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Conserved domains on  [gi|161077563|ref|NP_001096881|]
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uncharacterized protein Dmel_CG44774, isoform D [Drosophila melanogaster]

Protein Classification

FAM60A domain-containing protein( domain architecture ID 10634123)

FAM60A domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FAM60A pfam15396
Protein Family FAM60A; This protein family, FAM60A is a family of proteins is found in ...
2-269 9.52e-107

Protein Family FAM60A; This protein family, FAM60A is a family of proteins is found in eukaryotes. It is known to be a cell cycle protein that binds to the promoter of a gene transcription repressor complex, named SIN4-HDAC complex. This means that FAM60A has an important role to play in 'switching on' gene expression. Proteins in this family are typically between 179 and 324 amino acids in length.


:

Pssm-ID: 464703  Cd Length: 206  Bit Score: 320.48  E-value: 9.52e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077563    2 FNFHKPRVYRSADGCCICRAKSSSSRFTASRKYEKESMQCFNLNEPRNGEICNACVLLVKRYKRLPIGSKRHWGHVVDAR 81
Cdd:pfam15396   1 FSFHKPKVYRSADGCCICKAKSSSSRFTDSRKYEKEFMLCFNLHEPRNGEICNACVLLVKRWKKLPPGSKRNWRHVVDAR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077563   82 AGPGTKSMAKQKKRdnadaksraangsgnSFLPEKFAKNRKSKERAAteaaaarpSSLSLSTSAVNRPSSTSPT-SDHQH 160
Cdd:pfam15396  81 AGPGTKSLAKFKKR---------------SFIPEKFAKILKKNKKLK--------KTARQNSDAHSTTRSASPSsSDSPS 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077563  161 SDSNESYDDEQTlpankpyqtrkrtaaaalataneskepnnkrpkltgsYRRRQLVPQKNRRSVDNIPFFEENDLVRLEV 240
Cdd:pfam15396 138 NDSDEGSDTELT-------------------------------------KRRCQLKPKKNRSSPDNSPFLDLSYWKREKI 180
                         250       260
                  ....*....|....*....|....*....
gi 161077563  241 CCGVVFQSLslgSTYYIIDPELYKPCAKH 269
Cdd:pfam15396 181 CCGTIFKGP---HGEVIIDPRLLKPCCKH 206
 
Name Accession Description Interval E-value
FAM60A pfam15396
Protein Family FAM60A; This protein family, FAM60A is a family of proteins is found in ...
2-269 9.52e-107

Protein Family FAM60A; This protein family, FAM60A is a family of proteins is found in eukaryotes. It is known to be a cell cycle protein that binds to the promoter of a gene transcription repressor complex, named SIN4-HDAC complex. This means that FAM60A has an important role to play in 'switching on' gene expression. Proteins in this family are typically between 179 and 324 amino acids in length.


Pssm-ID: 464703  Cd Length: 206  Bit Score: 320.48  E-value: 9.52e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077563    2 FNFHKPRVYRSADGCCICRAKSSSSRFTASRKYEKESMQCFNLNEPRNGEICNACVLLVKRYKRLPIGSKRHWGHVVDAR 81
Cdd:pfam15396   1 FSFHKPKVYRSADGCCICKAKSSSSRFTDSRKYEKEFMLCFNLHEPRNGEICNACVLLVKRWKKLPPGSKRNWRHVVDAR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077563   82 AGPGTKSMAKQKKRdnadaksraangsgnSFLPEKFAKNRKSKERAAteaaaarpSSLSLSTSAVNRPSSTSPT-SDHQH 160
Cdd:pfam15396  81 AGPGTKSLAKFKKR---------------SFIPEKFAKILKKNKKLK--------KTARQNSDAHSTTRSASPSsSDSPS 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077563  161 SDSNESYDDEQTlpankpyqtrkrtaaaalataneskepnnkrpkltgsYRRRQLVPQKNRRSVDNIPFFEENDLVRLEV 240
Cdd:pfam15396 138 NDSDEGSDTELT-------------------------------------KRRCQLKPKKNRSSPDNSPFLDLSYWKREKI 180
                         250       260
                  ....*....|....*....|....*....
gi 161077563  241 CCGVVFQSLslgSTYYIIDPELYKPCAKH 269
Cdd:pfam15396 181 CCGTIFKGP---HGEVIIDPRLLKPCCKH 206
 
Name Accession Description Interval E-value
FAM60A pfam15396
Protein Family FAM60A; This protein family, FAM60A is a family of proteins is found in ...
2-269 9.52e-107

Protein Family FAM60A; This protein family, FAM60A is a family of proteins is found in eukaryotes. It is known to be a cell cycle protein that binds to the promoter of a gene transcription repressor complex, named SIN4-HDAC complex. This means that FAM60A has an important role to play in 'switching on' gene expression. Proteins in this family are typically between 179 and 324 amino acids in length.


Pssm-ID: 464703  Cd Length: 206  Bit Score: 320.48  E-value: 9.52e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077563    2 FNFHKPRVYRSADGCCICRAKSSSSRFTASRKYEKESMQCFNLNEPRNGEICNACVLLVKRYKRLPIGSKRHWGHVVDAR 81
Cdd:pfam15396   1 FSFHKPKVYRSADGCCICKAKSSSSRFTDSRKYEKEFMLCFNLHEPRNGEICNACVLLVKRWKKLPPGSKRNWRHVVDAR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077563   82 AGPGTKSMAKQKKRdnadaksraangsgnSFLPEKFAKNRKSKERAAteaaaarpSSLSLSTSAVNRPSSTSPT-SDHQH 160
Cdd:pfam15396  81 AGPGTKSLAKFKKR---------------SFIPEKFAKILKKNKKLK--------KTARQNSDAHSTTRSASPSsSDSPS 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077563  161 SDSNESYDDEQTlpankpyqtrkrtaaaalataneskepnnkrpkltgsYRRRQLVPQKNRRSVDNIPFFEENDLVRLEV 240
Cdd:pfam15396 138 NDSDEGSDTELT-------------------------------------KRRCQLKPKKNRSSPDNSPFLDLSYWKREKI 180
                         250       260
                  ....*....|....*....|....*....
gi 161077563  241 CCGVVFQSLslgSTYYIIDPELYKPCAKH 269
Cdd:pfam15396 181 CCGTIFKGP---HGEVIIDPRLLKPCCKH 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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