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Conserved domains on  [gi|161077142|ref|NP_001097337|]
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uncharacterized protein Dmel_CG4409 [Drosophila melanogaster]

Protein Classification

Ins_allergen_rp domain-containing protein( domain architecture ID 10535966)

Ins_allergen_rp domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ins_allergen_rp pfam06757
Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a ...
 81-264 7.11e-49

Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.


:

Pssm-ID: 462003  Cd Length: 173  Bit Score: 159.66  E-value: 7.11e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077142   81 DLSAFVALIPLQEVQSIAAHYYHHDAEFQRSYAFLASSDFADIKRKILQLPEVLEFTNYLGNNGLDVVKVMHSVAGVFKP 160
Cdd:pfam06757   5 DLQDFLALIPLEKIQDIVARYLLNDAEFQAAVRYLNSDEFKRLWQQLEALPEVRELLQYLEQAGLDIYDYINVLNDFLGL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077142  161 SILssaavnEPTKVTTTEDGssaageaqtGLHGMVERVLEILPQDQLYALFFDEFESNKQFAAFVDSISSPKFAKILSGL 240
Cdd:pfam06757  85 SGL------VPPSSTLLRTG---------GLRGFLQDLLAALPRDAIRALYEEKLKTSSEFAEFVRRLRSPEFQQLLERL 149

                         170       180
                  ....*....|....*....|....
gi 161077142  241 QNSMPLRNLLFVLHNNSIYVERIV 264
Cdd:pfam06757 150 RASPEVQRLLNKLRAHGVDVDELL 173
 
Name Accession Description Interval E-value
Ins_allergen_rp pfam06757
Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a ...
 81-264 7.11e-49

Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.


Pssm-ID: 462003  Cd Length: 173  Bit Score: 159.66  E-value: 7.11e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077142   81 DLSAFVALIPLQEVQSIAAHYYHHDAEFQRSYAFLASSDFADIKRKILQLPEVLEFTNYLGNNGLDVVKVMHSVAGVFKP 160
Cdd:pfam06757   5 DLQDFLALIPLEKIQDIVARYLLNDAEFQAAVRYLNSDEFKRLWQQLEALPEVRELLQYLEQAGLDIYDYINVLNDFLGL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077142  161 SILssaavnEPTKVTTTEDGssaageaqtGLHGMVERVLEILPQDQLYALFFDEFESNKQFAAFVDSISSPKFAKILSGL 240
Cdd:pfam06757  85 SGL------VPPSSTLLRTG---------GLRGFLQDLLAALPRDAIRALYEEKLKTSSEFAEFVRRLRSPEFQQLLERL 149

                         170       180
                  ....*....|....*....|....
gi 161077142  241 QNSMPLRNLLFVLHNNSIYVERIV 264
Cdd:pfam06757 150 RASPEVQRLLNKLRAHGVDVDELL 173
 
Name Accession Description Interval E-value
Ins_allergen_rp pfam06757
Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a ...
 81-264 7.11e-49

Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.


Pssm-ID: 462003  Cd Length: 173  Bit Score: 159.66  E-value: 7.11e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077142   81 DLSAFVALIPLQEVQSIAAHYYHHDAEFQRSYAFLASSDFADIKRKILQLPEVLEFTNYLGNNGLDVVKVMHSVAGVFKP 160
Cdd:pfam06757   5 DLQDFLALIPLEKIQDIVARYLLNDAEFQAAVRYLNSDEFKRLWQQLEALPEVRELLQYLEQAGLDIYDYINVLNDFLGL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077142  161 SILssaavnEPTKVTTTEDGssaageaqtGLHGMVERVLEILPQDQLYALFFDEFESNKQFAAFVDSISSPKFAKILSGL 240
Cdd:pfam06757  85 SGL------VPPSSTLLRTG---------GLRGFLQDLLAALPRDAIRALYEEKLKTSSEFAEFVRRLRSPEFQQLLERL 149

                         170       180
                  ....*....|....*....|....
gi 161077142  241 QNSMPLRNLLFVLHNNSIYVERIV 264
Cdd:pfam06757 150 RASPEVQRLLNKLRAHGVDVDELL 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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