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Conserved domains on  [gi|281427207|ref|NP_001093947|]
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pyrethroid hydrolase Ces2e precursor [Rattus norvegicus]

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate

CATH:  3.40.50.1820
EC:  3.1.1.-
Gene Ontology:  GO:0052689
PubMed:  8453375|3163407|8280778|9704093|11099800|37582413|31545554
SCOP:  3000102|4000699

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
30-536 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 676.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207   30 ASPIRNTHTGQVRGSFVHVKDTKsGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENlki 109
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGGK-PVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGS--- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  110 kmsrSPVSMSEDCLYLSIYTPAHTHKDSN-LPVMVWIHGGGLCWGMASTYDGSMLAAIEDVVVVTIQYRLGILGFFSTGD 188
Cdd:pfam00135  77 ----SGLEGSEDCLYLNVYTPKELKENKNkLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGD 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  189 EHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLPNLISNTSEV 268
Cdd:pfam00135 153 DEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQ 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  269 IYTMVANLSGCEPVDSEALMSCLREKSEEEMLAINNIVRTISG--------VVDGKFLPRHPLELLASVDFHPVPSIIGI 340
Cdd:pfam00135 233 RAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYGSvpfvpfgpVVDGDFLPEHPEELLKSGNFPKVPLLIGV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  341 NSDEYGWIIPMLHPD-STMKEINRETMRAVLKNTAVQMM--LPPECSDLLMEEYM--GDTEDSKTLQIQFNEMMGDFIFV 415
Cdd:pfam00135 313 TKDEGLLFAAYILDNvDILKALEEKLLRSLLIDLLYLLLvdLPEEISAALREEYLdwGDRDDPETSRRALVELLTDYLFN 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  416 IPALQVAHFQRS-HAPVYFYEFQHQSNFLKDirPPHVKADHGDELPYVIGYLFWdMKFVFTEEEKLLSRKMIKYWANFAR 494
Cdd:pfam00135 393 CPVIRFADLHASrGTPVYMYSFDYRGSSLRY--PKWVGVDHGDELPYVFGTPFV-GALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 281427207  495 HGNPN-SEGLPYWPAL-DHDEQYLQLDIQPVVGRALKARRLKFW 536
Cdd:pfam00135 470 TGNPNgPEGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
30-536 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 676.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207   30 ASPIRNTHTGQVRGSFVHVKDTKsGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENlki 109
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGGK-PVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGS--- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  110 kmsrSPVSMSEDCLYLSIYTPAHTHKDSN-LPVMVWIHGGGLCWGMASTYDGSMLAAIEDVVVVTIQYRLGILGFFSTGD 188
Cdd:pfam00135  77 ----SGLEGSEDCLYLNVYTPKELKENKNkLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGD 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  189 EHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLPNLISNTSEV 268
Cdd:pfam00135 153 DEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQ 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  269 IYTMVANLSGCEPVDSEALMSCLREKSEEEMLAINNIVRTISG--------VVDGKFLPRHPLELLASVDFHPVPSIIGI 340
Cdd:pfam00135 233 RAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYGSvpfvpfgpVVDGDFLPEHPEELLKSGNFPKVPLLIGV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  341 NSDEYGWIIPMLHPD-STMKEINRETMRAVLKNTAVQMM--LPPECSDLLMEEYM--GDTEDSKTLQIQFNEMMGDFIFV 415
Cdd:pfam00135 313 TKDEGLLFAAYILDNvDILKALEEKLLRSLLIDLLYLLLvdLPEEISAALREEYLdwGDRDDPETSRRALVELLTDYLFN 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  416 IPALQVAHFQRS-HAPVYFYEFQHQSNFLKDirPPHVKADHGDELPYVIGYLFWdMKFVFTEEEKLLSRKMIKYWANFAR 494
Cdd:pfam00135 393 CPVIRFADLHASrGTPVYMYSFDYRGSSLRY--PKWVGVDHGDELPYVFGTPFV-GALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 281427207  495 HGNPN-SEGLPYWPAL-DHDEQYLQLDIQPVVGRALKARRLKFW 536
Cdd:pfam00135 470 TGNPNgPEGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 36-522 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 526.52  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  36 THTGQVRGSFVhvkdtkSGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLEnlkikmSRSP 115
Cdd:cd00312    4 TPNGKVRGVDE------GGVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------WNAK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 116 VSMSEDCLYLSIYTPAHTHKDSNLPVMVWIHGGGLCWGMASTYDG-SMLAAIEDVVVVTIQYRLGILGFFSTGDEHARGN 194
Cdd:cd00312   72 LPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGdGLAREGDNVIVVSINYRLGVLGFLSTGDIELPGN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 195 WGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLPNLISNTSEVIYTMVA 274
Cdd:cd00312  152 YGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARGRAKRLA 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 275 NLSGCEPVDSEALMSCLREKSEEEMLAINNIV--------RTISGVVDGKFLPRHPLELLASVDFHPVPSIIGINSDEYG 346
Cdd:cd00312  232 RLLGCNDTSSAELLDCLRSKSAEELLDATRKLllfsyspfLPFGPVVDGDFIPDDPEELIKEGKFAKVPLIIGVTKDEGG 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 347 WIIPM-LHPDSTMKEINRETMRAVLKntAVQMMLPPECSDLLMEEYMGDTEDSKTLQIQFNEMMGDFIFVIPA-LQVAHF 424
Cdd:cd00312  312 YFAAMlLNFDAKLIIETNDRWLELLP--YLLFYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDLLFKCPArYFLAQH 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 425 QRSH-APVYFYEFQHQSNFLKDIRPPHVKADHGDELPYVIGYLFwdMKFVFTEEEKLLSRKMIKYWANFARHGNPNSEG- 502
Cdd:cd00312  390 RKAGgSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPL--LKEGLREEEEKLSRTMMKYWANFAKTGNPNTEGn 467

                        490       500
                 ....*....|....*....|.
gi 281427207 503 LPYWPA-LDHDEQYLQLDIQP 522
Cdd:cd00312  468 LVVWPAyTSESEKYLDINIEG 488
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
24-538 1.09e-172

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 497.87  E-value: 1.09e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  24 VQGQDSASPIRNTHTGQVRGSfvhvkdTKSGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLN 103
Cdd:COG2272    5 LAAAAAAAPVVRTEAGRVRGV------VEGGVRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 104 LENlkikmsrsPVSMSEDCLYLSIYTPAhTHKDSNLPVMVWIHGGGLCWGMAST--YDGSMLAAiEDVVVVTIQYRLGIL 181
Cdd:COG2272   79 PGG--------PAPGSEDCLYLNVWTPA-LAAGAKLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINYRLGAL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 182 GFF-----STGDEHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVA 256
Cdd:COG2272  149 GFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAG 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 257 LLPNLISnTSEVIYTMVANLSGCEPVDsealMSCLREKSEEEMLAINNIVRTISG-------VVDGKFLPRHPLELLASV 329
Cdd:COG2272  229 LSVLTLA-EAEAVGAAFAAALGVAPAT----LAALRALPAEELLAAQAALAAEGPgglpfgpVVDGDVLPEDPLEAFAAG 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 330 DFHPVPSIIGINSDEYGWIIPMlhpDSTMKEINRETMRAVLKNtavqmmLPPECSDLLMEEYmgdteDSKTLQIQFNEMM 409
Cdd:COG2272  304 RAADVPLLIGTNRDEGRLFAAL---LGDLGPLTAADYRAALRR------RFGDDADEVLAAY-----PAASPAEALAALA 369

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 410 GDFIFVIPALQVAH-FQRSHAPVYFYEFQHQSNFLKDIRPphvKADHGDELPYVIGYLFWDMKFVFTEEEKLLSRKMIKY 488
Cdd:COG2272  370 TDRVFRCPARRLAEaHAAAGAPVYLYRFDWRSPPLRGFGL---GAFHGAELPFVFGNLDAPALTGLTPADRALSDQMQAY 446

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 281427207 489 WANFARHGNPNSEGLPYWPALD-HDEQYLQLDIQP-VVGRALKARRLKFWTK 538
Cdd:COG2272  447 WVNFARTGDPNGPGLPEWPAYDpEDRAVMVFDAEPrVVNDPDAEERLDLWDG 498
PRK10162 PRK10162
acetyl esterase;
127-229 1.52e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 43.94  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 127 IYTPAHTHKdsnlPVMVWIHGGGLCWGMASTYDGSM--LAAIEDVVVVTIQYRLGILGFFSTGDEhargnwgylDQVAAL 204
Cdd:PRK10162  73 LYYPQPDSQ----ATLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIE---------EIVAVC 139

                         90       100
                 ....*....|....*....|....*
gi 281427207 205 RWVQQNIVHFGGNPDRVTIFGESAG 229
Cdd:PRK10162 140 CYFHQHAEDYGINMSRIGFAGDSAG 164
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
30-536 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 676.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207   30 ASPIRNTHTGQVRGSFVHVKDTKsGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENlki 109
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGGK-PVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGS--- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  110 kmsrSPVSMSEDCLYLSIYTPAHTHKDSN-LPVMVWIHGGGLCWGMASTYDGSMLAAIEDVVVVTIQYRLGILGFFSTGD 188
Cdd:pfam00135  77 ----SGLEGSEDCLYLNVYTPKELKENKNkLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLSTGD 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  189 EHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLPNLISNTSEV 268
Cdd:pfam00135 153 DEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNARQ 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  269 IYTMVANLSGCEPVDSEALMSCLREKSEEEMLAINNIVRTISG--------VVDGKFLPRHPLELLASVDFHPVPSIIGI 340
Cdd:pfam00135 233 RAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYGSvpfvpfgpVVDGDFLPEHPEELLKSGNFPKVPLLIGV 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  341 NSDEYGWIIPMLHPD-STMKEINRETMRAVLKNTAVQMM--LPPECSDLLMEEYM--GDTEDSKTLQIQFNEMMGDFIFV 415
Cdd:pfam00135 313 TKDEGLLFAAYILDNvDILKALEEKLLRSLLIDLLYLLLvdLPEEISAALREEYLdwGDRDDPETSRRALVELLTDYLFN 392

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  416 IPALQVAHFQRS-HAPVYFYEFQHQSNFLKDirPPHVKADHGDELPYVIGYLFWdMKFVFTEEEKLLSRKMIKYWANFAR 494
Cdd:pfam00135 393 CPVIRFADLHASrGTPVYMYSFDYRGSSLRY--PKWVGVDHGDELPYVFGTPFV-GALLFTEEDEKLSRKMMTYWTNFAK 469

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 281427207  495 HGNPN-SEGLPYWPAL-DHDEQYLQLDIQPVVGRALKARRLKFW 536
Cdd:pfam00135 470 TGNPNgPEGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 36-522 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 526.52  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  36 THTGQVRGSFVhvkdtkSGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLEnlkikmSRSP 115
Cdd:cd00312    4 TPNGKVRGVDE------GGVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------WNAK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 116 VSMSEDCLYLSIYTPAHTHKDSNLPVMVWIHGGGLCWGMASTYDG-SMLAAIEDVVVVTIQYRLGILGFFSTGDEHARGN 194
Cdd:cd00312   72 LPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGdGLAREGDNVIVVSINYRLGVLGFLSTGDIELPGN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 195 WGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVALLPNLISNTSEVIYTMVA 274
Cdd:cd00312  152 YGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARGRAKRLA 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 275 NLSGCEPVDSEALMSCLREKSEEEMLAINNIV--------RTISGVVDGKFLPRHPLELLASVDFHPVPSIIGINSDEYG 346
Cdd:cd00312  232 RLLGCNDTSSAELLDCLRSKSAEELLDATRKLllfsyspfLPFGPVVDGDFIPDDPEELIKEGKFAKVPLIIGVTKDEGG 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 347 WIIPM-LHPDSTMKEINRETMRAVLKntAVQMMLPPECSDLLMEEYMGDTEDSKTLQIQFNEMMGDFIFVIPA-LQVAHF 424
Cdd:cd00312  312 YFAAMlLNFDAKLIIETNDRWLELLP--YLLFYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDLLFKCPArYFLAQH 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 425 QRSH-APVYFYEFQHQSNFLKDIRPPHVKADHGDELPYVIGYLFwdMKFVFTEEEKLLSRKMIKYWANFARHGNPNSEG- 502
Cdd:cd00312  390 RKAGgSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPL--LKEGLREEEEKLSRTMMKYWANFAKTGNPNTEGn 467

                        490       500
                 ....*....|....*....|.
gi 281427207 503 LPYWPA-LDHDEQYLQLDIQP 522
Cdd:cd00312  468 LVVWPAyTSESEKYLDINIEG 488
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
24-538 1.09e-172

