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Conserved domains on  [gi|145334395|ref|NP_001078579|]
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sterol methyltransferase 1 [Arabidopsis thaliana]

Protein Classification

sterol methyltransferase( domain architecture ID 18602716)

sterol methyltransferase such as cycloartenol-C-24-methyltransferase that catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of cycloartenol to form 24-methylene cycloartenol

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047|GO:0016126|GO:0032259
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sterol_MT_C pfam08498
Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a ...
 271-336 1.11e-32

Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a methyltransferase domain (pfam08241) in fungal and plant sterol methyltransferases.


:

Pssm-ID: 430034  Cd Length: 66  Bit Score: 116.00  E-value: 1.11e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145334395  271 LSSFRLTAVGRFITKNMVKILEYIRLAPQGSQRVSNFLEQAAEGLVDGGRREIFTPMYFFLARKPE 336
Cdd:pfam08498   1 FTVFRMTKLGRFITHNLVGVLEKLGLAPKGTQKVAESLAKAADALVAGGKKGIFTPMYLFVARKPL 66
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 81-207 8.14e-29

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 108.16  E-value: 8.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  81 RHEHFLALqLGIQPGQKVLDVGCGIGGPLREIARFSNSVvTGLNNNEYQITRGKELNRLAGVDktCNFVKADFMKMPFPE 160
Cdd:COG2226   10 GREALLAA-LGLRPGARVLDLGCGTGRLALALAERGARV-TGVDISPEMLELARERAAEAGLN--VEFVVGDAEDLPFPD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 145334395 161 NSFDAVYAIEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMTDAFD 207
Cdd:COG2226   86 GSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAE 132
 
Name Accession Description Interval E-value
Sterol_MT_C pfam08498
Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a ...
 271-336 1.11e-32

Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a methyltransferase domain (pfam08241) in fungal and plant sterol methyltransferases.


Pssm-ID: 430034  Cd Length: 66  Bit Score: 116.00  E-value: 1.11e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145334395  271 LSSFRLTAVGRFITKNMVKILEYIRLAPQGSQRVSNFLEQAAEGLVDGGRREIFTPMYFFLARKPE 336
Cdd:pfam08498   1 FTVFRMTKLGRFITHNLVGVLEKLGLAPKGTQKVAESLAKAADALVAGGKKGIFTPMYLFVARKPL 66
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 81-207 8.14e-29

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 108.16  E-value: 8.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  81 RHEHFLALqLGIQPGQKVLDVGCGIGGPLREIARFSNSVvTGLNNNEYQITRGKELNRLAGVDktCNFVKADFMKMPFPE 160
Cdd:COG2226   10 GREALLAA-LGLRPGARVLDLGCGTGRLALALAERGARV-TGVDISPEMLELARERAAEAGLN--VEFVVGDAEDLPFPD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 145334395 161 NSFDAVYAIEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMTDAFD 207
Cdd:COG2226   86 GSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAE 132
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 98-192 1.65e-25

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 98.02  E-value: 1.65e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   98 VLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDktCNFVKADFMKMPFPENSFDAVYAIEATCH--A 175
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLN--VEFVQGDAEDLPFPDGSFDLVVSSGVLHHlpD 78

                          90
                  ....*....|....*..
gi 145334395  176 PDAYGCYKEIYRVLKPG 192
Cdd:pfam13649  79 PDLEAALREIARVLKPG 95
PLN02244 PLN02244
tocopherol O-methyltransferase
 47-201 2.05e-22

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 95.97  E-value: 2.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  47 KYYDLATSFYEYGWGESFH--------------FAQ-RWKGESLResikrhehFLALQLGIQPGQK-VLDVGCGIGGPLR 110
Cdd:PLN02244  63 EFYDESSGVWEDVWGEHMHhgyydpgasrgdhrQAQiRMIEESLA--------WAGVPDDDEKRPKrIVDVGCGIGGSSR 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395 111 EIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENSFDAVYAIEATCHAPDAYGCYKEIYRVLK 190
Cdd:PLN02244 135 YLARKYGANVKGITLSPVQAARANALAAAQGLSDKVSFQVADALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAA 214

                        170
                 ....*....|.
gi 145334395 191 PGQCFAAYEWC 201
Cdd:PLN02244 215 PGGRIIIVTWC 225
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 97-192 6.00e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 69.77  E-value: 6.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  97 KVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKtCNFVKADFMKMPF-PENSFDAVYAIEATCHA 175
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADN-VEVLKGDAEELPPeADESFDVIISDPPLHHL 79

                         90
                 ....*....|....*...
gi 145334395 176 PDAYGC-YKEIYRVLKPG 192
Cdd:cd02440   80 VEDLARfLEEARRLLKPG 97
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 89-199 2.06e-11

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 62.67  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   89 QLGIQPGQKVLDVGCGIGGPLREIARFSNSV--VTGL--NNNEYQITRGKelnrlAGVDKTCNFVKADFMKMPFPENSFD 164
Cdd:TIGR01934  34 LIGVFKGQKVLDVACGTGDLAIELAKSAPDRgkVTGVdfSSEMLEVAKKK-----SELPLNIEFIQADAEALPFEDNSFD 108

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 145334395  165 AV---YAIEATCHAPDAygcYKEIYRVLKPGQCFAAYE 199
Cdd:TIGR01934 109 AVtiaFGLRNVTDIQKA---LREMYRVLKPGGRLVILE 143
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
97-192 1.87e-05

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 45.10  E-value: 1.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395    97 KVLDVGCGIGGPLREIA-RFSNSVVTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENsFDAVYAIEATCHA 175
Cdd:smart00828   2 RVLDFGCGYGSDLIDLAeRHPHLQLHGYTISPEQAEVGRERIRALGLQGRIRIFYRDSAKDPFPDT-YDLVFGFEVIHHI 80

                           90
                   ....*....|....*..
gi 145334395   176 PDAYGCYKEIYRVLKPG 192
Cdd:smart00828  81 KDKMDLFSNISRHLKDG 97
 
Name Accession Description Interval E-value
Sterol_MT_C pfam08498
Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a ...
 271-336 1.11e-32

Sterol methyltransferase C-terminal; This domain is found to the C-terminus of a methyltransferase domain (pfam08241) in fungal and plant sterol methyltransferases.


Pssm-ID: 430034  Cd Length: 66  Bit Score: 116.00  E-value: 1.11e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145334395  271 LSSFRLTAVGRFITKNMVKILEYIRLAPQGSQRVSNFLEQAAEGLVDGGRREIFTPMYFFLARKPE 336
Cdd:pfam08498   1 FTVFRMTKLGRFITHNLVGVLEKLGLAPKGTQKVAESLAKAADALVAGGKKGIFTPMYLFVARKPL 66
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 81-207 8.14e-29

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 108.16  E-value: 8.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  81 RHEHFLALqLGIQPGQKVLDVGCGIGGPLREIARFSNSVvTGLNNNEYQITRGKELNRLAGVDktCNFVKADFMKMPFPE 160
Cdd:COG2226   10 GREALLAA-LGLRPGARVLDLGCGTGRLALALAERGARV-TGVDISPEMLELARERAAEAGLN--VEFVVGDAEDLPFPD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 145334395 161 NSFDAVYAIEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMTDAFD 207
Cdd:COG2226   86 GSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAE 132
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 48-192 3.57e-28

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 106.94  E-value: 3.57e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  48 YYDLATSFYEYGWGES--FHFAQRWKG-ESLRESIKRHEHFLALQLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLN 124
Cdd:COG2230    2 HYDLGNDFYRLFLDPTmtYSCAYFEDPdDTLEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVRVTGVT 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395 125 NNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPEnSFDAVYAIEATCHAPDAY--GCYKEIYRVLKPG 192
Cdd:COG2230   82 LSPEQLEYARERAAEAGLADRVEVRLADYRDLPADG-QFDAIVSIGMFEHVGPENypAYFAKVARLLKPG 150
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 98-192 1.65e-25

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 98.02  E-value: 1.65e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   98 VLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDktCNFVKADFMKMPFPENSFDAVYAIEATCH--A 175
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLN--VEFVQGDAEDLPFPDGSFDLVVSSGVLHHlpD 78

                          90
                  ....*....|....*..
gi 145334395  176 PDAYGCYKEIYRVLKPG 192
Cdd:pfam13649  79 PDLEAALREIARVLKPG 95
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 99-192 3.76e-25

