NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|148225760|ref|NP_001078968|]
View 

uncharacterized protein LOC209005 [Mus musculus]

Protein Classification

DNA topoisomerase 2-like domain-containing protein( domain architecture ID 1000163)

DNA topoisomerase 2-like domain-containing protein; DNA topoisomerase 2 alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 110-431 6.37e-03

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 40.03  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  110 KRKDILKKLKKEGYItgnnkvvcSLKELNKYRQYLTTLkidfernyvrEQKIIENQVNKLNEERRAYDNAAAAEFQW--- 186
Cdd:PTZ00108 1032 KKKDLVKELKKLGYV--------RFKDIIKKKSEKITA----------EEEEGAEEDDEADDEDDEEELGAAVSYDYlls 1093

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  187 ---W---------LLQEGKKASPQHERLIKLRHLNMINKELDKLEDTvgkrssLVMKEEDRQHWDDVKRKLNLHQEVEAD 254
Cdd:PTZ00108 1094 mpiWsltkekvekLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEA------LEEQEEVEEKEIAKEQRLKSKTKGKAS 1167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  255 W------QFKEMSLMTKIGDEVKRETKVEEHHR-KIREEINRKKQVMLQKRIAYHLQKLQEKESKEGKREESTSESKRPS 327
Cdd:PTZ00108 1168 KlrkpklKKKEKKKKKSSADKSKKASVVGNSKRvDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKK 1247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  328 ETAS--SIQKQPSFTEPKMSQEHLERKTSISSMRTSISERLMQESRESKSI-SQTTRTSFDEDQSSLYKLLETRFSPIAR 404
Cdd:PTZ00108 1248 NNSSksSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGgSKPSSPTKKKVKKRLEGSLAALKKKKKS 1327

                         330       340
                  ....*....|....*....|....*..
gi 148225760  405 RRSSLAEDQAFQEVLEPKYRHHSSGKK 431
Cdd:PTZ00108 1328 EKKTARKKKSKTRVKQASASQSSRLLR 1354
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 110-431 6.37e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 40.03  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  110 KRKDILKKLKKEGYItgnnkvvcSLKELNKYRQYLTTLkidfernyvrEQKIIENQVNKLNEERRAYDNAAAAEFQW--- 186
Cdd:PTZ00108 1032 KKKDLVKELKKLGYV--------RFKDIIKKKSEKITA----------EEEEGAEEDDEADDEDDEEELGAAVSYDYlls 1093

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  187 ---W---------LLQEGKKASPQHERLIKLRHLNMINKELDKLEDTvgkrssLVMKEEDRQHWDDVKRKLNLHQEVEAD 254
Cdd:PTZ00108 1094 mpiWsltkekvekLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEA------LEEQEEVEEKEIAKEQRLKSKTKGKAS 1167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  255 W------QFKEMSLMTKIGDEVKRETKVEEHHR-KIREEINRKKQVMLQKRIAYHLQKLQEKESKEGKREESTSESKRPS 327
Cdd:PTZ00108 1168 KlrkpklKKKEKKKKKSSADKSKKASVVGNSKRvDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKK 1247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  328 ETAS--SIQKQPSFTEPKMSQEHLERKTSISSMRTSISERLMQESRESKSI-SQTTRTSFDEDQSSLYKLLETRFSPIAR 404
Cdd:PTZ00108 1248 NNSSksSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGgSKPSSPTKKKVKKRLEGSLAALKKKKKS 1327

                         330       340
                  ....*....|....*....|....*..
gi 148225760  405 RRSSLAEDQAFQEVLEPKYRHHSSGKK 431
Cdd:PTZ00108 1328 EKKTARKKKSKTRVKQASASQSSRLLR 1354
 
Name Accession Description Interval E-value
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 110-431 6.37e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 40.03  E-value: 6.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  110 KRKDILKKLKKEGYItgnnkvvcSLKELNKYRQYLTTLkidfernyvrEQKIIENQVNKLNEERRAYDNAAAAEFQW--- 186
Cdd:PTZ00108 1032 KKKDLVKELKKLGYV--------RFKDIIKKKSEKITA----------EEEEGAEEDDEADDEDDEEELGAAVSYDYlls 1093

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  187 ---W---------LLQEGKKASPQHERLIKLRHLNMINKELDKLEDTvgkrssLVMKEEDRQHWDDVKRKLNLHQEVEAD 254
Cdd:PTZ00108 1094 mpiWsltkekvekLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEA------LEEQEEVEEKEIAKEQRLKSKTKGKAS 1167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  255 W------QFKEMSLMTKIGDEVKRETKVEEHHR-KIREEINRKKQVMLQKRIAYHLQKLQEKESKEGKREESTSESKRPS 327
Cdd:PTZ00108 1168 KlrkpklKKKEKKKKKSSADKSKKASVVGNSKRvDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKK 1247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148225760  328 ETAS--SIQKQPSFTEPKMSQEHLERKTSISSMRTSISERLMQESRESKSI-SQTTRTSFDEDQSSLYKLLETRFSPIAR 404
Cdd:PTZ00108 1248 NNSSksSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGgSKPSSPTKKKVKKRLEGSLAALKKKKKS 1327

                         330       340
                  ....*....|....*....|....*..
gi 148225760  405 RRSSLAEDQAFQEVLEPKYRHHSSGKK 431
Cdd:PTZ00108 1328 EKKTARKKKSKTRVKQASASQSSRLLR 1354
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH