NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|148235367|ref|NP_001091112|]
View 

taste receptor type 2 member 30 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606659)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tm_TAS2R43-like cd15027
mammalian taste receptor 2, subtype 43, and related proteins, member of the ...
3-294 2.84e-178

mammalian taste receptor 2, subtype 43, and related proteins, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (T2R) subtype 43, which functions as a bitter taste receptor. Also included are the closely related taste receptors TAS2R19, TAS2R20, TAS2R30, TAS2R31, TAS2R45 and TAS2R50. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


:

Pssm-ID: 320155  Cd Length: 292  Bit Score: 494.40  E-value: 2.84e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   3 TFLPIIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRI 82
Cdd:cd15027    1 SLLLIILSILVMAEFVLGNFANGFIALVNCIDWVKRQKISSVDQILTALAVSRIGLLWVILINWYATVFNPALYSLEVRI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  83 TAYNVWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTKEYEGNV 162
Cdd:cd15027   81 IIHIAWAVTNHFSTWLATSLSIFYLLKIANFSNLIFLYLKRRVKSVILVILLGSLVFLVFHLAVVNIDENVWVNEYEGNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 163 TWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYF 242
Cdd:cd15027  161 TWKTKLRDIIHLSNMTVFTLANFIPFTMSLISFLLLIFSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVISFLLLFAIYF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148235367 243 LSMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFLSVL 294
Cdd:cd15027  241 LSLIISVWSSNRLQNKPVLLLCQAIGILYPSSHSFILIWGNKKLKQAFLSFL 292
 
Name Accession Description Interval E-value
7tm_TAS2R43-like cd15027
mammalian taste receptor 2, subtype 43, and related proteins, member of the ...
3-294 2.84e-178

mammalian taste receptor 2, subtype 43, and related proteins, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (T2R) subtype 43, which functions as a bitter taste receptor. Also included are the closely related taste receptors TAS2R19, TAS2R20, TAS2R30, TAS2R31, TAS2R45 and TAS2R50. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320155  Cd Length: 292  Bit Score: 494.40  E-value: 2.84e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   3 TFLPIIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRI 82
Cdd:cd15027    1 SLLLIILSILVMAEFVLGNFANGFIALVNCIDWVKRQKISSVDQILTALAVSRIGLLWVILINWYATVFNPALYSLEVRI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  83 TAYNVWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTKEYEGNV 162
Cdd:cd15027   81 IIHIAWAVTNHFSTWLATSLSIFYLLKIANFSNLIFLYLKRRVKSVILVILLGSLVFLVFHLAVVNIDENVWVNEYEGNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 163 TWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYF 242
Cdd:cd15027  161 TWKTKLRDIIHLSNMTVFTLANFIPFTMSLISFLLLIFSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVISFLLLFAIYF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148235367 243 LSMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFLSVL 294
Cdd:cd15027  241 LSLIISVWSSNRLQNKPVLLLCQAIGILYPSSHSFILIWGNKKLKQAFLSFL 292
TAS2R pfam05296
Taste receptor protein (TAS2R); This family consists of several forms of eukaryotic taste ...
1-298 1.42e-83

Taste receptor protein (TAS2R); This family consists of several forms of eukaryotic taste receptor proteins (TAS2Rs). TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia in humans and mice, and are organized in the genome in clusters. The proteins are genetically linked to loci that influence bitter perception in mice and humans.


Pssm-ID: 283059  Cd Length: 303  Bit Score: 254.51  E-value: 1.42e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367    1 MITFLPIIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFY-SVE 79
Cdd:pfam05296   1 MLSALEGIFLIVAVVEFLLGILGNGFIVLVNCIDWVKKRKLSSIDLILTSLAISRICLQWLILLDNFIIVFFPNTYlSGK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   80 VRITAYNVWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTK--- 156
Cdd:pfam05296  81 LLRIISLFWTFLNHLSLWFATCLSVFYCLKIANFSHPIFLWLKWRISKVVPWLLLGSLLISFLNTVQIPNSIKASIDpel 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  157 -EYEGNVTWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFL 235
Cdd:pfam05296 161 iKYKRNTTWDLRVSKFELFSSLVLLNLGSLLPFIVFLISFLLLIFSLWRHTRQMQLNSTGFRDPSTEAHVRALKSLISFL 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148235367  236 LLCAIYFLSMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFLSVLRHVR 298
Cdd:pfam05296 241 ILYISYFLSFLISIISFLLPKNKLAFIFGEIVTYLYPSGHSFILILGNPKLKQAFLKILLKLK 303
 
Name Accession Description Interval E-value
7tm_TAS2R43-like cd15027
mammalian taste receptor 2, subtype 43, and related proteins, member of the ...
3-294 2.84e-178

mammalian taste receptor 2, subtype 43, and related proteins, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (T2R) subtype 43, which functions as a bitter taste receptor. Also included are the closely related taste receptors TAS2R19, TAS2R20, TAS2R30, TAS2R31, TAS2R45 and TAS2R50. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320155  Cd Length: 292  Bit Score: 494.40  E-value: 2.84e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   3 TFLPIIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRI 82
Cdd:cd15027    1 SLLLIILSILVMAEFVLGNFANGFIALVNCIDWVKRQKISSVDQILTALAVSRIGLLWVILINWYATVFNPALYSLEVRI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  83 TAYNVWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTKEYEGNV 162
Cdd:cd15027   81 IIHIAWAVTNHFSTWLATSLSIFYLLKIANFSNLIFLYLKRRVKSVILVILLGSLVFLVFHLAVVNIDENVWVNEYEGNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 163 TWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYF 242
Cdd:cd15027  161 TWKTKLRDIIHLSNMTVFTLANFIPFTMSLISFLLLIFSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVISFLLLFAIYF 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148235367 243 LSMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFLSVL 294
Cdd:cd15027  241 LSLIISVWSSNRLQNKPVLLLCQAIGILYPSSHSFILIWGNKKLKQAFLSFL 292
7tm_TAS2R14-like cd15019
mammalian taste receptor 2, subtype 14, member of the seven-transmembrane G protein-coupled ...
8-294 2.52e-113

mammalian taste receptor 2, subtype 14, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 14, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320147  Cd Length: 290  Bit Score: 329.49  E-value: 2.52e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   8 IFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVE--VRITaY 85
Cdd:cd15019    1 IFTIILSVEFIIGNLGNGFIALVNCMDWVKRRKISSVDQILTALAISRIGLLWLVFISWLISVLYPALLMTEkmLRII-N 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  86 NVWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTKEYEGNVTWK 165
Cdd:cd15019   80 ISWTVTNHFSIWLATCLSIFYFLKIANFSNSIFLYLKWRVKKVVSVTLLVSLVLLFLNIVLINTHIDVWIDGYKRNMSYS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 166 IKLR-SAMYHSNMTLT-MLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFL 243
Cdd:cd15019  160 SSSSnSAQFSKLLLFTnTMFTFIPFTVSLTTFLLLIFSLWKHLKKMQHNAKGSRDASTTAHIKALQTVIAFLLLYTIFFL 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 148235367 244 SMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFLSVL 294
Cdd:cd15019  240 SLLVQVWSSELLEKNLIILFCQVIGIAFPSGHSCVLILGNSKLRQASLSVL 290
7tm_TAS2R cd13950
mammalian taste receptors type 2, member of the seven-transmembrane G protein-coupled receptor ...
8-291 8.49e-93

mammalian taste receptors type 2, member of the seven-transmembrane G protein-coupled receptor superfamily; This group represents a family of mammalian taste receptors (TAS2Rs), which function as bitter taste receptors. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320088  Cd Length: 288  Bit Score: 277.52  E-value: 8.49e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   8 IFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPA-FYSVEVRITAYN 86
Cdd:cd13950    1 IFLIIIVGEFLIGILGNGFIVLVNCIDWIKSRKLSSIDFILTSLAISRIGLLWTIILNSILSVFYPDiYLSGNVLRTLDI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  87 VWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTKEY---EGNVT 163
Cdd:cd13950   81 LWMFLNHSSLWFATCLSVFYCLKIANFSHPFFLWLKWRINRVVPWLLLGSLLISLLISLPIVWVIYSVYQNNskeESNNT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 164 WKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFL 243
Cdd:cd13950  161 SKFQVKKTSYFYSFILLNLGSLIPFILSLISFFLLIFSLWRHTRQMQLNATGSRDPSTEAHIRAMKSMISFLILFIIYFL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 148235367 244 SMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFL 291
Cdd:cd13950  241 ALIITILSYSFLENKLAVLFCEVLMALYPSGHSFILILGNPKLKQAFL 288
TAS2R pfam05296
Taste receptor protein (TAS2R); This family consists of several forms of eukaryotic taste ...
1-298 1.42e-83

Taste receptor protein (TAS2R); This family consists of several forms of eukaryotic taste receptor proteins (TAS2Rs). TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia in humans and mice, and are organized in the genome in clusters. The proteins are genetically linked to loci that influence bitter perception in mice and humans.


Pssm-ID: 283059  Cd Length: 303  Bit Score: 254.51  E-value: 1.42e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367    1 MITFLPIIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFY-SVE 79
Cdd:pfam05296   1 MLSALEGIFLIVAVVEFLLGILGNGFIVLVNCIDWVKKRKLSSIDLILTSLAISRICLQWLILLDNFIIVFFPNTYlSGK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   80 VRITAYNVWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTK--- 156
Cdd:pfam05296  81 LLRIISLFWTFLNHLSLWFATCLSVFYCLKIANFSHPIFLWLKWRISKVVPWLLLGSLLISFLNTVQIPNSIKASIDpel 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  157 -EYEGNVTWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFL 235
Cdd:pfam05296 161 iKYKRNTTWDLRVSKFELFSSLVLLNLGSLLPFIVFLISFLLLIFSLWRHTRQMQLNSTGFRDPSTEAHVRALKSLISFL 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148235367  236 LLCAIYFLSMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFLSVLRHVR 298
Cdd:pfam05296 241 ILYISYFLSFLISIISFLLPKNKLAFIFGEIVTYLYPSGHSFILILGNPKLKQAFLKILLKLK 303
7tm_TAS2R13 cd15026
mammalian taste receptor 2, subtype 13, member of the seven-transmembrane G protein-coupled ...
8-291 1.37e-75

mammalian taste receptor 2, subtype 13, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 13, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320154  Cd Length: 287  Bit Score: 233.53  E-value: 1.37e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   8 IFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFY--SVEVRITaY 85
Cdd:cd15026    2 ILTLIIIAEFIFGNLSNGFIVLINCIDWVKKRKLSSIDKILLILAISRIGLIWETLVYWFKAQYYSSFFitGTELRII-V 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  86 NVWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTKEYEGNVTWK 165
Cdd:cd15026   81 FSWILSNHFSLWLATILSIFYLLKIANFSWPIFLYLKWRIKKVILMMLLGSLVFLFLNLIQINIHIEDWFYQYERNTTWN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 166 IKLRSAMYHSNMTLTMLANF--VPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFL 243
Cdd:cd15026  161 SMESDFAKFSELVLFNMTMFsvIPFTVALISFLLLIFSLWKHLQKMQLNSRGHRDPSTKAHRNALRIMVSFLLLYASYFL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 148235367 244 SMIISVCNfGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFL 291
Cdd:cd15026  241 SLLISWIA-QKHQSELAYIICIITGLFYPSSHSFILILGNSKLRQASL 287
7tm_TAS2R42 cd15024
mammalian taste receptor 2, subtype 42, member of the seven-transmembrane G protein-coupled ...
8-291 9.30e-71

mammalian taste receptor 2, subtype 42, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 42, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320152  Cd Length: 288  Bit Score: 221.06  E-value: 9.30e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   8 IFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSV-EVRITAYN 86
Cdd:cd15024    1 IFLILAIGEFIIGMLGNGFIGLVNCSDWVKNRKISLADCILTCLAISRIGQLLVILFDSFILVLWPHLYGTyKLAKVVSI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  87 VWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTKEY---EGNVT 163
Cdd:cd15024   81 LWTLTNHLTTWFATCLSIFYFLKIANFSHPLFLWLKWRISRVLLVLLLGSLFLLFFDFLLLETFSDFWLNIYtidEGNLT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 164 WKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFL 243
Cdd:cd15024  161 LSSEESKTLYVKSLILFSLIYLIPFLLSLTSLLLLFLSLVRHTRNLQLNSLGSRDSSTEAHKRAMKMVMSFLLLFIIHFF 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 148235367 244 SMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFL 291
Cdd:cd15024  241 SIQLAGWIFFFLWKKQAILFVMLTSNIFPSGHSFILILGNSKLRQTAL 288
7tm_TAS2R7-like cd15023
mammalian taste receptor 2, subtypes 7 and 9, member of the seven-transmembrane G ...
8-291 1.09e-57

mammalian taste receptor 2, subtypes 7 and 9, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtypes 7 and 9, which function as bitter taste receptors. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320151  Cd Length: 291  Bit Score: 187.68  E-value: 1.09e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   8 IFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFY--SVEVRITAY 85
Cdd:cd15023    2 IYMILIAGELTIGIWGNGFIVLVNCIGWLKRRDIALIDIILISLAISRICLLCVISLDGFIMVLFPDTYgnGKLMSIIDV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  86 nVWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDET-----VWTKEYEG 160
Cdd:cd15023   82 -FWTFTNHSSIWFTSCLSIFYLLKIANISHPLFLWLKWRINKVILAILLGSLVLSLIISVPKTENLWddfrkCVKTKHEE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 161 NVTWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAI 240
Cdd:cd15023  161 NITLKFKVSKTQGASKQVFLNLGVLVPFILSLISFLLLLFSLVRHTKQMQLHATGFRDPSTEAHMRAIKAVIIFLLLLIV 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 148235367 241 YFLSMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFL 291
Cdd:cd15023  241 YYLAFLVATSSYLIPQGKLVVMFGEIITLIFPSSHSFILIMGNSKLREAFL 291
7tm_TAS2R8 cd15022
mammalian taste receptor 2, subtype 8, member of the seven-transmembrane G protein-coupled ...
8-290 7.43e-57

mammalian taste receptor 2, subtype 8, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 8, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320150  Cd Length: 292  Bit Score: 185.75  E-value: 7.43e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   8 IFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVE-VRITAYN 86
Cdd:cd15022    2 IFIILITGEFIIGILGNGYIALVNWIDWIKKKKISSIDYILTSLAISRICLISVIVVNGIVIVLYPDVYENDkLQIVIST 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  87 VWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGP-----LLFLVCHLFVINMDETVWTKEYEGN 161
Cdd:cd15022   82 FWTFANYLSMWFATCLNVFYLLKIANFSHPLFLWLKWRIDRVVHWILLGCfaislLVSLILAIVLSDDYRFHAIAKHKRN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 162 VTWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIY 241
Cdd:cd15022  162 ITEMFHVSKIQYFEPLTLFNLFAIVPFTVSLISFFLLIRSLWRHTKQMKLSATGGRDPSTEAHVRAIKTVTSFLFFFFLY 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 148235367 242 FLSMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIF 290
Cdd:cd15022  242 YLSSLLVTFSYLMTEYKLAMMFGEIVAILYPLGHSLILIIGNNKLRQAS 290
7tm_TAS2R10 cd15021
mammalian taste receptor 2, subtype 10, member of the seven-transmembrane G protein-coupled ...
18-291 1.40e-53

mammalian taste receptor 2, subtype 10, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 10, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320149  Cd Length: 285  Bit Score: 176.81  E-value: 1.40e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  18 VIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRITAYN-VWAVTNHFSS 96
Cdd:cd15021   12 VLGVLGNGFIALVNCIDYARNKKLSKIGFILTGLAISRIFLIWIIILDAYVKLFSPHMLASGNLIEYISyIWVIINHLSV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  97 WLATSLSMFYLLRIANFSNLIFLRIKRRVKsVVLVILLGPLL--FLVCHLFVINMDETVwtKEYEGNVTWKIKLRSAMYH 174
Cdd:cd15021   92 WFATSLSIFYFLKIANFSHYIFLWLKRRID-VVFIFLIGCLLisWLISFPQVAKIINDI--KMKYRNTSWQLHLEKSEFF 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 175 SNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFLSMIISVCNFGR 254
Cdd:cd15021  169 INYVFTNLGVIFFFMVALITCFLLIISLWRHNRQMQSNVSGFRDLNTEAHVKAMKVLISFIILFILYFIGISIETLCFFL 248
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 148235367 255 LEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFL 291
Cdd:cd15021  249 PENKLLFIFGLTTACMYPCCHSFILILANSQLKQASL 285
7tm_TAS2R3 cd15020
mammalian taste receptor 2, subtype 3, member of the seven-transmembrane G protein-coupled ...
7-291 2.14e-53