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 96.97  E-value: 3.76e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   99 LDVGCGIGGPLREIARFSNSVvTGLNNNEYQITRGKELNRLAGVdktcNFVKADFMKMPFPENSFDAVYAIEATCHAPDA 178
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARV-TGVDISPEMLELAREKAPREGL----TFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDP 75

                          90
                  ....*....|....
gi 145334395  179 YGCYKEIYRVLKPG 192
Cdd:pfam08241  76 ERALREIARVLKPG 89
PLN02244 PLN02244
tocopherol O-methyltransferase
 47-201 2.05e-22

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 95.97  E-value: 2.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  47 KYYDLATSFYEYGWGESFH--------------FAQ-RWKGESLResikrhehFLALQLGIQPGQK-VLDVGCGIGGPLR 110
Cdd:PLN02244  63 EFYDESSGVWEDVWGEHMHhgyydpgasrgdhrQAQiRMIEESLA--------WAGVPDDDEKRPKrIVDVGCGIGGSSR 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395 111 EIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENSFDAVYAIEATCHAPDAYGCYKEIYRVLK 190
Cdd:PLN02244 135 YLARKYGANVKGITLSPVQAARANALAAAQGLSDKVSFQVADALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAA 214

                        170
                 ....*....|.
gi 145334395 191 PGQCFAAYEWC 201
Cdd:PLN02244 215 PGGRIIIVTWC 225
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 67-192 1.44e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 77.75  E-value: 1.44e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  67 AQRWKgESLRESIKRHehflalqlgIQPGQKVLDVGCGIGGPLREIARFSNSVvTGLNNNEYQITRGKELNRLAGVDktc 146
Cdd:COG2227    7 RDFWD-RRLAALLARL---------LPAGGRVLDVGCGTGRLALALARRGADV-TGVDISPEALEIARERAAELNVD--- 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 145334395 147 nFVKADFMKMPFPENSFDAVYAIEATCHAPDAYGCYKEIYRVLKPG 192
Cdd:COG2227   73 -FVQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPG 117
PRK08317 PRK08317
hypothetical protein; Provisional
 81-192 7.77e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 78.44  E-value: 7.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  81 RHEHFLALQlgIQPGQKVLDVGCGIGGPLREIARFSN--SVVTGLNNNEYQITRGKElnRLAGVDKTCNFVKADFMKMPF 158
Cdd:PRK08317   8 RARTFELLA--VQPGDRVLDVGCGPGNDARELARRVGpeGRVVGIDRSEAMLALAKE--RAAGLGPNVEFVRGDADGLPF 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 145334395 159 PENSFDAVYAIEATCHAPDAYGCYKEIYRVLKPG 192
Cdd:PRK08317  84 PDGSFDAVRSDRVLQHLEDPARALAEIARVLRPG 117
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 89-196 1.30e-15

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 75.19  E-value: 1.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  89 QLGIQPGQKVLDVGCGIGGPLREIARFSNSV--VTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENSFDAV 166
Cdd:PRK00216  46 WLGVRPGDKVLDLACGTGDLAIALAKAVGKTgeVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALPFPDNSFDAV 125

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 145334395 167 yAIeatchapdAYG---------CYKEIYRVLKPGQCFA 196
Cdd:PRK00216 126 -TI--------AFGlrnvpdidkALREMYRVLKPGGRLV 155
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 97-192 6.00e-15

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 69.77  E-value: 6.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  97 KVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKtCNFVKADFMKMPF-PENSFDAVYAIEATCHA 175
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADN-VEVLKGDAEELPPeADESFDVIISDPPLHHL 79

                         90
                 ....*....|....*...
gi 145334395 176 PDAYGC-YKEIYRVLKPG 192
Cdd:cd02440   80 VEDLARfLEEARRLLKPG 97
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 70-192 2.08e-13

