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Conserved domains on  [gi|281364548|ref|NP_001097109|]
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PDGF- and VEGF-related factor 3, isoform E [Drosophila melanogaster]

Protein Classification

PDGF domain-containing protein( domain architecture ID 10065270)

PDGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 282-365 1.33e-21

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


:

Pssm-ID: 238079  Cd Length: 86  Bit Score: 88.58  E-value: 1.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364548 282 ATCRIPQKRCQLVQQDP---SKIYTPHCTILHRCSedsGCCPSRSQICAAKSTHNVELHFFVKSS--KHRSVIEKRTFVN 356
Cdd:cd00135    1 SSCKPRETLVEISEELPdetNTIFKPPCVEVKRCG---GCCNDESLECVPTETSNVTMQVLKISPkrKPRSKLVEISFEE 77


                 ....*....
gi 281364548 357 HTECHCIER 365
Cdd:cd00135   78 HTECECRPR 86
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 282-365 1.33e-21

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 88.58  E-value: 1.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364548 282 ATCRIPQKRCQLVQQDP---SKIYTPHCTILHRCSedsGCCPSRSQICAAKSTHNVELHFFVKSS--KHRSVIEKRTFVN 356
Cdd:cd00135    1 SSCKPRETLVEISEELPdetNTIFKPPCVEVKRCG---GCCNDESLECVPTETSNVTMQVLKISPkrKPRSKLVEISFEE 77


                 ....*....
gi 281364548 357 HTECHCIER 365
Cdd:cd00135   78 HTECECRPR 86
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 299-363 1.09e-09

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 54.73  E-value: 1.09e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281364548   299 SKIYTPHCTILHRCSedsGCCPSRSQICAAKSTHNVELHFFVKSSKHRSVIEKRTFVNHTECHCI 363
Cdd:smart00141  21 NFLFKPPCVTVKRCG---GCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCECR 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 277-372 3.54e-08

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 52.32  E-value: 3.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364548 277 QVLKEATCRIPQKRCQLVQQDPSKI---YTPHCTILHRCSedsGCCPSRSQICAAKSTHNVELHFFV----KSSKHRSVI 349
Cdd:PHA02661  41 DTSDKSSCQPRDTVVQLSDEYPGNTndrYNPRCVTVRRCG---GCCNDESQICTPTETSNVTVTVMLtsvsGSTGATSNF 117

                         90       100
                 ....*....|....*....|...
gi 281364548 350 EKRTFVNHTECHCIERSTYNEET 372
Cdd:PHA02661 118 QTISVEEHTKCKCEFKTTPPPTT 140
PDGF pfam00341
PDGF/VEGF domain;
297-362 1.51e-07

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 48.82  E-value: 1.51e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281364548  297 DPSKIYTPHCTILHRCSedsGCCPSRSQICAAKSTHNVELHFFVKSSKHRSVIEKR---TFVNHTECHC 362
Cdd:pfam00341  17 ETNAFFKPSCVEVQRCS---GCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELvevSFEEHVQCEC 82
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 282-365 1.33e-21

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 88.58  E-value: 1.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364548 282 ATCRIPQKRCQLVQQDP---SKIYTPHCTILHRCSedsGCCPSRSQICAAKSTHNVELHFFVKSS--KHRSVIEKRTFVN 356
Cdd:cd00135    1 SSCKPRETLVEISEELPdetNTIFKPPCVEVKRCG---GCCNDESLECVPTETSNVTMQVLKISPkrKPRSKLVEISFEE 77


                 ....*....
gi 281364548 357 HTECHCIER 365
Cdd:cd00135   78 HTECECRPR 86
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 299-363 1.09e-09

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 54.73  E-value: 1.09e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281364548   299 SKIYTPHCTILHRCSedsGCCPSRSQICAAKSTHNVELHFFVKSSKHRSVIEKRTFVNHTECHCI 363
Cdd:smart00141  21 NFLFKPPCVTVKRCG---GCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCECR 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 277-372 3.54e-08

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 52.32  E-value: 3.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281364548 277 QVLKEATCRIPQKRCQLVQQDPSKI---YTPHCTILHRCSedsGCCPSRSQICAAKSTHNVELHFFV----KSSKHRSVI 349
Cdd:PHA02661  41 DTSDKSSCQPRDTVVQLSDEYPGNTndrYNPRCVTVRRCG---GCCNDESQICTPTETSNVTVTVMLtsvsGSTGATSNF 117

                         90       100
                 ....*....|....*....|...
gi 281364548 350 EKRTFVNHTECHCIERSTYNEET 372
Cdd:PHA02661 118 QTISVEEHTKCKCEFKTTPPPTT 140
PDGF pfam00341
PDGF/VEGF domain;
297-362 1.51e-07

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 48.82  E-value: 1.51e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281364548  297 DPSKIYTPHCTILHRCSedsGCCPSRSQICAAKSTHNVELHFFVKSSKHRSVIEKR---TFVNHTECHC 362
Cdd:pfam00341  17 ETNAFFKPSCVEVQRCS---GCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELvevSFEEHVQCEC 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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