NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|145334221|ref|NP_001078491|]
View 

GTP binding protein beta 1 [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-364 2.81e-81

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 249.94  E-value: 2.81e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221  52 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSL 131
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 132 SstadkdgTVPVSRMLTGHRGYVSCCQYVPneDAHLITSSG-DQTCILWDVTTGLKTSVFggefqSGHTADVLSVSISGS 210
Cdd:cd00200   81 E-------TGECVRTLTGHTSYVSSVAFSP--DGRILSSSSrDKTIKVWDVETGKCLTTL-----RGHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 211 npNWFISGSC-DSTARLWDTRAASRaVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHgdgeN 289
Cdd:cd00200  147 --GTFVASSSqDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH----E 219

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334221 290 GPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLGlqqdSHRNRISCLGLSADGSALCTGSWDSNLKIWA 364
Cdd:cd00200  220 NGVNSVAFSPDGYLLASG-SEDGTIRVWDLRTGECVQTLS----GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-364 2.81e-81

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 249.94  E-value: 2.81e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221  52 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSL 131
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 132 SstadkdgTVPVSRMLTGHRGYVSCCQYVPneDAHLITSSG-DQTCILWDVTTGLKTSVFggefqSGHTADVLSVSISGS 210
Cdd:cd00200   81 E-------TGECVRTLTGHTSYVSSVAFSP--DGRILSSSSrDKTIKVWDVETGKCLTTL-----RGHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 211 npNWFISGSC-DSTARLWDTRAASRaVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHgdgeN 289
Cdd:cd00200  147 --GTFVASSSqDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH----E 219

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334221 290 GPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLGlqqdSHRNRISCLGLSADGSALCTGSWDSNLKIWA 364
Cdd:cd00200  220 NGVNSVAFSPDGYLLASG-SEDGTIRVWDLRTGECVQTLS----GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
52-363 1.75e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 1.75e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221  52 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSL 131
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 132 SSTAdkdgtvpVSRMLTGHRGYVSCCQYVPNEDaHLITSSGDQTCILWDVTTGLKTSVFGgefqsGHTADVLSVSISgSN 211
Cdd:COG2319  192 ATGK-------LLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLT-----GHSGSVRSVAFS-PD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 212 PNWFISGSCDSTARLWDTrAASRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHGDgengP 291
Cdd:COG2319  258 GRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG----A 332

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145334221 292 VTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLglqqDSHRNRISCLGLSADGSALCTGSWDSNLKIW 363
Cdd:COG2319  333 VRSVAFSPDGKTLASG-SDDGTVRLWDLATGELLRTL----TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 236-271 1.57e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.57e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 145334221   236 VRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYD 271
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-271 2.02e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.02e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145334221  236 VRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYD 271
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 241-362 1.04e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 241 GHEGDVNTVKFFP-DGYRFGTGSDDGTCRLYDIRT-GHQLQVYQP--HGDGENGPVTSIAFSVSGRLLFAGYASNNTCYV 316
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEeGLTQNISDPivHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 145334221 317 WDTLLGEVVLDLglqqDSHRNRISCLGLSADGSALCTGSWDSNLKI 362
Cdd:PTZ00421 153 WDVERGKAVEVI----KCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-364 2.81e-81

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 249.94  E-value: 2.81e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221  52 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSL 131
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 132 SstadkdgTVPVSRMLTGHRGYVSCCQYVPneDAHLITSSG-DQTCILWDVTTGLKTSVFggefqSGHTADVLSVSISGS 210
Cdd:cd00200   81 E-------TGECVRTLTGHTSYVSSVAFSP--DGRILSSSSrDKTIKVWDVETGKCLTTL-----RGHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 211 npNWFISGSC-DSTARLWDTRAASRaVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHgdgeN 289
Cdd:cd00200  147 --GTFVASSSqDGTIKLWDLRTGKC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH----E 219

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334221 290 GPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLGlqqdSHRNRISCLGLSADGSALCTGSWDSNLKIWA 364
Cdd:cd00200  220 NGVNSVAFSPDGYLLASG-SEDGTIRVWDLRTGECVQTLS----GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
52-363 1.75e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 194.74  E-value: 1.75e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221  52 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSL 131
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 132 SSTAdkdgtvpVSRMLTGHRGYVSCCQYVPNEDaHLITSSGDQTCILWDVTTGLKTSVFGgefqsGHTADVLSVSISgSN 211
Cdd:COG2319  192 ATGK-------LLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLT-----GHSGSVRSVAFS-PD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 212 PNWFISGSCDSTARLWDTrAASRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHGDgengP 291
Cdd:COG2319  258 GRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG----A 332