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 68.02  E-value: 2.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  70 WKGESLRESIKRHEHFLALQLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKtCNFV 149
Cdd:COG0500    2 WDSYYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGN-VEFL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 145334395 150 KADFMK-MPFPENSFDAVYAIEATCHAPDAY--GCYKEIYRVLKPG 192
Cdd:COG0500   81 VADLAElDPLPAESFDLVVAFGVLHHLPPEEreALLRELARALKPG 126
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
94-197 1.82e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 62.53  E-value: 1.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  94 PGQKVLDVGCGIGGPLREIA-RFSNSVVTGLNNNEYQITRGKElnRLAGVDktcnFVKADFMKMPFPEnSFDAVYAIEAT 172
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAeRFPGARVTGVDLSPEMLARARA--RLPNVR----FVVADLRDLDPPE-PFDLVVSNAAL 73

                         90       100
                 ....*....|....*....|....*
gi 145334395 173 CHAPDAYGCYKEIYRVLKPGQCFAA 197
Cdd:COG4106   74 HWLPDHAALLARLAAALAPGGVLAV 98
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 92-232 1.95e-12

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 63.98  E-value: 1.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   92 IQPGQKVLDVGCGIGGPLREIAR--FSNSVVTGLNNNEYQITRGKELNRLAGVDKtCNFVKADFMKMP--FPENSFDAVY 167
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISEEAIEKARENAQKLGFDN-VEFEQGDIEELPelLEDDKFDVVI 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334395  168 AIEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMTDAFDPDNAEHQKIKGEIEIGDGLPDIRLT 232
Cdd:pfam13847  80 SNCVLNHIPDPDKVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAGCVGGAILKKKLYE 144
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 89-249 1.36e-11

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 65.16  E-value: 1.36e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  89 QLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGkeLNRLAGVDKTCNFVKADFMKMPFPENSFDAVYA 168
Cdd:PLN02336 261 KLDLKPGQKVLDVGCGIGGGDFYMAENFDVHVVGIDLSVNMISFA--LERAIGRKCSVEFEVADCTKKTYPDNSFDVIYS 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395 169 IEATCHAPDAYGCYKEIYRVLKPGQCFAAYEWCMT-DAFDPDNAEHQKIKGEieigdglpDIRLTTKCLEALKQAGF-EV 246
Cdd:PLN02336 339 RDTILHIQDKPALFRSFFKWLKPGGKVLISDYCRSpGTPSPEFAEYIKQRGY--------DLHDVQAYGQMLKDAGFdDV 410


                 ...
gi 145334395 247 IWE 249
Cdd:PLN02336 411 IAE 413
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 89-199 2.06e-11

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 62.67  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   89 QLGIQPGQKVLDVGCGIGGPLREIARFSNSV--VTGL--NNNEYQITRGKelnrlAGVDKTCNFVKADFMKMPFPENSFD 164
Cdd:TIGR01934  34 LIGVFKGQKVLDVACGTGDLAIELAKSAPDRgkVTGVdfSSEMLEVAKKK-----SELPLNIEFIQADAEALPFEDNSFD 108

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 145334395  165 AV---YAIEATCHAPDAygcYKEIYRVLKPGQCFAAYE 199
Cdd:TIGR01934 109 AVtiaFGLRNVTDIQKA---LREMYRVLKPGGRLVILE 143
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 99-192 1.63e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 54.30  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   99 LDVGCGIGGPLREIAR-FSNSVVTGLNNNEYQITRGKE-LNRLAGVDKTC-NFVKADFMKMPFPenSFDAVYAIEATCHA 175
Cdd:pfam08242   1 LEIGCGTGTLLRALLEaLPGLEYTGLDISPAALEAARErLAALGLLNAVRvELFQLDLGELDPG--SFDVVVASNVLHHL 78

                          90
                  ....*....|....*..
gi 145334395  176 PDAYGCYKEIYRVLKPG 192
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPG 95
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
91-192 4.31e-09

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 55.91  E-value: 4.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   91 GIQPGQKVLDVGCGIGgplrEIA-RFSNSV-----VTGLNNNEYQITRGKELNRLAGVdKTCNFVKADFMKMPFPENSFD 164
Cdd:pfam01209  39 GVKRGNKFLDVAGGTG----DWTfGLSDSAgssgkVVGLDINENMLKEGEKKAKEEGK-YNIEFLQGNAEELPFEDDSFD 113

