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Conserved domains on  [gi|442616929|ref|NP_001097031|]
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uncharacterized protein Dmel_CG8028, isoform C [Drosophila melanogaster]

Protein Classification

MCT family MFS transporter( domain architecture ID 13023897)

monocarboxylate transporter (MCT) family major facilitator superfamily (MFS) transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
39-531 5.00e-79

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 252.86  E-value: 5.00e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  39 GILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFL 118
Cdd:cd17352    1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 119 GTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCL 198
Cdd:cd17352   81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 199 LILTGLNAHAVFGMLVMHpvewhmrrvpiqpeeqeelkelsptvvirvqpetplkatreepnfhtadpgarklshaeeqm 278
Cdd:cd17352  161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 279 lkvlssrassitslgnwsgpvvvsdaspqmmhslqtsrrpstiagasgavapahatkkswvrtivdfldltLLKKPIFVN 358
Cdd:cd17352  179 -----------------------------------------------------------------------LLKDPTFVL 187
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 359 IVLGITFALYSDITFFTMQPVYLFELGYSRPDTATIIAIGAAADLASRIFLAITA--VCIQVPSRYIYLAGAVFTVFARF 436
Cdd:cd17352  188 LALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAdkPRIGRLYLYIFTLLILGLSLLAF 267
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 437 AFNgiTQFVGMACITAVIGFLRTWLHVPLPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIVGFIRDKTRDYIFVFHI 516
Cdd:cd17352  268 PLA--TTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYF 345
                        490
                 ....*....|....*
gi 442616929 517 LNGFMILCAAPWVLE 531
Cdd:cd17352  346 CGACLLLSGVLLFLL 360
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
39-531 5.00e-79

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 252.86  E-value: 5.00e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  39 GILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFL 118
Cdd:cd17352    1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 119 GTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCL 198
Cdd:cd17352   81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 199 LILTGLNAHAVFGMLVMHpvewhmrrvpiqpeeqeelkelsptvvirvqpetplkatreepnfhtadpgarklshaeeqm 278
Cdd:cd17352  161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 279 lkvlssrassitslgnwsgpvvvsdaspqmmhslqtsrrpstiagasgavapahatkkswvrtivdfldltLLKKPIFVN 358
Cdd:cd17352  179 -----------------------------------------------------------------------LLKDPTFVL 187
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 359 IVLGITFALYSDITFFTMQPVYLFELGYSRPDTATIIAIGAAADLASRIFLAITA--VCIQVPSRYIYLAGAVFTVFARF 436
Cdd:cd17352  188 LALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAdkPRIGRLYLYIFTLLILGLSLLAF 267
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 437 AFNgiTQFVGMACITAVIGFLRTWLHVPLPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIVGFIRDKTRDYIFVFHI 516
Cdd:cd17352  268 PLA--TTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYF 345
                        490
                 ....*....|....*
gi 442616929 517 LNGFMILCAAPWVLE 531
Cdd:cd17352  346 CGACLLLSGVLLFLL 360
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
32-204 4.29e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 73.75  E-value: 4.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  32 EAPDGGWGILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVT 111
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 112 GGILYFLGTGMQLFATSTLHLIMAFsVVQGFAFGLMVPTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMS 190
Cdd:COG2271   81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
                        170
                 ....*....|....
gi 442616929 191 WYGFRGCLLILTGL 204
Cdd:COG2271  160 AFGWRAAFLILGLP 173
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
34-231 6.80e-14

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 74.01  E-value: 6.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929   34 PDGGWGILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGG 113
Cdd:TIGR00892  12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  114 ILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYG 193
Cdd:TIGR00892  92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 442616929  194 FRGCLLILTGLNAHAVFGMLVMHPVEWHMRRVPIQPEE 231
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKE 209
MFS_1 pfam07690
Major Facilitator Superfamily;
69-206 2.77e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.05  E-value: 2.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929   69 KSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMqLFATSTLHLIMAFSVVQGFAFGLMV 148
Cdd:pfam07690  25 EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-LLFASSLWLLLVLRVLQGLGAGALF 103
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442616929  149 PTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNA 206
Cdd:pfam07690 104 PAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
39-531 5.00e-79

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 252.86  E-value: 5.00e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  39 GILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFL 118
Cdd:cd17352    1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 119 GTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCL 198
Cdd:cd17352   81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 199 LILTGLNAHAVFGMLVMHpvewhmrrvpiqpeeqeelkelsptvvirvqpetplkatreepnfhtadpgarklshaeeqm 278
Cdd:cd17352  161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 279 lkvlssrassitslgnwsgpvvvsdaspqmmhslqtsrrpstiagasgavapahatkkswvrtivdfldltLLKKPIFVN 358
Cdd:cd17352  179 -----------------------------------------------------------------------LLKDPTFVL 187
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 359 IVLGITFALYSDITFFTMQPVYLFELGYSRPDTATIIAIGAAADLASRIFLAITA--VCIQVPSRYIYLAGAVFTVFARF 436
Cdd:cd17352  188 LALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAdkPRIGRLYLYIFTLLILGLSLLAF 267
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 437 AFNgiTQFVGMACITAVIGFLRTWLHVPLPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPIVGFIRDKTRDYIFVFHI 516
Cdd:cd17352  268 PLA--TTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYF 345
                        490
                 ....*....|....*
gi 442616929 517 LNGFMILCAAPWVLE 531
Cdd:cd17352  346 CGACLLLSGVLLFLL 360
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
57-209 2.10e-17

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 84.37  E-value: 2.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  57 LPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAF 136
Cdd:cd17423   19 LRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLGFLLASFATSLLHLYLCI 98
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442616929 137 SVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNAHAV 209
Cdd:cd17423   99 GLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLLSALSLHLV 171
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
32-204 4.29e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 73.75  E-value: 4.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  32 EAPDGGWGILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVT 111
Cdd:COG2271    1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 112 GGILYFLGTGMQLFATSTLHLIMAFsVVQGFAFGLMVPTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMS 190
Cdd:COG2271   81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
                        170
                 ....*....|....
gi 442616929 191 WYGFRGCLLILTGL 204
Cdd:COG2271  160 AFGWRAAFLILGLP 173
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
34-231 6.80e-14

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 74.01  E-value: 6.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929   34 PDGGWGILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGG 113
Cdd:TIGR00892  12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  114 ILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYG 193
Cdd:TIGR00892  92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 442616929  194 FRGCLLILTGLNAHAVFGMLVMHPVEWHMRRVPIQPEE 231
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKE 209
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
40-236 7.66e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 66.92  E-value: 7.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  40 ILVCIGMALPFTSALAALPSFGLVFGEFlksiGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLG 119
Cdd:COG2814   13 LALALGAFLSGLGIGIVLPALPLIAADL----GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 120 TGMQLFATStLHLIMAFSVVQGFAFGLMVPTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCL 198
Cdd:COG2814   89 SLLCALAPS-LWLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 442616929 199 LILTGLNAHAVFGMLVMHPVEWHMRRVPIQPEEQEELK 236
Cdd:COG2814  168 LVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLR 205
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
37-204 9.03e-12

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 66.70  E-value: 9.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  37 GWGILVCIGMALPFTSALaaLPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILY 116
Cdd:cd17422    1 GWAVAVAFFFVEVFTYGV--IKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 117 FLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRG 196
Cdd:cd17422   79 SLGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRY 158

                 ....*...
gi 442616929 197 CLLILTGL 204
Cdd:cd17422  159 CLLVVGAL 166
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
39-223 2.69e-10

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 62.10  E-value: 2.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  39 GILVCIGMALPFTSALaalpsfGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFL 118
Cdd:cd17425    7 ATMIVQGLTLGFPSCI------GIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 119 GTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCL 198
Cdd:cd17425   81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
                        170       180
                 ....*....|....*....|....*
gi 442616929 199 LILTGLNAHAVFGMLVMHPVEWHMR 223
Cdd:cd17425  161 LVFGGVLLNCCVCGAVMRPFCSNTR 185
MFS_1 pfam07690
Major Facilitator Superfamily;
69-206 2.77e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.05  E-value: 2.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929   69 KSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMqLFATSTLHLIMAFSVVQGFAFGLMV 148
Cdd:pfam07690  25 EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-LLFASSLWLLLVLRVLQGLGAGALF 103
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442616929  149 PTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLNA 206
Cdd:pfam07690 104 PAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
40-225 1.72e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 59.05  E-value: 1.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  40 ILVCIGMALP---FTSALAALPSFGlvfgeflKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILY 116
Cdd:COG0477   17 LALALGTFLEgldFTIVNVALPSIA-------ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 117 FLGTGMQLFATSTLHLImAFSVVQGFAFGLMVPTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFR 195
Cdd:COG0477   90 GLASLLCGLAPSPELLI-AARALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
                        170       180       190
                 ....*....|....*....|....*....|
gi 442616929 196 GCLLILTGLNAHAVFGMLVMHPVEWHMRRV 225
Cdd:COG0477  169 WIFLINAPLGLLALVLRLRLPESRGLLLAL 198
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
37-226 2.02e-09

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 59.59  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  37 GWGIL-VCIGMALPftsALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGIL 115
Cdd:cd17355    1 GWVVLaVTFLILIL---SWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 116 YFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTF-NHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGF 194
Cdd:cd17355   78 LAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVaAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGW 157
                        170       180       190
                 ....*....|....*....|....*....|..
gi 442616929 195 RGCLLILTGLNAhavfgmLVMHPVEWHMRRVP 226
Cdd:cd17355  158 RTALLVLALLAL------LVLVPVLLLLRRRP 183
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
40-226 3.94e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 58.73  E-value: 3.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  40 ILVCIGMALPFTSalaalpsFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLG 119
Cdd:COG2807   24 VLVALNLRPAITS-------VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 120 TGMQLFATSTLHLImAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLL 199
Cdd:COG2807   97 LLLRSLAPSVALLL-AGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALA 175
                        170       180
                 ....*....|....*....|....*..
gi 442616929 200 ILTGLnahAVFGMLVMHPVEWHMRRVP 226
Cdd:COG2807  176 VWALL---ALLALLLWLPLLRRRPAAA 199
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
59-200 9.91e-09

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 57.15  E-value: 9.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  59 SFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSV 138
Cdd:cd17429   21 ALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSLGWVLSAYATNVHYLFISFGV 100
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442616929 139 VQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLI 200
Cdd:cd17429  101 TAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFI 162
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
46-215 1.50e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 56.79  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  46 MALPFTSALAALPSFGLVFG-------EFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFL 118
Cdd:COG0738    6 YRRALIAIYLLFFLWGFATAlwgplipALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 119 GTGMQLFATSTLHLIMAFsVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQklmswygfrgcL 198
Cdd:COG0738   86 GLLLFALAPSYPLLLLAL-FLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGG-----------L 153
                        170
                 ....*....|....*..
gi 442616929 199 LILTGLNAHAVFGMLVM 215
Cdd:COG0738  154 LILLGLSLSWHLPYLIL 170
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
37-219 1.98e-08

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 56.28  E-value: 1.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  37 GWGIL----VCIGMALPFTSALAalpsfgLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTG 112
Cdd:cd17430    1 GWAVLfgcfVITGFSYAFPKAVS------VFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVG 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 113 GILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMwmsfAQTLIGLGSMLYPIVM----QKL 188
Cdd:cd17430   75 GLLASLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPL----ANGLAAAGSPVFLSALsplgQIL 150
                        170       180       190
                 ....*....|....*....|....*....|.
gi 442616929 189 MSWYGFRGCLLILTGLNAHAVFGMLVMHPVE 219
Cdd:cd17430  151 LEEYGWRGGFLILGGLLLNCCTCGAVMRPLD 181
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
36-245 1.52e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.73  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  36 GGWGILVCIGMAlpFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGIL 115
Cdd:COG2223    2 GRWRVLLLATLA--FFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 116 YFLGTGMQLFATSTLHLImAFSVVQGFAFGLMVPTCYTTFNHYFVKNRV-MWMSFAQTLIGLGSMLYPIVMQKLMSWYGF 194
Cdd:COG2223   80 LGIGLLLLALAVSYWLLL-LLGLLLGIGGGGSFAVGIALVSKWFPPDRRgLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442616929 195 RGCLLILtglnahAVFGMLVMHPVEWHMRRVPIQPEEQEELKELSPTVVIR 245
Cdd:COG2223  159 RNAFLIL------GILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALR 203
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
59-238 5.46e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 52.04  E-value: 5.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  59 SFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLhLIMAFSV 138
Cdd:cd06174   14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW-LLLLGRF 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 139 VQGFAFGLMVPTCYTTFNHYFV-KNRVMWMSFAQTLIGLGSMLYPIVMQKLMSW--YGFRGCLLILTGLNAHAVFGMLVM 215
Cdd:cd06174   93 LLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLV 172
                        170       180
                 ....*....|....*....|...
gi 442616929 216 HPVEWHMRRVPIQPEEQEELKEL 238
Cdd:cd06174  173 VPDPPESARAKNEEASSKSVLKL 195
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
37-218 1.04e-06

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 50.97  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  37 GW----GILVCIGMALPFTSALAALpsfglvFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTG 112
Cdd:cd17427    1 GWavvfGAFISIGFSYAFPKAITVF------FKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAG 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 113 GILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVM--WMSFAQTLIGLgSMLYPIvMQKLMS 190
Cdd:cd17427   75 GLLCSLGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIanGLAMAGSPVFL-STLAPL-NQFLFN 152
                        170       180
                 ....*....|....*....|....*...
gi 442616929 191 WYGFRGCLLILTGLNAHAVFGMLVMHPV 218
Cdd:cd17427  153 QFGWRGSFLILGGLLLNCCVAGSLMRPL 180
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
48-219 1.13e-06

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 50.87  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  48 LPFTSALAAL-----PSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGM 122
Cdd:cd17314    5 LYVSFLLSAMstgfiLSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 123 QLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILT 202
Cdd:cd17314   85 LSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILG 164
                        170
                 ....*....|....*..
gi 442616929 203 GLNAHAVFGMLVMHPVE 219
Cdd:cd17314  165 ILAAIVLSVVSLLGFKE 181
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
7-215 1.79e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 1.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929   7 VWLTIEH--RLQSRPAYQMKKSKSYTLEAPDGGWGILVCIGMALpFTSALAALPSFglvfgefLKSIGAETSAMAIITSA 84
Cdd:cd17473  169 VLLFLPEpaRKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLL-FYVIPIQLPFL-------LQERGGGSAALIGLALA 240
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  85 FFSSMSF-AGLFSGSLFQRFGMRQVGVTGGILYFLGTGMqLFATSTLHLIMAFSVVQGFAFGLMVPTCYT-TFNHYFVKN 162
Cdd:cd17473  241 IASLAGAiGALLFGRLKRRLGKRRLLAIGFALMALGFLL-LALASGLWVVLLGAILAGLGFGLLLPTLNSwAMSLVPPEL 319
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442616929 163 RVMWMSFAQTLIGLGSMLYPIVMQKLMSWY-GFRGCLLILTGLNAHAVFGMLVM 215
Cdd:cd17473  320 RGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLL 373
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
37-218 4.99e-06

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 49.11  E-value: 4.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  37 GWGILVCIGMALPFTSALAAlpSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILY 116
Cdd:cd17426    1 GWAVVLGAFISIGFSYAFPK--SITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 117 FLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRvmwmSFAQTLIGLGSMLYPIVMQKLMSW----Y 192
Cdd:cd17426   79 GAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKR----PLANGLAMAGSPVFLSTLAPLNQWffdiF 154
                        170       180
                 ....*....|....*....|....*.
gi 442616929 193 GFRGCLLILTGLNAHAVFGMLVMHPV 218
Cdd:cd17426  155 GWRGSFLILGGLLLNCCVAGSLMRPI 180
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
60-204 5.70e-06

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 48.65  E-value: 5.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  60 FGLVFGEFLKSIGAETSAMAIITSAF-FSSMSFAGLfsGSLFQRFGMRQVGVT-GGILYFLGTGMQLFATSTLHLIMAFS 137
Cdd:cd17424   22 ISIFFVEFQNYFAQDYARTAWIHSIVdCTTMLCAPL--GSLISNHLSCQVGIIlGGLLASTGLILSSFATSLEYLYLTLG 99
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442616929 138 VVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGL 204
Cdd:cd17424  100 VLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGF 166
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
54-226 8.15e-06

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 48.28  E-value: 8.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  54 LAALPSFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLI 133
Cdd:cd17421   16 MGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSAGFLISIFATSVPFLY 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 134 MAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVmQKLMSWYGFRGCLLILTGLNAHAVFGML 213
Cdd:cd17421   96 VSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFALAPFT-QLLLDEYDWQGALLIFGGIMLNLVASGM 174
                        170
                 ....*....|...
gi 442616929 214 VMHPVEWHMRRVP 226
Cdd:cd17421  175 LLRPIDFSLLKDP 187
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
37-204 9.24e-06

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 47.89  E-value: 9.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  37 GWGILVCIGMA--LPFTSALAAlpsfGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGI 114
Cdd:cd17428    1 GWVIVFVSFLAqfLCYGSPLAV----GVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 115 LYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGF 194
Cdd:cd17428   77 MVAGGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGL 156
                        170
                 ....*....|
gi 442616929 195 RGCLLILTGL 204
Cdd:cd17428  157 DGCLLIVGAL 166
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
46-200 1.00e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 47.94  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  46 MALPFTSALAALPSFGLVFGeflksigAETSAMAIITSAFfsSMSFAG--LFSGSLFQRFGMRQVGVTGGILYFLGTGMQ 123
Cdd:cd17321    8 AALDVTIVNVALPTIARDLG-------ASPSQLQWVVNAY--LLAFAAllLLAGRLGDRFGRKRVFLIGLALFGLASLLC 78
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442616929 124 LFATSTLHLImAFSVVQGFAFGLMVPTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLI 200
Cdd:cd17321   79 ALAPSLAFLI-AARALQGIGAAAIMPASLALIAATFpGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI 155
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
63-204 1.50e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.57  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  63 VFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLImAFSVVQGF 142
Cdd:cd17325   18 ILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLL-LARFLQGL 96
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442616929 143 AFGLMVPTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGL 204
Cdd:cd17325   97 ASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
38-217 1.89e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 1.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  38 WGILVCIGMALPFTSALAALPSFGLVFGEFLKSI-GAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILY 116
Cdd:COG2271  177 LALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLL 256
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 117 FLGTGMQLFA-TSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRV-MWMSFAQTLIGLGSMLYPIVMQKLMSWYGF 194
Cdd:COG2271  257 LAALALLLLAlLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARgTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
                        170       180
                 ....*....|....*....|...
gi 442616929 195 RGCLLILTGLNAHAVFGMLVMHP 217
Cdd:COG2271  337 QAAFLLLAALALLAALLALLLLR 359
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
40-215 6.54e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.26  E-value: 6.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  40 ILVCIGMALPFTSALAALPSFGLVFGEFLksIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLG 119
Cdd:cd17325  201 LLALFLAIFVLAFAFGALEPFLPLYAAEL--GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 120 TGMQLFATStLHLIMAFSVVQGFAFGLMVPTcYTTFNHYFVKNRV--MWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGC 197
Cdd:cd17325  279 LLLLPLATS-FWLLLLLLALLGLGLGLVFPA-TLALLADIVPPEGrgTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
                        170
                 ....*....|....*...
gi 442616929 198 LLILTGLNAHAVFGMLVM 215
Cdd:cd17325  357 FLAAAALLLLAAVLFLLL 374
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
39-184 7.46e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 45.26  E-value: 7.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  39 GILVCIGMALPFTSALAALPSFGLVFGEFLKsiGAETSAMAIITSAFFSSMSFAgLFSGSLFQRFGMRQVGVTGGILYFL 118
Cdd:cd17473    1 LITLLLASTLTVMAGAAIAPALPAIAQHFVP--NSELLVPLLLTLPALFIALFA-PLAGWLADRFGRKRLLIAGLLLYGI 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442616929 119 GTGMQLFATStLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFV-KNRVMWMSFAQTLIGLGSMLYPIV 184
Cdd:cd17473   78 GGVAGLFLDS-LYALLASRALLGIGVAGIMTLATALIGDYFEgEERAKMLGLQSAAMSLGGVVFLLL 143
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
46-215 1.20e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 44.52  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  46 MALPFTSALAALPSFGLVFG---EFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLF-QRFGMRQVGVTGGILYFLGTG 121
Cdd:cd17490  197 LFFSLLAILQQMITFSTTFGftpLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCF 276
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 122 MQLFaTSTLHLIMAFSVVQGFAFGLMvptcYTTFNHYFVKN-----RVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRG 196
Cdd:cd17490  277 LIPF-APNLTLLYLLQALNGFGTGIL----FPLLMSLSIEGvpaeqRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQT 351
                        170
                 ....*....|....*....
gi 442616929 197 CLLILTGLNAHAVFGMLVM 215
Cdd:cd17490  352 GFFVIGVIALLAAILSLAY 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
38-178 1.42e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  38 WGILVCIGMALPFTSALAALPSFglvfgeFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYF 117
Cdd:COG2814  211 LLLLLAFLLGFGFFALFTYLPLY------LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442616929 118 LGTGMqLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYF-VKNRVMWMSFAQTLIGLGS 178
Cdd:COG2814  285 LGLLL-LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFLGG 345
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
67-245 1.71e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.12  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  67 FLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATStLHLIMAFSVVQGFAFGl 146
Cdd:cd17489   22 YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS-VALLLVLRLIHGIGWG- 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 147 MVPTCYTTF--NHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGLnahAVFGMLVMhpveWHMRR 224
Cdd:cd17489  100 AFTTAAATLvaDIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVL---ALLALLLV----FLVKD 172
                        170       180
                 ....*....|....*....|.
gi 442616929 225 VPIQPEEQEELKELSPTVVIR 245
Cdd:cd17489  173 PPPVAAEEAEAGTRAFRRLVE 193
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
59-204 1.71e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.07  E-value: 1.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  59 SFGLVFGEFLKSI-GAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFS 137
Cdd:COG0738  228 AIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLA 307
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442616929 138 VVqGFAFGLMVPTCYTTFNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLILTGL 204
Cdd:COG0738  308 LV-GLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVC 373
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
76-201 1.96e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 43.75  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  76 SAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTF 155
Cdd:cd17353   38 ASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTA 117
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 442616929 156 NHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLIL 201
Cdd:cd17353  118 VKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLIL 163
MFS_1 pfam07690
Major Facilitator Superfamily;
38-182 1.99e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929   38 WGILVCIGMALPFTSALAALPSFGLVFGeflksigAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYF 117
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLYQEVLG-------LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLI 276
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442616929  118 LGTG--MQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKNRV-MWMSFAQTLIGLGSMLYP 182
Cdd:pfam07690 277 LAALglLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERgTASGLYNTAGSLGGALGP 344
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
38-218 3.33e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 43.32  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  38 WGILVCIGM-ALPFTSALAALPSFGLVFGeflksIGAETSAMAIITSAFFSSmsFAGLFSGSLFQRFG-MRQVGVTGGIL 115
Cdd:COG2807  218 WLLTLFFGLqSLLYYAVVAWLPPILRDAG-----LSAATAGLLLSLFQLAGI--PGSLLVPLLADRLGdRRPLLLLLGLL 290
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 116 YFLGTGMQLFATSTLhlIMAFSVVQGFAFGLMVPTCYTTFNHYF--VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYG 193
Cdd:COG2807  291 GLAGLLGLLLAPGSL--PWLWAVLLGLGQGGLFPLALTLIGLRArtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG 368
                        170       180
                 ....*....|....*....|....*..
gi 442616929 194 -FRGCLLILTGLN-AHAVFGMLVMHPV 218
Cdd:COG2807  369 sWTAALLLLAALAvLMLVAGLLAGRPY 395
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
69-184 4.12e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.94  E-value: 4.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  69 KSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATStLHLIMAFSVVQGFAFGLMV 148
Cdd:cd17474   27 EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS-FALLLAGRALQGIGAAGLG 105
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 442616929 149 PTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIV 184
Cdd:cd17474  106 PLALTLIGDLFeGGERAKAMGLYEAALGLGIAVGPLL 142
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
40-213 4.44e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.56  E-value: 4.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  40 ILVCIgMALPFTSALAALPSFGLVFGEFlksiGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLG 119
Cdd:cd17320    3 LLALL-VALGPLAIDMYLPALPAIARDL----GASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 120 TgMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFN-HYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCL 198
Cdd:cd17320   78 S-LLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRdLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIF 156
                        170
                 ....*....|....*
gi 442616929 199 LILTGLNAHAVFGML 213
Cdd:cd17320  157 VFLALLGLLLLLLVL 171
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
40-210 5.10e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 42.57  E-value: 5.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  40 ILVCIGMALPFTSALAALPSFGLVFGEFLKS-IGAETSAMAIITSAFFssmsfaGLFSGSLFQRFGMRQVGVTGGILYFL 118
Cdd:cd17330  180 LLVYFLIALAFAGLESVFSLFLKDRFGFSPSqIGLLLALVGIAGILAQ------LLLIPRLAKRLGERKLLRLGLLLAII 253
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 119 GTGMQLFAtSTLHLIMAFSVVQGFAFGLMVPtCYTTFNHYFV--KNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRG 196
Cdd:cd17330  254 GLLLLPFA-SSVPLLVLAAAILAFGTGIVFP-ALSALLSKSVpsKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGV 331
                        170
                 ....*....|....
gi 442616929 197 CLLILTGLNAHAVF 210
Cdd:cd17330  332 PFLLAAGLLLIALF 345
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
41-226 7.49e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.18  E-value: 7.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  41 LVCIGMALPFTSALAalpsFGLVFGEFLKSIGAETSAMA-IITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLG 119
Cdd:COG2223  209 LLSLLYFGTFGSFIG----FSSWLPPYLVDQFGLSAATAgLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 120 TGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYG-FRGC 197
Cdd:COG2223  285 LLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAA 364
                        170       180
                 ....*....|....*....|....*....
gi 442616929 198 LLILTGLnahAVFGMLVMHPVEWHMRRVP 226
Cdd:COG2223  365 FLVFAVL---ALVALVLTLLLYRRPRRAA 390
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
59-200 8.80e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 41.88  E-value: 8.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  59 SFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRqvgvtggilYFLGTGMqlFATSTLHLIMAFS- 137
Cdd:cd17312   21 NFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIR---------RFMSAGL--LLSALANIFMGFSt 89
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442616929 138 ---------VVQGFAFGLMVPTCYTTFNHYF-VKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCLLI 200
Cdd:cd17312   90 slwffavlwGLNGLFQSMGWPPCVKLLGNWFsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLV 162
MFS_UhpC cd17488
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ...
59-204 8.84e-04

Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341041 [Multi-domain]  Cd Length: 364  Bit Score: 41.62  E-value: 8.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  59 SFGLVFGEFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRqvgvtggilYFLGTGmqLFATSTLHLIMAFS- 137
Cdd:cd17488   21 SFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPR---------YFMGIG--LIATGIINILFGFSs 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 138 ---------VVQGFAFGLMVPTCYTTFNHYFVKN-RVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFR------GCLLIL 201
Cdd:cd17488   90 slwafavlwTLNAFFQGWGWPPCARLLTHWYSRNeRGFWWSIWNTSHNIGGALIPILTGFAALTYGWRagmyvpGIIAIL 169

                 ...
gi 442616929 202 TGL 204
Cdd:cd17488  170 MGI 172
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
41-216 1.20e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.43  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  41 LVCIGMALPFTSALAALPSFGlvfgeflKSIGAetSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGT 120
Cdd:cd17489  201 LILFLASIAYGAISTFLPLYA-------AERGI--SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGL 271
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 121 GMQLFATSTLHLIMAFsVVQGFAFGLMVPtcytTFNHYFVK-----NRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFR 195
Cdd:cd17489  272 LLLSFAGSPWMLLLAA-VLYGLGFGLLFP----ALQALAVDlvpphRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYR 346
                        170       180
                 ....*....|....*....|.
gi 442616929 196 GCLLILTGLnahAVFGMLVMH 216
Cdd:cd17489  347 AMFLLAAVV---VLLALVLYI 364
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
66-204 1.27e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 41.40  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  66 EFLKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLHLImAFSVVQGFAFG 145
Cdd:cd17319   28 TIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLY-VLRFLLGVAEA 106
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442616929 146 LMVPTCYTTFNHYFVKNRvmwMSFAQTL----IGLGSMLYPIVMQKLMSWYGFRGcLLILTGL 204
Cdd:cd17319  107 GFFPGAIKALAEWFPARE---RGRATGLfnsgAPLGAAIGPPLSGWLLLLFGWRW-AFIIEGL 165
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
406-526 1.29e-03