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145334221 292 VTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLglqqDSHRNRISCLGLSADGSALCTGSWDSNLKIW 363
Cdd:COG2319  333 VRSVAFSPDGKTLASG-SDDGTVRLWDLATGELLRTL----TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
36-363 1.82e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 184.34  E-value: 1.82e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221  36 AAQGRTRVSFGATDLVCCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQ 115
Cdd:COG2319   54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 116 SVACGGLDSVCSIFSLSSTAdkdgtvpVSRMLTGHRGYVSCCQYVPNeDAHLITSSGDQTCILWDVTTGLKTSVFggefq 195
Cdd:COG2319  134 TLASGSADGTVRLWDLATGK-------LLRTLTGHSGAVTSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRTL----- 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 196 SGHTADVLSVSISgSNPNWFISGSCDSTARLWDTrAASRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTG 275
Cdd:COG2319  201 TGHTGAVRSVAFS-PDGKLLASGSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 276 HQLQVYQPHgdgeNGPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLglqqDSHRNRISCLGLSADGSALCTGS 355
Cdd:COG2319  279 ELLRTLTGH----SGGVNSVAFSPDGKLLASG-SDDGTVRLWDLATGKLLRTL----TGHTGAVRSVAFSPDGKTLASGS 349


                 ....*...
gi 145334221 356 WDSNLKIW 363
Cdd:COG2319  350 DDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
54-319 4.00e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 4.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221  54 RTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSLSs 133
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA- 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 134 tadkdgTVPVSRMLTGHRGYVSCCQYVPNeDAHLITSSGDQTCILWDVTTGLKTSVFGgefqsGHTADVLSVSISGsNPN 213
Cdd:COG2319  235 ------TGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTLT-----GHSGGVNSVAFSP-DGK 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 214 WFISGSCDSTARLWDTrAASRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHGdgenGPVT 293
Cdd:COG2319  302 LLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT----GAVT 376

                        250       260
                 ....*....|....*....|....*.
gi 145334221 294 SIAFSVSGRLLFAGyASNNTCYVWDT 319
Cdd:COG2319  377 SVAFSPDGRTLASG-SADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
52-274 1.79e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.76  E-value: 1.79e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221  52 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNALTSQKTHAIKLPCAWVMTCAFSPNGQSVACGGLDSVCSIFSL 131
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 132 SSTAdkdgtvpVSRMLTGHRGYVSCCQYVPNeDAHLITSSGDQTCILWDVTTGLKTSVFggefqSGHTADVLSVSISgSN 211
Cdd:COG2319  276 ATGE-------LLRTLTGHSGGVNSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRTL-----TGHTGAVRSVAFS-PD 341

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145334221 212 PNWFISGSCDSTARLWDTrAASRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRT 274
Cdd:COG2319  342 GKTLASGSDDGTVRLWDL-ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 144-371 7.45e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 7.45e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 144 SRMLTGHRGYVSCCQYVPNEDaHLITSSGDQTCILWDVTTGLKTSVFggefqSGHTADVLSVSISGSNpNWFISGSCDST 223
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTL-----KGHTGPVRDVAASADG-TYLASGSSDKT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 224 ARLWDTRAaSRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTGHQLQVYQPHgdgeNGPVTSIAFSVSGRL 303
Cdd:cd00200   75 IRLWDLET-GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH----TDWVNSVAFSPDGTF 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145334221 304 LFagyasnntcyvwdtllgevvldlglqqdshrnrisclglsadgsalcTGSWDSNLKIWAFGGHRRV 371
Cdd:cd00200  150 VA-----------------------------------------------SSSQDGTIKLWDLRTGKCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
177-363 3.64e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 3.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 177 ILWDVTTGLKTSVFGGEFQSGHTADVLSVSISGSNPNWFISGSCDSTARLWDTRAASRAVRTFHGHEGDVNTVKFFPDGY 256
Cdd:COG2319   12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 257 RFGTGSDDGTCRLYDIRTGHQLQVYQPHGDgengPVTSIAFSVSGRLLFAGyASNNTCYVWDTLLGEVVLDLglqqDSHR 336
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASG-SADGTVRLWDLATGKLLRTL----TGHS 162