                          90       100
                  ....*....|....*....|....*...
gi 145334395  165 AVYAIEATCHAPDAYGCYKEIYRVLKPG 192
Cdd:pfam01209 114 IVTISFGLRNFPDYLKVLKEAFRVLKPG 141
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
65-196 1.07e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 54.23  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  65 HFAQRWKGESLRESIKR-----HEHFLAlQLGIQPGQKVLDVGCGIG---GPLREIARFsnsvVTGLNNNEY--QITRGK 134
Cdd:COG4976   13 QYADSYDAALVEDLGYEapallAEELLA-RLPPGPFGRVLDLGCGTGllgEALRPRGYR----LTGVDLSEEmlAKAREK 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145334395 135 ELNRlagvdktcNFVKADFMKMPFPENSFDAVYAIEATCHAPDAYGCYKEIYRVLKPGQCFA 196
Cdd:COG4976   88 GVYD--------RLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFI 141
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 46-204 1.31e-08

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 54.98  E-value: 1.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  46 NKYYDLATSFYEYGWGESFHFAQrwkgeslreSIKRHEHFLAlQLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNN 125
Cdd:PTZ00098  14 NQYSDEGIKAYEFIFGEDYISSG---------GIEATTKILS-DIELNENSKVLDIGSGLGGGCKYINEKYGAHVHGVDI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395 126 NEYQITRGKElnRLAGVDKTcNFVKADFMKMPFPENSFDAVYAIEATCHAP--DAYGCYKEIYRVLKPGQCFAAYEWCMT 203
Cdd:PTZ00098  84 CEKMVNIAKL--RNSDKNKI-EFEANDILKKDFPENTFDMIYSRDAILHLSyaDKKKLFEKCYKWLKPNGILLITDYCAD 160


                 .
gi 145334395 204 D 204
Cdd:PTZ00098 161 K 161
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 89-196 8.93e-07

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 49.21  E-value: 8.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   89 QLGIQPGQKVLDVGCGIGGPLREIA-RFSNSVVTGLNNNEYQITRGKELNRlagvdKTCNFVKADFMKMPFPENSFDAVY 167
Cdd:TIGR02072  29 EKGIFIPASVLDIGCGTGYLTRALLkRFPQAEFIALDISAGMLAQAKTKLS-----ENVQFICGDAEKLPLEDSSFDLIV 103

                          90       100       110
                  ....*....|....*....|....*....|.
gi 145334395  168 AIEAT--CHAPDAYgcYKEIYRVLKPGQCFA 196
Cdd:TIGR02072 104 SNLALqwCDDLSQA--LSELARVLKPGGLLA 132
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 90-247 1.03e-06

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 49.25  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   90 LGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQITRGKElnRLAGVD-------KTCNFVKadfmkmpFPENs 162
Cdd:pfam02353  57 LGLKPGMTLLDIGCGWGGLMRRAAERYDVNVVGLTLSKNQYKLARK--RVAAEGlarkvevLLQDYRD-------FDEP- 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  163 FDAVYAIEATCH-APDAYGCY-KEIYRVLKPGQCFAAYewCMTDAFDPDNAEHQK----IKGEIEIGDGLPDIRLTTKCL 236
Cdd:pfam02353 127 FDRIVSVGMFEHvGHENYDTFfKKLYNLLPPGGLMLLH--TITGLHPDETSERGLplkfIDKYIFPGGELPSISMIVESS 204

                         170
                  ....*....|.
gi 145334395  237 EAlkqAGFEVI 247
Cdd:pfam02353 205 SE---AGFTVE 212
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
97-192 1.87e-05

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 45.10  E-value: 1.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395    97 KVLDVGCGIGGPLREIA-RFSNSVVTGLNNNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENsFDAVYAIEATCHA 175
Cdd:smart00828   2 RVLDFGCGYGSDLIDLAeRHPHLQLHGYTISPEQAEVGRERIRALGLQGRIRIFYRDSAKDPFPDT-YDLVFGFEVIHHI 80

                           90
                   ....*....|....*..
gi 145334395   176 PDAYGCYKEIYRVLKPG 192
Cdd:smart00828  81 KDKMDLFSNISRHLKDG 97
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 94-192 2.04e-05