mammalian taste receptor 2, subtype 3, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 3, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320148  Cd Length: 290  Bit Score: 176.43  E-value: 2.14e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   7 IIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRITAYN 86
Cdd:cd15020    1 IVFLVLTITEFILGIWVNGFIGLVNCIHWIKSKKISLSDFIITNLALSRIILLCIIITDSLLLVFYPHFHDSGIIMQIID 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  87 V-WAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLF-LVCHLFVIN---MDETVWTKEYEGN 161
Cdd:cd15020   81 IfWTFANHLSIWLVTCLSVFYCLKIANFSHPAFLWLKWRVSRVVVWILLGSVLFsFFSTAALIKkfkIYSALRQMRLTEN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 162 VTWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIY 241
Cdd:cd15020  161 CTEDIRRKEIEYYVAHILGALWSVIPFIVSLISYLLLILSLRRHTQQMQHHTTGSRDPSTEAHVRATKIILSFLLLFIFY 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 148235367 242 FLSMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQIFL 291
Cdd:cd15020  241 FVAFFIGSSSFFLPDTKLAIMIGELITAAYPSVHSFILILQNNKLKQAFL 290
7tm_TAS2R1 cd15016
mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled ...
7-290 2.85e-43

mammalian taste receptor 2, subtype 1, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 1, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320144  Cd Length: 283  Bit Score: 150.06  E-value: 2.85e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   7 IIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEvriTAYN 86
Cdd:cd15016    1 IIHLLFAVIQFLTGIFANGFIVVVNGIDLIKQRKMAPLDLLLSCLATSRICLQLFIFYLNLAVLSLIKFSVFA---ENFV 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  87 VWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLV-----CHLFVINMDETVWTKEYEGN 161
Cdd:cd15016   78 IFMFVNELGLWFATWLGVFYCAKIATIAHPLFLWLKMRISKLVPWLILGSLLYASitsvfHSKYTWPISQKLLLSFFSSN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 162 VTWKIKLRSAMyhsNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIY 241
Cdd:cd15016  158 ATTQIKEISAL---QLSLLIFELSLPLLIFLVAVLLLIFSLGRHTRQMRTTAAGTRDPSRSAHISALLSILSFLILYLSH 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148235367 242 FLSMII---SVCNFGRLekqpVFMFCQAIIFSYPSTHPFILILGNKKLKQIF 290
Cdd:cd15016  235 YMAAALlssQIFQFGSL----FFLFCILVIGAYPSGHSIILILGNPKLKQNA 282
7tm_TAS2R40-like cd15908
taste receptor 2, subtypes 39 and 40, and similar receptors, member of the seven-transmembrane ...
11-288 1.28e-34

taste receptor 2, subtypes 39 and 40, and similar receptors, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtypes 39 and 40, which function as bitter taste receptors. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (taste of glutamate MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320574  Cd Length: 289  Bit Score: 127.58  E-value: 1.28e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  11 ILIVVIF--VIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRITAYNVW 88
Cdd:cd15908    2 YLVILGIesIIGILGNGFIVAINLTEWVRSKRLSTSDRILIFLSLSRLCLQSWMMLENVCSLFFPSFYNEDNVYKTFKVI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  89 AV-TNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTKEYE-----GNV 162
Cdd:cd15908   82 FMfLNYSSLWFAAWLSVFYCVKIANFTHPLFLWLKWRITSLMPWLLILSVLISFSTSLPFSWDVYNVYCNSSiplpsSNS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 163 TWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYF 242
Cdd:cd15908  162 TKKKYIKETNLVNLIFLYNVGIFLPLIMFILSATLLILSLKRHTLQMQNNATGSRDPSMEAHMGAIKAISSFLILYIFNF 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 148235367 243 LSMIISVCN-FGRLEKQPVfmFCQAIIFSYPSTHPFILILGNKKLKQ 288
Cdd:cd15908  242 VALILTLSNiFDTNSTWNI--LCKIIMAAYPAGHSILLILGNPKLRR 286
7tm_TAS2R16 cd15017
mammalian taste receptor 2, subtype 16, member of the seven-transmembrane G protein-coupled ...
7-287 2.21e-34

