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Conserved domains on  [gi|157384932|ref|NP_001094832|]
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kelch repeat and BTB domain-containing protein 13 [Homo sapiens]

Protein Classification

kelch repeat and BTB domain-containing protein 13( domain architecture ID 13034542)

kelch repeat and BTB domain-containing protein 13 (KBTBD13) may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicate the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated nemaline myopathy (NEM)

Gene Ontology:  GO:0005515|GO:1990756
PubMed:  17120193|27521773|10603472|15544948
SCOP:  4001139|4003219

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-89 4.82e-43

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 146.42  E-value: 4.82e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   6 QTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALaAEDELLQAVECA 85
Cdd:cd18320    1 MQKVKVWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIMLRVLAGERPIL-NGEEILQAIECA 79


                 ....
gi 157384932  86 AFLQ 89
Cdd:cd18320   80 AFLQ 83
BACK_KBTBD13 cd18486
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 101-187 4.84e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle-specific protein. Autosomal dominant mutations may cause nemaline myopathy (NEM); these disease-associated mutations are located in conserved Kelch repeats and are predicted to disrupt the beta-propeller structure. KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicate the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM.


:

Pssm-ID: 350561  Cd Length: 89  Bit Score: 125.27  E-value: 4.84e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 101 LTSDNCALLCDAAAAFGLRDVFHSAALFICDGERELAAEL-ALPEARA-YVAALRPSSYAAVSTHTPAPGFLEDASRTLC 178
Cdd:cd18486    1 INSDNCVLMYQAAATFGLLDLFHSAALFIRDIYSELREDLdCLPEDLLdYVESLVPSTYVAVGTHTPAPGFLEDASRTVC 80


                 ....*....
gi 157384932 179 YLDEEEDAW 187
Cdd:cd18486   81 YLDEEENTW 89
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
141-383 3.30e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 104.47  E-value: 3.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 141 ALPEARAYVAALRPSSYAAVSThtpapGFLEDASRTLCY-LDEEEDAWRTLAALPLEAsTLLAGVATLGNKLYIVGGVRG 219
Cdd:COG3055    8 DLPTPRSEAAAALLDGKVYVAG-----GLSGGSASNSFEvYDPATNTWSELAPLPGPP-RHHAAAVAQDGKLYVFGGFTG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 220 ASKEVVEL--GFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAG 297
Cdd:COG3055   82 ANPSSTPLndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 298 VPCAQAC-GRLFVCLWRpadttavvEYAVRTDAWLPVAELRRPQSyGHCMVAHRDSLYVV--RNGPSDDflhcaIDCLNL 374
Cdd:COG3055  162 LAAAVLPdGKILVIGGR--------NGSGFSNTWTTLAPLPTARA-GHAAAVLGGKILVFggESGFSDE-----VEAYDP 227


                 ....*....
gi 157384932 375 ATGQWTALP 383
Cdd:COG3055  228 ATNTWTALG 236
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-89 4.82e-43

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 146.42  E-value: 4.82e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   6 QTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALaAEDELLQAVECA 85
Cdd:cd18320    1 MQKVKVWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIMLRVLAGERPIL-NGEEILQAIECA 79


                 ....
gi 157384932  86 AFLQ 89
Cdd:cd18320   80 AFLQ 83
BACK_KBTBD13 cd18486
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 101-187 4.84e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle-specific protein. Autosomal dominant mutations may cause nemaline myopathy (NEM); these disease-associated mutations are located in conserved Kelch repeats and are predicted to disrupt the beta-propeller structure. KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicate the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM.


Pssm-ID: 350561  Cd Length: 89  Bit Score: 125.27  E-value: 4.84e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 101 LTSDNCALLCDAAAAFGLRDVFHSAALFICDGERELAAEL-ALPEARA-YVAALRPSSYAAVSTHTPAPGFLEDASRTLC 178
Cdd:cd18486    1 INSDNCVLMYQAAATFGLLDLFHSAALFIRDIYSELREDLdCLPEDLLdYVESLVPSTYVAVGTHTPAPGFLEDASRTVC 80