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 45.65  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  94 PGQKVLDVGCGIGGPLREIARFSNSV-VTGLNNNEYQITRGKELNRLagvdKTCNFVKADFMKMPFPENSFDAVYAIEAT 172
Cdd:PLN02490 113 RNLKVVDVGGGTGFTTLGIVKHVDAKnVTILDQSPHQLAKAKQKEPL----KECKIIEGDAEDLPFPTDYADRYVSAGSI 188

                         90       100
                 ....*....|....*....|
gi 145334395 173 CHAPDAYGCYKEIYRVLKPG 192
Cdd:PLN02490 189 EYWPDPQRGIKEAYRVLKIG 208
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 86-192 3.70e-05

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 44.36  E-value: 3.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  86 LALQLGIQPGQKVLDVGCGIGGPLREiARFSNSVVTGLNNNEYQITRGKELNRLAgvdktcNFVKADFMKMPFPENSFDA 165
Cdd:PRK10258  34 LLAMLPQRKFTHVLDAGCGPGWMSRY-WRERGSQVTALDLSPPMLAQARQKDAAD------HYLAGDIESLPLATATFDL 106

                         90       100
                 ....*....|....*....|....*..
gi 145334395 166 VYAIEATCHAPDAYGCYKEIYRVLKPG 192
Cdd:PRK10258 107 AWSNLAVQWCGNLSTALRELYRVVRPG 133
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 91-192 7.23e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 42.63  E-value: 7.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  91 GIQPGQKVLDVGCGIGGPLREiARFSNSVVTGLNNNEYQITRGKE-LNRLAGVDktCNFVKADFMKMPFPENSFDAV--- 166
Cdd:COG1041   23 GAKEGDTVLDPFCGTGTILIE-AGLLGRRVIGSDIDPKMVEGAREnLEHYGYED--ADVIRGDARDLPLADESVDAIvtd 99

                         90       100       110
                 ....*....|....*....|....*....|..
gi 145334395 167 --YAIEATCHAPDAYGCYK----EIYRVLKPG 192
Cdd:COG1041  100 ppYGRSSKISGEELLELYEkaleEAARVLKPG 131
Methyltransf_29 pfam03141
Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative ...
 98-265 1.39e-04

Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase.


Pssm-ID: 335237 [Multi-domain]  Cd Length: 506  Bit Score: 43.45  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   98 VLDVGCGI---GGPLreiarFSNSVVT---GLNNN-EYQIT----RGkeLNRLAGVDKTcnfvkadfMKMPFPENSFDAV 166
Cdd:pfam03141 121 ALDVGCGVasfGAYL-----LSRDVLTmsfAPKDVhEAQVQfaleRG--IPAMLGVLGT--------KRLPYPSRSFDLA 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  167 YAieATC----HAPDayGCY-KEIYRVLKPGQCFAayeWCMTDAFDPDNAEHQKIKGEIEigdglpdiRLTTK-CLEALK 240
Cdd:pfam03141 186 HC--SRCripwTAND--GILlLEVDRVLRPGGYFV---LSGPPVYARTEEDLQEIWKEME--------DLTKSlCWKLVA 250

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 145334395  241 QAGFEVIWEK----------------DLAKDSPVP---WYLPLD 265
Cdd:pfam03141 251 KKGDIAIWQKplnnscynkrepgkkpPLCKDSDDPdaaWYVPME 294
arsM PRK11873
arsenite methyltransferase;
92-196 1.64e-04

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 42.63  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  92 IQPGQKVLDVGCGIG----------GPLREiarfsnsvVTGLNNNEYQITRGKELNRLAGVDKTcNFVKADFMKMPFPEN 161
Cdd:PRK11873  75 LKPGETVLDLGSGGGfdcflaarrvGPTGK--------VIGVDMTPEMLAKARANARKAGYTNV-EFRLGEIEALPVADN 145

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 145334395 162 SFDAvyaIEATC---HAPDAYGCYKEIYRVLKPGQCFA 196
Cdd:PRK11873 146 SVDV---IISNCvinLSPDKERVFKEAFRVLKPGGRFA 180
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
136-235 2.15e-04

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 41.39  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395 136 LNRLAGVDKTCNfvkADFMKmPFPENSFDAVYA---IEatcH--APDAYGCYKEIYRVLKPG-----------QCFAAYE 199
Cdd:COG4627   24 IVPAPGVDIVGD---LTDPL-PFPDNSVDAIYSshvLE---HldYEEAPLALKECYRVLKPGgilrivvpdleHVARLYL 96

