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Conserved domains on  [gi|161078181|ref|NP_001097743|]
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uncharacterized protein Dmel_CG4565 [Drosophila melanogaster]

Protein Classification

histone-lysine N-methyltransferase SETMAR( domain architecture ID 14410657)

histone-lysine N-methyltransferase SETMAR methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation

EC:  2.1.1.357
Gene Symbol:  SETMAR
Gene Ontology:  GO:0005515|GO:1904047|GO:0016279
PubMed:  20620605|12372294|17013555

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 16-267 5.36e-111

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


:

Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 320.40  E-value: 5.36e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  16 DGLDYILESVLMPSDGSkefkfladEYNSVLLNPCHCKGA-CE-NSEVCAHGGQYEFTEDGSELI-LRNSANPVIECNDM 92
Cdd:cd10544    1 PDFQYTPENVPGPGADT--------DPNEITFPGCDCKTSsCEpETCSCLRKYGPNYDDDGCLLDfDGKYSGPVFECNSM 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  93 CKCCrNTCSNRLVYSGPRKHLEIFDSPVYGsKGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKlGLMNYILVLNE 172
Cdd:cd10544   73 CKCS-ESCQNRVVQNGLQFKLQVFKTPKKG-WGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTK-GDMNYIIVLRE 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 173 YTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDCPIPKIGIFAARDIAAKEELCFHYGGEGQYKK-------- 244
Cdd:cd10544  150 HLSSGKVLETFVDPTYIGNIGRFLNHSCEPNLFMVPVRVDSMVPKLALFAARDIVAGEELSFDYSGEFSNSVesvtlarq 229

                        250       260
                 ....*....|....*....|....*
gi 161078181 245 --MTGGKTCLCGASKCTGFMPNTEI 267
Cdd:cd10544  230 deSKSRKPCLCGAENCRGFLPFDES 254
 
Name Accession Description Interval E-value
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 16-267 5.36e-111

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 320.40  E-value: 5.36e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  16 DGLDYILESVLMPSDGSkefkfladEYNSVLLNPCHCKGA-CE-NSEVCAHGGQYEFTEDGSELI-LRNSANPVIECNDM 92
Cdd:cd10544    1 PDFQYTPENVPGPGADT--------DPNEITFPGCDCKTSsCEpETCSCLRKYGPNYDDDGCLLDfDGKYSGPVFECNSM 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  93 CKCCrNTCSNRLVYSGPRKHLEIFDSPVYGsKGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKlGLMNYILVLNE 172
Cdd:cd10544   73 CKCS-ESCQNRVVQNGLQFKLQVFKTPKKG-WGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTK-GDMNYIIVLRE 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 173 YTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDCPIPKIGIFAARDIAAKEELCFHYGGEGQYKK-------- 244
Cdd:cd10544  150 HLSSGKVLETFVDPTYIGNIGRFLNHSCEPNLFMVPVRVDSMVPKLALFAARDIVAGEELSFDYSGEFSNSVesvtlarq 229

                        250       260
                 ....*....|....*....|....*
gi 161078181 245 --MTGGKTCLCGASKCTGFMPNTEI 267
Cdd:cd10544  230 deSKSRKPCLCGAENCRGFLPFDES 254
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 111-239 1.05e-27

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 103.18  E-value: 1.05e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181   111 KHLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGlmnyilVLNEYTSDKKQQVTIvDPSRRG 190
Cdd:smart00317   1 NKLEVFKSPGKGW-GVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDG------AKAFYLFDIDSDLCI-DARRKG 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 161078181   191 NIGRYLNHSCEPNCHIAAVRIDCPIpKIGIFAARDIAAKEELCFHYGGE 239
Cdd:smart00317  73 NLARFINHSCEPNCELLFVEVNGDD-RIVIFALRDIKPGEELTIDYGSD 120
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
110-260 4.50e-25

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 96.57  E-value: 4.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 110 RKHLEIFDSPVYGsKGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLglMNYILVLNEYTsdkkqqvtIVDPSRR 189
Cdd:COG2940    5 HPRIEVRPSPIHG-RGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPL--HTYLFELDDDG--------VIDGALG 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161078181 190 GNIGRYLNHSCEPNChiaavRIDCPIPKIGIFAARDIAAKEELCFHYGGEGQYKKMtggkTCLCGasKCTG 260
Cdd:COG2940   74 GNPARFINHSCDPNC-----EADEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEY----PCRCP--NCRG 133
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 125-237 4.91e-20

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 82.96  E-value: 4.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  125 GLRTTAKITKGGYICEYAGE-LLTVPEARSRLHDNEKLGLMNYILVLNEYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPN 203
Cdd:pfam00856   3 GLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWARFINHSCDPN 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 161078181  204 CHIAAVRIDCpIPKIGIFAARDIAAKEELCFHYG 237
Cdd:pfam00856  83 CEVRVVYVNG-GPRIVIFALRDIKPGEELTIDYG 115
 
Name Accession Description Interval E-value
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 16-267 5.36e-111

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 320.40  E-value: 5.36e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  16 DGLDYILESVLMPSDGSkefkfladEYNSVLLNPCHCKGA-CE-NSEVCAHGGQYEFTEDGSELI-LRNSANPVIECNDM 92
Cdd:cd10544    1 PDFQYTPENVPGPGADT--------DPNEITFPGCDCKTSsCEpETCSCLRKYGPNYDDDGCLLDfDGKYSGPVFECNSM 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  93 CKCCrNTCSNRLVYSGPRKHLEIFDSPVYGsKGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKlGLMNYILVLNE 172
Cdd:cd10544   73 CKCS-ESCQNRVVQNGLQFKLQVFKTPKKG-WGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTK-GDMNYIIVLRE 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 173 YTSDKKQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDCPIPKIGIFAARDIAAKEELCFHYGGEGQYKK-------- 244
Cdd:cd10544  150 HLSSGKVLETFVDPTYIGNIGRFLNHSCEPNLFMVPVRVDSMVPKLALFAARDIVAGEELSFDYSGEFSNSVesvtlarq 229

                        250       260
                 ....*....|....*....|....*
gi 161078181 245 --MTGGKTCLCGASKCTGFMPNTEI 267
Cdd:cd10544  230 deSKSRKPCLCGAENCRGFLPFDES 254
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 49-237 1.41e-42

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 144.82  E-value: 1.41e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  49 PCHCKGACENSE-VCA--HGGQYEFTEDGsELILRNSANPVIECNDMCKCCRnTCSNRLVYSGPRKHLEIFDSPVYGSkG 125
Cdd:cd10538   26 GCKCKDDCLDSKcACAaeSDGIFAYTKNG-LLRLNNSPPPIFECNSKCSCDD-DCKNRVVQRGLQARLQVFRTSKKGW-G 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 126 LRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGlMNYILVLNEY-TSDKKQQVTIVDPSRRGNIGRYLNHSCEPNC 204
Cdd:cd10538  103 VRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSG-GSYLFDLDEFsDSDGDGEELCVDATFCGNVSRFINHSCDPNL 181

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 161078181 205 HIAAVRIDCP---IPKIGIFAARDIAAKEELCFHYG 237
Cdd:cd10538  182 FPFNVVIDHDdlrYPRIALFATRDILPGEELTFDYG 217
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 50-262 1.13e-39

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 138.19  E-value: 1.13e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  50 CHCKGAC--ENSEVCAHGGQYEFTEDGSELILRNSANPVIECNDMCKCcRNTCSNRLVYSGPRKHLEIFDSPVYGSKGLR 127
Cdd:cd10542   25 CECTEDChnNNPTCCPAESGVKFAYDKQGRLRLPPGTPIYECNSRCKC-GPDCPNRVVQRGRKVPLCIFRTSNGRGWGVK 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 128 TTAKITKGGYICEYAGELLTVPEA--RSRLHDNEKlglMNYILVLNEYTSDkkqQVTIVDPSRRGNIGRYLNHSCEPNCH 205
Cdd:cd10542  104 TLEDIKKGTFVMEYVGEIITSEEAerRGKIYDANG---RTYLFDLDYNDDD---CEYTVDAAYYGNISHFINHSCDPNLA 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161078181 206 IAAVRIDCP---IPKIGIFAARDIAAKEELCFHYGGEG--------QYKKMTGGKTCLCGASKCTGFM 262
Cdd:cd10542  178 VYAVWINHLdprLPRIAFFAKRDIKAGEELTFDYLMTGtggssestIPKPKDVRVPCLCGSKNCRKYL 245
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 50-258 5.59e-35

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 125.53  E-value: 5.59e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  50 CHCKGACeNSEVCAHGG---QYEFTEDGSELILRNSANP--VIECNDMCKCCRNtCSNRLVYSGPRKHLEIFDSPVYGSk 124
Cdd:cd10543   27 CSCRDDC-SSDNCVCGRlsvRCWYDKEGRLLPDFNKLDPplIFECNRACSCWRN-CRNRVVQNGIRYRLQLFRTRGMGW- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMNyilvlneytsdKKQQVTIVDPSRRGNIGRYLNHSCEPNc 204
Cdd:cd10543  104 GVRALQDIPKGTFVCEYIGELISDSEADSREDDSYLFDLDN-----------KDGETYCIDARRYGNISRFINHLCEPN- 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161078181 205 hIAAVRI-----DCPIPKIGIFAARDIAAKEELCFHYGGEG---QYKKMtggkTCLCGASKC 258
Cdd:cd10543  172 -LIPVRVfvehqDLRFPRIAFFASRDIKAGEELGFDYGEKFwriKGKYF----TCRCGSPKC 228
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 50-260 2.30e-34

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 125.48  E-value: 2.30e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  50 CHCKGACENSEVCAHGGQyefTEDGSELILRNSANP----------------VIECNDMCKCcRNTCSNRLVYSGPRKHL 113
Cdd:cd10517   56 CDCTDGCRDKSKCACQQL---TIEATAATPGGQINPsagyqyrrlmeklptgVYECNSRCKC-DKRCYNRVVQNGLQVRL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 114 EIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEA--RSRLHDNEKLGLMNYILVLNE----YTSDKKQQVTIVDPS 187
Cdd:cd10517  132 QVFKTEKKGW-GIRCLDDIPKGSFVCIYAGQILTEDEAneEGLQYGDEYFAELDYIEVVEKlkegYESDVEEHCYIIDAK 210

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161078181 188 RRGNIGRYLNHSCEPNCHIAAVRI---DCPIPKIGIFAARDIAAKEELCFHYGGEgQYKKMTGGKTCLCGASKCTG 260
Cdd:cd10517  211 SEGNLGRYLNHSCSPNLFVQNVFVdthDLRFPWVAFFASRYIRAGTELTWDYNYE-VGSVPGKVLYCYCGSSNCRG 285
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 125-259 1.38e-28

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 105.80  E-value: 1.38e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMN-YILVLNEytsdkkqqVTIVDPSRRGNIGRYLNHSCEPN 203
Cdd:cd10531   13 GVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGKSNfYILSLSD--------DVVIDATRKGNLSRFINHSCEPN 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 161078181 204 ChIAAVRIDCPIPKIGIFAARDIAAKEELCFHYgGEGQYkkMTGGKTCLCGASKCT 259
Cdd:cd10531   85 C-ETQKWIVNGEYRIGIFALRDIPAGEELTFDY-NFVNY--NEAKQVCLCGAQNCR 136
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 43-258 2.61e-28

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 108.10  E-value: 2.61e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  43 NSVLLNPCHCKGACENSE-VCahgGQYE----FTEDGSELILRNSANP--VIECNDMCKCCRNtCSNRLVYSGPRKHLEI 115
Cdd:cd10535   20 NITHLQYCVCIDDCSSSNcMC---GQLSmrcwYDKDGRLLPEFNMAEPplIFECNHACSCWRN-CRNRVVQNGLRARLQL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 116 FDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEARSRLHDneklglmNYILVLNeytsDKKQQVTIVDPSRRGNIGRY 195
Cdd:cd10535   96 YRTRDMGW-GVRSLQDIPPGTFVCEYVGELISDSEADVREED-------SYLFDLD----NKDGEVYCIDARFYGNVSRF 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 196 LNHSCEPNchIAAVRI-----DCPIPKIGIFAARDIAAKEELCFHYGGEGQYKKmtgGK--TCLCGASKC 258
Cdd:cd10535  164 INHHCEPN--LVPVRVfmahqDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIK---GKlfSCRCGSPKC 228
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 33-260 7.02e-28

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 106.86  E-value: 7.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  33 KEFKFLADEYNSVLLNPCHCKGACENSEVCAhggQYEFTEDGSELILRNSANP----------------VIECNDMCKCC 96
Cdd:cd10541    1 KPFYYIPDISYGKFLVGCDCTDGCRDKSKCA---CHQLTIQATACTPGGQDNPtagyqykrleeclptgVYECNKLCKCD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  97 RNTCSNRLVYSGPRKHLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEArsrlhdnEKLGLMNyilvLNEYTSD 176
Cdd:cd10541   78 PNMCQNRLVQHGLQVRLQLFKTQNKGW-GIRCLDDIAKGTFVCIYAGKILTDDFA-------DKEGLEM----GDEYFAN 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 177 K---KQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDC---PIPKIGIFAARDIAAKEELCFHYG---GEGQYKKMtg 247
Cdd:cd10541  146 LdhiEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDThdlRFPWVAFFASKRIKAGTELTWDYNyevGSVEGKEL-- 223

                        250
                 ....*....|...
gi 161078181 248 gkTCLCGASKCTG 260
Cdd:cd10541  224 --LCCCGSNECRG 234
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 111-239 1.05e-27

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 103.18  E-value: 1.05e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181   111 KHLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGlmnyilVLNEYTSDKKQQVTIvDPSRRG 190
Cdd:smart00317   1 NKLEVFKSPGKGW-GVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDG------AKAFYLFDIDSDLCI-DARRKG 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 161078181   191 NIGRYLNHSCEPNCHIAAVRIDCPIpKIGIFAARDIAAKEELCFHYGGE 239
Cdd:smart00317  73 NLARFINHSCEPNCELLFVEVNGDD-RIVIFALRDIKPGEELTIDYGSD 120
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 43-258 1.62e-27

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 106.25  E-value: 1.62e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  43 NSVLLNPCHCKGACENSEVCAhgGQYE----FTEDGSELILRNSANP--VIECNDMCKCCRnTCSNRLVYSGPRKHLEIF 116
Cdd:cd10533   20 NITHLQHCTCVDDCSSSNCLC--GQLSircwYDKDGRLLQEFNKIEPplIFECNQACSCWR-NCKNRVVQSGIKVRLQLY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 117 DSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEARSRLHDneklglmNYILVLNeytsDKKQQVTIVDPSRRGNIGRYL 196
Cdd:cd10533   97 RTAKMGW-GVRALQTIPQGTFICEYVGELISDAEADVREDD-------SYLFDLD----NKDGEVYCIDARYYGNISRFI 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161078181 197 NHSCEPNchIAAVRI-----DCPIPKIGIFAARDIAAKEELCFHYgGEGQYKKMTGGKTCLCGASKC 258
Cdd:cd10533  165 NHLCDPN--IIPVRVfmlhqDLRFPRIAFFSSRDIRTGEELGFDY-GDRFWDIKSKYFTCQCGSEKC 228
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 50-262 3.69e-27

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 105.36  E-value: 3.69e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  50 CHCKGaCENSEVCAHGGQYEFTEDGSELILRNSANPVIECNDMCKCCRNtCSNRLVYSGPRKHLEIFDSPVYGSKGLRTT 129
Cdd:cd10532   25 CDCSD-CFFGKCCPAEAGVLFAYNEHGQLKIPPGTPIYECNSRCKCGPD-CPNRVVQKGTQYSLCIFRTSNGRGWGVKTL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 130 AKITKGGYICEYAGELLTVPEA--RSRLHDNEKLglmNYILVLnEYTSDKkqqvTIVDPSRRGNIGRYLNHSCEPNCHIA 207
Cdd:cd10532  103 QKIKKNSFVMEYVGEVITSEEAerRGQFYDSKGI---TYLFDL-DYESDE----FTVDAARYGNVSHFVNHSCDPNLQVF 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161078181 208 AVRI---DCPIPKIGIFAARDIAAKEELCFHYGGEG-----------QYKKMTGGKTCLCGASKCTGFM 262
Cdd:cd10532  175 NVFIdnlDTRLPRIALFSTRTIKAGEELTFDYQMKGsgdlssdsidnSPAKKRVRTVCKCGAVTCRGYL 243
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 125-262 4.17e-27

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 102.27  E-value: 4.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMN-YILVLNeytSDKkqqvtIVDPSRRGNIGRYLNHSCEPN 203
Cdd:cd19172   15 GLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREGNRHyYFMALK---SDE-----IIDATKKGNLSRFINHSCEPN 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161078181 204 CHIAAVRIDCPIpKIGIFAARDIAAKEELCFHY-----GGEGQykkmtggkTCLCGASKCTGFM 262
Cdd:cd19172   87 CETQKWTVNGEL-RVGFFAKRDIPAGEELTFDYqferyGKEAQ--------KCYCGSPNCRGYI 141
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 41-237 4.21e-27

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 104.79  E-value: 4.21e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  41 EYNSVLLNP---CHCKGAC-ENSEVCA----HGGQYEFTEDGselILRNSANPVIECNDMCKCcRNTCSNRLVYSGPRKH 112
Cdd:cd10545   12 PPGVSLPVPstgCDCKNRCtDGASDCAcvkkNGGEIPYNFNG---RLIRAKPAIYECGPLCKC-PPSCYNRVTQKGLRYR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 113 LEIFDSpvyGSKG--LRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKL----------------GLMNYILVLNEYT 174
Cdd:cd10545   88 LEVFKT---AERGwgVRSWDSIPAGSFICEYVGELLDTSEADTRSGNDDYLfdidnrqtnrgwdggqRLDVGMSDGERSS 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161078181 175 SDKKQQVT-IVDPSRRGNIGRYLNHSCEPNCHIAAVRI---DCPIPKIGIFAARDIAAKEELCFHYG 237
Cdd:cd10545  165 AEDEESSEfTIDAGSFGNVARFINHSCSPNLFVQCVLYdhnDLRLPRVMLFAADNIPPLQELTYDYG 231
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 81-262 4.27e-27

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 105.86  E-value: 4.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  81 NSANPVIECNDMCKCcRNTCSNRLVYSGPRKHLEIFDSPVYGSKGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEK 160
Cdd:cd19473   76 NSRLPIYECHEGCAC-SDDCPNRVVERGRKVPLQIFRTSDGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRDAATI 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 161 LGLMN-YILVLneytsDKKQQVTIVDPSRRGNI-----------GRYLNHSCEPNCHIAAV---RIDCPIPKIGIFAARD 225
Cdd:cd19473  155 AQRKDvYLFAL-----DKFSDPDSLDPRLRGDPyeidgefmsgpTRFINHSCDPNLRIFARvgdHADKHIHDLAFFAIKD 229

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 161078181 226 IAAKEELCFHY-----------GGEGQYKKMTggkTCLCGASKCTGFM 262
Cdd:cd19473  230 IPRGTELTFDYvdgvtgldddaGDEEKEKEMT---KCLCGSPKCRGYL 274
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 112-262 1.77e-26

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 100.44  E-value: 1.77e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 112 HLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMNYILVLNeytsdkkqQVTIVDPSRRGN 191
Cdd:cd19174    1 GLERFRTEDKGW-GVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNHSHHYCLNLD--------SGMVIDGYRMGN 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161078181 192 IGRYLNHSCEPNCHIAAVRIDcPIPKIGIFAARDIAAKEELCFHYGGEGQykKMTGGKTCLCGASKCTGFM 262
Cdd:cd19174   72 EARFVNHSCDPNCEMQKWSVN-GVYRIGLFALKDIPAGEELTYDYNFHSF--NVEKQQPCKCGSPNCRGVI 139
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 125-262 5.80e-26

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 99.31  E-value: 5.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMNYILVlneyTSDKKQqvtIVDPSRRGNIGRYLNHSCEPNC 204
Cdd:cd19173   15 GLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITNFYML----TLDKDR---IIDAGPKGNLSRFMNHSCQPNC 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 161078181 205 HIAAVRIDCpIPKIGIFAARDIAAKEELCFHYGGEGQykkMTGGKTCLCGASKCTGFM 262
Cdd:cd19173   88 ETQKWTVNG-DTRVGLFAVRDIPAGEELTFNYNLDCL---GNEKKVCRCGAPNCSGFL 141
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 69-262 5.82e-26

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 102.65  E-value: 5.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  69 EFTEDGSELILRNSANPVIECNDMCKCCRNtCSNRLVYSGPRKHLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTV 148
Cdd:cd20073   52 SFAYDEYGRVRANTGSIIYECNENCDCGIN-CPNRVVQRGRKLPLEIFKTKHKGW-GLRCPRFIKAGTFIGVYLGEVITQ 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 149 PEARSRLHDNEKLGLmNYILVLNEYTSDKKQQVTiVDPSRRGNIGRYLNHSCEPNCHIAAVRID---CPIPKIGIFAARD 225
Cdd:cd20073  130 SEAEIRGKKYDNVGV-TYLFDLDLFEDQVDEYYT-VDAQYCGDVTRFINHSCDPNLAIYSVLRDksdSKIYDLAFFAIKD 207

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 161078181 226 IAAKEELCFHYGGE--------------GQYKKMTGGKTCLCGASKCTGFM 262
Cdd:cd20073  208 IPALEELTFDYSGRnnfdqlgfignrsnSKYINLKNKRPCYCGSANCRGWL 258
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
110-260 4.50e-25

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 96.57  E-value: 4.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 110 RKHLEIFDSPVYGsKGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLglMNYILVLNEYTsdkkqqvtIVDPSRR 189
Cdd:COG2940    5 HPRIEVRPSPIHG-RGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPL--HTYLFELDDDG--------VIDGALG 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161078181 190 GNIGRYLNHSCEPNChiaavRIDCPIPKIGIFAARDIAAKEELCFHYGGEGQYKKMtggkTCLCGasKCTG 260
Cdd:COG2940   74 GNPARFINHSCDPNC-----EADEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEY----PCRCP--NCRG 133
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 40-260 2.92e-23

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 95.28  E-value: 2.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  40 DEYNSVLLNPCHCKGACENSEVCA--HGGQYEFTEDGSEL-----------ILRNSANPVIECNDMCKCCRNTCSNRLVY 106
Cdd:cd10523   24 DISNGAFVDSCDCTDGCIDILKCAclQLTARAFSKSESSPskggrgykykrLQEPIPSGLYECNVSCKCNRMLCQNRVVQ 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 107 SGPRKHLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELL------TVPEARSRLHDNE---KLGLMNYILVLNEytsDK 177
Cdd:cd10523  104 HGLQVRLQVFKTEKKGW-GVRCLDDIDKGTFVCIYAGRVLsrarspTEPLPPKLELPSEnevEVVTSWLILSKKR---KL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 178 KQQVTIVDPSRRGNIGRYLNHSCEPNCHIAAVRIDC---PIPKIGIFAARDIAAKEELCFHYGgegqYKKMTGGKT---C 251
Cdd:cd10523  180 RENVCFLDASKEGNVGRFLNHSCCPNLFVQNVFVDThdkNFPWVAFFTNRVVKAGTELTWDYS----YDAGTSPEQeipC 255


                 ....*....
gi 161078181 252 LCGASKCTG 260
Cdd:cd10523  256 LCGVNKCQK 264
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 50-236 4.23e-23

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 94.57  E-value: 4.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  50 CHCKGACENSE--VCAHGGQYEFTEDGSELILRNSANPVIECNDMCKCCRNtCSNRLVYSGPRKHLEIFDSPVYGSKGLR 127
Cdd:cd10525   24 CECQDCLSQPVggCCPGASKHRFAYNEQGQVKVRPGLPIYECNSRCRCGPD-CPNRVVQKGIQYDLCIFRTDNGRGWGVR 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 128 TTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGlMNYILVLnEYTSDkkqqVTIVDPSRRGNIGRYLNHSCEPNCHIA 207
Cdd:cd10525  103 TLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG-ATYLFDL-DYVED----VYTVDAAYYGNISHFVNHSCDPNLQVY 176

                        170       180       190
                 ....*....|....*....|....*....|..
gi 161078181 208 AVRIDC---PIPKIGIFAARDIAAKEELCFHY 236
Cdd:cd10525  177 NVFIDNldeRLPRIALFATRTIRAGEELTFDY 208
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 112-262 4.55e-22

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 89.22  E-value: 4.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 112 HLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMNYILVlneyTSDKKQqvtIVDPSRRGN 191
Cdd:cd19210    3 EVEIFRTLGRGW-GLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYML----TLDKDR---IIDAGPKGN 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161078181 192 IGRYLNHSCEPNCHIAAVRIDCPIpKIGIFAARDIAAKEELCFHYGGEGqykkMTGGKT-CLCGASKCTGFM 262
Cdd:cd19210   75 YARFMNHCCQPNCETQKWTVNGDT-RVGLFALCDIKAGTELTFNYNLEC----LGNGKTvCKCGAPNCSGFL 141
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 125-258 6.84e-21

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 86.11  E-value: 6.84e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEkLGLMNYILVLNEYTsdkkqqvtIVDPSRRGNIGRYLNHSCEP 202
Cdd:cd10518   27 GLFAKRPIAAGEMVIEYVGEVIrpIVADKREKRYDEE-GGGGTYMFRIDEDL--------VIDATKKGNIARFINHSCDP 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 161078181 203 NCHIAAVRIDcPIPKIGIFAARDIAAKEELCFHY--GGEgQYKKMtggkTCLCGASKC 258
Cdd:cd10518   98 NCYAKIITVD-GEKHIVIFAKRDIAPGEELTYDYkfPIE-DEEKI----PCLCGAPNC 149
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 125-262 9.90e-21

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 85.43  E-value: 9.90e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMNYILVlneyTSDKKQqvtIVDPSRRGNIGRYLNHSCEPNC 204
Cdd:cd19211   15 GLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYML----TIDKDR---IIDAGPKGNYSRFMNHSCQPNC 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 161078181 205 HIAAVRIDCPIpKIGIFAARDIAAKEELCFHYGGEGQYKKMTggkTCLCGASKCTGFM 262
Cdd:cd19211   88 ETQKWTVNGDT-RVGLFAVCDIPAGTELTFNYNLDCLGNEKT---VCRCGAPNCSGFL 141
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 125-262 2.52e-20

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 84.59  E-value: 2.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMN-YILVLneyTSDKkqqvtIVDPSRRGNIGRYLNHSCEPN 203
Cdd:cd19212   15 GLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNfYMLTV---TKDR-----IIDAGPKGNYSRFMNHSCNPN 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 204 CHIAAVRIDCPIpKIGIFAARDIAAKEELCFHYggegQYKKMTGGKT-CLCGASKCTGFM 262
Cdd:cd19212   87 CETQKWTVNGDV-RVGLFALCDIPAGMELTFNY----NLDCLGNGRTeCHCGADNCSGFL 141
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 125-237 4.91e-20

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 82.96  E-value: 4.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181  125 GLRTTAKITKGGYICEYAGE-LLTVPEARSRLHDNEKLGLMNYILVLNEYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPN 203
Cdd:pfam00856   3 GLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWARFINHSCDPN 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 161078181  204 CHIAAVRIDCpIPKIGIFAARDIAAKEELCFHYG 237
Cdd:pfam00856  83 CEVRVVYVNG-GPRIVIFALRDIKPGEELTIDYG 115
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 111-237 5.31e-20

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 82.68  E-value: 5.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 111 KHLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEA--RSRLHDNEKLglmNYILVLNeytsdkKQQVtiVDPSR 188
Cdd:cd10519    1 KRLLLGKSDVAGW-GLFLKEPIKKDEFIGEYTGELISQDEAdrRGKIYDKYNS---SYLFNLN------DQFV--VDATR 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 161078181 189 RGNIGRYLNHSCEPNCH--IAAVRIDCpipKIGIFAARDIAAKEELCFHYG 237
Cdd:cd10519   69 KGNKIRFANHSSNPNCYakVMMVNGDH---RIGIFAKRDIEAGEELFFDYG 116
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 125-262 7.01e-20

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 83.23  E-value: 7.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMNYILVlnEYTSDKkqqvtIVDPSRRGNIGRYLNHSCEPNC 204
Cdd:cd19175   13 GLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKGEKNFYMC--EIDKDM-----VIDATFKGNLSRFINHSCDPNC 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 161078181 205 HIAAVRIDcPIPKIGIFAARDIAAKEELCFHYggegQYKKMTGGKTCLCGASKCTGFM 262
Cdd:cd19175   86 ELQKWQVD-GETRIGVFAIRDIKKGEELTYDY----QFVQFGADQDCHCGSKNCRGKL 138
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 115-262 2.50e-18

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 79.36  E-value: 2.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 115 IFDSPVYGsKGLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGLmnYILVLNEYTsdkkqqvtIVDPSRRGNI 192
Cdd:cd19170   18 VYRSPIHG-RGLFCKRNIDAGEMVIEYAGEVIrsVLTDKREKYYESKGIGC--YMFRIDDDE--------VVDATMHGNA 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 193 GRYLNHSCEPNCHIAAVRIDcPIPKIGIFAARDIAAKEELCFHYGGEGQYKKMtggkTCLCGASKCTGFM 262
Cdd:cd19170   87 ARFINHSCEPNCYSRVVNID-GKKHIVIFALRRILRGEELTYDYKFPIEDVKI----PCTCGSKKCRKYL 151
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 125-262 8.63e-18

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 77.86  E-value: 8.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGLmnYILVLNEYTsdkkqqvtIVDPSRRGNIGRYLNHSCEP 202
Cdd:cd19171   27 GLYAARDIEKHTMVIEYIGEIIrnEVANRREKIYESQNRGI--YMFRIDNDW--------VIDATMTGGPARYINHSCNP 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161078181 203 NCHIAAVRIDcPIPKIGIFAARDIAAKEELCFHYGG--EGQYKKMtggkTCLCGASKCTGFM 262
Cdd:cd19171   97 NCVAEVVTFD-KEKKIIIISNRRIAKGEELTYDYKFdfEDDQHKI----PCLCGAPNCRKWM 153
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 110-258 4.45e-17

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 75.92  E-value: 4.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 110 RKHLEIFDSPVYgSKGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGL-MNYILVLNEYTsdkkqqvtIVDPSR 188
Cdd:cd20072   12 KKQLKFARSAIH-NWGLYAMENISAKDMVIEYVGEVIRQQVADEREKRYLRQGIgSSYLFRIDDDT--------VVDATK 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 189 RGNIGRYLNHSCEPNCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHYGGEGQYKKMtggkTCLCGASKC 258
Cdd:cd20072   83 KGNIARFINHCCDPNCTAKIIKVEGE-KRIVIYAKRDIAAGEELTYDYKFPREEDKI----PCLCGAPNC 147
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 103-237 8.31e-17

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 74.92  E-value: 8.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 103 RLVYSGPRKHLEIFDSPVYGsKGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGLMNYILVLNEYtsdkKQQVT 182
Cdd:cd10528    9 ELILSGKEEGLKVIEIDGKG-RGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTGCYMYYFQY----KGKTY 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 161078181 183 IVDPSRR-GNIGRYLNHSC-EPNCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHYG 237
Cdd:cd10528   84 CVDATKEsGRLGRLINHSKkKPNLKTKLLVIDGV-PHLILVAKRDIKPGEELLYDYG 139
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 120-237 2.37e-16

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 73.14  E-value: 2.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 120 VYGSKGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLglmNYILVLNEYTSdkkqqvtIVDPSRRGNIGRYLNHS 199
Cdd:cd10522   11 SHNGLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYDP---LYPFDLNGDIL-------VIDAGKKGNLTRFINHS 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 161078181 200 CEPNCHiAAVRIDCPIPKIGIFAARDIAAKEELCFHYG 237
Cdd:cd10522   81 DQPNLE-LIVRTLKGEQHIGFVAIRDIKPGEELFISYG 117
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 110-262 9.52e-16

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 72.36  E-value: 9.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 110 RKHLEIFDSPVYGsKGLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGLmnYILVLNEYTsdkkqqvtIVDPS 187
Cdd:cd19206   13 KEAVGVYRSPIHG-RGLFCKRNIDAGEMVIEYSGNVIrsILTDKREKYYDSKGIGC--YMFRIDDSE--------VVDAT 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161078181 188 RRGNIGRYLNHSCEPNCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHYggEGQYKKMTGGKTCLCGASKCTGFM 262
Cdd:cd19206   82 MHGNAARFINHSCEPNCYSRVINIDGQ-KHIVIFAMRKIYRGEELTYDY--KFPIEDASNKLPCNCGAKKCRKFL 153
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 124-233 5.29e-15

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 69.61  E-value: 5.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 124 KGLRTTAKITKGGYICEYAGELLTVPEARsrlHDNEKLGLMN-YILVlneYTSDKKQQVtIVDPSRRGNIGRYLNHSCEP 202
Cdd:cd10529   17 KGLVATEDISPGEPILEYKGEVSLRSEFK---EDNGFFKRPSpFVFF---YDGFEGLPL-CVDARKYGNEARFIRRSCRP 89

                         90       100       110
                 ....*....|....*....|....*....|.
gi 161078181 203 NCHIAAVRIDCPIPKIGIFAARDIAAKEELC 233
Cdd:cd10529   90 NAELRHVVVSNGELRLFIFALKDIRKGTEIT 120
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 108-236 5.30e-14

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 66.86  E-value: 5.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 108 GPRKHLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEA--RSRLHDNEklgLMNYILVLNeytSDkkqqvTIVD 185
Cdd:cd19218    1 GSKKHLLLAPSDVAGW-GIFIKDPVQKNEFISEYCGEIISQDEAdrRGKVYDKY---MCSFLFNLN---ND-----FVVD 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 161078181 186 PSRRGNIGRYLNHSCEPNCHiAAVRIDCPIPKIGIFAARDIAAKEELCFHY 236
Cdd:cd19218   69 ATRKGNKIRFANHSVNPNCY-AKVMMVNGDHRIGIFAKRAIQTGEELFFDY 118
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 110-258 6.15e-14

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 67.36  E-value: 6.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 110 RKHLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEARSRLHDNEKLGL-MNYILVLNEYTsdkkqqvtIVDPSR 188
Cdd:cd19169   12 KKQLKFAKSRIHDW-GLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIgSSYLFRVDDDT--------IIDATK 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 189 RGNIGRYLNHSCEPNCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHYGGEGQYKKMtggkTCLCGASKC 258
Cdd:cd19169   83 CGNLARFINHSCNPNCYAKIITVESQ-KKIVIYSKRPIAVNEEITYDYKFPIEDEKI----PCLCGAPQC 147
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 108-236 2.91e-13

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 65.47  E-value: 2.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 108 GPRKHLEIFDSPVYGSkGLRTTAKITKGGYICEYAGELLTVPEA--RSRLHDNEklgLMNYILVLNeytsdkkqQVTIVD 185
Cdd:cd19217    3 GLKKHLLLAPSDVAGW-GTFIKESVQKNEFISEYCGELISQDEAdrRGKVYDKY---MSSFLFNLN--------NDFVVD 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 161078181 186 PSRRGNIGRYLNHSCEPNCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHY 236
Cdd:cd19217   71 ATRKGNKIRFANHSVNPNCYAKVVMVNGD-HRIGIFAKRAIQQGEELFFDY 120
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 192-237 1.72e-12

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 61.11  E-value: 1.72e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 161078181 192 IGRYLNHSCEPNCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHYG 237
Cdd:cd08161   28 LARFINHSCEPNCEFEEVYVGGK-PRVFIVALRDIKAGEELTVDYG 72
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 115-262 7.50e-11

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 59.27  E-value: 7.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 115 IFDSPVYGsKGLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGLmnYILVLNEYTsdkkqqvtIVDPSRRGNI 192
Cdd:cd19207   18 VYRSAIHG-RGLFCKRNIDAGEMVIEYSGIVIrsVLTDKREKFYDSKGIGC--YMFRIDDFD--------VVDATMHGNA 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 193 GRYLNHSCEPNCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHYggEGQYKKMTGGKTCLCGASKCTGFM 262
Cdd:cd19207   87 ARFINHSCEPNCYSRVIHVEGQ-KHIVIFALRKIYRGEELTYDY--KFPIEDASNKLPCNCGAKRCRRFL 153
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 125-260 1.39e-10

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 58.50  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGlMNYILVLNeytsdkkqQVTIVDPSRRGNIGRYLNHSCEP 202
Cdd:cd19204   27 GLFAMEPIAADEMVIEYVGQNIrqVVADMREKRYVQEGIG-SSYLFRVD--------HDTIIDATKCGNLARFINHCCTP 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 161078181 203 NCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHYGGEGQYKKMtggkTCLCGASKCTG 260
Cdd:cd19204   98 NCYAKVITIESQ-KKIVIYSKQPIGVNEEITYDYKFPIEDNKI----PCLCGTENCRG 150
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 125-260 3.59e-10

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 57.37  E-value: 3.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGlMNYILVLNeytsdkkqQVTIVDPSRRGNIGRYLNHSCEP 202
Cdd:cd19205   27 GLFAMEPIAADEMVIEYVGQNIrqVIADMREKRYEDEGIG-SSYMFRVD--------HDTIIDATKCGNFARFINHSCNP 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 161078181 203 NCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHYGGEGQYKKMtggkTCLCGASKCTG 260
Cdd:cd19205   98 NCYAKVITVESQ-KKIVIYSKQHINVNEEITYDYKFPIEDVKI----PCLCGSENCRG 150
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 125-237 1.36e-09

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 54.89  E-value: 1.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELLTVPEARSRLHdneKLGLMNYILVLNEytsDKKQQVtivDPSRRGNIGRYLNHSCEP-- 202
Cdd:cd19168   15 GLFAAEDIKEGEFVIEYTGELISHDEGVRREH---RRGDVSYLYLFEE---QEGIWV---DAAIYGNLSRYINHATDKvk 85

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 161078181 203 --NChIAAVRIDCPIPKIGIFAARDIAAKEELCFHYG 237
Cdd:cd19168   86 tgNC-MPKIMYVNHEWRIKFTAIKDIKIGEELFFNYG 121
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 125-262 7.74e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 50.78  E-value: 7.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGLMNYiLVLNEYtsdkkqqvtIVDPSRRGNIGRYLNHSCEP 202
Cdd:cd19208   28 GLYAARDIEKHTMVIEYIGTIIrnEVANRKEKLYESQNRGVYMF-RIDNDH---------VIDATLTGGPARYINHSCAP 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 161078181 203 NCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHYG---GEGQYKkmtggKTCLCGASKCTGFM 262
Cdd:cd19208   98 NCVAEVVTFEKG-HKIIISSSRRIQKGEELCYDYKfdfEDDQHK-----IPCHCGAVNCRKWM 154
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 125-262 9.47e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 50.46  E-value: 9.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 125 GLRTTAKITKGGYICEYAGELL--TVPEARSRLHDNEKLGLMNYiLVLNEYtsdkkqqvtIVDPSRRGNIGRYLNHSCEP 202
Cdd:cd19209   29 GLYAAKDLEKHTMVIEYIGTIIrnEVANRREKIYEEQNRGIYMF-RINNEH---------VIDATLTGGPARYINHSCAP 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 203 NCHIAAVRIDCPiPKIGIFAARDIAAKEELCFHYggEGQYKKMTGGKTCLCGASKCTGFM 262
Cdd:cd19209   99 NCVAEVVTFDKE-DKIIIISSRRIPKGEELTYDY--QFDFEDDQHKIPCHCGAWNCRKWM 155
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 132-242 7.20e-07

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 47.40  E-value: 7.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 132 ITKGGYICEYAGElltVPEARSRLHD--NEKLGLMnyilvlneYTSDKKQQVTIVdPSRRGNIGRYL----NHSCE---- 201
Cdd:cd10539   24 IKDLTIIAEYTGD---VDYIRNREFDdnDSIMTLL--------LAGDPSKSLVIC-PDKRGNIARFIsginNHTKDgkkk 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 161078181 202 PNCHIAAVRIDCPIpKIGIFAARDIAAKEELCFHY-GGEGQY 242
Cdd:cd10539   92 QNCKCVRYSINGEA-RVLLVATRDIAKGERLYYDYnGYEHEY 132
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 195-258 1.03e-06

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 46.60  E-value: 1.03e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161078181 195 YLNHSCEPNCHIaavrIDCPIPKIGIFAARDIAAKEELCFHYGGEGQYK-------KMTGGKTCLCgaSKC 258
Cdd:cd20071   58 LLNHSCDPNAVV----VFDGNGTLRVRALRDIKAGEELTISYIDPLLPRterrrelLEKYGFTCSC--PRC 122
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 112-239 2.42e-06

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 45.32  E-value: 2.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 112 HLEIFDSPVYGsKGLRTTAKITKGGYIcEYAGELLTVPEARSrlhDNEKLGLMNYILvlneytsdkkqqvtivdpsrRGN 191
Cdd:cd10540    1 RLEVKPSTLKG-RGVFATRPIKKGEVI-EEAPVIVLPKEEYQ---HLCKTVLDHYVF--------------------SWG 55

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 161078181 192 IGRYL---------NHSCEPNchiAAVRIDCPIPKIGIFAARDIAAKEELCFHYGGE 239
Cdd:cd10540   56 DGCLAlalgygsmfNHSYTPN---AEYEIDFENQTIVFYALRDIEAGEELTINYGDD 109
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 124-232 9.75e-06

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 44.70  E-value: 9.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181 124 KGLRTTAKITKGGYICEYAGEL----------------LTVPEARSRLHDNEKLglmnYIlvlneytsdkkqqvtivDPS 187
Cdd:cd19183   14 FGLFADRPIPAGDPIQELLGEIglqseyiadpenqyqiLGAPKPHVFFHPQSPL----YI-----------------DTR 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 161078181 188 RRGNIGRYLNHSCEPNCHIAAVRIDC-PIPKIGIFAARDIAAKEEL 232
Cdd:cd19183   73 RSGSVARFIRRSCRPNAELVTVASDSgSVLKFVLYASRDISPGEEI 118
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 196-237 1.54e-03

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 38.82  E-value: 1.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 161078181 196 LNHSCEPNCHIAAVRidcpiPKIGIFAARDIAAKEELCFHYG 237
Cdd:cd10536  154 LNHSCDPNTIRSFYG-----NTIVVRATRPIKKGEEITICYG 190
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 37-103 4.17e-03

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 35.86  E-value: 4.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078181   37 FLADEYNSVLLNPCHCKGaCENSE-VCAH--GGQYEFTEDGSELILRNSANPVIECNDMCKcCRNTCSNR 103
Cdd:pfam05033  32 IYPKEFLLIIPQGCDCGD-CSSEKcSCAQlnGGEFRFPYDKDGLLVPESKPPIYECNPLCG-CPPSCPNR 99
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 196-240 5.45e-03

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 37.43  E-value: 5.45e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 161078181 196 LNHScePNCHIAAVRIDCPIPKIGIFAARDIAAKEELCFHYGGEG 240
Cdd:cd10527  183 LNHS--PDAPNVRYEYDEDEGSFVLVATRDIAAGEEVFISYGPKS 225
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 194-237 6.05e-03

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 36.10  E-value: 6.05e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 161078181 194 RYLNHSCEPNCHIAAVridcPIPKIGIFAARDIAAKEELCFHYG 237
Cdd:cd10524   78 AFINHDCRPNCKFVPT----GKSTACVKVLRDIEPGEEITVYYG 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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