                 ....*....
gi 157384932 179 YLDEEEDAW 187
Cdd:cd18486   81 YLDEEENTW 89
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
141-383 3.30e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 104.47  E-value: 3.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 141 ALPEARAYVAALRPSSYAAVSThtpapGFLEDASRTLCY-LDEEEDAWRTLAALPLEAsTLLAGVATLGNKLYIVGGVRG 219
Cdd:COG3055    8 DLPTPRSEAAAALLDGKVYVAG-----GLSGGSASNSFEvYDPATNTWSELAPLPGPP-RHHAAAVAQDGKLYVFGGFTG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 220 ASKEVVEL--GFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAG 297
Cdd:COG3055   82 ANPSSTPLndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 298 VPCAQAC-GRLFVCLWRpadttavvEYAVRTDAWLPVAELRRPQSyGHCMVAHRDSLYVV--RNGPSDDflhcaIDCLNL 374
Cdd:COG3055  162 LAAAVLPdGKILVIGGR--------NGSGFSNTWTTLAPLPTARA-GHAAAVLGGKILVFggESGFSDE-----VEAYDP 227


                 ....*....
gi 157384932 375 ATGQWTALP 383
Cdd:COG3055  228 ATNTWTALG 236
PHA03098 PHA03098
kelch-like protein; Provisional
 203-356 6.26e-12

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 67.49  E-value: 6.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 203 GVATLGNKLYIVGGVRGaSKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAA 282
Cdd:PHA03098 289 GSVVLNNVIYFIGGMNK-NNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGE 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157384932 283 GCWSFVADLPQPAAGVPCAQACGRLFVC--LWRPADTTAVVE-YAVRTDAWLPVAELRRPQsYGHCMVAHRDSLYVV 356
Cdd:PHA03098 368 SKWREEPPLIFPRYNPCVVNVNNLIYVIggISKNDELLKTVEcFSLNTNKWSKGSPLPISH-YGGCAIYHDGKIYVI 443
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 13-101 5.81e-10

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 56.16  E-value: 5.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932    13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAE--DELLQAvecAAFLQA 90
Cdd:smart00225   6 VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEEnvEELLEL---ADYLQI 82

                           90
                   ....*....|.
gi 157384932    91 PALARFLEHNL 101
Cdd:smart00225  83 PGLVELCEEFL 93
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 247-292 1.46e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 53.38  E-value: 1.46e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157384932  247 PRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLP 292
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 7-101 2.69e-06

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 46.10  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932    7 TLVqvwVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRpaLAAEDELLQAVECAA 86
Cdd:pfam00651  14 TLV---VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK--LISEENVDDLLAAAD 88

                          90
                  ....*....|....*
gi 157384932   87 FLQAPALARFLEHNL 101
Cdd:pfam00651  89 KLQIPSLVDKCEEFL 103
Kelch smart00612
Kelch domain;
259-298 3.50e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 43.70  E-value: 3.50e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157384932   259 RLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGV 298
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGH 40
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 180-244 2.94e-03

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 39.77  E-value: 2.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157384932  180 LDEEEDAWRTLAALPLEASTLLAGVAtLGNKLYIVGGVR-GASKEVVELGFCYDPDGGTWHEFPSP 244
Cdd:TIGR03548 147 LSNDTSGWEELPEFPGEARVQPVCQA-LHGKLYVFGGFQlGGDAIIYTDGYAYSPKTNTWQTVADP 211
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-89 4.82e-43

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 146.42  E-value: 4.82e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   6 QTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALaAEDELLQAVECA 85
Cdd:cd18320    1 MQKVKVWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEIRLQGLSARGFRIMLRVLAGERPIL-NGEEILQAIECA 79


                 ....
gi 157384932  86 AFLQ 89
Cdd:cd18320   80 AFLQ 83
BACK_KBTBD13 cd18486
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 101-187 4.84e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle-specific protein. Autosomal dominant mutations may cause nemaline myopathy (NEM); these disease-associated mutations are located in conserved Kelch repeats and are predicted to disrupt the beta-propeller structure. KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicate the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM.


Pssm-ID: 350561  Cd Length: 89  Bit Score: 125.27  E-value: 4.84e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 101 LTSDNCALLCDAAAAFGLRDVFHSAALFICDGERELAAEL-ALPEARA-YVAALRPSSYAAVSTHTPAPGFLEDASRTLC 178
Cdd:cd18486    1 INSDNCVLMYQAAATFGLLDLFHSAALFIRDIYSELREDLdCLPEDLLdYVESLVPSTYVAVGTHTPAPGFLEDASRTVC 80


