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Conserved domains on  [gi|144226227|ref|NP_001077374|]
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fetuin-B isoform 1 precursor [Mus musculus]

Protein Classification

C1 family peptidase; cystatin family protein( domain architecture ID 10945459)

C1 family peptidase (also called papain family protein) is a papain-like cysteine peptidase that catalyzes the hydrolysis of peptide bonds in substrates using a catalytic dyad of Cys and His residues| cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 157-241 3.78e-14

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 67.36  E-value: 3.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227  157 CPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQ---ASCSLQhsDSEP 233
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKkllEDCPLL--DEKW 79


                  ....*...
gi 144226227  234 VGICQGST 241
Cdd:pfam00031  80 LGLCSAQV 87
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 34-122 5.17e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 47.81  E-value: 5.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227    34 LHPLGCNDSEVLAVAGFALQNINRDQKDGYMLSLNRVHDVREhyQEDMGSLFYLTLDVLETDCHVLSRKaQKDCKprmFY 113
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKS--QVVAGTNYYLKVEVGETNCKKLSVD-LENCP---FL 79


                   ....*....
gi 144226227   114 ESVYGQCKA 122
Cdd:smart00043  80 DQGEKFCTA 88
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 157-241 3.78e-14

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 67.36  E-value: 3.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227  157 CPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQ---ASCSLQhsDSEP 233
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKkllEDCPLL--DEKW 79


                  ....*...
gi 144226227  234 VGICQGST 241
Cdd:pfam00031  80 LGLCSAQV 87
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 153-237 5.74e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 64.76  E-value: 5.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227   153 TCPDCPSPIDLSNPSALEAATESLAKFNSKSpSKKYEL--VKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQ---ASCSLQ 227
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKS-NDKYELrvIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSvdlENCPFL 79

                           90
                   ....*....|
gi 144226227   228 HsdsEPVGIC 237
Cdd:smart00043  80 D---QGEKFC 86
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 156-230 2.52e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 54.40  E-value: 2.52e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 144226227 156 DCPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQASCSLQHSD 230
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCK 75
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 34-122 5.17e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 47.81  E-value: 5.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227    34 LHPLGCNDSEVLAVAGFALQNINRDQKDGYMLSLNRVHDVREhyQEDMGSLFYLTLDVLETDCHVLSRKaQKDCKprmFY 113
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKS--QVVAGTNYYLKVEVGETNCKKLSVD-LENCP---FL 79


                   ....*....
gi 144226227   114 ESVYGQCKA 122
Cdd:smart00043  80 DQGEKFCTA 88
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 34-130 9.00e-04

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 38.08  E-value: 9.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227   34 LHPLGCNDSEVLAVAGFALQNINRdQKDGYMLSLNRVHDVREhyQEDMGSLFYLTLDVLETDChVLSRKAQKDCKPRMfy 113
Cdd:pfam00031   3 LSPIPDNSPELQEALDFALAEYNA-KTDNYYFELVEVKRAKS--QVVAGTNYFIKVEVGETDC-SKSKKLLEDCPLLD-- 76

                          90
                  ....*....|....*..
gi 144226227  114 ESVYGQCKamFHINKPR 130
Cdd:pfam00031  77 EKWLGLCS--AQVYKVP 91
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 34-122 1.04e-03

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 38.22  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227  34 LHPLGCNDSEVLAVAGFALQNINRDQKDGYmLSLNRVHDVREhyQEDMGSLFYLTLDVLETDCHVLSRKaqKDCKPRMFY 113
Cdd:cd00042    3 PSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKS--QVVAGTNYYITVEAGDTNCKKSSVP--LDCPDCKLL 77

                         90
                 ....*....|
gi 144226227 114 ES-VYGQCKA 122
Cdd:cd00042   78 EEgKKKFCTA 87
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 157-241 3.78e-14

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 67.36  E-value: 3.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227  157 CPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQ---ASCSLQhsDSEP 233
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKkllEDCPLL--DEKW 79


                  ....*...
gi 144226227  234 VGICQGST 241
Cdd:pfam00031  80 LGLCSAQV 87
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 153-237 5.74e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 64.76  E-value: 5.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227   153 TCPDCPSPIDLSNPSALEAATESLAKFNSKSpSKKYEL--VKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQ---ASCSLQ 227
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKS-NDKYELrvIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSvdlENCPFL 79

                           90
                   ....*....|
gi 144226227   228 HsdsEPVGIC 237
Cdd:smart00043  80 D---QGEKFC 86
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 156-230 2.52e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 54.40  E-value: 2.52e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 144226227 156 DCPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQASCSLQHSD 230
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCK 75
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 34-122 5.17e-07

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 47.81  E-value: 5.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227    34 LHPLGCNDSEVLAVAGFALQNINRDQKDGYMLSLNRVHDVREhyQEDMGSLFYLTLDVLETDCHVLSRKaQKDCKprmFY 113
Cdd:smart00043   6 PSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKS--QVVAGTNYYLKVEVGETNCKKLSVD-LENCP---FL 79


                   ....*....
gi 144226227   114 ESVYGQCKA 122
Cdd:smart00043  80 DQGEKFCTA 88
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 34-130 9.00e-04

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 38.08  E-value: 9.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227   34 LHPLGCNDSEVLAVAGFALQNINRdQKDGYMLSLNRVHDVREhyQEDMGSLFYLTLDVLETDChVLSRKAQKDCKPRMfy 113
Cdd:pfam00031   3 LSPIPDNSPELQEALDFALAEYNA-KTDNYYFELVEVKRAKS--QVVAGTNYFIKVEVGETDC-SKSKKLLEDCPLLD-- 76

                          90
                  ....*....|....*..
gi 144226227  114 ESVYGQCKamFHINKPR 130
Cdd:pfam00031  77 EKWLGLCS--AQVYKVP 91
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 34-122 1.04e-03

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 38.22  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226227  34 LHPLGCNDSEVLAVAGFALQNINRDQKDGYmLSLNRVHDVREhyQEDMGSLFYLTLDVLETDCHVLSRKaqKDCKPRMFY 113
Cdd:cd00042    3 PSDIPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKS--QVVAGTNYYITVEAGDTNCKKSSVP--LDCPDCKLL 77

                         90
                 ....*....|
gi 144226227 114 ES-VYGQCKA 122
Cdd:cd00042   78 EEgKKKFCTA 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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