mammalian taste receptor 2, subtype 16, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 16, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320145  Cd Length: 285  Bit Score: 126.64  E-value: 2.21e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   7 IIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRITayn 86
Cdd:cd15017    1 LFFMIIFVLESLAAIVQNGFIVTVLGREWVRCRRLPPGDMILACLGISRFCLQWISILNNFLSYFDFNYVFWYFGII--- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  87 vWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFlvCHLFVINMD-------ETVWTKEYE 159
Cdd:cd15017   78 -WDFFNTLTFWLTSLLAVFYCVKISSFTHPIFLWLKWRISRLVPWLLLGSLII--SCLSIIPSIvgnyiqaQLITSGNSS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 160 GNVTWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCA 239
Cdd:cd15017  155 GNSTLIYRLQAFQQYYFIPHQMVMLSIPFLLFLVSIILLMFSLCQHLGQMRHHSPGPCDPSTQAHTTALKSLAFFLIFFT 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 148235367 240 IYFLSMIISVCNFgRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLK 287
Cdd:cd15017  235 SYFLTLIISIIKI-IFVKNSWFWAWEAVIYAGISIHSTSLMLSSPKLR 281
7tm_TAS2R41-like cd15018
mammalian taste receptor 2, subtype 41, member of the seven-transmembrane G protein-coupled ...
7-290 6.27e-32

mammalian taste receptor 2, subtype 41, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 41, which functions as a bitter taste receptor. Also included is the closely related TAS2R60. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320146  Cd Length: 290  Bit Score: 120.60  E-value: 6.27e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   7 IIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRITAYN 86
Cdd:cd15018    1 IFLVLILFLLCLVAIVGNGFIVVALGREWLLRRTLLPCDKLLVSLGASRFCLQWVVMGKNIYVFLHPVAFPYNPVLQFLS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  87 V-WAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLL--FLVCHLFVI---NMDETVWTKEYEG 160
Cdd:cd15018   81 FhWDFLNSATLWFCTWLSVFYCVKIATFTHPVFLWLKWRFSGWVPWLLLGSVGisSLTTILFFIgnhSIYQNYLRRGLSS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 161 NVTWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAI 240
Cdd:cd15018  161 NNTTYNWRRSLEKFYFFSLKLITWSIPTSVFLISMVLLINSLRRHTKKMLHNLSSLQDPSTQAHIKALKALISFLILFAS 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 148235367 241 YFLSMIISVCNFGRLEKQPVFMFcQAIIFSYPSTHPFILILGNKKLKQIF 290
Cdd:cd15018  241 YFLSLVLSAAGVFPSQEVRYWVW-QIVIYLCIAVHPFILLFSNPKLRGVF 289
7tm_TAS2R38 cd15025
mammalian taste receptor 2, subtype 38, member of the seven-transmembrane G protein-coupled ...
7-289 1.21e-26