                 ....*....
gi 157384932 179 YLDEEEDAW 187
Cdd:cd18486   81 YLDEEENTW 89
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
141-383 3.30e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 104.47  E-value: 3.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 141 ALPEARAYVAALRPSSYAAVSThtpapGFLEDASRTLCY-LDEEEDAWRTLAALPLEAsTLLAGVATLGNKLYIVGGVRG 219
Cdd:COG3055    8 DLPTPRSEAAAALLDGKVYVAG-----GLSGGSASNSFEvYDPATNTWSELAPLPGPP-RHHAAAVAQDGKLYVFGGFTG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 220 ASKEVVEL--GFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAG 297
Cdd:COG3055   82 ANPSSTPLndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 298 VPCAQAC-GRLFVCLWRpadttavvEYAVRTDAWLPVAELRRPQSyGHCMVAHRDSLYVV--RNGPSDDflhcaIDCLNL 374
Cdd:COG3055  162 LAAAVLPdGKILVIGGR--------NGSGFSNTWTTLAPLPTARA-GHAAAVLGGKILVFggESGFSDE-----VEAYDP 227


                 ....*....
gi 157384932 375 ATGQWTALP 383
Cdd:COG3055  228 ATNTWTALG 236
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 9-88 4.26e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 84.26  E-value: 4.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   9 VQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEDeLLQAVECAAFL 88
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASN-LLELLEAANFL 79
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
236-404 3.41e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.36  E-value: 3.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 236 GTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQAC-GRLFV----- 309
Cdd:COG3055    1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQdGKLYVfggft 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 310 -CLWRPADTTAVVEYAVRTDAWLPVAELRRPqSYGHCMVAHRDSLYVVrNGPSDDFLHCAIDCLNLATGQWTALPGqFVN 388
Cdd:COG3055   81 gANPSSTPLNDVYVYDPATNTWTKLAPMPTP-RGGATALLLDGKIYVV-GGWDDGGNVAWVEVYDPATGTWTQLAP-LPT 157

                        170
                 ....*....|....*.
gi 157384932 389 SKGALFTAVVRGDTVY 404
Cdd:COG3055  158 PRDHLAAAVLPDGKIL 173
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
141-309 1.13e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 74.04  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 141 ALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRtlcyLDEEEDAWRTLAALPlEASTLLAGVATLGNKLYIVGGVRGa 220
Cdd:COG3055  107 PMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEV----YDPATGTWTQLAPLP-TPRDHLAAAVLPDGKILVIGGRNG- 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 221 skevvelgfcyDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEfqRTPISSVERYDPAAGCWSFVADLPQPAAGVPC 300
Cdd:COG3055  181 -----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGE--SGFSDEVEAYDPATNTWTALGELPTPRHGHAA 247


                 ....*....
gi 157384932 301 AQACGRLFV 309
Cdd:COG3055  248 VLTDGKVYV 256
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
185-279 1.27e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.87  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 185 DAWRTLAALPLEASTLlaGVATLGNKLYIVGGVRGASKEVvelgFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIG 264
Cdd:COG3055  185 NTWTTLAPLPTARAGH--AAAVLGGKILVFGGESGFSDEV----EAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIG 258

                         90
                 ....*....|....*....
gi 157384932 265 GEFQ---RTP-ISSVERYD 279
Cdd:COG3055  259 GETKpgvRTPlVTSAEVYD 277
PHA03098 PHA03098
kelch-like protein; Provisional
 203-356 6.26e-12

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 67.49  E-value: 6.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 203 GVATLGNKLYIVGGVRGaSKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAA 282
Cdd:PHA03098 289 GSVVLNNVIYFIGGMNK-NNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGE 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157384932 283 GCWSFVADLPQPAAGVPCAQACGRLFVC--LWRPADTTAVVE-YAVRTDAWLPVAELRRPQsYGHCMVAHRDSLYVV 356
Cdd:PHA03098 368 SKWREEPPLIFPRYNPCVVNVNNLIYVIggISKNDELLKTVEcFSLNTNKWSKGSPLPISH-YGGCAIYHDGKIYVI 443
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-89 1.06e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 61.04  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   9 VQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATL--------QVLRGDRPALAAEDELLQ 80
Cdd:cd18319    4 VQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLdfintskvHESQGDSTDTLEENELLE 83

                         90
                 ....*....|
gi 157384932  81 A-VECAAFLQ 89
Cdd:cd18319   84 DlVEAASFLQ 93
PHA03098 PHA03098
kelch-like protein; Provisional
 201-393 1.15e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 66.71  E-value: 1.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 201 LAGVATLGNKLYIVGGVR-GASKEVVElgfCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQR-TPISSVERY 278
Cdd:PHA03098 335 NPGVTVFNNRIYVIGGIYnSISLNTVE---SWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNdELLKTVECF 411

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 279 DPAAGCWSFVADLPQPAAGVPCAQACGRLFVC-----LWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHrDSL 353
Cdd:PHA03098 412 SLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIggisyIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFN-NKI 490