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 145334395 200 WCMTDAFDPdnAEHQKIKGEIEIGDGLPDIRLTTKC 235
Cdd:COG4627   97 AEYDAALDV--AELRLAGPIDPLGIILGERLAGLAA 130
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 91-192 2.25e-04

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 42.19  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  91 GIQPGQKVLDVGCGIGgplrEIARF------SNSVVTGLN--NNEYQITRGKELNRLAGVDKTCNFVKADFMKMPFPENS 162
Cdd:PLN02233  70 GAKMGDRVLDLCCGSG----DLAFLlsekvgSDGKVMGLDfsSEQLAVAASRQELKAKSCYKNIEWIEGDATDLPFDDCY 145

                         90       100       110
                 ....*....|....*....|....*....|
gi 145334395 163 FDAVYAIEATCHAPDAYGCYKEIYRVLKPG 192
Cdd:PLN02233 146 FDAITMGYGLRNVVDRLKAMQEMYRVLKPG 175
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 84-192 2.50e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 40.87  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   84 HFLALQLGIQP-GQKVLDVGCGIGGPLREIARFsNSVVTGLNNNEYQITRGKELNRlagvdktcnFVKADFMKMPFPENS 162
Cdd:pfam13489  11 DLLLRLLPKLPsPGRVLDFGCGTGIFLRLLRAQ-GFSVTGVDPSPIAIERALLNVR---------FDQFDEQEAAVPAGK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 145334395  163 FDAVYAIEATCHAPDAYGCYKEIYRVLKPG 192
Cdd:pfam13489  81 FDVIVAREVLEHVPDPPALLRQIAALLKPG 110
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 74-166 2.55e-04

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 41.19  E-value: 2.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   74 SLRESIKRHEHFLAlqlGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGLNNNEYQ-----------ITRGKELN-RLAG 141
Cdd:pfam01170  11 PLKETLAAAMVNLA---GWKPGDPLLDPMCGSGTILIEAALMGANIAPGKFDARVRaplygsdidrrMVQGARLNaENAG 87

                          90       100
                  ....*....|....*....|....*
gi 145334395  142 VDKTCNFVKADFMKMPFPENSFDAV 166
Cdd:pfam01170  88 VGDLIEFVQADAADLPLLEGSVDVI 112
rADc smart00650
Ribosomal RNA adenine dimethylases;
89-168 2.70e-04

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 40.96  E-value: 2.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395    89 QLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTglnnneYQITRG--KEL-NRLAGVDKTcNFVKADFMKMPFPENSFDA 165
Cdd:smart00650   8 AANLRPGDTVLEIGPGKGALTEELLERAKRVTA------IEIDPRlaPRLrEKFAAADNL-TVIHGDALKFDLPKLQPYK 80


                   ...
gi 145334395   166 VYA 168
Cdd:smart00650  81 VVG 83
MetW pfam07021
Methionine biosynthesis protein MetW; This family consists of several bacterial and one ...
 83-177 5.31e-04

Methionine biosynthesis protein MetW; This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalyzed by the products of the metXW genes and is equivalent to the first step in enterobacteria, gram-positive bacteria and fungi, except that in these microorganizms the reaction is catalyzed by a single polypeptide (the product of the metA gene in Escherichia coli and the met5 gene product in Neurospora crassa). In Pseudomonas putida, as in gram-positive bacteria and certain fungi, the second and third steps are a direct sulfhydrylation that converts the O-acyl-L-homoserine into homocysteine and further methylation to yield methionine. The latter reaction can be mediated by either of the two methionine synthetases present in the cells.


