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Conserved domains on  [gi|156523248|ref|NP_001096033|]
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proline-rich transmembrane protein 2 [Mus musculus]

Protein Classification

CD225/dispanin family protein( domain architecture ID 10517436)

CD225/dispanin family protein similar to Homo sapiens tumor suppressor candidate 5 (TUSC5), which may be involved in fat metabolism, and synapse differentiation-inducing gene protein 1 (SynDIG1), which may regulate AMPA receptor content at nascent synapses and have a role in postsynaptic development and maturation. CD225 is an interferon-inducible transmembrane protein associated with interferon induced cell growth suppression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD225 pfam04505
Interferon-induced transmembrane protein; This family includes the human leukocyte antigen ...
 270-336 1.33e-28

Interferon-induced transmembrane protein; This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.


:

Pssm-ID: 461336  Cd Length: 68  Bit Score: 105.66  E-value: 1.33e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156523248  270 KPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIA 336
Cdd:pfam04505   1 PPPDYLVWSIFSTLCCCLPLGIVAIVYSVKVRDRKAAGDYEGAQRASRTAKCLNIIALVLGLVVIIL 67
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 14-215 4.72e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 4.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248   14 VEDSSKTQTEGPRHSEEGLGPVQVVAEIPDQPEALQPGPGItAAPVDSGPkaeLAPETTETPVETPETVQAT-----DLS 88
Cdd:PHA03247 2788 VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL-PPPTSAQP---TAPPPPPGPPPPSLPLGGSvapggDVR 2863

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248   89 LNPEEGSKASPSPSPSEARQEPASKPDVNRETAAEEGSEPQSTAPPEPTSEPAFQINTQSDPQPTSQPPPKPPLQAEPPT 168
Cdd:PHA03247 2864 RRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 156523248  169 QEDPTTEVLTESTG--EKQENGAVVPL----------QAGDGEEGPAPQPHSPPSTKTP 215
Cdd:PHA03247 2944 APTTDPAGAGEPSGavPQPWLGALVPGrvavprfrvpQPAPSREAPASSTPPLTGHSLS 3002
 
Name Accession Description Interval E-value
CD225 pfam04505
Interferon-induced transmembrane protein; This family includes the human leukocyte antigen ...
 270-336 1.33e-28

Interferon-induced transmembrane protein; This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.


Pssm-ID: 461336  Cd Length: 68  Bit Score: 105.66  E-value: 1.33e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156523248  270 KPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIA 336
Cdd:pfam04505   1 PPPDYLVWSIFSTLCCCLPLGIVAIVYSVKVRDRKAAGDYEGAQRASRTAKCLNIIALVLGLVVIIL 67
PHA03247 PHA03247
large tegument protein UL36; Provisional
 14-215 4.72e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 4.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248   14 VEDSSKTQTEGPRHSEEGLGPVQVVAEIPDQPEALQPGPGItAAPVDSGPkaeLAPETTETPVETPETVQAT-----DLS 88
Cdd:PHA03247 2788 VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL-PPPTSAQP---TAPPPPPGPPPPSLPLGGSvapggDVR 2863

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248   89 LNPEEGSKASPSPSPSEARQEPASKPDVNRETAAEEGSEPQSTAPPEPTSEPAFQINTQSDPQPTSQPPPKPPLQAEPPT 168
Cdd:PHA03247 2864 RRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 156523248  169 QEDPTTEVLTESTG--EKQENGAVVPL----------QAGDGEEGPAPQPHSPPSTKTP 215
Cdd:PHA03247 2944 APTTDPAGAGEPSGavPQPWLGALVPGrvavprfrvpQPAPSREAPASSTPPLTGHSLS 3002
 
Name Accession Description Interval E-value
CD225 pfam04505
Interferon-induced transmembrane protein; This family includes the human leukocyte antigen ...
 270-336 1.33e-28

Interferon-induced transmembrane protein; This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.


Pssm-ID: 461336  Cd Length: 68  Bit Score: 105.66  E-value: 1.33e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 156523248  270 KPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIA 336
Cdd:pfam04505   1 PPPDYLVWSIFSTLCCCLPLGIVAIVYSVKVRDRKAAGDYEGAQRASRTAKCLNIIALVLGLVVIIL 67
PHA03247 PHA03247
large tegument protein UL36; Provisional
 14-215 4.72e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 4.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248   14 VEDSSKTQTEGPRHSEEGLGPVQVVAEIPDQPEALQPGPGItAAPVDSGPkaeLAPETTETPVETPETVQAT-----DLS 88
Cdd:PHA03247 2788 VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL-PPPTSAQP---TAPPPPPGPPPPSLPLGGSvapggDVR 2863

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248   89 LNPEEGSKASPSPSPSEARQEPASKPDVNRETAAEEGSEPQSTAPPEPTSEPAFQINTQSDPQPTSQPPPKPPLQAEPPT 168
Cdd:PHA03247 2864 RRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 156523248  169 QEDPTTEVLTESTG--EKQENGAVVPL----------QAGDGEEGPAPQPHSPPSTKTP 215
Cdd:PHA03247 2944 APTTDPAGAGEPSGavPQPWLGALVPGrvavprfrvpQPAPSREAPASSTPPLTGHSLS 3002
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
57-186 1.00e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.91  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248  57 APVDSGPKAELAPETTEtPVETPETVQATDLSLNPEEGSKASPSPSPSEARQEPASKPDVNRETAAEEGSEPQSTAPPEP 136
Cdd:PRK14971 369 ASGGRGPKQHIKPVFTQ-PAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAV 447

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 156523248 137 TsePAFQINTQSDPQPTSQPPPKPPLQAEPPTQEDPTTEVLTESTGEKQE 186
Cdd:PRK14971 448 R--PAQFKEEKKIPVSKVSSLGPSTLRPIQEKAEQATGNIKEAPTGTQKE 495
PHA03247 PHA03247
large tegument protein UL36; Provisional
 42-224 1.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248   42 PDQPEALQPGPGiTAAPVDSGPKAELAPETTETPVETPETVQATDLSLNPEEGSKASPSPSPSEARQEPASKPDVNRETA 121
Cdd:PHA03247 2804 PADPPAAVLAPA-AALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPP 2882

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248  122 AEEGSEPQSTAPPEPTSEPafqintqsdpqptsqpppkpPLQAEPPTQEDPTTEVLTESTGEKQENGAVVPlqagdgEEG 201
Cdd:PHA03247 2883 VRRLARPAVSRSTESFALP--------------------PDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP------PPP 2936

                         170       180
                  ....*....|....*....|...
gi 156523248  202 PAPQPHSPPSTKTPPANGAPPRV 224
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAGEPSGAV 2959
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
42-223 4.55e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.06  E-value: 4.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248  42 PDQPEALqPGPGITAAPVDSGPKAELAPETTETPVETPETVQATDLSLNPEEGSKA-SPSPSPSEARQEPASKPDVNRET 120
Cdd:PRK07003 374 ARVAGAV-PAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAaPAPPATADRGDDAADGDAPVPAK 452

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248 121 AAEEGsePQSTAPPEPTSEPAFQINTQSDPQPTsqpppkpplQAEPPTQEDPTTEVLTESTGEKQENGAVVPLQAGDGEE 200
Cdd:PRK07003 453 ANARA--SADSRCDERDAQPPADSGSASAPASD---------APPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDA 521

                        170       180
                 ....*....|....*....|...
gi 156523248 201 GPAPQPHSPPSTKTPPANGAPPR 223
Cdd:PRK07003 522 PAAAAPPAPEARPPTPAAAAPAA 544
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 78-266 7.00e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.43  E-value: 7.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248  78 TPETVQATDLSLNPEEGSKASPSPSPSEARQEPAskpdvnretAAEEGSEPQSTAPPEPTSEPAFQINTQSDPQPTSQPP 157
Cdd:PRK07764 583 QVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPA---------APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHH 653

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156523248 158 PKPPLQAEPPTQEDPTTEVLTESTGEKQENGAVVPLQAGDGEEgPAPQPHSPPSTKTPPANGAPPRVLQKLVEEDRIGRA 237
Cdd:PRK07764 654 PKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGA-APAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPS 732

                        170       180
                 ....*....|....*....|....*....
gi 156523248 238 HGGHPGSPrgsLSRHPSSQLAGPGVEGGE 266
Cdd:PRK07764 733 PAADDPVP---LPPEPDDPPDPAGAPAQP 758
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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