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 157384932 354 YVVrNGPSDDFLHCAIDCLNLATGQWTaLPGQFVNSKGAL 393
Cdd:PHA03098 491 YVV-GGDKYEYYINEIEVYDDKTNTWT-LFCKFPKVIGSL 528
PHA03098 PHA03098
kelch-like protein; Provisional
 180-292 2.57e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 65.56  E-value: 2.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 180 LDEEEDAWRTLAALPLEastlLAGVATL--GNKLYIVGGVRGASK-EVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGF 256
Cdd:PHA03098 411 FSLNTNKWSKGSPLPIS----HYGGCAIyhDGKIYVIGGISYIDNiKVYNIVESYNPVTNKWTELSSLNFPRINASLCIF 486

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157384932 257 DGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLP 292
Cdd:PHA03098 487 NNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFP 522
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 13-101 5.81e-10

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 56.16  E-value: 5.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932    13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAE--DELLQAvecAAFLQA 90
Cdd:smart00225   6 VGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEEnvEELLEL---ADYLQI 82

                           90
                   ....*....|.
gi 157384932    91 PALARFLEHNL 101
Cdd:smart00225  83 PGLVELCEEFL 93
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 247-292 1.46e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 53.38  E-value: 1.46e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157384932  247 PRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLP 292
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-77 2.60e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 51.85  E-value: 2.60e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157384932   7 TLVqvwVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEDE 77
Cdd:cd18287   26 TFV---VEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTLTDLKE 93
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-81 8.78e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 49.47  E-value: 8.78e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157384932   9 VQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAED--ELLQA 81
Cdd:cd18186    4 VTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENveELLAA 78
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 13-104 1.12e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 46.85  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932  13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEDELLQAVECAAFLQAPA 92
Cdd:cd18300   16 VEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGDCVGLIVLANRLCLPR 95

                         90
                 ....*....|..
gi 157384932  93 LARFLEHNLTSD 104
Cdd:cd18300   96 LVALCEQYIVKE 107
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-105 1.47e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 47.00  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932  13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEDelLQAVECAA-FLQ-- 89
Cdd:cd18255   25 ADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDC--IQDVLGAAvHLQml 102

                         90
                 ....*....|....*...
gi 157384932  90 --APALARFLEHNLTSDN 105
Cdd:cd18255  103 pvVELCEEFLKSAMSVEN 120
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 7-101 2.69e-06

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 46.10  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932    7 TLVqvwVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRpaLAAEDELLQAVECAA 86
Cdd:pfam00651  14 TLV---VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK--LISEENVDDLLAAAD 88

                          90
                  ....*....|....*
gi 157384932   87 FLQAPALARFLEHNL 101
Cdd:pfam00651  89 KLQIPSLVDKCEEFL 103
Kelch smart00612
Kelch domain;
259-298 3.50e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 43.70  E-value: 3.50e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157384932   259 RLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGV 298
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGH 40
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 9-98 3.63e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 45.96  E-value: 3.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   9 VQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEdELLQAVECAAFL 88
Cdd:cd18263   16 VQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWE-NLFEATCTALQL 94

                         90
                 ....*....|.
gi 157384932  89 QA-PALARFLE 98
Cdd:cd18263   95 QIsGALALCLD 105
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 202-244 5.38e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.37  E-value: 5.38e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 157384932  202 AGVATLGNKLYIVGGVRGA-SKEVVElgfCYDPDGGTWHEFPSP 244
Cdd:pfam01344   5 AGVVVVGGKIYVIGGFDGNqSLNSVE---VYDPETNTWSKLPSM 45
Kelch smart00612
Kelch domain;
210-258 1.47e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.16  E-value: 1.47e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 157384932   210 KLYIVGGVRGAskEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDG 258
Cdd:smart00612   1 KIYVVGGFDGG--QRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_6 pfam13964
Kelch motif;
247-294 3.84e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 3.84e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 157384932  247 PRYDTALAGFDGRLYAIGGEFQRTPISS-VERYDPAAGCWSFVADLPQP 294
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNkLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-96 7.94e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 42.11  E-value: 7.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932  13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEDelLQAVECAA-FLQAP 91
Cdd:cd18251   30 VEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDN--VQETLTAAcQLQIP 107


                 ....*
gi 157384932  92 ALARF 96
Cdd:cd18251  108 EVIGF 112
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-105 9.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 42.09  E-value: 9.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932  13 VGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAeDELLQAVECAAFLQA-- 90
Cdd:cd18264   35 AEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSL-DTLEDTLEAASYLQVte 113

                         90
                 ....*....|....*..
gi 157384932  91 --PALARFLEHNLTSDN 105
Cdd:cd18264  114 aiGLCSQYLINNLAPEN 130
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-90 1.98e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 41.24  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   9 VQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDR---------PALAAED--E 77
Cdd:cd18256   23 VQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVvevtvsnvqELLVAADmlQ 102

                         90
                 ....*....|....
gi 157384932  78 LLQAVE-CAAFLQA 90
Cdd:cd18256  103 LTEVVEiCCEFLKG 116
PHA02790 PHA02790
Kelch-like protein; Provisional
 194-308 2.81e-04

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 43.11  E-value: 2.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932 194 PLEASTLLAGVATLGNKLYIVGGVRGASKevVELGFCYDPdggTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTpiS 273
Cdd:PHA02790 304 PMNSPRLYASGVPANNKLYVVGGLPNPTS--VERWFHGDA---AWVNMPSLLKPRCNPAVASINNVIYVIGGHSETD--T 376

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157384932 274 SVERYDPAAGCWSFvadlpQPAAGVPCAQACGRLF 308
Cdd:PHA02790 377 TTEYLLPNHDQWQF-----GPSTYYPHYKSCALVF 406
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-105 3.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 40.20  E-value: 3.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   7 TLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAEDeLLQAVECAA 86
Cdd:cd18253   19 TDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTEN-VQYLFETSS 97

                         90       100
                 ....*....|....*....|...
gi 157384932  87 FLQAPAL----ARFLEHNLTSDN 105
Cdd:cd18253   98 LFQISPLrdacAKFLEEQLDPCN 120
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-105 4.98e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 40.17  E-value: 4.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   3 RGPQTLVQVWV----GGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAeDEL 78
Cdd:cd18239   18 RGEGLLCDVTLvpgdGDETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYTAKLSLNM-DNL 96

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157384932  79 LQAVECAAFLQA-PALA---RFLEHNLTSDN 105
Cdd:cd18239   97 QDTLEAASFLQIlPVLDfckVLLISGVTLEN 127
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-96 8.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 39.55  E-value: 8.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932  18 FQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLR--GDRPALAAEDELLQAvecAAFLQAPALAR 95
Cdd:cd18244   42 FQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYygTIELSMLTVHEILQA---AMYVQLTEVVK 118


                 .
gi 157384932  96 F 96
Cdd:cd18244  119 F 119
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-105 8.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 39.37  E-value: 8.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   4 GPQTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALaAEDELLQAVE 83
Cdd:cd18265   21 GTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRI-QEDNVESVLE 99

                         90       100
                 ....*....|....*....|....*.
gi 157384932  84 CAAFLQAPAL----ARFLEHNLTSDN 105
Cdd:cd18265  100 ASDLLQVSKLreacVRFLEGQLHPCN 125
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-105 9.96e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 39.22  E-value: 9.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   7 TLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRL-GVLSAGGFRATLQVLRGDRPALAAE--DELLQAVE 83
Cdd:cd18254   23 TDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELLLDFAYSSRIIINEEnaESLLEAGD 102

                         90       100
                 ....*....|....*....|...
gi 157384932  84 CAAFLQA-PALARFLEHNLTSDN 105
Cdd:cd18254  103 MLQFHDVrDAAAEFLEKNLYPSN 125
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 247-291 1.78e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.16  E-value: 1.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 157384932  247 PRYDTALAGFDGRLYAIGGEFQRTPISS--VERYDPAAGCWSFVADL 291
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGDLSSsdVLVYDPETNVWTEVPRL 47
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 180-244 2.94e-03

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 39.77  E-value: 2.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157384932  180 LDEEEDAWRTLAALPLEASTLLAGVAtLGNKLYIVGGVR-GASKEVVELGFCYDPDGGTWHEFPSP 244
Cdd:TIGR03548 147 LSNDTSGWEELPEFPGEARVQPVCQA-LHGKLYVFGGFQlGGDAIIYTDGYAYSPKTNTWQTVADP 211
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-105 3.99e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 37.44  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384932   9 VQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRATLQVLRGDRPALAAE--DELLQAvecAA 86
Cdd:cd18250   24 VTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDnvEALLRA---AD 100

                         90       100
                 ....*....|....*....|...
gi 157384932  87 FLQAP----ALARFLEHNLTSDN 105
Cdd:cd18250  101 LFQFPsvkeACCAYLQQRLDVSN 123
Kelch_6 pfam13964
Kelch motif;
204-248 4.78e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.00  E-value: 4.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 157384932  204 VATLGNKLYIVGGvRGASKEVVELGFCYDPDGGTWHEFPSPHQPR 248
Cdd:pfam13964   7 VVSVGGYIYVFGG-YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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