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 497.87  E-value: 1.09e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  24 VQGQDSASPIRNTHTGQVRGSfvhvkdTKSGVHTFLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLN 103
Cdd:COG2272    5 LAAAAAAAPVVRTEAGRVRGV------VEGGVRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 104 LENlkikmsrsPVSMSEDCLYLSIYTPAhTHKDSNLPVMVWIHGGGLCWGMAST--YDGSMLAAiEDVVVVTIQYRLGIL 181
Cdd:COG2272   79 PGG--------PAPGSEDCLYLNVWTPA-LAAGAKLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINYRLGAL 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 182 GFF-----STGDEHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSPMSQGLFHGAIMESGVA 256
Cdd:COG2272  149 GFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAG 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 257 LLPNLISnTSEVIYTMVANLSGCEPVDsealMSCLREKSEEEMLAINNIVRTISG-------VVDGKFLPRHPLELLASV 329
Cdd:COG2272  229 LSVLTLA-EAEAVGAAFAAALGVAPAT----LAALRALPAEELLAAQAALAAEGPgglpfgpVVDGDVLPEDPLEAFAAG 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 330 DFHPVPSIIGINSDEYGWIIPMlhpDSTMKEINRETMRAVLKNtavqmmLPPECSDLLMEEYmgdteDSKTLQIQFNEMM 409
Cdd:COG2272  304 RAADVPLLIGTNRDEGRLFAAL---LGDLGPLTAADYRAALRR------RFGDDADEVLAAY-----PAASPAEALAALA 369

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 410 GDFIFVIPALQVAH-FQRSHAPVYFYEFQHQSNFLKDIRPphvKADHGDELPYVIGYLFWDMKFVFTEEEKLLSRKMIKY 488
Cdd:COG2272  370 TDRVFRCPARRLAEaHAAAGAPVYLYRFDWRSPPLRGFGL---GAFHGAELPFVFGNLDAPALTGLTPADRALSDQMQAY 446

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|..
gi 281427207 489 WANFARHGNPNSEGLPYWPALD-HDEQYLQLDIQP-VVGRALKARRLKFWTK 538
Cdd:COG2272  447 WVNFARTGDPNGPGLPEWPAYDpEDRAVMVFDAEPrVVNDPDAEERLDLWDG 498
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
127-230 2.55e-19

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 86.47  E-value: 2.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 127 IYTPAHTHKdsNLPVMVWIHGGGLCWGMASTYDG--SMLAAIEDVVVVTIQYRLGilgffstgDEHargnwGYLDQV--- 201
Cdd:COG0657    3 VYRPAGAKG--PLPVVVYFHGGGWVSGSKDTHDPlaRRLAARAGAAVVSVDYRLA--------PEH-----PFPAALeda 67

                         90       100       110
                 ....*....|....*....|....*....|
gi 281427207 202 -AALRWVQQNIVHFGGNPDRVTIFGESAGG 230
Cdd:COG0657   68 yAALRWLRANAAELGIDPDRIAVAGDSAGG 97
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 142-230 1.85e-13

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 69.55  E-value: 1.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  142 MVWIHGGGLCWGMASTYDGSM--LAAIEDVVVVTIQYRLGilgffstgDEH---ArgnwGYLDQVAALRWVQQNIVHFGG 216
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHDRLCrrLAAEAGAVVVSVDYRLA--------PEHpfpA----AYDDAYAALRWLAEQAAELGA 68

                          90
                  ....*....|....
gi 281427207  217 NPDRVTIFGESAGG 230
Cdd:pfam07859  69 DPSRIAVAGDSAGG 82
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 125-230 2.68e-10

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 60.27  E-value: 2.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  125 LSIYTPAHThkDSNLPVMVWIHGGGlcW------GMASTYDGSMLAAIE-DVVVVTIQYRLgilgffsTGDEHARgnwgy 197
Cdd:pfam20434   1 LDIYLPKNA--KGPYPVVIWIHGGG--WnsgdkeADMGFMTNTVKALLKaGYAVASINYRL-------STDAKFP----- 64