                        170       180
                 ....*....|....*....|....*..
gi 145334221 337 NRISCLGLSADGSALCTGSWDSNLKIW 363
Cdd:COG2319  163 GAVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 236-271 1.57e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 1.57e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 145334221   236 VRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYD 271
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-88 2.77e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.77e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 145334221    52 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWN 88
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
236-271 2.02e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.02e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145334221  236 VRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYD 271
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
52-88 2.63e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 145334221   52 CCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWN 88
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-88 4.04e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 4.04e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 145334221  51 VCCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWN 88
Cdd:cd00200  252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 241-362 1.04e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 241 GHEGDVNTVKFFP-DGYRFGTGSDDGTCRLYDIRT-GHQLQVYQP--HGDGENGPVTSIAFSVSGRLLFAGYASNNTCYV 316
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEeGLTQNISDPivHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 145334221 317 WDTLLGEVVLDLglqqDSHRNRISCLGLSADGSALCTGSWDSNLKI 362
Cdd:PTZ00421 153 WDVERGKAVEVI----KCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 105-355 2.82e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 105 VMTCAFSPNGQSVACGGLDSVCSIFSLSSTAD--KDGTVPVSRmLTGHRGYVSCC--QYVPNEDAhliTSSGDQTCILWD 180
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKdgRDIHYPVVE-LASRSKLSGICwnSYIKSQVA---SSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 181 VT-TGLKTSVfggefqSGHTADVLSVSISGSNPNWFISGSCDSTARLWDTRAASR--AVRTfhghEGDVNTVKFFPD-GY 256
Cdd:PLN00181 562 VArSQLVTEM------KEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSigTIKT----KANICCVQFPSEsGR 631

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 257 RFGTGSDDGTCRLYDIRTGhqlQVYQPHGDGENGPVTSIAFSVSGRLLFAgyASNNTCYVWDTLLGEVvldlGLQQD--- 333
Cdd:PLN00181 632 SLAFGSADHKVYYYDLRNP---KLPLCTMIGHSKTVSYVRFVDSSTLVSS--STDNTLKLWDLSMSIS----GINETplh 702

                        250       260
                 ....*....|....*....|....*
gi 145334221 334 ---SHRNRISCLGLSADGSALCTGS 355
Cdd:PLN00181 703 sfmGHTNVKNFVGLSVSDGYIATGS 727
WD40 COG2319
WD40 repeat [General function prediction only];
47-89 3.61e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 3.61e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 145334221  47 ATDLVCCRTLQGHTGKVYSLDWTPERNRIVSASQDGRLIVWNA 89
Cdd:COG2319  359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 pfam00400
WD domain, G-beta repeat;
196-228 4.26e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 4.26e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 145334221  196 SGHTADVLSVSISgSNPNWFISGSCDSTARLWD 228
Cdd:pfam00400   8 EGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 130-275 4.40e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.19  E-value: 4.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221 130 SLSSTA----DKDGTVPVSR-MLTGHRGYVSCCQYVPNEDAHLITSSGDQTCILWDV-TTGLKTSVFGG--EFQsGHTAD 201
Cdd:PTZ00421  49 QLGSTAvlkhTDYGKLASNPpILLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpEEGLTQNISDPivHLQ-GHTKK 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145334221 202 VLSVSISGSNPNWFISGSCDSTARLWDTRAAsRAVRTFHGHEGDVNTVKFFPDGYRFGTGSDDGTCRLYDIRTG 275
Cdd:PTZ00421 128 VGIVSFHPSAMNVLASAGADMVVNVWDVERG-KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 196-228 1.73e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 145334221   196 SGHTADVLSVSISGSNpNWFISGSCDSTARLWD 228
Cdd:smart00320   9 KGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-180 2.15e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.15e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 145334221   145 RMLTGHRGYVSCCQYVPNEDaHLITSSGDQTCILWD 180
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 261-343 2.64e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 2.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334221  261 GSDDGTCRLYdiRTGHQlQVYQPHGDGENGPVTSIAFSVSGRLLFAGYaSNNTCYVWDTLLGEVVLDLglqqDSHRNRIS 340
Cdd:pfam12894  13 ATEDGELLLH--RLNWQ-RVWTLSPDKEDLEVTSLAWRPDGKLLAVGY-SDGTVRLLDAENGKIVHHF----SAGSDLIT 84


                  ...
gi 145334221  341 CLG 343
Cdd:pfam12894  85 CLG 87
WD40 pfam00400
WD domain, G-beta repeat;
335-363 3.34e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|....*....
gi 145334221  335 HRNRISCLGLSADGSALCTGSWDSNLKIW 363
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
145-180 4.02e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145334221  145 RMLTGHRGYVSCCQYVPNEDaHLITSSGDQTCILWD 180
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 333-363 5.22e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 5.22e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 145334221   333 DSHRNRISCLGLSADGSALCTGSWDSNLKIW 363
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH