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Conserved domains on  [gi|161083174|ref|NP_001097587|]
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lost and found, isoform C [Drosophila melanogaster]

Protein Classification

low-density lipoprotein receptor class A repeat-containing protein( domain architecture ID 10640772)

low-density lipoprotein receptor class A repeat-containing protein contains one or more cysteine-rich repeats that plays a central role in mammalian cholesterol metabolism

Gene Ontology:  GO:0005041|GO:0015031|GO:0005509

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 216-247 1.83e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 1.83e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 161083174   216 TCKDFTCATREfCIHPDLLCDGINHCGDNSDE 247
Cdd:smart00192   3 PPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
 
Name Accession Description Interval E-value
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 216-247 1.83e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 1.83e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 161083174   216 TCKDFTCATREfCIHPDLLCDGINHCGDNSDE 247
Cdd:smart00192   3 PPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 220-247 2.31e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.73  E-value: 2.31e-06
                         10        20
                 ....*....|....*....|....*...
gi 161083174 220 FTCATREfCIHPDLLCDGINHCGDNSDE 247
Cdd:cd00112    6 FRCANGR-CIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
216-247 4.47e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.31  E-value: 4.47e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 161083174  216 TCK--DFTCATREfCIHPDLLCDGINHCGDNSDE 247
Cdd:pfam00057   2 TCSpnEFQCGSGE-CIPRSWVCDGDPDCGDGSDE 34
 
Name Accession Description Interval E-value
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 216-247 1.83e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.16  E-value: 1.83e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 161083174   216 TCKDFTCATREfCIHPDLLCDGINHCGDNSDE 247
Cdd:smart00192   3 PPGEFQCDNGR-CIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 220-247 2.31e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 43.73  E-value: 2.31e-06
                         10        20
                 ....*....|....*....|....*...
gi 161083174 220 FTCATREfCIHPDLLCDGINHCGDNSDE 247
Cdd:cd00112    6 FRCANGR-CIPSSWVCDGEDDCGDGSDE 32
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
216-247 4.47e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 40.31  E-value: 4.47e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 161083174  216 TCK--DFTCATREfCIHPDLLCDGINHCGDNSDE 247
Cdd:pfam00057   2 TCSpnEFQCGSGE-CIPRSWVCDGDPDCGDGSDE 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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