLMK 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 164 DGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADLF 243
Cdd:cd18237   23 DVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQY 102

                         90
                 ....*....|
gi 133901840 244 LIDCL--MCC 251
Cdd:cd18237  103 QIEPVkkMCV 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 164 DGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADLF 243
Cdd:cd18339   23 DVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLL 102

                         90
                 ....*....|.
gi 133901840 244 -LIDCLMCCCE 253
Cdd:cd18339  103 qLMDVRQNCCD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 164 DGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADLF 243
Cdd:cd18240   19 DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLPAADQF 98

                         90
                 ....*....|.
gi 133901840 244 LIDCLM-CCCE 253
Cdd:cd18240   99 NIMGIVkACCD 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 178 KRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADLFLIDCLMCCCEKILI 257
Cdd:cd18252   38 KAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLV 117

                 .
gi 133901840 258 K 258
Cdd:cd18252  118 R 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 164 DGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADLF 243
Cdd:cd18335   21 DVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLL 100

                         90
                 ....*....|....*
gi 133901840 244 LIDCLMCCCEKILIK 258
Cdd:cd18335  101 QLSQVVEVCCHFLMK 115

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 171 NKKIYVQKRYLATKSTYFWNIFFGDFKEKEqeaVEIPGvKYDDVIQFLNFIHHTDSQINIETIENMMVLADLFLIDCLMC 250
Cdd:PHA03098  20 GGIIKVHKIILSSSSEYFKKMFKNNFKENE---INLNI-DYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLIN 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133901840 251 CCEKILIK-ADSVNLAKKLIWAERFAL----NELMDHCLDGFKKM---QDFVEFRKNEFYAGVSDD 308
Cdd:PHA03098  96 LCINYIIKiIDDNNCIDIYRFSFFYGCkklySAAYNYIRNNIELIyndPDFIYLSKNELIKILSDD 161

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 164 DGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADLF 243
Cdd:cd18247   21 DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVGASFL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 162 YFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKyDDVIQFL-NFIHHTDSQINIETIENMMVLA 240
Cdd:cd18272   32 FADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVS-ESVFQLLvDYIYHGTVKLRVEELQETYEVA 110

                         90       100       110
                 ....*....|....*....|....*....|
gi 133901840 241 DLFLIDCLMCCCEKILIKADSVNLAKKLIW 270
Cdd:cd18272  111 DMYQLTALFEECSRFLARTVQVRNCLQVMW 140

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 164 DGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADLF 243
Cdd:cd18238   17 DVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASLL 96

                         90
                 ....*....|.
gi 133901840 244 LIDCLM-CCCE 253
Cdd:cd18238   97 QVEEVAkACCE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 172 KKIYVQKRYLATKSTYFWNIFFGDFKEKEQEaVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADLFLIDCLMCC 251
Cdd:cd18282   21 QRIPAHKYVLATGSSVFYAMFYGGLAENKNE-IEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARA 99

                 .
gi 133901840 252 C 252
Cdd:cd18282  100 C 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 151 KMLDFSTNHPDYFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINI 230
Cdd:cd18337   12 KKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTGRLELKE 91

                         90       100
                 ....*....|....*....|....*...
gi 133901840 231 ETIENMMVLADLFLIDCLMCCCEKILIK 258
Cdd:cd18337   92 DNIECLLSTACLLQLSQVVEACCKFLMK 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 162 YFDGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIhHTDSQINIETI-ENMMVLA 240
Cdd:cd18343   21 FTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFI-YTGKAPNLDKMaDNLLAAA 99

                         90       100
                 ....*....|....*....|..
gi 133901840 241 DLFLIDCLMCCCEKILIKADSV 262
Cdd:cd18343  100 DKYALERLKVMCEEALCNNLSV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 133901840 164 DGVLLVENKKIYVQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNF 220
Cdd:cd18306   20 DVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNY 76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133901840 164 DGVLLVENKKIY-VQKRYLATKSTYFWNIFFGDFKEKEQEAVEIPGVKYDDVIQFLNFIHHTDSQINIETIENMMVLADL 242
Cdd:cd18274   24 DIVVEVDHGKTFsCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASI 103

                         90
                 ....*....|....*
gi 133901840 243 FLIDCLMCCCEKILI 257
Cdd:cd18274  104 FQIPSLQDQCAQFMI 118