Pssm-ID: 399779  Cd Length: 193  Bit Score: 40.52  E-value: 5.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395   83 EHFLALQLGIQPGQKVLDVGCGIGGPLREIArfsnsvvtglnnNEYQIT-RGKELNR---LAGVDKTCNFVKADFMK--M 156
Cdd:pfam07021   2 ADFRYILEWIPPGSRVLDLGCGDGTLLYLLK------------EEKGVDgYGIELDAagvAECVAKGLYVIQGDLDEglE 69

                          90       100
                  ....*....|....*....|....
gi 145334395  157 PFPENSFDAVY---AIEATcHAPD 177
Cdd:pfam07021  70 HFPDKSFDYVIlsqTLQAT-RNPR 92
PRK05785 PRK05785
hypothetical protein; Provisional
 27-188 1.05e-03

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 40.06  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  27 HVFHGGNEEERKAnYTDMVnKYYDLATSFYeygwgeSFHFAQRWKgeslRESIKrhehfLALQLGIQPGqKVLDVGCGIG 106
Cdd:PRK05785   2 MGLGATWEELQEA-YNKIP-KAYDRANRFI------SFNQDVRWR----AELVK-----TILKYCGRPK-KVLDVAAGKG 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395 107 GPLREIARFSNSVVTGLNNNEyqitrgkELNRLAGV--DKtcnfVKADFMKMPFPENSFDAV---YAIEATCHAPDAygc 181
Cdd:PRK05785  64 ELSYHFKKVFKYYVVALDYAE-------NMLKMNLVadDK----VVGSFEALPFRDKSFDVVmssFALHASDNIEKV--- 129


                 ....*..
gi 145334395 182 YKEIYRV 188
Cdd:PRK05785 130 IAEFTRV 136
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 73-192 1.44e-03

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 39.89  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  73 ESLRESIKRHehfLALQLGiQPGQKVLDVGCGIGgplreiaRFSNSVVTGLNnneyqitrGKELNRLAGVD--------- 143
Cdd:PRK11088  68 QPLRDAVANL---LAERLD-EKATALLDIGCGEG-------YYTHALADALP--------EITTMQLFGLDiskvaikya 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 145334395 144 ----KTCNFVKADFMKMPFPENSFDAVYAIEATCHApdaygcyKEIYRVLKPG 192
Cdd:PRK11088 129 akryPQVTFCVASSHRLPFADQSLDAIIRIYAPCKA-------EELARVVKPG 174
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 92-166 4.15e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 38.20  E-value: 4.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  92 IQPGQKVLDVGCGIG-GPLREIARFSNSVVTGLnnnEYQ------ITRGKELNRLAGVdktCNFVKADFMKMP--FPENS 162
Cdd:COG4123   35 VKKGGRVLDLGTGTGvIALMLAQRSPGARITGV---EIQpeaaelARRNVALNGLEDR---ITVIHGDLKEFAaeLPPGS 108


                 ....
gi 145334395 163 FDAV 166
Cdd:COG4123  109 FDLV 112
PRK14968 PRK14968
putative methyltransferase; Provisional
 84-166 5.31e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 37.57  E-value: 5.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  84 HFLALQLGIQPGQKVLDVGCGiGGPLREIARFSNSVVTGLNNNEYQITRGKELNRLAGVDKTC-NFVKADFMKmPFPENS 162
Cdd:PRK14968  13 FLLAENAVDKKGDRVLEVGTG-SGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNGvEVIRSDLFE-PFRGDK 90


                 ....
gi 145334395 163 FDAV 166
Cdd:PRK14968  91 FDVI 94
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
87-166 5.51e-03

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 38.21  E-value: 5.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145334395  87 ALQ-LGIQPGQKVLDVGCGIGG---PLreiARFSNSVVtGLNNNEYQITRGKE---LNRLAGVDktcnFVKAD----FMK 155
Cdd:PRK13168 289 ALEwLDPQPGDRVLDLFCGLGNftlPL---ARQAAEVV-GVEGVEAMVERAREnarRNGLDNVT----FYHANleedFTD 360

                         90
                 ....*....|.
gi 145334395 156 MPFPENSFDAV 166
Cdd:PRK13168 361 QPWALGGFDKV 371
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
70-140 8.08e-03

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 37.91  E-value: 8.08e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145334395  70 WKG-ESLRESikrHEHFLAL---QLGIQPGQKVLDVGCGIGGPLREIARFSNSVVTGlnnneyqITRGKELNRLA 140
Cdd:PRK11705 142 WKDaDTLEEA---QEAKLDLicrKLQLKPGMRVLDIGCGWGGLARYAAEHYGVSVVG-------VTISAEQQKLA 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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