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Conserved domains on  [gi|152963555|ref|NP_001093262|]
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tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A [Mus musculus]

Protein Classification

GCD14_N and GCD14 domain-containing protein( domain architecture ID 13573464)

GCD14_N and GCD14 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 64-287 1.86e-158

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


:

Pssm-ID: 312288  Cd Length: 242  Bit Score: 440.77  E-value: 1.86e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555   64 GWVYVLHPTPELWTVNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADK 143
Cdd:pfam08704   1 GFVYVLQPTPELWTLNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  144 AREEFQEHRLSQWVTVHTQDVCCSGF--GVVHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALA 221
Cdd:pfam08704  81 AREEFREHGIDQLVTVTHRDVCKEGFltEVSGKADAVFLDLPSPWEAVPHAWKALKVEGGRFCSFSPCIEQVQRTCQALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  222 AHGFTELSTLEVLPQVYNVRTVSLPLPDLG--------ANNLETNMGSDASPFRSGT--------PMKETVGHTGYLTFA 285
Cdd:pfam08704 161 ELGFTEISTLEVLLRVYDVRTVSLPVIDLGidrekeneRTRTEGLSNDDKSEDNSGNsmlgtalkPMSEAVGHTGYLTFA 240


                  ..
gi 152963555  286 TK 287
Cdd:pfam08704 241 TK 242
GCD14_N super family cl37887
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 23-58 3.90e-03

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


The actual alignment was detected with superfamily member pfam14801:

Pssm-ID: 434222  Cd Length: 51  Bit Score: 34.78  E-value: 3.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 152963555   23 GSMVAVRVQRGAQTQTRHGVLRHSvDLIGRPFGSKV 58
Cdd:pfam14801  17 GRKHTITLEPGGEFHTHRGAIRHD-DLIGRPEGSVV 51
 
Name Accession Description Interval E-value
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 64-287 1.86e-158

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 440.77  E-value: 1.86e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555   64 GWVYVLHPTPELWTVNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADK 143
Cdd:pfam08704   1 GFVYVLQPTPELWTLNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  144 AREEFQEHRLSQWVTVHTQDVCCSGF--GVVHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALA 221
Cdd:pfam08704  81 AREEFREHGIDQLVTVTHRDVCKEGFltEVSGKADAVFLDLPSPWEAVPHAWKALKVEGGRFCSFSPCIEQVQRTCQALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  222 AHGFTELSTLEVLPQVYNVRTVSLPLPDLG--------ANNLETNMGSDASPFRSGT--------PMKETVGHTGYLTFA 285
Cdd:pfam08704 161 ELGFTEISTLEVLLRVYDVRTVSLPVIDLGidrekeneRTRTEGLSNDDKSEDNSGNsmlgtalkPMSEAVGHTGYLTFA 240


                  ..
gi 152963555  286 TK 287
Cdd:pfam08704 241 TK 242
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 12-288 7.38e-71

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 218.88  E-value: 7.38e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  12 EGDTAILSLGHGSMVAVRVQRGAQTQTRHGVLRHSvDLIGRPFGSKVICSRGGWVYVLHPTPELWTVNLPHRTQILYSTD 91
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHD-DLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  92 IALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADKAREEFQEHRLSQWVTVHTQDVcCSGFGv 171
Cdd:COG2519   80 AGYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDI-REGID- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555 172 VHVADAVFLDIPSPWEAVGHAWDALKVeGGRFCSFSPCIEQVQRTCQALAAHGFTELSTLEVLPQVYNVRTVSL-Plpdl 250
Cdd:COG2519  158 EGDVDAVFLDMPDPWEALEAVAKALKP-GGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVrP---- 232

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 152963555 251 gannlETNMgsdaspfrsgtpmketVGHTGYLTFATKT 288
Cdd:COG2519  233 -----EHRM----------------VGHTGFLVFARKL 249
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 92-150 8.10e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 40.00  E-value: 8.10e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 152963555  92 IALITMMLELRPGSVVCESGTGSGsvSHAIIRS--VAPTGHLHTVEFHQQRADKAREEFQE 150
Cdd:PRK13942  65 VAIMCELLDLKEGMKVLEIGTGSG--YHAAVVAeiVGKSGKVVTIERIPELAEKAKKTLKK 123
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 23-58 3.90e-03

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 34.78  E-value: 3.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 152963555   23 GSMVAVRVQRGAQTQTRHGVLRHSvDLIGRPFGSKV 58
Cdd:pfam14801  17 GRKHTITLEPGGEFHTHRGAIRHD-DLIGRPEGSVV 51
 
Name Accession Description Interval E-value
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 64-287 1.86e-158

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 440.77  E-value: 1.86e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555   64 GWVYVLHPTPELWTVNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADK 143
Cdd:pfam08704   1 GFVYVLQPTPELWTLNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  144 AREEFQEHRLSQWVTVHTQDVCCSGF--GVVHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALA 221
Cdd:pfam08704  81 AREEFREHGIDQLVTVTHRDVCKEGFltEVSGKADAVFLDLPSPWEAVPHAWKALKVEGGRFCSFSPCIEQVQRTCQALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  222 AHGFTELSTLEVLPQVYNVRTVSLPLPDLG--------ANNLETNMGSDASPFRSGT--------PMKETVGHTGYLTFA 285
Cdd:pfam08704 161 ELGFTEISTLEVLLRVYDVRTVSLPVIDLGidrekeneRTRTEGLSNDDKSEDNSGNsmlgtalkPMSEAVGHTGYLTFA 240


                  ..
gi 152963555  286 TK 287
Cdd:pfam08704 241 TK 242
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 12-288 7.38e-71

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 218.88  E-value: 7.38e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  12 EGDTAILSLGHGSMVAVRVQRGAQTQTRHGVLRHSvDLIGRPFGSKVICSRGGWVYVLHPTPELWTVNLPHRTQILYSTD 91
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHD-DLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  92 IALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADKAREEFQEHRLSQWVTVHTQDVcCSGFGv 171
Cdd:COG2519   80 AGYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDI-REGID- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555 172 VHVADAVFLDIPSPWEAVGHAWDALKVeGGRFCSFSPCIEQVQRTCQALAAHGFTELSTLEVLPQVYNVRTVSL-Plpdl 250
Cdd:COG2519  158 EGDVDAVFLDMPDPWEALEAVAKALKP-GGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVrP---- 232

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 152963555 251 gannlETNMgsdaspfrsgtpmketVGHTGYLTFATKT 288
Cdd:COG2519  233 -----EHRM----------------VGHTGFLVFARKL 249
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 93-163 4.55e-06

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 45.95  E-value: 4.55e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 152963555  93 ALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADKAREEFQEHRLSQWVTVHTQD 163
Cdd:COG4122    6 RLLYLLARLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGD 76
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 93-202 2.10e-05

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 44.31  E-value: 2.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  93 ALITMMLELRPGSVVCESGTGSGSVShAIIRSVAptGHLHTVEFHQQRADKAREEFQEHRLSQwVTVHTQDvccsGF-GV 171
Cdd:COG2518   56 ARMLEALDLKPGDRVLEIGTGSGYQA-AVLARLA--GRVYSVERDPELAERARERLAALGYDN-VTVRVGD----GAlGW 127

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 152963555 172 VHVA--DAVFL-----DIPSPWeavghaWDALKvEGGR 202
Cdd:COG2518  128 PEHApfDRIIVtaaapEVPEAL------LEQLA-PGGR 158
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 98-226 1.01e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 41.52  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  98 MLELRPGSVVCESGTGSGSVSHAIIRSvapTGHLHTVEFHQQRADKAREEFQEHRLSqwVTVHTQDVCCSGFG-----VV 172
Cdd:COG2226   17 ALGLRPGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAEAGLN--VEFVVGDAEDLPFPdgsfdLV 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 152963555 173 HVADaVFLDIPSPWEAVGHAWDALKvEGGRFCSFSPCIEQVQRTCQALAAHGFT 226
Cdd:COG2226   92 ISSF-VLHHLPDPERALAEIARVLK-PGGRLVVVDFSPPDLAELEELLAEAGFE 143
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 99-233 1.04e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 43.23  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555  99 LELRPGSVVCESGTGSGSVSHAIIRSvAPTGHLHTVEFHQQRADKAREEFQEHRLSQwVTVhtqdvccsgfgVVHVADAV 178
Cdd:COG2242  243 LALRPGDVLWDIGAGSGSVSIEAARL-APGGRVYAIERDPERAALIRANARRFGVPN-VEV-----------VEGEAPEA 309

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 152963555 179 FLDIPSP------------WEAVGHAWDALKvEGGRFCSFSPCIEQVQRTCQALAAHGF-TELSTLEV 233
Cdd:COG2242  310 LADLPDPdavfiggsggnlPEILEACWARLR-PGGRLVANAVTLETLALALEALAELGYgGELVQVQV 376
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 92-150 8.10e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 40.00  E-value: 8.10e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 152963555  92 IALITMMLELRPGSVVCESGTGSGsvSHAIIRS--VAPTGHLHTVEFHQQRADKAREEFQE 150
Cdd:PRK13942  65 VAIMCELLDLKEGMKVLEIGTGSG--YHAAVVAeiVGKSGKVVTIERIPELAEKAKKTLKK 123
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
92-150 2.83e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 38.26  E-value: 2.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 152963555  92 IALITMMLELRPGSVVCESGTGSGSVShAIIRSVAptGHLHTVEFHQQRADKAREEFQE 150
Cdd:PRK00312  67 VARMTELLELKPGDRVLEIGTGSGYQA-AVLAHLV--RRVFSVERIKTLQWEAKRRLKQ 122
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
93-202 3.22e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 38.12  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963555   93 ALITMMLELRPGSVVCESGTGSGSVSHAIIRSVAPTGHLHTVEFHQQRADKAREEFQEHRLSQwVTVHTQDvccsG---- 168
Cdd:pfam01135  63 AMMLELLELKPGMRVLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLEN-VIVVVGD----Grqgw 137

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 152963555  169 -----FGVVHVADAVfLDIPSPWeavghaWDALKvEGGR 202
Cdd:pfam01135 138 pefapYDAIHVGAAA-PEIPEAL------IDQLK-EGGR 168
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
102-164 3.64e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 38.09  E-value: 3.64e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 152963555 102 RPGSVVCESGTGSGSVSHAIIRSVAptGHLHTVEFHQQRADKAREEFQEHRLSQWVTVHTQDV 164
Cdd:COG4076   34 KPGDVVLDIGTGSGLLSMLAARAGA--KKVYAVEVNPDIAAVARRIIAANGLSDRITVINADA 94
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 23-58 3.90e-03

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 34.78  E-value: 3.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 152963555   23 GSMVAVRVQRGAQTQTRHGVLRHSvDLIGRPFGSKV 58
Cdd:pfam14801  17 GRKHTITLEPGGEFHTHRGAIRHD-DLIGRPEGSVV 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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