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 41.34  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 406 RIFLAITAVCIQVPSRYIYLAGAVFTVFARFAFNGITQFVGMACITAVIGFLRTWLHVpLPLVFADYLPKERFATGYGLF 485
Cdd:cd17428  236 KLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWSI-FPYVTTKTVGIEKLGHAYGIL 314
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 442616929 486 MFIQGNAMFLIGPIVGFIRDKTRDYIFVFH------ILNGFMILCAA 526
Cdd:cd17428  315 MFFAGLGNSLGPPIVGWFYDWTQTYDIAFYfsgfcvLLGGFLLLLAA 361
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
75-200 1.41e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.05  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  75 TSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGMQLFATSTLhLIMAFSVVQGFAFGLMVPTCYTT 154
Cdd:cd17316   35 LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPI-LLLVLRFLQGIGIGGEYPGASTY 113
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442616929 155 FN-HYFVKNRVMWMSFAQTLIGLGSML----YPIVMQKLMSWYGFRGCLLI 200
Cdd:cd17316  114 VAeFAPSKRRGFALGLLQSGWALGALLaalvASLLIPLLSGDWGWRILFLI 164
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
41-149 1.45e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  41 LVCIGMALPFTSAL-------AALPSFGLVFGEFLKSIGAETSAMA-IITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTG 112
Cdd:cd17321  161 LVALLLARTFSGAVlaafllgAALGGLLFLLPLYLQGVLGYSPLQAgLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 442616929 113 GILYFLGTGMQLF--ATSTLHLIMAFSVVQGFAFGLMVP 149
Cdd:cd17321  241 LLLTAVGLLLLALlgADSSVWLLLPGLVLLGLGLGLFAT 279
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
73-149 2.42e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 40.25  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  73 AETSAMAIITSAFFssMSFAGLFSGSLFQRFGMRQVGVTGGILYFLGTGM--QLFATSTLHLIMAFSVVQGFAFGL-MVP 149
Cdd:cd17503  213 AFESGLVLAPGGLA--SAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLlaFLTPDTSLWLIILPLFIRGLGMGLvFMP 290
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
40-194 2.61e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.28  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  40 ILVCIGMALPFTSALAALPSFGLVFGEFLKSIGAETSAMAIITSAFFssMSFAGLFSGSLFQRFGMRQVGVTGGILYFL- 118
Cdd:cd17316  179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLG--ALVGALIAGLLSDRIGRKKTLVIGLILSGIl 256
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442616929 119 GTGMQLFATSTLHLIMAFSVVQGFAFGLMVPTCYTTFNHYFVKN-RVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGF 194
Cdd:cd17316  257 ALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEvRATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
40-200 3.59e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 39.87  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929  40 ILVCIGMALPFTSALAALPSFGlvfgeflKSIGAETSAMAIITSAFFSSMSFAGLFSGSLFQRFGMRQVGVTGGILYFLG 119
Cdd:cd17503    2 LLGAFMAILDTTIVNVALPTIM-------GDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLG 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 120 TGMQLFATStLHLIMAFSVVQGFAFGLMVPTCYTT-FNHYFVKNRVMWMSFAQTLIGLGSMLYPIVMQKLMSWYGFRGCL 198
Cdd:cd17503   75 SLLCGLAPN-LASLIIFRILQGFGGGVLIPLAQTIlLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF 153

                 ..
gi 442616929 199 LI 200
Cdd:cd17503  154 YI 155
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
421-530 7.79e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 38.68  E-value: 7.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442616929 421 RYIYLAGAVFTVFARFAFnGITQFVGMACITAVIGFLRTWLH-VPLPLVFADYLPKERFATGYGLFMFIQGNAMFLIGPI 499
Cdd:cd17370  264 KKLLILGYLSLALAYLGF-ALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLI 342
                         90       100       110
                 ....*....|....*....|....*....|..
gi 442616929 500 VGFIRDKT-RDYIFVFhilNGFMILCAAPWVL 530
Cdd:cd17370  343 AGYLWDLIsPSAAFLF---SAVLALIALLLLL 371
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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