mammalian taste receptor 2, subtype 38, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (T2R) subtype 38, which functions as a bitter taste receptor. Genetic variants of human TAS2R38 influence the ability to taste synthetic compounds 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC). Thus, sensitivity to the bitter taste of PROP is often used as a marker for individual differences in taste perception that can affect food preferences and intake. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320153  Cd Length: 293  Bit Score: 106.46  E-value: 1.21e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   7 IIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRV---GLLWVLLLHWYATQL--NPAFYSVEVR 81
Cdd:cd15025    1 ITFLFLSVLEFAVGILANAFIVLVNFWDVVKRQPLNNCDIVLLCLSITRLflqGLLFLDAIQLTHFQQmkDPLSHSYQAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  82 ITaynVWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLF------LVCHLFVINMDETVWT 155
Cdd:cd15025   81 IM---LWMIANQVSLWLAACLSLLYCSKIARFSHTFLLCLASWVSRRIPQMLLGSLLFscictvLCVWDFFSRSHSTVTS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 156 KEYEGNVTWKIKLRSAMYHSNMTLTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFL 235
Cdd:cd15025  158 SLHMNNTELNLQIEKLNFFYSFLFCNVGSVPPFLLFLVSSGVLIISLGRHMRTMKAQTSGSRDPSLEAHIRALKSLVSFL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148235367 236 LLCAIYFLSMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLKQI 289
Cdd:cd15025  238 CFYVVSFCAALISVPLLLLWHNKIGVMVCVGIMAACPSGHAAILISGNAKLRRV 291
7tm_TAS2R39 cd15015
mammalian taste receptor 2, subtype 39, member of the seven-transmembrane G protein-coupled ...
7-288 7.54e-23

mammalian taste receptor 2, subtype 39, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (T2R) subtype 39, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (taste of glutamate MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320143  Cd Length: 289  Bit Score: 95.75  E-value: 7.54e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   7 IIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRITAYN 86
Cdd:cd15015    1 ILILTLVATECTIGIIASGIIMAVNAVSWVQKKAVSITTRILLLLSVSRIGLQSIMLIEITSSIFNLSFYNSVLYRVSKV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  87 VWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVIL-LGPLLFLVCHLFVINMDETVWTKEYEGNVTWK 165
Cdd:cd15015   81 SFVFLNYCSLWFAALLSFFHFVKIANFSYPLFFKLKWRISELMPWLLwLSVFISFSSSMFFINHKTTVCNNSSLSSNICN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 166 IKLRSAMYHSNMT----LTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIY 241
Cdd:cd15015  161 FTMKLYVSEINVVnvafLFNLGILPPLTMFIATATLLIFSLRRHTLHMRNNATGSRNPSMEAHMQAIKETSCFLFLYILN 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 148235367 242 FLSMIISVCNFGRLEKQPVFMfCQAIIFSYPSTHPFILILGNKKLKQ 288
Cdd:cd15015  241 AAALFLSTSNIFDASLFWSNV-CRIILPVYPAGHSVLLIQDNPGLRR 286
7tm_TAS2R4 cd15013
mammalian taste receptor 2, subtype 4, member of the seven-transmembrane G protein-coupled ...
7-287 1.53e-20

mammalian taste receptor 2, subtype 4, member of the seven-transmembrane G protein-coupled receptor superfamily; This group includes the mammalian taste receptor 2 (TAS2R) subtype 4, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (the taste of glutamate, MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320141  Cd Length: 286  Bit Score: 89.48  E-value: 1.53e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   7 IIFSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFVDQILTALAVSRVGLLWVLLLHWYATQLNPAFYSVEVRITAYN 86
Cdd:cd15013    1 IFVFIASVVFNFVGIVANLFIIVVNCKTWVKSHRISSSDRILFSLAITRFLMLGLFLLNTIYIATFPGSRSVYFSTFFLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  87 VWAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLL---FLVCHLFVINMDETVWTKEYEGNVT 163
Cdd:cd15013   81 CWKFLDSNSLWFVTLLNILYCVKITNFQHSVFLLLKRNLSPKTPWLLLACLLisaFTTLLYIVLSQISPFPEHIIGRNNT 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 164 wKIKLRSAMYHSNMTLtMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFL 243
Cdd:cd15013  161 -SFDISDGILTLVASL-ILSSSLQFILNVTSASLLIHSLRRHIQKMQKNATSFWNPQTEAHVGAMKLMIYFLILYIPYSI 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 148235367 244 SMIISVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGNKKLK 287
Cdd:cd15013  239 ATLLYFLPSYMGKNLRAQSICMIFTTLYSPGHSVLIIITHPKLK 282
7tm_TAS2R40 cd15014
mammalian taste receptor 2, subtype 40, member of the seven-transmembrane G-protein coupled ...
5-288 4.32e-20

