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Conserved domains on  [gi|197384598|ref|NP_001094971|]
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uncharacterized protein LOC333588 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PGC7_Stella super family cl21352
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 3-98 9.87e-07

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


The actual alignment was detected with superfamily member pfam15549:

Pssm-ID: 464759  Cd Length: 166  Bit Score: 45.68  E-value: 9.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197384598    3 EEQYQKSSKSPEKKLKTVEFKKKKCVRFLLPHKADKEKKPSSLRDTDESKFRCECRHCQMCGGNTSGVSVGTRteavspS 82
Cdd:pfam15549  74 QQRRWERTLLSQRKKAFLRHIRRRRLDHMAPYPVEREQRISPSGDRAQNRFRCLCRYCQSHRPNISGMSGERN------P 147

                          90
                  ....*....|....*.
gi 197384598   83 SSWEKLTLDLSNLTLN 98
Cdd:pfam15549 148 SSWETLVQGLSGLNLS 163
 
Name Accession Description Interval E-value
PGC7_Stella pfam15549
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 3-98 9.87e-07

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


Pssm-ID: 464759  Cd Length: 166  Bit Score: 45.68  E-value: 9.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197384598    3 EEQYQKSSKSPEKKLKTVEFKKKKCVRFLLPHKADKEKKPSSLRDTDESKFRCECRHCQMCGGNTSGVSVGTRteavspS 82
Cdd:pfam15549  74 QQRRWERTLLSQRKKAFLRHIRRRRLDHMAPYPVEREQRISPSGDRAQNRFRCLCRYCQSHRPNISGMSGERN------P 147

                          90
                  ....*....|....*.
gi 197384598   83 SSWEKLTLDLSNLTLN 98
Cdd:pfam15549 148 SSWETLVQGLSGLNLS 163
SPX_BAH1-like cd14482
SPX domain of the E3 ubiquitin-protein ligase BAH1/NLA and similar proteins; This region has ...
 3-66 1.70e-05

SPX domain of the E3 ubiquitin-protein ligase BAH1/NLA and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. BAH1 (benzoic acid hypersensitive 1) appears to function as an E3 ubiquitin ligase; the protein contains an SPX and a RING finger domain. It has been suggested that BAH1/NLA is involved in the regulation of plant immune responses, probably via a pathway of salicylic acid biosynthesis that includes benzoic acid as an intermediate.


Pssm-ID: 269903  Cd Length: 156  Bit Score: 41.95  E-value: 1.70e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 197384598   3 EEQYQKSSKSPEKKLKTVEFKK-----KKCVRFLLPHKADkekkPSSLRDTDESKFRCECRHCQMCGGN 66
Cdd:cd14482    7 EEYLRGEQEKFLEKCSHVEYKRlkkvlKKCRSDRSLQADD----TNDDQASSDSSASCCPGSCPVCDGM 71
 
Name Accession Description Interval E-value
PGC7_Stella pfam15549
PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the ...
 3-98 9.87e-07

PGC7/Stella/Dppa3 domain; The domain belongs to a fast evolving family known only from the placental mammals. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization. This suggests that it might bind methylated DNA sequences directly. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins.


Pssm-ID: 464759  Cd Length: 166  Bit Score: 45.68  E-value: 9.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197384598    3 EEQYQKSSKSPEKKLKTVEFKKKKCVRFLLPHKADKEKKPSSLRDTDESKFRCECRHCQMCGGNTSGVSVGTRteavspS 82
Cdd:pfam15549  74 QQRRWERTLLSQRKKAFLRHIRRRRLDHMAPYPVEREQRISPSGDRAQNRFRCLCRYCQSHRPNISGMSGERN------P 147

                          90
                  ....*....|....*.
gi 197384598   83 SSWEKLTLDLSNLTLN 98
Cdd:pfam15549 148 SSWETLVQGLSGLNLS 163
SPX_BAH1-like cd14482
SPX domain of the E3 ubiquitin-protein ligase BAH1/NLA and similar proteins; This region has ...
 3-66 1.70e-05

SPX domain of the E3 ubiquitin-protein ligase BAH1/NLA and similar proteins; This region has been named the SPX domain after (Syg1, Pho81 and XPR1). The domain is found at the amino terminus of a variety of proteins. BAH1 (benzoic acid hypersensitive 1) appears to function as an E3 ubiquitin ligase; the protein contains an SPX and a RING finger domain. It has been suggested that BAH1/NLA is involved in the regulation of plant immune responses, probably via a pathway of salicylic acid biosynthesis that includes benzoic acid as an intermediate.


Pssm-ID: 269903  Cd Length: 156  Bit Score: 41.95  E-value: 1.70e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 197384598   3 EEQYQKSSKSPEKKLKTVEFKK-----KKCVRFLLPHKADkekkPSSLRDTDESKFRCECRHCQMCGGN 66
Cdd:cd14482    7 EEYLRGEQEKFLEKCSHVEYKRlkkvlKKCRSDRSLQADD----TNDDQASSDSSASCCPGSCPVCDGM 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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