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 281427207  198 lDQV----AALRWVQQNIVHFGGNPDRVTIFGESAGG 230
Cdd:pfam20434  65 -AQIqdvkAAIRFLRANAAKYGIDTNKIALMGFSAGG 100
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
127-267 5.43e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 59.65  E-value: 5.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 127 IYTPAHTHKdsnLPVMVWIHGGGlcWGMASTYDG--SMLAAiEDVVVVTIQYRlgilgffstGDEHARGNWG---YLDQV 201
Cdd:COG1506   14 LYLPADGKK---YPVVVYVHGGP--GSRDDSFLPlaQALAS-RGYAVLAPDYR---------GYGESAGDWGgdeVDDVL 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 281427207 202 AALRWVQQnivHFGGNPDRVTIFGESAGGISVSSHVVspMSQGLFHGAIMESGVALLPNLISNTSE 267
Cdd:COG1506   79 AAIDYLAA---RPYVDPDRIGIYGHSYGGYMALLAAA--RHPDRFKAAVALAGVSDLRSYYGTTRE 139
COG4099 COG4099
Predicted peptidase [General function prediction only];
126-230 1.50e-04

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 43.42  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 126 SIYTPAHTHKDSNLPVMVWIHGGG---------LCWGmASTYDGSMLAAIEDVVVVTIQYRLGilGFFSTGDehargnwg 196
Cdd:COG4099   36 RLYLPKGYDPGKKYPLVLFLHGAGergtdnekqLTHG-APKFINPENQAKFPAIVLAPQCPED--DYWSDTK-------- 104

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 281427207 197 YLDQV-AALRWVQQnivHFGGNPDRVTIFGESAGG 230
Cdd:COG4099  105 ALDAVlALLDDLIA---EYRIDPDRIYLTGLSMGG 136
PRK10162 PRK10162
acetyl esterase;
127-229 1.52e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 43.94  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 127 IYTPAHTHKdsnlPVMVWIHGGGLCWGMASTYDGSM--LAAIEDVVVVTIQYRLGILGFFSTGDEhargnwgylDQVAAL 204
Cdd:PRK10162  73 LYYPQPDSQ----ATLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIE---------EIVAVC 139

                         90       100
                 ....*....|....*....|....*
gi 281427207 205 RWVQQNIVHFGGNPDRVTIFGESAG 229
Cdd:PRK10162 140 CYFHQHAEDYGINMSRIGFAGDSAG 164
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
125-232 2.75e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 40.22  E-value: 2.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 125 LSIYTPA-HTHKDSNLPVMVWIHGGGLC-------WGMASTYDgSMLAA--IEDVVVVTIQYRLGilgffSTGDEHARGN 194
Cdd:COG2382   97 VWVYLPPgYDNPGKKYPVLYLLDGGGGDeqdwfdqGRLPTILD-NLIAAgkIPPMIVVMPDGGDG-----GDRGTEGPGN 170

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 281427207 195 WGYLDQVAA--LRWVQQNiVHFGGNPDRVTIFGESAGGIS 232
Cdd:COG2382  171 DAFERFLAEelIPFVEKN-YRVSADPEHRAIAGLSMGGLA 209
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 127-230 3.01e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 39.51  E-value: 3.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207 127 IYTPAHTHKDsnLPVMVWIHGGGLCWGMASTYdGSMLAAiEDVVVVTIQYRlgilgFF--STGDEHargNWGYLDQ---V 201
Cdd:COG1073   27 LYLPAGASKK--YPAVVVAHGNGGVKEQRALY-AQRLAE-LGFNVLAFDYR-----GYgeSEGEPR---EEGSPERrdaR 94

                         90       100
                 ....*....|....*....|....*....
gi 281427207 202 AALRWVQQnivHFGGNPDRVTIFGESAGG 230
Cdd:COG1073   95 AAVDYLRT---LPGVDPERIGLLGISLGG 120
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
168-256 3.60e-03

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 39.14  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427207  168 DVVVVTIQYRLGilGFFSTGDEHA-RGNWG---YLDQVAALRW-VQQNIVhfggNPDRVTIFGESAGGISVSshVVSPMS 242
Cdd:pfam00326  14 GYVVAIANGRGS--GGYGEAFHDAgKGDLGqneFDDFIAAAEYlIEQGYT----DPDRLAIWGGSYGGYLTG--AALNQR 85

                          90
                  ....*....|....
gi 281427207  243 QGLFHGAIMESGVA 256
Cdd:pfam00326  86 PDLFKAAVAHVPVV 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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