mammalian taste receptor 2, subtype 40, member of the seven-transmembrane G-protein coupled receptor superfamily; This group includes the mammalian taste receptor 2 (T2R) subtype 40, which functions as a bitter taste receptor. The human TAS2R family contains about 25 functional members, which are glycoproteins and have the ability to form both homomeric and heteromeric receptor complexes. Five basic tastes are perceived by animals: bitter, sweet, sour, salty, and umami (taste of glutamate MSG). Among these, sour and salty are mediated by ion channels, while the perception of umami and sweet tastes is mediated by the TAS1R taste receptors, which belong to the class C GPCR family. The TAS2Rs in humans have a short extracellular N-terminus and the ligand binds within the transmembrane domain, whereas the TAS1Rs have a large N-terminal extracellular domain composed of the Venus flytrap module that forms the orthosteric (primary) ligand binding site. Signal transduction of bitter taste involves binding of bitter compounds to TAS2Rs linked to the alpha-subunit of gustducin, a heterotrimeric G protein expressed in taste receptor cells. This G-alpha subunit stimulates phosphodiesterase and decreases cAMP and cGMP levels. Further steps in the signaling cascade is still unknown. The beta-gamma-subunit of gustducin also mediates bitter taste transduction by activating phospholipase C, which leads to an increased formation of IP3 (inositol triphosphate) and DAG (diacylglycerol), thereby causing release of Ca2+ from intracellular stores and enhanced neurotransmitter release.


Pssm-ID: 320142  Cd Length: 290  Bit Score: 88.46  E-value: 4.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   5 LPIIFSILIVVIFVIGNfanGFIALVNSIEWVKRQKISFVDQILTALAVSRVGL-LWVLLLHWYATqLNPAFYSVEVRIT 83
Cdd:cd15014    2 IPFVVSTIECIVGIIGN---GFITVIYGTEWVRSKRLPTGERLMLMLSFSRLLLqIWMMVEITYSL-LFPIIYNHNAMYK 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  84 AYNVWAV-TNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVksVVLVILLGPLLFLVCHLFVINMDETVWTKEYEGNV 162
Cdd:cd15014   78 LFKVISVfLNYCNLWFAAWLNVFYCLKIVNFAHPLFLLMKQKI--IVLMPRLLSLSVLVSLSLSSFFSKDIFNVYVNTSV 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 163 TWKIKLRSAMYHSNMT-------LTMLANFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFL 235
Cdd:cd15014  156 PIPSSNSTKMKYFFETnvlnlafLYYMGIFVPLFMFIMAATLLITSLKRHTLHMESSTTGSRDSSMEAHIGAIKSTSYSL 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148235367 236 LLCAIYFLSMIISVCN-FGRLEKQPVfmFCQAIIFSYPSTHPFILILGNKKLKQ 288
Cdd:cd15014  236 ILYIINALALFISMSNiFGAYSSWNS--LCKIIMTAYPAGQSVHLILRNPGLRR 287
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
9-283 2.03e-06

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 48.19  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367   9 FSILIVVIFVIGNFANGFIALVNSIEWVKRQKISFvdqILTALAVSR-VGLLWVLLLHWYATQLNPAFYSVEVRITAYNV 87
Cdd:cd14964    1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRL---LLASLAACDlLASLVVLVLFFLLGLTEASSRPQALCYLIYLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367  88 WAVTNHFSSWLATSLSMFYLLRIANFSNLIFLRIKRRVKSVVLVILLGPLLFLVCHLFVINMDETVWTKEYEgNVTWKIK 167
Cdd:cd14964   78 WYGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGS-CYLICTT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148235367 168 LRSAMYHSNMTLtmlanFVPLTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFLSMII 247
Cdd:cd14964  157 IYLTWGFLLVSF-----LLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLLCWLPFSIVFIL 231
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 148235367 248 SVCNFGRLEKQPVFMFCQAIIFSYPSTHPFILILGN 283
Cdd:cd14964  232 HALVAAGQGLNLLSILANLLAVLASTLNPFIYCLGN 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH